{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:09:31Z","timestamp":1769242171918,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.yjmcc.2015.04.026","type":"journal-article","created":{"date-parts":[[2015,5,3]],"date-time":"2015-05-03T03:08:00Z","timestamp":1430622480000},"page":"179-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Interplay between the E2F pathway and \u03b2-adrenergic signaling in the pathological hypertrophic response of myocardium"],"prefix":"10.1016","volume":"84","author":[{"given":"Jennifer L.","family":"Major","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maysoon","family":"Salih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balwant S.","family":"Tuana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2015.04.026_bb0005","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI24144","article-title":"Toward transcriptional therapies for the failing heart: chemical screens to modulate genes","volume":"115","author":"McKinsey","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0010","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.biocel.2008.02.020","article-title":"Molecular regulation of cardiac hypertrophy","volume":"40","author":"Barry","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0015","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.phrs.2009.11.012","article-title":"Molecular targets and regulators of cardiac hypertrophy","volume":"61","author":"Rohini","year":"2010","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0020","doi-asserted-by":"crossref","first-page":"H252","DOI":"10.1152\/ajpheart.00149.2014","article-title":"HDAC6 contributes to pathological responses of heart and skeletal muscle to chronic angiotensin-II signaling","volume":"307","author":"Demos-Davies","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0025","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.tcb.2008.08.003","article-title":"E2F\u2014at the crossroads of life and death","volume":"18","author":"Polager","year":"2008","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0030","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1128\/MCB.25.6.2486-2497.2005","article-title":"Overlapping roles of pocket proteins in the myocardium are unmasked by germ line deletion of p130 plus heart-specific deletion of Rb","volume":"25","author":"MacLellan","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0035","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.4161\/cc.7.23.7240","article-title":"E2F3 plays an essential role in cardiac development and function","volume":"7","author":"King","year":"2008","journal-title":"Cell Cycle"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0040","doi-asserted-by":"crossref","first-page":"14932","DOI":"10.1073\/pnas.0902408106","article-title":"Mutation of p107 exacerbates the consequences of Rb loss in embryonic tissues and causes cardiac and blood vessel defects","volume":"106","author":"Berman","year":"2009","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0045","doi-asserted-by":"crossref","first-page":"21388","DOI":"10.1074\/jbc.M212612200","article-title":"Inhibition of E2F abrogates the development of cardiac myocyte hypertrophy","volume":"278","author":"Vara","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0050","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1161\/01.RES.0000159705.17322.57","article-title":"Divergent siblings: E2F2 and E2F4 but not E2F1 and E2F3 induce DNA synthesis in cardiomyocytes without activation of apoptosis","volume":"96","author":"Ebelt","year":"2005","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/cvr\/cvn194","article-title":"E2F2 expression induces proliferation of terminally differentiated cardiomyocytes in vivo","volume":"80","author":"Ebelt","year":"2008","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0060","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.healun.2009.09.017","article-title":"Reversible regulation of the retinoblastoma protein\/E2F-1 pathway during \u201creverse cardiac remodelling\u201d after ventricular unloading","volume":"29","author":"Wohlschlaeger","year":"2010","journal-title":"J Heart Lung Transplant"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0065","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1161\/CIRCHEARTFAILURE.112.966705","article-title":"Agonist-induced hypertrophy and diastolic dysfunction are associated with selective reduction in glucose oxidation: a metabolic contribution to heart failure with normal ejection fraction","volume":"5","author":"Mori","year":"2012","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0070","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/sj.onc.1201975","article-title":"E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription","volume":"17","author":"Cartwright","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0075","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1101\/gad.1239304","article-title":"A role for E2F6 in distinguishing G1\/S- and G2\/M-specific transcription","volume":"18","author":"Giangrande","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0080","doi-asserted-by":"crossref","first-page":"C189","DOI":"10.1152\/ajpcell.00630.2004","article-title":"Activating E2Fs mediate transcriptional regulation of human E2F6 repressor","volume":"290","author":"Lyons","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0085","doi-asserted-by":"crossref","first-page":"9190","DOI":"10.1073\/pnas.95.16.9190","article-title":"Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6","volume":"95","author":"Gaubatz","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0090","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1073\/pnas.95.6.2850","article-title":"E2F-6, a member of the E2F family that can behave as a transcriptional repressor","volume":"95","author":"Trimarchi","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0095","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1096\/fj.11-203174","article-title":"The E2F6 repressor activates gene expression in myocardium resulting in dilated cardiomyopathy","volume":"26","author":"Westendorp","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0100","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/01.RES.88.3.333","article-title":"Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of Connexin43","volume":"88","author":"Gutstein","year":"2001","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0105","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbamem.2003.10.019","article-title":"Remodelling of gap junctions and connexin expression in heart disease","volume":"1662","author":"Severs","year":"2004","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0110","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.cell.2006.02.048","article-title":"The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases","volume":"125","author":"Song","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0115","doi-asserted-by":"crossref","first-page":"4377","DOI":"10.1073\/pnas.0611726104","article-title":"Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction","volume":"104","author":"Fielitz","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0120","doi-asserted-by":"crossref","first-page":"e64711","DOI":"10.1371\/journal.pone.0064711","article-title":"Increased beta2-adrenoceptors in doxorubicin-induced cardiomyopathy in Rat","volume":"8","author":"Merlet","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0125","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/BJ20050030","article-title":"Splice variants of the cyclic nucleotide phosphodiesterase PDE4D are differentially expressed and regulated in rat tissue","volume":"388","author":"Jin","year":"2005","journal-title":"Biochem J"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0130","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1126\/science.283.5402.655","article-title":"\u00df-arrestin-dependent formation of \u00df2 adrenergic receptor-Src protein kinase complexes","volume":"283","author":"Luttrell","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0135","doi-asserted-by":"crossref","first-page":"5777","DOI":"10.1038\/ncomms6777","article-title":"The switching role of \u03b2-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes","volume":"5","author":"Shin","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0235","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.201012049","article-title":"Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes","volume":"194","author":"Sdek","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0145","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1038\/sj.onc.1203010","article-title":"Regulation by Gi2 proteins of v-fms-induced proliferation and transformation via Src-kinase and STAT3","volume":"18","author":"Corre","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0150","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.RES.0000038488.38975.1A","article-title":"Involvement of extracellular signal-regulated kinases 1\/2 in cardiac hypertrophy and cell death","volume":"91","author":"Bueno","year":"2002","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0155","doi-asserted-by":"crossref","first-page":"e92926","DOI":"10.1371\/journal.pone.0092926","article-title":"Src is required for mechanical stretch-induced cardiomyocyte hypertrophy through angiotensin II type 1 receptor-dependent \u03b2-arrestin2 pathways","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0160","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1161\/CIRCULATIONAHA.109.896357","article-title":"A-kinase anchoring proteins: getting to the heart of the matter","volume":"121","author":"Scott","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0165","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/CIRCRESAHA.111.250464","article-title":"Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current","volume":"109","author":"Beca","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0170","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.ydbio.2010.08.033","article-title":"Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation","volume":"347","author":"Chang","year":"2010","journal-title":"Dev Biol"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0175","doi-asserted-by":"crossref","first-page":"14190","DOI":"10.1074\/jbc.M111.219923","article-title":"MTOR complex 2 targets Akt for proteasomal degradation via phosphorylation at the hydrophobic motif","volume":"286","author":"Wu","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0180","first-page":"19","article-title":"Physiological regulation of Akt activity and stability","volume":"2","author":"Liao","year":"2010","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0185","doi-asserted-by":"crossref","first-page":"11960","DOI":"10.1073\/pnas.220413597","article-title":"Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A","volume":"97","author":"Fang","year":"2000","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0190","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1161\/01.RES.0000079794.57578.F1","article-title":"Inducible cAMP early repressor (ICER) is a negative-feedback regulator of cardiac hypertrophy and an important mediator of cardiac myocyte apoptosis in response to \u03b2-adrenergic receptor stimulation","volume":"93","author":"Tomita","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0195","first-page":"20734","article-title":"Antagonism of E2F\u20131 regulated Bnip3 transcription by NF-\u00ce\u00baB is essential for basal cell survival","volume":"105","author":"Shaw","year":"2008"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0200","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1161\/CIRCRESAHA.107.164731","article-title":"The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes","volume":"102","author":"Yurkova","year":"2008","journal-title":"Circ Res"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0205","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.yjmcc.2012.09.004","article-title":"Anti-apoptotic function of the E2F transcription factor 4 (E2F4)\/p130, a member of retinoblastoma gene family in cardiac myocytes","volume":"53","author":"Dingar","year":"2012","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0210","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1074\/jbc.M506576200","article-title":"\u03b2-Arrestin-dependent, G protein-independent ERK1\/2 activation by the \u03b22 adrenergic receptor","volume":"281","author":"Shenoy","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0215","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0008-6363(00)00076-6","article-title":"Mechanical stress-induced cardiac hypertrophy: mechanisms and signal transduction pathways","volume":"47","author":"Ruwhof","year":"2000","journal-title":"Cardiovascular Res"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0220","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1073\/pnas.0610906104","article-title":"Genetic inhibition of cardiac ERK1\/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo","volume":"104","author":"Purcell","year":"2007","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0225","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1091\/mbc.E08-02-0171","article-title":"E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1","volume":"19","author":"Yang","year":"2008","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.yjmcc.2015.04.026_bb0230","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/sj.cdd.4402062","article-title":"E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1","volume":"14","author":"Yang","year":"2006","journal-title":"Cell Death Differ"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281500142X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281500142X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T18:58:05Z","timestamp":1537642685000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228281500142X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":46,"alternative-id":["S002228281500142X"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.04.026","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interplay between the E2F pathway and \u03b2-adrenergic signaling in the pathological hypertrophic response of myocardium","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.04.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}