{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:32:47Z","timestamp":1790721167864,"version":"4.1.0"},"reference-count":152,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.yjmcc.2015.04.004","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T15:52:13Z","timestamp":1428767533000},"page":"131-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Genome-wide association studies of late-onset cardiovascular disease"],"prefix":"10.1016","volume":"83","author":[{"given":"J.Gustav","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Newton-Cheh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2015.04.004_bb0005","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0010","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrd4051","article-title":"Validating therapeutic targets through human genetics","volume":"12","author":"Plenge","year":"2013","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0015","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1056\/NEJMp0808414","article-title":"An uncertain future for cardiovascular drug development?","volume":"360","author":"Garber","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0020","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrcardio.2014.84","article-title":"Lipid lowering with PCSK9 inhibitors","volume":"11","author":"Dadu","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0025","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1056\/NEJMoa1400284","article-title":"Targeting APOC3 in the familial chylomicronemia syndrome","volume":"371","author":"Gaudet","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0030","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1126\/science.1156409","article-title":"Genetic mapping in human disease","volume":"322","author":"Altshuler","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0035","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1001\/jama.291.18.2204","article-title":"Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring","volume":"291","author":"Lloyd-Jones","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0040","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1001\/jama.2010.1690","article-title":"Association between familial atrial fibrillation and risk of new-onset atrial fibrillation","volume":"304","author":"Lubitz","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0045","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMoa052948","article-title":"Association of parental heart failure with risk of heart failure in offspring","volume":"355","author":"Lee","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0050","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1161\/01.STR.24.9.1366","article-title":"Familial aggregation of stroke. The Framingham study","volume":"24","author":"Kiely","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0055","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0140-6736(95)91436-6","article-title":"Sibling risks of abdominal aortic aneurysm","volume":"346","author":"Baird","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0060","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0741-5214(97)70261-1","article-title":"Familial thoracic aortic dilatations and dissections: a case control study","volume":"25","author":"Biddinger","year":"1997","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0065","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/01.HYP.0000256957.10242.75","article-title":"Genome-wide linkage mapping for valve calcification susceptibility loci in hypertensive sibships: the hypertension genetic epidemiology network study","volume":"49","author":"Bella","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0070","doi-asserted-by":"crossref","first-page":"9362","DOI":"10.1073\/pnas.0903103106","article-title":"Potential etiologic and functional implications of genome-wide association loci for human diseases and traits","volume":"106","author":"Hindorff","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0075","doi-asserted-by":"crossref","first-page":"i185","DOI":"10.1093\/bioinformatics\/btu273","article-title":"GRASP: analysis of genotype\u2013phenotype results from 1390 genome-wide association studies and corresponding open access database","volume":"30","author":"Leslie","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0080","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/gerona\/glu166","article-title":"GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy","volume":"70","author":"Broer","year":"2015","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0085","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1093\/hmg\/ddu139","article-title":"Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90years of age","volume":"23","author":"Deelen","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0090","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng.2480","article-title":"Large-scale association analysis identifies new risk loci for coronary artery disease","volume":"45","author":"Deloukas","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0095","doi-asserted-by":"crossref","first-page":"e94661","DOI":"10.1371\/journal.pone.0094661","article-title":"Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease","volume":"9","author":"Escott-Price","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/978-1-60761-247-6_14","article-title":"Genome-wide association study in humans","volume":"573","author":"Smith","year":"2009","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0105","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0110","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1086\/496902","article-title":"High-resolution whole-genome association study of Parkinson disease","volume":"77","author":"Maraganore","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0115","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1126\/science.1124779","article-title":"A common genetic variant is associated with adult and childhood obesity","volume":"312","author":"Herbert","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0120","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/ng1790","article-title":"A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization","volume":"38","author":"Arking","year":"2006","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0125","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.1135245","article-title":"A genome-wide association study identifies IL23R as an inflammatory bowel disease gene","volume":"314","author":"Duerr","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0130","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.1141634","article-title":"A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity","volume":"316","author":"Frayling","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0135","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1126\/science.1142358","article-title":"Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels","volume":"316","author":"Saxena","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0140","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.1142447","article-title":"A common allele on chromosome 9 associated with coronary heart disease","volume":"316","author":"McPherson","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0145","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.1142842","article-title":"A common variant on chromosome 9p21 affects the risk of myocardial infarction","volume":"316","author":"Helgadottir","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0150","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng1195-241","article-title":"Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results","volume":"11","author":"Lander","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0155","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00125817-200203000-00002","article-title":"A comprehensive review of genetic association studies","volume":"4","author":"Hirschhorn","year":"2002","journal-title":"Genet Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0160","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/gepi.20303","article-title":"Estimation of the multiple testing burden for genomewide association studies of nearly all common variants","volume":"32","author":"Pe'er","year":"2008","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0165","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/gepi.20297","article-title":"Estimation of significance thresholds for genomewide association scans","volume":"32","author":"Dudbridge","year":"2008","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0170","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/ng.823","article-title":"Genome partitioning of genetic variation for complex traits using common SNPs","volume":"43","author":"Yang","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0175","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1161\/CIRCGENETICS.111.959817","article-title":"Common genetic variation in the 3\u2032-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the aortagen consortium","volume":"5","author":"Mitchell","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0180","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/CIRCGENETICS.108.823245","article-title":"COL4A1 is associated with arterial stiffness by genome-wide association scan","volume":"2","author":"Tarasov","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0185","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1056\/NEJMoa071906","article-title":"COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps","volume":"357","author":"Plaisier","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0190","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1016\/j.ijcard.2013.03.149","article-title":"Shared and non-shared familial susceptibility of coronary heart disease, ischemic stroke, peripheral artery disease and aortic disease","volume":"168","author":"Calling","year":"2013","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0195","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1161\/CIRCGENETICS.111.961292","article-title":"Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies","volume":"5","author":"Murabito","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0200","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1093\/eurheartj\/eht222","article-title":"The impact of susceptibility loci for coronary artery disease on other vascular domains and recurrence risk","volume":"34","author":"Tragante","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0205","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/ng.622","article-title":"Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm","volume":"42","author":"Gretarsdottir","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0210","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1093\/eurheartj\/ehr075","article-title":"Association of a sequence variant in DAB2IP with coronary heart disease","volume":"33","author":"Harrison","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0215","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature06846","article-title":"A variant associated with nicotine dependence, lung cancer and peripheral arterial disease","volume":"452","author":"Thorgeirsson","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0220","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1093\/hmg\/ddt141","article-title":"A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm","volume":"22","author":"Jones","year":"2013","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0225","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ng.72","article-title":"The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm","volume":"40","author":"Helgadottir","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0230","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1161\/CIRCGENETICS.113.000022","article-title":"Impact of inherited genetic variants associated with lipid profile, hypertension, and coronary artery disease on the risk of intracranial and abdominal aortic aneurysms","volume":"6","author":"van 't Hof","year":"2013","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0235","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1126\/science.1253026","article-title":"Cell biology. Dysfunctional mechanosensing in aneurysms","volume":"344","author":"Humphrey","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0240","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/ng.783","article-title":"Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population","volume":"43","author":"Wang","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0245","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jacc.2012.10.051","article-title":"Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis","volume":"61","author":"Chan","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0250","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jacc.2010.11.075","article-title":"Influence of 9p21.3 genetic variants on clinical and angiographic outcomes in early-onset myocardial infarction","volume":"58","author":"Ardissino","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0255","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0140-6736(10)61996-4","article-title":"Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies","volume":"377","author":"Reilly","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0260","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1161\/ATVBAHA.109.189522","article-title":"Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus","volume":"29","author":"Jarinova","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0265","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/ATVBAHA.109.196832","article-title":"ANRIL expression is associated with atherosclerosis risk at chromosome 9p21","volume":"30","author":"Holdt","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0270","doi-asserted-by":"crossref","first-page":"e1000899","DOI":"10.1371\/journal.pgen.1000899","article-title":"Chromosome 9p21 SNPs associated with multiple disease phenotypes correlate with ANRIL expression","volume":"6","author":"Cunnington","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0275","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1093\/hmg\/dds224","article-title":"Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells","volume":"21","author":"Motterle","year":"2012","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0280","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nature08801","article-title":"Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice","volume":"464","author":"Visel","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0285","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nature09753","article-title":"9p21 DNA variants associated with coronary artery disease impair interferon-gamma signalling response","volume":"470","author":"Harismendy","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0290","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jacc.2012.08.1020","article-title":"Interferon-gamma activates expression of p15 and p16 regardless of 9p21.3 coronary artery disease risk genotype","volume":"61","author":"Almontashiri","year":"2013","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0295","doi-asserted-by":"crossref","first-page":"e1003588","DOI":"10.1371\/journal.pgen.1003588","article-title":"Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks","volume":"9","author":"Holdt","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0300","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nature09266","article-title":"From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus","volume":"466","author":"Musunuru","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0305","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.cmet.2013.12.006","article-title":"The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion","volume":"19","author":"Gustafsen","year":"2014","journal-title":"Cell Metab"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0310","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1097\/MOL.0000000000000110","article-title":"Sortilin and lipoprotein metabolism: making sense out of complexity","volume":"25","author":"Strong","year":"2014","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0315","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.2174\/1871527313666141023151642","article-title":"The implications of sortilin\/Vps10p domain receptors in neurological and human diseases","volume":"13","author":"Wilson","year":"2014","journal-title":"CNS neurol disord drug targets"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0320","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/01.CIR.0000155611.41961.BB","article-title":"Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction","volume":"111","author":"Fischer","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0325","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1161\/CIRCULATIONAHA.110.974899","article-title":"Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction","volume":"124","author":"O'Donnell","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0330","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/ng.2676","article-title":"Genome-wide meta-analysis identifies new susceptibility loci for migraine","volume":"45","author":"Anttila","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0335","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/ng.3154","article-title":"Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection","volume":"47","author":"Debette","year":"2014","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0340","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature10405","article-title":"Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk","volume":"478","author":"Ehret","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0345","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1161\/HYPERTENSIONAHA.111.00275","article-title":"Genetic predisposition to higher blood pressure increases coronary artery disease risk","volume":"61","author":"Lieb","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0350","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/ng.2795","article-title":"Common variants associated with plasma triglycerides and risk for coronary artery disease","volume":"45","author":"Do","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0355","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0360","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1056\/NEJMoa0902604","article-title":"Genetic variants associated with Lp(a) lipoprotein level and coronary disease","volume":"361","author":"Clarke","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0365","doi-asserted-by":"crossref","first-page":"e1001212","DOI":"10.1371\/journal.pmed.1001212","article-title":"The effect of elevated body mass index on ischemic heart disease risk: causal estimates from a Mendelian randomisation approach","volume":"9","author":"Nordestgaard","year":"2012","journal-title":"PLoS Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0370","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/ng.2528","article-title":"Identification of seven loci affecting mean telomere length and their association with disease","volume":"45","author":"Codd","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0375","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/aje\/kwj346","article-title":"Leukocyte telomere length and cardiovascular disease in the cardiovascular health study","volume":"165","author":"Fitzpatrick","year":"2007","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0380","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/S0140-6736(12)60110-X","article-title":"The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis","volume":"379","author":"Interleukin-6 Receptor Mendelian Randomisation Analysis C","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0385","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(12)60312-2","article-title":"Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study","volume":"380","author":"Voight","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0390","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1001\/jama.2009.954","article-title":"Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease","volume":"302","author":"Elliott","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0395","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3945\/ajcn.112.044545","article-title":"Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease","volume":"98","author":"van Meurs","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0400","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1161\/CIRCULATIONAHA.113.002251","article-title":"Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease","volume":"128","author":"Sabater-Lleal","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0405","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1161\/CIRCULATIONAHA.109.923383","article-title":"PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry","volume":"121","author":"Casas","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0410","doi-asserted-by":"crossref","first-page":"f4262","DOI":"10.1136\/bmj.f4262","article-title":"Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts","volume":"347","author":"Palmer","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0415","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2796.2012.02576.x","article-title":"Genetically elevated bilirubin and risk of ischaemic heart disease: three Mendelian randomization studies and a meta-analysis","volume":"273","author":"Stender","year":"2013","journal-title":"J Intern Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0420","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/eurheartj\/ehu208","article-title":"Mendelian randomization studies in coronary artery disease","volume":"35","author":"Jansen","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0425","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/ng.623","article-title":"Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction","volume":"42","author":"Bezzina","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0430","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S1474-4422(12)70234-X","article-title":"Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies","volume":"11","author":"Traylor","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0435","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/CIRCGENETICS.108.835173","article-title":"Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: a large-scale genetic association study","volume":"2","author":"Smith","year":"2009","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0440","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ng.1081","article-title":"Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke","volume":"44","author":"International Stroke Genetics C","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0445","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/ana.23838","article-title":"Ischemic stroke is associated with the ABO locus: the EuroCLOT study","volume":"73","author":"Williams","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0450","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1212\/WNL.0000000000000707","article-title":"Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12","volume":"83","author":"Kilarski","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0455","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1111\/ene.12183","article-title":"Are 25 SNPs from the CARDIoGRAM study associated with ischaemic stroke?","volume":"20","author":"Lovkvist","year":"2013","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0460","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/STROKEAHA.113.002707","article-title":"Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants","volume":"45","author":"Dichgans","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0465","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/ng.2397","article-title":"Common variants at 6p21.1 are associated with large artery atherosclerotic stroke","volume":"44","author":"Holliday","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0470","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/ng.920","article-title":"Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque","volume":"43","author":"Bis","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0475","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1056\/NEJMoa0900094","article-title":"Genomewide association studies of stroke","volume":"360","author":"Ikram","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0480","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/STROKEAHA.110.594010","article-title":"Genetic variant on chromosome 12p13 does not show association to ischemic stroke in 3 Swedish case-control studies","volume":"42","author":"Olsson","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0485","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMc0910050","article-title":"Failure to validate association between 12p13 variants and ischemic stroke","volume":"362","author":"International Stroke Genetics C","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0490","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1161\/CIRCGENETICS.109.895763","article-title":"Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium","volume":"3","author":"Smith","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0495","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1161\/CIRCGENETICS.110.959205","article-title":"Genome-wide significance and replication of the chromosome 12p11.22 locus near the PTHLH gene for peripartum cardiomyopathy","volume":"4","author":"Horne","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0500","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1093\/eurheartj\/ehr105","article-title":"A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy","volume":"32","author":"Villard","year":"2011","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0505","doi-asserted-by":"crossref","first-page":"e1001167","DOI":"10.1371\/journal.pgen.1001167","article-title":"Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy","volume":"6","author":"Stark","year":"2010","journal-title":"PLoS Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0510","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/eurheartj\/eht251","article-title":"A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy","volume":"35","author":"Meder","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0515","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/CIRCGENETICS.112.965277","article-title":"Formin homology 2 domain containing 3 variants associated with hypertrophic cardiomyopathy","volume":"6","author":"Wooten","year":"2013","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0520","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ajhg.2011.01.016","article-title":"Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy","volume":"88","author":"Norton","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0525","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/ng.309","article-title":"A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia","volume":"41","author":"Dhandapany","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0530","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature06007","article-title":"Variants conferring risk of atrial fibrillation on chromosome 4q25","volume":"448","author":"Gudbjartsson","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0535","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/ng.417","article-title":"A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke","volume":"41","author":"Gudbjartsson","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0540","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/ng.416","article-title":"Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry","volume":"41","author":"Benjamin","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0545","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ng.537","article-title":"Common variants in KCNN3 are associated with lone atrial fibrillation","volume":"42","author":"Ellinor","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0550","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/ng.2261","article-title":"Meta-analysis identifies six new susceptibility loci for atrial fibrillation","volume":"44","author":"Ellinor","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0555","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1161\/CIRCULATIONAHA.114.009892","article-title":"Integrating genetic, transcriptional, and functional analyses to identify 5 novel genes for atrial fibrillation","volume":"130","author":"Sinner","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0560","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.jacc.2013.12.015","article-title":"Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese","volume":"63","author":"Lubitz","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0565","doi-asserted-by":"crossref","first-page":"e1002158","DOI":"10.1371\/journal.pgen.1002158","article-title":"Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals","volume":"7","author":"Arking","year":"2011","journal-title":"PLoS Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0570","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1365-2796.2012.02563.x","article-title":"Genetic polymorphisms for estimating risk of atrial fibrillation: a literature-based meta-analysis","volume":"272","author":"Smith","year":"2012","journal-title":"J Intern Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0575","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jacc.2009.11.041","article-title":"Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation","volume":"55","author":"Husser","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0580","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.hrthm.2013.02.018","article-title":"Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion","volume":"10","author":"Parvez","year":"2013","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0585","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jacc.2012.01.070","article-title":"Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation","volume":"60","author":"Parvez","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0590","doi-asserted-by":"crossref","first-page":"e86245","DOI":"10.1371\/journal.pone.0086245","article-title":"Atrial fibrillation associated chromosome 4q25 variants are not associated with PITX2c expression in human adult left atrial appendages","volume":"9","author":"Gore-Panter","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0595","doi-asserted-by":"crossref","first-page":"9753","DOI":"10.1073\/pnas.0912585107","article-title":"Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification","volume":"107","author":"Wang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0600","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/CIRCRESAHA.107.161182","article-title":"Pitx2c and Nkx2-5 are required for the formation and identity of the pulmonary myocardium","volume":"101","author":"Mommersteeg","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0605","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/eurjhf\/hfs176","article-title":"Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study","volume":"15","author":"Smith","year":"2013","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0610","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng.781","article-title":"A rare variant in MYH6 is associated with high risk of sick sinus syndrome","volume":"43","author":"Holm","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0615","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1016\/j.jacc.2014.04.018","article-title":"The prevalence, incidence, progression, and risks of aortic valve sclerosis: a systematic review and meta-analysis","volume":"63","author":"Coffey","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0620","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa1109034","article-title":"Genetic associations with valvular calcification and aortic stenosis","volume":"368","author":"Thanassoulis","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0625","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1161\/CIRCGENETICS.113.000400","article-title":"Lipoprotein(a) levels, genotype, and incident aortic valve stenosis: a prospective mendelian randomization study and replication in a case-control cohort","volume":"7","author":"Arsenault","year":"2014","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0630","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jacc.2013.09.038","article-title":"Elevated lipoprotein(a) and risk of aortic valve stenosis in the general population","volume":"63","author":"Kamstrup","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0635","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1161\/01.CIR.90.2.844","article-title":"Characterization of the early lesion of \u2018degenerative\u2019 valvular aortic stenosis. Histological and immunohistochemical studies","volume":"90","author":"Otto","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0640","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/01.ATV.16.4.523","article-title":"Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of \u2018degenerative\u2019 valvular aortic stenosis","volume":"16","author":"O'Brien","year":"1996","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0645","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1161\/ATVBAHA.114.304015","article-title":"Carotid plaque, intima-media thickness, and incident aortic stenosis: a prospective cohort study","volume":"34","author":"Martinsson","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0650","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1001\/jama.2014.13959","article-title":"Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis","volume":"312","author":"Smith","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0655","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature13127","article-title":"Guidelines for investigating causality of sequence variants in human disease","volume":"508","author":"MacArthur","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0660","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cell.2013.09.001","article-title":"Distilling pathophysiology from complex disease genetics","volume":"155","author":"Chakravarti","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0665","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ng2047","article-title":"Tissue-specific transcriptional regulation has diverged significantly between human and mouse","volume":"39","author":"Odom","year":"2007","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0670","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/nm.2504","article-title":"Diseases in a dish: modeling human genetic disorders using induced pluripotent cells","volume":"17","author":"Tiscornia","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0675","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1222794","article-title":"Systematic localization of common disease-associated variation in regulatory DNA","volume":"337","author":"Maurano","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0680","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Consortium","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0685","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project","volume":"45","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0690","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature12787","article-title":"An atlas of active enhancers across human cell types and tissues","volume":"507","author":"Andersson","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0695","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"Roadmap Epigenomics","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0700","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrg3207","article-title":"Transcription factors: from enhancer binding to developmental control","volume":"13","author":"Spitz","year":"2012","journal-title":"Nat Rev"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0705","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s12033-009-9239-8","article-title":"The current state of chromatin immunoprecipitation","volume":"45","author":"Collas","year":"2010","journal-title":"Mol Biotechnol"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0710","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nrg3454","article-title":"Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data","volume":"14","author":"Dekker","year":"2013","journal-title":"Nat Rev"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0715","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMp1500523","article-title":"A new initiative on precision medicine","volume":"372","author":"Collins","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0720","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/ng.582","article-title":"Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci","volume":"42","author":"Stahl","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0725","article-title":"Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials","volume":"131","author":"Mega","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0730","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1093\/eurheartj\/ehs354","article-title":"Interleukin-6 receptor pathways in abdominal aortic aneurysm","volume":"34","author":"Harrison","year":"2013","journal-title":"Eur Heart J"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0735","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.ajhg.2011.10.002","article-title":"Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1","volume":"89","author":"Bown","year":"2011","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0740","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1161\/CIRCGENETICS.113.000165","article-title":"A variant in LDLR is associated with abdominal aortic aneurysm","volume":"6","author":"Bradley","year":"2013","journal-title":"Circ Cardiovasc Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0745","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/ng.934","article-title":"Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1","volume":"43","author":"Lemaire","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb0750","doi-asserted-by":"crossref","first-page":"e1004469","DOI":"10.1371\/journal.pgen.1004469","article-title":"A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach","volume":"10","author":"Traylor","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb9900","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.001513","article-title":"Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: a prospective cohort study","volume":"4","author":"Landenhed","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.yjmcc.2015.04.004_bb9800","first-page":"988","volume":"131","author":"Martinsson","year":"2015","journal-title":"Sundquist K. Temporal trends in the incidence and prognosis of aortic stenosis: a nationwide study of theSwedish population. Circulation"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815001054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815001054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T11:20:01Z","timestamp":1537701601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282815001054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":152,"alternative-id":["S0022282815001054"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.04.004","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide association studies of late-onset cardiovascular disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}