{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:12:10Z","timestamp":1788829930230,"version":"build-2803163510"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010257","name":"Collaborative Innovation Center for Cardiovascular Disease Translational Medicine","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010257","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.yjmcc.2014.11.006","type":"journal-article","created":{"date-parts":[[2014,11,16]],"date-time":"2014-11-16T20:27:57Z","timestamp":1416169677000},"page":"145-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":66,"special_numbering":"C","title":["Pellino1-mediated TGF-\u03b21 synthesis contributes to mechanical stress induced cardiac fibroblast activation"],"prefix":"10.1016","volume":"79","author":[{"given":"Juan","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuanzhu","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linli","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanfu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.yjmcc.2014.11.006_bb0005","doi-asserted-by":"crossref","first-page":"H1043","DOI":"10.1152\/ajpheart.00990.2002","article-title":"Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus","volume":"284","author":"Morisco","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10.1016\/j.yjmcc.2014.11.006_bb0010","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCULATIONAHA.113.001878","article-title":"Pathological ventricular remodeling: mechanisms: part 1 of 2","volume":"128","author":"Burchfield","year":"2013","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.yjmcc.2014.11.006_bb0015","doi-asserted-by":"crossref","first-page":"H1015","DOI":"10.1152\/ajpheart.00023.2006","article-title":"Cardiac fibroblasts: friend or foe?","volume":"291","author":"Baudino","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.yjmcc.2014.11.006_bb0020","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pharmthera.2009.05.002","article-title":"Cardiac fibroblasts: at the heart of myocardial remodeling","volume":"123","author":"Porter","year":"2009","journal-title":"Pharmacol Ther"},{"issue":"2","key":"10.1016\/j.yjmcc.2014.11.006_bb0025","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cardiores.2006.10.002","article-title":"The role of TGF-beta signaling in myocardial infarction and cardiac remodeling","volume":"74","author":"Bujak","year":"2007","journal-title":"Cardiovasc Res"},{"issue":"5","key":"10.1016\/j.yjmcc.2014.11.006_bb0030","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1161\/HYPERTENSIONAHA.109.147611","article-title":"Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling","volume":"55","author":"Huang","year":"2010","journal-title":"Hypertension"},{"issue":"1-2","key":"10.1016\/j.yjmcc.2014.11.006_bb0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1023\/A:1007046105745","article-title":"Cyclic stretch induces the release of growth promoting factors from cultured neonatal cardiomyocytes and cardiac fibroblasts","volume":"208","author":"Ruwhof","year":"2000","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.11.006_bb0040","doi-asserted-by":"crossref","first-page":"603","DOI":"10.4049\/jimmunol.176.1.603","article-title":"NF-kappaB and activator protein 1 response elements and the role of histone modifications in IL-1beta-induced TGF-beta1 gene transcription","volume":"176","author":"Lee","year":"2006","journal-title":"J Immunol"},{"issue":"19","key":"10.1016\/j.yjmcc.2014.11.006_bb0045","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.1016\/j.febslet.2006.07.046","article-title":"Pellino proteins are more than scaffold proteins in TLR\/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases","volume":"580","author":"Schauvliege","year":"2006","journal-title":"FEBS Lett"},{"issue":"13","key":"10.1016\/j.yjmcc.2014.11.006_bb0050","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.1074\/jbc.M212112200","article-title":"Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)\u2013IRAK\u2013tumor necrosis factor receptor-associated factor 6 (TRAF6) complex","volume":"278","author":"Jiang","year":"2003","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.yjmcc.2014.11.006_bb0055","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/ni1383","article-title":"Smad6 negatively regulates interleukin 1-receptor\u2013Toll-like receptor signaling through direct interaction with the adaptor Pellino-1","volume":"7","author":"Choi","year":"2006","journal-title":"Nat Immunol"},{"issue":"5","key":"10.1016\/j.yjmcc.2014.11.006_bb0060","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nm.3111","article-title":"Peli1 promotes microglia-mediated CNS inflammation by regulating Traf3 degradation","volume":"19","author":"Xiao","year":"2013","journal-title":"Nat Med"},{"issue":"4","key":"10.1016\/j.yjmcc.2014.11.006_bb0065","doi-asserted-by":"crossref","first-page":"H1712","DOI":"10.1152\/ajpheart.00124.2004","article-title":"NF-kappaB activation is required for the development of cardiac hypertrophy in vivo","volume":"287","author":"Li","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"22","key":"10.1016\/j.yjmcc.2014.11.006_bb0070","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1161\/01.CIR.0000148176.33730.3F","article-title":"In vivo cardiac gene transfer of Kv4.3 abrogates the hypertrophic response in rats after aortic stenosis","volume":"110","author":"Lebeche","year":"2004","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2014.11.006_bb0075","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/08037059209077497","article-title":"Pathologic hypertrophy with fibrosis: the structural basis for myocardial failure","volume":"1","author":"Weber","year":"1992","journal-title":"Blood Press"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.11.006_bb0080","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00335.2010","article-title":"Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects","volume":"299","author":"Lopez","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"10.1016\/j.yjmcc.2014.11.006_bb0085","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/cvr\/cvq308","article-title":"Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart","volume":"89","author":"Creemers","year":"2011","journal-title":"Cardiovasc Res"},{"issue":"10","key":"10.1016\/j.yjmcc.2014.11.006_bb0090","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/ni.1777","article-title":"Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production","volume":"10","author":"Chang","year":"2009","journal-title":"Nat Immunol"},{"issue":"8","key":"10.1016\/j.yjmcc.2014.11.006_bb0095","doi-asserted-by":"crossref","first-page":"8231","DOI":"10.1007\/s11033-012-1671-3","article-title":"TWEAK\/Fn14 promotes the proliferation and collagen synthesis of rat cardiac fibroblasts via the NF-small ka, CyrillicB pathway","volume":"39","author":"Chen","year":"2012","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.yjmcc.2014.11.006_bb0100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2014.02.017","article-title":"Cardiac fibroblast in development and wound healing","volume":"70","author":"Deb","year":"2014","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.11.006_bb0105","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.it.2008.10.001","article-title":"The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling","volume":"30","author":"Moynagh","year":"2009","journal-title":"Trends Immunol"},{"issue":"3","key":"10.1016\/j.yjmcc.2014.11.006_bb0110","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1582-4934.2007.00040.x","article-title":"Pellino proteins: novel players in TLR and IL-1R signalling","volume":"11","author":"Schauvliege","year":"2007","journal-title":"J Cell Mol Med"},{"issue":"5","key":"10.1016\/j.yjmcc.2014.11.006_bb0115","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s00395-011-0182-z","article-title":"The TIR\/BB-loop mimetic AS-1 prevents cardiac hypertrophy by inhibiting IL-1R-mediated MyD88-dependent signaling","volume":"106","author":"Zhu","year":"2011","journal-title":"Basic Res Cardiol"},{"issue":"3","key":"10.1016\/j.yjmcc.2014.11.006_bb0120","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/cvr\/cvp237","article-title":"NF-kappaB activation is required for adaptive cardiac hypertrophy","volume":"84","author":"Zelarayan","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"8","key":"10.1016\/j.yjmcc.2014.11.006_bb0125","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.11.006_bb0130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/HYPERTENSIONAHA.109.135467","article-title":"Induction of mitogen-activated protein kinases is proportional to the amount of pressure overload","volume":"55","author":"Esposito","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2014.11.006_bb0135","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/cvr\/cvu007","article-title":"Silencing of Pellino1 improves post-infarct cardiac dysfunction and attenuates left ventricular remodelling in mice","volume":"102","author":"Wu","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2014.11.006_bb0140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yjmcc.2012.11.006","article-title":"Syndecan-4 signaling via NFAT regulates extracellular matrix production and cardiac myofibroblast differentiation in response to mechanical stress","volume":"54","author":"Herum","year":"2013","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.11.006_bb0145","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrcardio.2012.158","article-title":"Myofibroblast-mediated mechanisms of pathological remodelling of the heart","volume":"10","author":"Weber","year":"2013","journal-title":"Nat Rev Cardiol"},{"issue":"5","key":"10.1016\/j.yjmcc.2014.11.006_bb0150","doi-asserted-by":"crossref","first-page":"e5704","DOI":"10.1371\/journal.pone.0005704","article-title":"The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury","volume":"4","author":"Leemans","year":"2009","journal-title":"PLoS ONE"},{"issue":"6","key":"10.1016\/j.yjmcc.2014.11.006_bb0155","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1165\/rcmb.2008-0371OC","article-title":"Activation of Toll-like receptor 3 augments myofibroblast differentiation","volume":"40","author":"Sugiura","year":"2009","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"8","key":"10.1016\/j.yjmcc.2014.11.006_bb0160","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1681\/ASN.2009070722","article-title":"TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury","volume":"21","author":"Pulskens","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.yjmcc.2014.11.006_bb0165","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/cmi.2011.60","article-title":"Peli: a family of signal-responsive E3 ubiquitin ligases mediating TLR signaling and T-cell tolerance","volume":"9","author":"Jin","year":"2012","journal-title":"Cell Mol Immunol"},{"issue":"22","key":"10.1016\/j.yjmcc.2014.11.006_bb0170","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1038\/sj.onc.1210413","article-title":"Ubiquitin-mediated activation of TAK1 and IKK","volume":"26","author":"Adhikari","year":"2007","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.11.006_bb0175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.mrrev.2009.01.001","article-title":"Translational regulation mechanisms of AP-1 proteins","volume":"682","author":"Vesely","year":"2009","journal-title":"Mutat Res"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.11.006_bb0180","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.yjmcc.2008.10.019","article-title":"Angiotensin II promotes poly(ADP-ribosyl)ation of c-Jun\/c-Fos in cardiac fibroblasts","volume":"46","author":"Huang","year":"2009","journal-title":"J Mol Cell Cardiol"},{"issue":"28","key":"10.1016\/j.yjmcc.2014.11.006_bb0185","doi-asserted-by":"crossref","first-page":"16483","DOI":"10.1074\/jbc.270.28.16483","article-title":"The regulation of AP-1 activity by mitogen-activated protein kinases","volume":"270","author":"Karin","year":"1995","journal-title":"J Biol Chem"},{"issue":"10","key":"10.1016\/j.yjmcc.2014.11.006_bb0190","doi-asserted-by":"crossref","first-page":"7808","DOI":"10.1074\/jbc.M108133200","article-title":"Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1","volume":"277","author":"McDermott","year":"2002","journal-title":"J Biol Chem"},{"issue":"19","key":"10.1016\/j.yjmcc.2014.11.006_bb0195","doi-asserted-by":"crossref","first-page":"18842","DOI":"10.1074\/jbc.M500620200","article-title":"Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light","volume":"280","author":"Tanos","year":"2005","journal-title":"J Biol Chem"},{"issue":"12","key":"10.1016\/j.yjmcc.2014.11.006_bb0200","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.cellsig.2006.05.012","article-title":"Low cell cholesterol levels increase NFkappaB activity through a p38 MAPK-dependent mechanism","volume":"18","author":"Calleros","year":"2006","journal-title":"Cell Signal"},{"issue":"8","key":"10.1016\/j.yjmcc.2014.11.006_bb0205","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1006\/jmcc.1997.0457","article-title":"Differential protein expression and subcellular distribution of TGFbeta1, beta2 and beta3 in cardiomyocytes during pressure overload-induced hypertrophy","volume":"29","author":"Li","year":"1997","journal-title":"J Mol Cell Cardiol"},{"issue":"21","key":"10.1016\/j.yjmcc.2014.11.006_bb0210","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1161\/01.CIR.99.21.2750","article-title":"Dilated cardiomyopathy is associated with significant changes in collagen type I\/III ratio","volume":"99","author":"Pauschinger","year":"1999","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2014.11.006_bb0215","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/01.CIR.0000020689.12472.E0","article-title":"Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats","volume":"106","author":"Kuwahara","year":"2002","journal-title":"Circulation"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282814003484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282814003484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T08:54:19Z","timestamp":1589273659000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282814003484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":43,"alternative-id":["S0022282814003484"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2014.11.006","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pellino1-mediated TGF-\u03b21 synthesis contributes to mechanical stress induced cardiac fibroblast activation","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2014.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}