{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T10:55:21Z","timestamp":1787914521044,"version":"build-2784847793"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.yjmcc.2015.04.012","type":"journal-article","created":{"date-parts":[[2015,5,2]],"date-time":"2015-05-02T20:40:17Z","timestamp":1430599217000},"page":"143-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"special_numbering":"C","title":["Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2"],"prefix":"10.1016","volume":"84","author":[{"given":"Hui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimu","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan J.","family":"Mathis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Janicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sao-Cong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taixing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2015.04.012_bb0005","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.cell.2005.11.007","article-title":"A genomic and functional inventory of deubiquitinating enzymes","volume":"123","author":"Nijman","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0010","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrm2673","article-title":"Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways","volume":"10","author":"Schulman","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbamcr.2004.10.003","article-title":"Mechanism and function of deubiquitinating enzymes","volume":"1695","author":"Amerik","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0020","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.yjmcc.2006.07.015","article-title":"Into the heart: the emerging role of the ubiquitin-proteasome system","volume":"41","author":"Willis","year":"2006","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0025","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/01.CIR.0000086978.95976.41","article-title":"A20 is dynamically regulated in the heart and inhibits the hypertrophic response","volume":"108","author":"Cook","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0030","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1161\/CIRCULATIONAHA.106.656835","article-title":"Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction","volume":"115","author":"Li","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0035","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1161\/HYPERTENSIONAHA.110.149963","article-title":"Tumor suppressor A20 protects against cardiac hypertrophy and fibrosis by blocking transforming growth factor-beta-activated kinase 1-dependent signaling","volume":"56","author":"Huang","year":"2010","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0040","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/76006","article-title":"Identification of the familial cylindromatosis tumour-suppressor gene","volume":"25","author":"Bignell","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0045","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/cdd.2009.43","article-title":"CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes","volume":"17","author":"Sun","year":"2010","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0050","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/ncomms1776","article-title":"CYLD negatively regulates transforming growth factor-beta-signalling via deubiquitinating Akt","volume":"3","author":"Lim","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0055","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ccr.2012.04.026","article-title":"Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer","volume":"21","author":"Nikolaou","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0060","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbrc.2012.02.118","article-title":"A pro-inflammatory role of deubiquitinating enzyme cylindromatosis (CYLD) in vascular smooth muscle cells","volume":"420","author":"Liu","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0065","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1161\/ATVBAHA.109.189480","article-title":"Nrf2 protects against maladaptive cardiac responses to hemodynamic stress","volume":"29","author":"Li","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0070","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/cvr\/cvr010","article-title":"Up-regulation of p27(kip1) contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy","volume":"90","author":"Li","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0075","doi-asserted-by":"crossref","first-page":"748524","DOI":"10.1155\/2014\/748524","article-title":"Nrf2 deficiency exaggerates doxorubicin-induced cardiotoxicity and cardiac dysfunction","volume":"2014","author":"Li","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0080","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.yjmcc.2014.04.006","article-title":"Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins","volume":"72","author":"Wang","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0085","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2337\/db10-1164","article-title":"Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo","volume":"60","author":"Tan","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0090","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ni1315","article-title":"Regulation of T cell development by the deubiquitinating enzyme CYLD","volume":"7","author":"Reiley","year":"2006","journal-title":"Nat Immunol"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0095","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1172\/JCI22811","article-title":"Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload","volume":"116","author":"O'Connell","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0100","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1007\/s10554-014-0454-4","article-title":"Non-invasive in vivo measurement of cardiac output in C57BL\/6 mice using high frequency transthoracic ultrasound: evaluation of gender and body weight effects","volume":"30","author":"Dominguez","year":"2014","journal-title":"Int J Cardiovasc Imaging"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0105","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/CIRCRESAHA.108.193318","article-title":"The I{kappa}B kinase {beta}\/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression","volume":"105","author":"Hikoso","year":"2009","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0110","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1161\/CIRCRESAHA.109.202200","article-title":"Antioxidant amelioration of dilated cardiomyopathy caused by conditional deletion of NEMO\/IKKgamma in cardiomyocytes","volume":"106","author":"Kratsios","year":"2010","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0115","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature10189","article-title":"Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis","volume":"475","author":"DeNicola","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0120","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cardiores.2007.07.014","article-title":"Role of mitochondria in angiotensin II-induced reactive oxygen species and mitogen-activated protein kinase activation","volume":"76","author":"Zhang","year":"2007","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0125","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.cardiores.2004.01.039","article-title":"Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway","volume":"62","author":"Fu","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0130","doi-asserted-by":"crossref","first-page":"H3524","DOI":"10.1152\/ajpheart.00919.2007","article-title":"p38 and ERK1\/2 MAPKs mediate the interplay of TNF-alpha and IL-10 in regulating oxidative stress and cardiac myocyte apoptosis","volume":"293","author":"Dhingra","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2014.10.002","article-title":"Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF-kappaB both in vitro and in vivo","volume":"79","author":"Zeng","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0140","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.molcel.2010.01.035","article-title":"Loss of the tumor suppressor CYLD enhances Wnt\/beta-catenin signaling through K63-linked ubiquitination of Dvl","volume":"37","author":"Tauriello","year":"2010","journal-title":"Mol Cell"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0145","doi-asserted-by":"crossref","first-page":"15884","DOI":"10.1074\/jbc.M609952200","article-title":"Deubiquitinating enzyme CYLD regulates the peripheral development and naive phenotype maintenance of B cells","volume":"282","author":"Jin","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0150","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/eji.201041313","article-title":"A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies","volume":"41","author":"Hovelmeyer","year":"2011","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0155","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.biochem.78.082307.091526","article-title":"Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes","volume":"78","author":"Reyes-Turcu","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0160","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1517\/14728220903025762","article-title":"Targeting the Nrf2 pathway against cardiovascular disease","volume":"13","author":"Li","year":"2009","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0165","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.freeradbiomed.2011.04.022","article-title":"Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo","volume":"51","author":"Brewer","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0170","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.yjmcc.2014.10.017","article-title":"Redox regulation of cardiomyocyte cell cycling via an ERK1\/2 and c-Myc-dependent activation of cyclin D2 transcription","volume":"79","author":"Murray","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0175","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.freeradbiomed.2005.08.006","article-title":"Activation of AP-1 through reactive oxygen species by angiotensin II in rat cardiomyocytes","volume":"39","author":"Wu","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0180","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1096\/fj.00-0827fje","article-title":"Redox-sensitive intermediates mediate angiotensin II-induced p38 MAP kinase activation, AP-1 binding activity, and TGF-beta expression in adult ventricular cardiomyocytes","volume":"15","author":"Wenzel","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0185","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cell.2009.04.042","article-title":"Defining the human deubiquitinating enzyme interaction landscape","volume":"138","author":"Sowa","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0190","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1182\/blood-2009-10-248526","article-title":"CYLD regulates angiogenesis by mediating vascular endothelial cell migration","volume":"115","author":"Gao","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0195","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1517\/14728222.2013.809064","article-title":"The promise of CaMKII inhibition for heart disease: preventing heart failure and arrhythmias","volume":"17","author":"Westenbrink","year":"2013","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0200","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.cell.2008.04.041","article-title":"A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy","volume":"133","author":"Ago","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2015.04.012_bb0205","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.coph.2009.11.004","article-title":"Novel aspects of the roles of Rac1 GTPase in the cardiovascular system","volume":"10","author":"Sawada","year":"2010","journal-title":"Curr Opin Pharmacol"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815001273?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815001273?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T13:17:35Z","timestamp":1566652655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282815001273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":41,"alternative-id":["S0022282815001273"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.04.012","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deubiquitinating enzyme CYLD mediates pressure overload-induced cardiac maladaptive remodeling and dysfunction via downregulating Nrf2","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}