{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:52:58Z","timestamp":1792882378268,"version":"4.5.0"},"reference-count":109,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100010578","name":"Deutsche Gesellschaft f\u00fcr Kardiologie-Herz und Kreislaufforschung.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010578","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000764","name":"King&apos;s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010872","name":"King&apos;s College Hospital NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010872","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.yjmcc.2014.02.002","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T08:01:46Z","timestamp":1392105706000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":100,"special_numbering":"C","title":["Redox regulation of cardiac hypertrophy"],"prefix":"10.1016","volume":"73","author":[{"given":"Can M.","family":"Sag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celio X.C.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2014.02.002_bb0005","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling-concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an international forum on cardiac remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0010","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2741\/2681","article-title":"Physiological myocardial hypertrophy: how and why?","volume":"13","author":"Catalucci","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0015","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1172\/JCI24682","article-title":"Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure","volume":"115","author":"Shiojima","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0020","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0140-6736(06)68074-4","article-title":"Controversies in ventricular remodelling","volume":"367","author":"Opie","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0025","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/CIRCRESAHA.111.255216","article-title":"Redox signaling in cardiac physiology and pathology","volume":"111","author":"Burgoyne","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0030","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol Rev"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0035","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1172\/JCI200524408","article-title":"Oxygen, oxidative stress, hypoxia, and heart failure","volume":"115","author":"Giordano","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0040","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2010.01.009","article-title":"Inactivation of peroxiredoxin I by phosphorylation allows localized H2O2 accumulation for cell signaling","volume":"140","author":"Woo","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0045","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1089\/ars.2012.4914","article-title":"Reductive stress linked to small HSPs, G6PD, and Nrf2 pathways in heart disease","volume":"18","author":"Brewer","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0050","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1161\/01.HYP.0000032031.30374.32","article-title":"Activation of NADPH oxidase during progression of cardiac hypertrophy to failure","volume":"40","author":"Li","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0055","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI21968","article-title":"Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load","volume":"115","author":"Takimoto","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0060","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCRESAHA.110.232306","article-title":"Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure","volume":"108","author":"Dai","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0065","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.cardfail.2008.06.006","article-title":"Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice","volume":"14","author":"Xu","year":"2008","journal-title":"J Card Fail"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0070","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.freeradbiomed.2009.05.004","article-title":"Mitochondria and reactive oxygen species","volume":"47","author":"Kowaltowski","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0075","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.jacc.2012.08.1021","article-title":"Mitochondria as a therapeutic target in heart failure","volume":"61","author":"Bayeva","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0080","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1161\/01.RES.85.4.357","article-title":"Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium","volume":"85","author":"Ide","year":"1999","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0085","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.1128\/MCB.24.21.9414-9423.2004","article-title":"Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function","volume":"24","author":"Conrad","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0090","doi-asserted-by":"crossref","first-page":"33669","DOI":"10.1074\/jbc.M111.284612","article-title":"Thioredoxin reductase-2 is essential for keeping low levels of H(2)O(2) emission from isolated heart mitochondria","volume":"286","author":"Stanley","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0095","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1161\/CIRCULATIONAHA.108.822403","article-title":"Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging","volume":"119","author":"Dai","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0100","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1096\/fj.11-184622","article-title":"The sarcoplasmic reticulum luminal thiol oxidase ERO1 regulates cardiomyocyte excitation-coupled calcium release and response to hemodynamic load","volume":"25","author":"Chin","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0105","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.freeradbiomed.2010.04.030","article-title":"NADPH oxidases in cardiovascular disease","volume":"49","author":"Brandes","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0110","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.freeradbiomed.2009.07.023","article-title":"Nox proteins in signal transduction","volume":"47","author":"Brown","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1089\/ars.2013.5262","article-title":"Endoplasmic reticulum stress and nox-mediated reactive oxygen species signaling in the peripheral vasculature: potential role in hypertension","volume":"20","author":"Santos","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0120","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1161\/CIRCULATIONAHA.112.090977","article-title":"Pathological cardiac hypertrophy alters intracellular targeting of phosphodiesterase type 5 from nitric oxide synthase-3 to natriuretic peptide signaling","volume":"126","author":"Zhang","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0125","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1172\/JCI200314172","article-title":"Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension","volume":"111","author":"Landmesser","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0130","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/nature09599","article-title":"S-glutathionylation uncouples eNOS and regulates its cellular and vascular function","volume":"468","author":"Chen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0135","first-page":"1323","article-title":"Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia\/reperfusion injury","volume":"2011","author":"Kaludercic","year":"1813","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0140","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/ars.2012.4616","article-title":"Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts","volume":"20","author":"Kaludercic","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0145","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/HYPERTENSIONAHA.112.191478","article-title":"Knockdown of cytochrome P450 2E1 inhibits oxidative stress and apoptosis in the cTnT(R141W) dilated cardiomyopathy transgenic mice","volume":"60","author":"Lu","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0150","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1111\/j.1742-4658.2008.06489.x","article-title":"Mammalian xanthine oxidoreductase \u2014 mechanism of transition from xanthine dehydrogenase to xanthine oxidase","volume":"275","author":"Nishino","year":"2008","journal-title":"FEBS J"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0155","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1161\/01.RES.0000200181.59551.71","article-title":"Xanthine oxidoreductase inhibition causes reverse remodeling in rats with dilated cardiomyopathy","volume":"98","author":"Minhas","year":"2006","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0160","series-title":"Free radicals in biology and medicine","author":"Halliwell","year":"2007"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0165","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0170","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0140-6736(11)60894-5","article-title":"In search of new therapeutic targets and strategies for heart failure: recent advances in basic science","volume":"378","author":"Shah","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0175","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.freeradbiomed.2011.01.003","article-title":"Redox signaling in cardiac myocytes","volume":"50","author":"Santos","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0180","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.cell.2008.04.041","article-title":"A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy","volume":"133","author":"Ago","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0185","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1161\/CIRCRESAHA.111.263665","article-title":"Neurohormonal regulation of cardiac histone deacetylase 5 nuclear localization by phosphorylation-dependent and phosphorylation-independent mechanisms","volume":"110","author":"Haworth","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0190","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/hc0302.103712","article-title":"Pivotal role of a gp91(phox)-containing NADPH oxidase in angiotensin II-induced cardiac hypertrophy in mice","volume":"105","author":"Bendall","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0195","doi-asserted-by":"crossref","first-page":"7432","DOI":"10.1073\/pnas.0510444103","article-title":"Requirement of Rac1 in the development of cardiac hypertrophy","volume":"103","author":"Satoh","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0200","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0022-2828(03)00145-7","article-title":"NADPH oxidase-derived superoxide anion mediates angiotensin II-induced cardiac hypertrophy","volume":"35","author":"Nakagami","year":"2003","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0205","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1152\/physiolgenomics.00029.2005","article-title":"Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy","volume":"26","author":"Hingtgen","year":"2006","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0210","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/01.RES.0000100665.67510.F5","article-title":"Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling","volume":"93","author":"Izumiya","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0215","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/hc0402.102863","article-title":"Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist-induced cardiomyocyte hypertrophy","volume":"105","author":"Hirotani","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0220","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1006\/bbrc.2001.6068","article-title":"Reactive oxygen species in mechanical stress-induced cardiac hypertrophy","volume":"289","author":"Aikawa","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0225","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1161\/01.CIR.0000157148.59308.F5","article-title":"Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras","volume":"111","author":"Kuster","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0230","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.yjmcc.2006.05.009","article-title":"Strain-stimulated hypertrophy in cardiac myocytes is mediated by reactive oxygen species-dependent Ras S-glutathiolation","volume":"41","author":"Pimentel","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0235","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/01.RES.0000099504.30207.F5","article-title":"Contrasting roles of NADPH oxidase isoforms in pressure-overload versus angiotensin II-induced cardiac hypertrophy","volume":"93","author":"Byrne","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0240","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1161\/CIRCRESAHA.113.301787","volume":"113","author":"Sciarretta","year":"2013","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0245","doi-asserted-by":"crossref","first-page":"18121","DOI":"10.1073\/pnas.1009700107","article-title":"NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis","volume":"107","author":"Zhang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0250","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1681\/ASN.2012040373","article-title":"NADPH-oxidase 4 protects against kidney fibrosis during chronic renal injury","volume":"23","author":"Nlandu Khodo","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0255","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1161\/CIRCRESAHA.112.267054","article-title":"Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase","volume":"110","author":"Schroder","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0260","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.freeradbiomed.2011.04.022","article-title":"Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo","volume":"51","author":"Brewer","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0265","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1089\/ars.2012.4550","article-title":"NADPH oxidases in heart failure: poachers or gamekeepers?","volume":"18","author":"Zhang","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0270","doi-asserted-by":"crossref","first-page":"15565","DOI":"10.1073\/pnas.1002178107","article-title":"NADPH oxidase 4 (Nox4) is a major source of oxidative stress in the failing heart","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0275","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1515\/BC.2006.167","article-title":"Redox regulation of the hypoxia-inducible factor","volume":"387","author":"Pouyssegur","year":"2006","journal-title":"Biol Chem"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0280","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1126\/science.1144318","article-title":"Cysteine redox sensor in PKGIa enables oxidant-induced activation","volume":"317","author":"Burgoyne","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0285","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1089\/ars.2012.4818","article-title":"Redox regulation of sodium and calcium handling","volume":"18","author":"Wagner","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0290","doi-asserted-by":"crossref","first-page":"21827","DOI":"10.1074\/jbc.M603952200","article-title":"Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation","volume":"281","author":"Brennan","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0295","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","article-title":"A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation","volume":"133","author":"Erickson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0300","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/nm.2506","article-title":"Oxidation of CaMKII determines the cardiotoxic effects of aldosterone","volume":"17","author":"He","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0305","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1161\/CIRCULATIONAHA.113.003313","article-title":"Oxidized CaMKII triggers atrial fibrillation","volume":"128","author":"Purohit","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0310","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1172\/JCI65268","article-title":"Diabetes increases mortality after myocardial infarction by oxidizing CaMKII","volume":"123","author":"Luo","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0315","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/CIRCULATIONAHA.110.943431","article-title":"Differential cardiac remodeling in preload versus afterload","volume":"122","author":"Toischer","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0320","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cardiores.2006.02.019","article-title":"Redox regulation of cardiac calcium channels and transporters","volume":"71","author":"Zima","year":"2006","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0325","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCRESAHA.108.184457","article-title":"Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure","volume":"103","author":"Terentyev","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0330","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ceca.2004.07.001","article-title":"Nitroxyl triggers Ca2+ release from skeletal and cardiac sarcoplasmic reticulum by oxidizing ryanodine receptors","volume":"37","author":"Cheong","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0335","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1161\/01.RES.0000253904.53601.c9","article-title":"Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling","volume":"100","author":"Tocchetti","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0340","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00395-013-0385-6","article-title":"Ionizing radiation regulates cardiac Ca handling via increased ROS and activated CaMKII","volume":"108","author":"Sag","year":"2013","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0345","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.yjmcc.2011.07.016","article-title":"CaMKII-dependent SR Ca leak contributes to doxorubicin-induced impaired Ca handling in isolated cardiac myocytes","volume":"51","author":"Sag","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0350","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1126\/science.1202768","article-title":"X-ROS signaling: rapid mechano-chemo transduction in heart","volume":"333","author":"Prosser","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0355","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/j.yjmcc.2005.08.010","article-title":"Tachycardia increases NADPH oxidase activity and RyR2 S-glutathionylation in ventricular muscle","volume":"39","author":"Sanchez","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0360","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1089\/ars.2012.5057","article-title":"HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization","volume":"19","author":"Sivakumaran","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0365","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1161\/01.RES.80.1.76","article-title":"Hydroxyl radical inhibits sarcoplasmic reticulum Ca(2+)-ATPase function by direct attack on the ATP binding site","volume":"80","author":"Xu","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0370","first-page":"H823","article-title":"Free radicals enhance Na+\/Ca2+ exchange in ventricular myocytes","volume":"271","author":"Goldhaber","year":"1996","journal-title":"Am J Physiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0375","first-page":"337","article-title":"Free radicals irreversibly decrease Ca2+ currents in isolated guinea-pig ventricular myocytes","volume":"292","author":"Gill","year":"1995","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0380","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s00424-008-0477-6","article-title":"Oxidation of multiple methionine residues impairs rapid sodium channel inactivation","volume":"456","author":"Kassmann","year":"2008","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0385","doi-asserted-by":"crossref","first-page":"9921","DOI":"10.1074\/jbc.R110.175489","article-title":"Redox signaling and cardiac sarcomeres","volume":"286","author":"Sumandea","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0390","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.bpj.2009.05.037","article-title":"Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence","volume":"97","author":"Grutzner","year":"2009","journal-title":"Biophys J"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0395","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1161\/CIRCRESAHA.112.270827","article-title":"et al. Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function","volume":"111","author":"Gao","year":"2012","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0400","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-Induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"Sano","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0405","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cmet.2009.05.005","article-title":"Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy","volume":"9","author":"Krishnan","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0410","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/CIRCULATIONAHA.111.030775","article-title":"NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation","volume":"124","author":"Craige","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0415","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1172\/JCI65112","article-title":"NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth","volume":"123","author":"Jaba","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0420","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/cvr\/cvq308","article-title":"Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart","volume":"89","author":"Creemers","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0425","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrcardio.2012.158","article-title":"Myofibroblast-mediated mechanisms of pathological remodelling of the heart","volume":"10","author":"Weber","year":"2013","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0430","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1172\/JCI44824","article-title":"Pivotal role of cardiomyocyte TGF-beta signaling in the murine pathological response to sustained pressure overload","volume":"121","author":"Koitabashi","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0435","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0440","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1096\/fj.05-4642fje","article-title":"Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase","volume":"20","author":"Johar","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0445","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jacc.2005.09.051","article-title":"Involvement of the nicotinamide adenosine dinucleotide phosphate oxidase isoform Nox2 in cardiac contractile dysfunction occurring in response to pressure overload","volume":"47","author":"Grieve","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0450","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1161\/HYPERTENSIONAHA.107.101980","article-title":"Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction","volume":"51","author":"Looi","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0455","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/01.RES.0000261657.76299.ff","article-title":"Critical role of the NAD(P)H oxidase subunit p47phox for left ventricular remodeling\/dysfunction and survival after myocardial infarction","volume":"100","author":"Doerries","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0460","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/HYPERTENSIONAHA.109.135392","article-title":"Critical role of apoptosis signal-regulating kinase 1 in aldosterone\/salt-induced cardiac inflammation and fibrosis","volume":"54","author":"Nakamura","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2014.02.572","article-title":"Endothelial NADPH oxidase-2 promotes interstitial cardiac fibrosis and diastolic dysfunction through pro-inflammatory effects and endothelial\u2013mesenchymal transition","author":"Murdoch CE","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0470","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1161\/01.CIR.0000144303.24894.1C","article-title":"Allopurinol attenuates left ventricular remodeling and dysfunction after experimental myocardial infarction: a new action for an old drug?","volume":"110","author":"Engberding","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0475","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/MAJ.0b013e318157388f","article-title":"Oxidative stress and cardiac repair\/remodeling following infarction","volume":"334","author":"Sun","year":"2007","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0480","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/jcp.56.3.194","article-title":"Increased Nox2 expression in human cardiomyocytes after acute myocardial infarction","volume":"56","author":"Krijnen","year":"2003","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0485","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1161\/01.CIR.0000016721.84535.00","article-title":"Beneficial effects of long-term use of the antioxidant probucol in heart failure in the rat","volume":"105","author":"Sia","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0490","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1253\/circj.CJ-08-0072","article-title":"Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: the possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase","volume":"72","author":"Masano","year":"2008","journal-title":"Circ J"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0495","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.lfs.2007.07.019","article-title":"Nitric oxide and cardiac function","volume":"81","author":"Rastaldo","year":"2007","journal-title":"Life Sci"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0500","doi-asserted-by":"crossref","first-page":"13258","DOI":"10.1073\/pnas.1100286108","article-title":"Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia\u2013reperfusion","volume":"108","author":"Fauconnier","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0510","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1001\/jama.293.11.1338","article-title":"Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial","volume":"293","author":"Lonn","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0515","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1056\/NEJMoa1007097","article-title":"Residual NADPH oxidase and survival in chronic granulomatous disease","volume":"363","author":"Kuhns","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0520","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1161\/CIRCULATIONAHA.107.737031","article-title":"Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy","volume":"117","author":"Moens","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0525","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1161\/CIRCULATIONAHA.111.038919","article-title":"Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease","volume":"125","author":"Cunnington","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0530","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jacc.2010.12.044","article-title":"Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy","volume":"58","author":"Dai","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0535","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/HYPERTENSIONAHA.109.130351","article-title":"Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy","volume":"54","author":"Graham","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0540","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1161\/CIRCULATIONAHA.109.872481","article-title":"Thioredoxin-1 gene therapy enhances angiogenic signaling and reduces ventricular remodeling in infarcted myocardium of diabetic rats","volume":"121","author":"Samuel","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0545","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/cvr\/cvt150","article-title":"Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy","volume":"100","author":"Kannan","year":"2013","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2014.02.002_bb0550","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1152\/physrev.00018.2010","article-title":"CaMKII in the cardiovascular system: sensing redox states","volume":"91","author":"Erickson","year":"2011","journal-title":"Physiol Rev"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281400042X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281400042X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:23:43Z","timestamp":1758313423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228281400042X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":109,"alternative-id":["S002228281400042X"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2014.02.002","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Redox regulation of cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2014.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}