{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:18:31Z","timestamp":1790713111751,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00c3\u00a4rt-Lungfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL082772"],"award-info":[{"award-number":["R01-HL082772"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL73898"],"award-info":[{"award-number":["R01-HL73898"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-HL082772-0351"],"award-info":[{"award-number":["R01-HL082772-0351"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.yjmcc.2014.07.014","type":"journal-article","created":{"date-parts":[[2014,8,2]],"date-time":"2014-08-02T17:02:21Z","timestamp":1406998941000},"page":"174-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Biglycan deficiency: Increased aortic aneurysm formation and lack of atheroprotection"],"prefix":"10.1016","volume":"75","author":[{"given":"Tao","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel C.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia G.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan H.","family":"Yoder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"M\u00fceller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens W.","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin Jon","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa R.","family":"Tannock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.yjmcc.2014.07.014_bb0005","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1359\/jbmr.2002.17.7.1180","article-title":"Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers\u2013Danlos-like changes in bone and other connective tissues","volume":"17","author":"Corsi","year":"2002","journal-title":"J Bone Miner Res"},{"issue":"7","key":"10.1016\/j.yjmcc.2014.07.014_bb0010","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1096\/fj.01-0848com","article-title":"Abnormal collagen fibrils in tendons of biglycan\/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritis","volume":"16","author":"Ameye","year":"2002","journal-title":"FASEB J"},{"issue":"21","key":"10.1016\/j.yjmcc.2014.07.014_bb0015","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1161\/CIRCULATIONAHA.106.653980","article-title":"Biglycan deficiency causes spontaneous aortic dissection and rupture in mice","volume":"115","author":"Heegaard","year":"2007","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.yjmcc.2014.07.014_bb0020","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/(SICI)1097-0029(19970815)38:4<428::AID-JEMT10>3.0.CO;2-L","article-title":"Elastic fiber during development and aging","volume":"38","author":"Pasquali-Ronchetti","year":"1997","journal-title":"Microsc Res Tech"},{"issue":"6","key":"10.1016\/j.yjmcc.2014.07.014_bb0025","first-page":"e85","article-title":"Heart disease and stroke statistics\u20142006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"113","author":"Thom","year":"2006","journal-title":"Circulation"},{"issue":"9470","key":"10.1016\/j.yjmcc.2014.07.014_bb0030","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(05)66459-8","article-title":"Abdominal aortic aneurysm","volume":"365","author":"Sakalihasan","year":"2005","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.07.014_bb0035","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1006\/jsre.1997.5201","article-title":"Proteoglycan gene expression is decreased in abdominal aortic aneurysms","volume":"74","author":"Tamarina","year":"1998","journal-title":"J Surg Res"},{"issue":"2","key":"10.1016\/j.yjmcc.2014.07.014_bb0040","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0021-9150(02)00231-9","article-title":"Decreased biglycan expression and differential decorin localization in human abdominal aortic aneurysms","volume":"165","author":"Theocharis","year":"2002","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.yjmcc.2014.07.014_bb0045","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1194\/jlr.M700329-JLR200","article-title":"Angiotensin II increases vascular proteoglycan content preceding and contributing to atherosclerosis development","volume":"49","author":"Huang","year":"2008","journal-title":"J Lipid Res"},{"issue":"5","key":"10.1016\/j.yjmcc.2014.07.014_bb0050","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/ATVBAHA.106.134080","article-title":"Early human atherosclerosis: accumulation of lipid and proteoglycans in intimal thickenings followed by macrophage infiltration","volume":"27","author":"Nakashima","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.yjmcc.2014.07.014_bb0055","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/01.CIR.98.6.519","article-title":"Comparison of apolipoprotein and proteoglycan deposits in human coronary atherosclerotic plaques: co-localization of biglycan with apolipoproteins","volume":"98","author":"O'Brien","year":"1998","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.07.014_bb0060","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.atherosclerosis.2014.03.037","article-title":"Increased atherosclerosis in mice with increased vascular biglycan content","volume":"235","author":"Thompson","year":"2014","journal-title":"Atherosclerosis"},{"issue":"8","key":"10.1016\/j.yjmcc.2014.07.014_bb0180","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1194\/jlr.P040139","article-title":"Prevention of TGFb induction attenuates angiotensin II-stimulated vascular biglycan and atherosclerosis in Ldlr \u2212\/\u2212 mice","volume":"54","author":"Tang","year":"2013","journal-title":"J Lipid Res"},{"issue":"11","key":"10.1016\/j.yjmcc.2014.07.014_bb0070","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1172\/JCI7818","article-title":"Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice","volume":"105","author":"Daugherty","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2014.07.014_bb0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.2011.06332.x","article-title":"Relevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms","volume":"1245","author":"Bruemmer","year":"2011","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"10.1016\/j.yjmcc.2014.07.014_bb0080","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/01.ATV.15.5.551","article-title":"The response-to-retention hypothesis of early atherogenesis","volume":"15","author":"Williams","year":"1995","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.07.014_bb0085","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/1746","article-title":"Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice","volume":"20","author":"Xu","year":"1998","journal-title":"Nat Genet"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.07.014_bb0090","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/03008207.2012.715700","article-title":"Decreased body fat, elevated plasma transforming growth factor-beta levels, and impaired BMP4-like signaling in biglycan-deficient mice","volume":"54","author":"Tang","year":"2013","journal-title":"Connect Tissue Res"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.07.014_bb0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.carpath.2012.05.005","article-title":"Altered collagen expression in jugular veins in multiple sclerosis","volume":"22","author":"Coen","year":"2013","journal-title":"Cardiovasc Pathol"},{"issue":"4","key":"10.1016\/j.yjmcc.2014.07.014_bb0100","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00395-010-0091-6","article-title":"Proatherogenic effects of estradiol in a model of accelerated atherosclerosis in ovariectomized ApoE-deficient mice","volume":"105","author":"Freudenberger","year":"2010","journal-title":"Basic Res Cardiol"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.07.014_bb0185","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/03008207.2012.715700","article-title":"Decreased body fat, elevated plasma transforming growth factor-beta levels, and impaired BMP4-like signaling in biglycan-deficient mice","volume":"54","author":"Tang","year":"2012","journal-title":"Connect Tissue Res"},{"issue":"3","key":"10.1016\/j.yjmcc.2014.07.014_bb0110","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1161\/hq0302.105378","article-title":"Accumulation of biglycan and perlecan, but not versican, in lesions of murine models of atherosclerosis","volume":"22","author":"Kunjathoor","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.07.014_bb0115","first-page":"43","article-title":"Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell proliferation","volume":"103","author":"Tran-Lundmark","year":"2008","journal-title":"Circ Res"},{"issue":"10","key":"10.1016\/j.yjmcc.2014.07.014_bb0120","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1194\/jlr.M400019-JLR200","article-title":"Atherosclerosis in perlecan heterozygous mice","volume":"45","author":"Vikramadithyan","year":"2004","journal-title":"J Lipid Res"},{"issue":"10","key":"10.1016\/j.yjmcc.2014.07.014_bb0125","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1161\/CIRCULATIONAHA.107.714147","article-title":"Biglycan is required for adaptive remodeling after myocardial infarction","volume":"117","author":"Westermann","year":"2008","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.07.014_bb0130","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.2516","article-title":"Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway","volume":"218","author":"Gomez","year":"2009","journal-title":"J Pathol"},{"issue":"6","key":"10.1016\/j.yjmcc.2014.07.014_bb0135","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1161\/ATVBAHA.107.141069","article-title":"Developmental basis of vascular smooth muscle diversity","volume":"27","author":"Majesky","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"4","key":"10.1016\/j.yjmcc.2014.07.014_bb0140","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s11883-010-0111-x","article-title":"Novel genetic mechanisms for aortic aneurysms","volume":"12","author":"Tromp","year":"2010","journal-title":"Curr Atheroscler Rep"},{"issue":"5\u20136","key":"10.1016\/j.yjmcc.2014.07.014_bb0145","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0753-3322(03)00065-9","article-title":"Extracellular matrix remodeling and matrix metalloproteinases in the vascular wall during aging and in pathological conditions","volume":"57","author":"Jacob","year":"2003","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10.1016\/j.yjmcc.2014.07.014_bb0150","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1247\/csf.25.69","article-title":"Elastic and collagenous networks in vascular diseases","volume":"25","author":"Arteaga-Solis","year":"2000","journal-title":"Cell Struct Funct"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.07.014_bb0155","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ng0194-64","article-title":"Mutations in the fibrillin gene responsible for dominant ectopia lentis and neonatal Marfan syndrome","volume":"6","author":"Kainulainen","year":"1994","journal-title":"Nat Genet"},{"issue":"6","key":"10.1016\/j.yjmcc.2014.07.014_bb0160","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1074\/jbc.M109540200","article-title":"Molecular interactions of biglycan and decorin with elastic fiber components: biglycan forms a ternary complex with tropoelastin and microfibril-associated glycoprotein 1","volume":"277","author":"Reinboth","year":"2002","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.yjmcc.2014.07.014_bb0165","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.2353\/ajpath.2008.070875","article-title":"Retrovirally mediated overexpression of glycosaminoglycan-deficient biglycan in arterial smooth muscle cells induces tropoelastin synthesis and elastic fiber formation in vitro and in neointimae after vascular injury","volume":"173","author":"Hwang","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.yjmcc.2014.07.014_bb0170","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1161\/01.ATV.14.1.115","article-title":"Glycosaminoglycan fractions from human arteries presenting diverse susceptibilities to atherosclerosis have different binding affinities to plasma low density lipoprotein","volume":"14","author":"Cardoso","year":"1994","journal-title":"Arterioscler Thromb"},{"issue":"2","key":"10.1016\/j.yjmcc.2014.07.014_bb0175","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1172\/JCI108491","article-title":"The glycosaminoglycans of the human artery and their changes in atherosclerosis","volume":"58","author":"Stevens","year":"1976","journal-title":"J Clin Invest"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282814002405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282814002405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:23:20Z","timestamp":1758313400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282814002405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":35,"alternative-id":["S0022282814002405"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2014.07.014","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biglycan deficiency: Increased aortic aneurysm formation and lack of atheroprotection","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2014.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}