{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:16:22Z","timestamp":1781237782253,"version":"3.54.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004074","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["090532\/Z\/09\/Z"],"award-info":[{"award-number":["090532\/Z\/09\/Z"]}],"id":[{"id":"10.13039\/501100004074","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MRC Hub","award":["G0900747 91070"],"award-info":[{"award-number":["G0900747 91070"]}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/12\/55\/29695"],"award-info":[{"award-number":["FS\/12\/55\/29695"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CH\/07\/01\/23735"],"award-info":[{"award-number":["CH\/07\/01\/23735"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.yjmcc.2015.06.005","type":"journal-article","created":{"date-parts":[[2015,6,13]],"date-time":"2015-06-13T23:32:15Z","timestamp":1434238335000},"page":"207-214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC"],"prefix":"10.1016","volume":"85","author":[{"given":"Ruairidh I.R.","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa Sheikhali","family":"Babaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mun-Kit","family":"Choy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Andrew","family":"Owens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy J.A.","family":"Chico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Keenan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nizar","family":"Yonan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Santib\u00e1\u00f1ez","family":"Koref","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard D.","family":"Keavney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.yjmcc.2015.06.005_bb0005","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/heart.86.5.516","article-title":"Population prevalence, incidence, and predictors of atrial fibrillation in the Renfrew\/Paisley study","volume":"86","author":"Stewart","year":"2001","journal-title":"Heart"},{"issue":"4","key":"10.1016\/j.yjmcc.2015.06.005_bb0010","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1161\/CIRCEP.108.786665","article-title":"Familial aggregation of atrial fibrillation: a study in Danish twins","volume":"2","author":"Christophersen","year":"2009","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"6","key":"10.1016\/j.yjmcc.2015.06.005_bb0015","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/ng.2261","article-title":"Meta-analysis identifies six new susceptibility loci for atrial fibrillation","volume":"44","author":"Ellinor","year":"2012","journal-title":"Nat Genet"},{"issue":"6929","key":"10.1016\/j.yjmcc.2015.06.005_bb0020","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nature01434","article-title":"Genetics of gene expression surveyed in maize, mouse and man","volume":"422","author":"Schadt","year":"2003","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.yjmcc.2015.06.005_bb0025","doi-asserted-by":"crossref","first-page":"e1000899","DOI":"10.1371\/journal.pgen.1000899","article-title":"Chromosome 9p21 SNPs associated with multiple disease phenotypes correlate with ANRIL expression","volume":"6","author":"Cunnington","year":"2010","journal-title":"PLoS Genet"},{"issue":"Database issue","key":"10.1016\/j.yjmcc.2015.06.005_bb0030","doi-asserted-by":"crossref","first-page":"D64","DOI":"10.1093\/nar\/gks1048","article-title":"The UCSC Genome Browser database: extensions and updates 2013","volume":"41","author":"Meyer","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.yjmcc.2015.06.005_bb0035","author":"Hindorff LA"},{"issue":"4","key":"10.1016\/j.yjmcc.2015.06.005_bb0040","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin Chem"},{"issue":"5","key":"10.1016\/j.yjmcc.2015.06.005_bb0045","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1086\/521987","article-title":"Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering","volume":"81","author":"Browning","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"7422","key":"10.1016\/j.yjmcc.2015.06.005_bb0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature11632","article-title":"An integrated map of genetic variation from 1,092 human genomes","volume":"491","author":"Abecasis","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.yjmcc.2015.06.005_bb0055","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"issue":"5576","key":"10.1016\/j.yjmcc.2015.06.005_bb0060","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1126\/science.1069424","article-title":"The structure of haplotype blocks in the human genome","volume":"296","author":"Gabriel","year":"2002","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.yjmcc.2015.06.005_bb0065","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/ng.2394","article-title":"Mapping cis- and trans-regulatory effects across multiple tissues in twins","volume":"44","author":"Grundberg","year":"2012","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.yjmcc.2015.06.005_bb0070","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.hrthm.2013.10.051","article-title":"Gene expression and genetic variation in human atria","volume":"11","author":"Lin","year":"2014","journal-title":"Heart Rhythm"},{"issue":"7492","key":"10.1016\/j.yjmcc.2015.06.005_bb0075","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature13138","article-title":"Obesity-associated variants within FTO form long-range functional connections with IRX3","volume":"507","author":"Smemo","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.yjmcc.2015.06.005_bb0080","doi-asserted-by":"crossref","first-page":"e85144","DOI":"10.1371\/journal.pone.0085144","article-title":"Role of caveolin-1 in atrial fibrillation as an anti-fibrotic signaling molecule in human atrial fibroblasts","volume":"9","author":"Yi","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.yjmcc.2015.06.005_bb0085","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.bbalip.2010.04.001","article-title":"Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae","volume":"1801","author":"Fu","year":"2010","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1016\/j.yjmcc.2015.06.005_bb0090","doi-asserted-by":"crossref","first-page":"e11004","DOI":"10.1371\/journal.pone.0011004","article-title":"Proinflammatory phenotype and increased caveolin-1 in alveolar macrophages with silenced CFTR mRNA","volume":"5","author":"Xu","year":"2010","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.yjmcc.2015.06.005_bb0095","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S1471-4906(01)02161-5","article-title":"Caveolae and caveolin in immune cells: distribution and functions","volume":"23","author":"Harris","year":"2002","journal-title":"Trends Immunol"},{"issue":"2","key":"10.1016\/j.yjmcc.2015.06.005_bb0100","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0008-6363(02)00273-0","article-title":"Structural correlate of atrial fibrillation in human patients","volume":"54","author":"Kostin","year":"2002","journal-title":"Cardiovasc Res"},{"issue":"25","key":"10.1016\/j.yjmcc.2015.06.005_bb0105","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1038\/sj.onc.1206625","article-title":"Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells","volume":"22","author":"Burgermeister","year":"2003","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.yjmcc.2015.06.005_bb0110","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1093\/europace\/eur131","article-title":"Beneficial effect of pioglitazone on the outcome of catheter ablation in patients with paroxysmal atrial fibrillation and type 2 diabetes mellitus","volume":"13","author":"Gu","year":"2011","journal-title":"Europace"},{"issue":"6","key":"10.1016\/j.yjmcc.2015.06.005_bb0115","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1536\/ihj.14-107","article-title":"Beneficial effects of pioglitazone on retardation of persistent atrial fibrillation progression in diabetes mellitus patients","volume":"55","author":"Liu","year":"2014","journal-title":"Int Heart J"},{"issue":"1","key":"10.1016\/j.yjmcc.2015.06.005_bb0120","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1124\/jpet.113.211722","article-title":"Distinct properties of telmisartan on agonistic activities for peroxisome proliferator-activated receptor gamma among clinically used angiotensin II receptor blockers: drug-target interaction analyses","volume":"349","author":"Kakuta","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"10.1016\/j.yjmcc.2015.06.005_bb0125","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/1755-5922.12073","article-title":"Effect of telmisartan on atrial fibrillation recurrences in patients with hypertension: a systematic review and meta-analysis","volume":"32","author":"Pan","year":"2014","journal-title":"Cardiovasc Ther"},{"issue":"26","key":"10.1016\/j.yjmcc.2015.06.005_bb0130","doi-asserted-by":"crossref","first-page":"14632","DOI":"10.1073\/pnas.260501097","article-title":"Calsarcins, a novel family of sarcomeric calcineurin-binding proteins","volume":"97","author":"Frey","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.yjmcc.2015.06.005_bb0135","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.ymgme.2006.12.008","article-title":"Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy","volume":"90","author":"Arola","year":"2007","journal-title":"Mol Genet Metab"},{"issue":"3","key":"10.1016\/j.yjmcc.2015.06.005_bb0140","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCGENETICS.111.961631","article-title":"Whole genome expression differences in human left and right atria ascertained by RNA sequencing","volume":"5","author":"Hsu","year":"2012","journal-title":"Circ Cardiovasc Genet"},{"issue":"2","key":"10.1016\/j.yjmcc.2015.06.005_bb0145","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/nar\/gkq817","article-title":"A comparison of RNA-Seq and high-density exon array for detecting differential gene expression between closely related species","volume":"39","author":"Liu","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.yjmcc.2015.06.005_bb0150","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1161\/CIRCGENETICS.110.958058","article-title":"PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression","volume":"4","author":"Kirchhof","year":"2011","journal-title":"Circ Cardiovasc Genet"},{"issue":"10","key":"10.1016\/j.yjmcc.2015.06.005_bb0155","doi-asserted-by":"crossref","first-page":"e26389","DOI":"10.1371\/journal.pone.0026389","article-title":"Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue","volume":"6","author":"Kahr","year":"2011","journal-title":"PLoS One"},{"issue":"7151","key":"10.1016\/j.yjmcc.2015.06.005_bb0160","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature06007","article-title":"Variants conferring risk of atrial fibrillation on chromosome 4q25","volume":"448","author":"Gudbjartsson","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.yjmcc.2015.06.005_bb0165","doi-asserted-by":"crossref","first-page":"e86245","DOI":"10.1371\/journal.pone.0086245","article-title":"Atrial fibrillation associated chromosome 4q25 variants are not associated with PITX2c expression in human adult left atrial appendages","volume":"9","author":"Gore-Panter","year":"2014","journal-title":"PLoS One"},{"issue":"21","key":"10.1016\/j.yjmcc.2015.06.005_bb0170","doi-asserted-by":"crossref","first-page":"5081","DOI":"10.1242\/dev.129.21.5081","article-title":"Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions","volume":"129","author":"Liu","year":"2002","journal-title":"Development"},{"issue":"21","key":"10.1016\/j.yjmcc.2015.06.005_bb0175","doi-asserted-by":"crossref","first-page":"9753","DOI":"10.1073\/pnas.0912585107","article-title":"Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification","volume":"107","author":"Wang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"10.1016\/j.yjmcc.2015.06.005_bb0180","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1242\/dev.128.11.2039","article-title":"Regulation of left-right asymmetry by thresholds of Pitx2c activity","volume":"128","author":"Liu","year":"2001","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.yjmcc.2015.06.005_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jmg.40.1.1","article-title":"Fanconi anaemia","volume":"40","author":"Tischkowitz","year":"2003","journal-title":"J Med Genet"},{"issue":"51","key":"10.1016\/j.yjmcc.2015.06.005_bb0190","doi-asserted-by":"crossref","first-page":"49638","DOI":"10.1074\/jbc.M209386200","article-title":"The anti-apoptotic function of Hsp70 in the interferon-inducible double-stranded RNA-dependent protein kinase-mediated death signaling pathway requires the Fanconi anemia protein, FANCC","volume":"277","author":"Pang","year":"2002","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.yjmcc.2015.06.005_bb0195","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.gene.2013.06.051","article-title":"Lowered expression levels of a tumor suppressor gene\u2014caveolin-1 within dysregulated gene networks of Fanconi anemia","volume":"527","author":"Shyamsunder","year":"2013","journal-title":"Gene"},{"issue":"14","key":"10.1016\/j.yjmcc.2015.06.005_bb0200","doi-asserted-by":"crossref","first-page":"14310","DOI":"10.1074\/jbc.M413222200","article-title":"Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase","volume":"280","author":"Diaz-Perales","year":"2005","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.yjmcc.2015.06.005_bb0205","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/08037050310001057","article-title":"Angiotensin AT1\/AT2 receptors: regulation, signalling and function","volume":"12","author":"Kaschina","year":"2003","journal-title":"Blood Press"},{"issue":"12","key":"10.1016\/j.yjmcc.2015.06.005_bb0210","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1161\/01.CIR.0000090688.49283.67","article-title":"Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans","volume":"108","author":"Sanders","year":"2003","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.yjmcc.2015.06.005_bb0215","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0735-1097(03)00464-9","article-title":"Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation","volume":"41","author":"Kumagai","year":"2003","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.yjmcc.2015.06.005_bb0220","first-page":"31","article-title":"Role of the renin\u2013angiotensin\u2013aldosterone system in atrial fibrillation and cardiac remodeling","volume":"20","author":"Healey","year":"2005","journal-title":"Curr Opin Cardiol"},{"issue":"4","key":"10.1016\/j.yjmcc.2015.06.005_bb0225","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/clpt.2010.123","article-title":"The role of renin\u2013angiotensin system blockade therapy in the prevention of atrial fibrillation: a meta-analysis of randomized controlled trials","volume":"88","author":"Zhang","year":"2010","journal-title":"Clin Pharmacol Ther"},{"issue":"10","key":"10.1016\/j.yjmcc.2015.06.005_bb0230","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1056\/NEJM199809033391003","article-title":"Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins","volume":"339","author":"Haissaguerre","year":"1998","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.yjmcc.2015.06.005_bb0235","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0008-6363(02)00223-7","article-title":"Mother rotors and fibrillatory conduction: a mechanism of atrial fibrillation","volume":"54","author":"Jalife","year":"2002","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.yjmcc.2015.06.005_bb0240","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1161\/CIRCEP.114.001632","article-title":"Left atrial transcriptional changes associated with atrial fibrillation susceptibility and persistence","volume":"8","author":"Deshmukh","year":"2015","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"8","key":"10.1016\/j.yjmcc.2015.06.005_bb0245","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/ng.416","article-title":"Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry","volume":"41","author":"Benjamin","year":"2009","journal-title":"Nat Genet"},{"issue":"8","key":"10.1016\/j.yjmcc.2015.06.005_bb0250","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1038\/ng.417","article-title":"A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke","volume":"41","author":"Gudbjartsson","year":"2009","journal-title":"Nat Genet"},{"issue":"3","key":"10.1016\/j.yjmcc.2015.06.005_bb0255","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ng.537","article-title":"Common variants in KCNN3 are associated with lone atrial fibrillation","volume":"42","author":"Ellinor","year":"2010","journal-title":"Nat Genet"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815001911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815001911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T02:01:07Z","timestamp":1652407267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282815001911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":51,"alternative-id":["S0022282815001911"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.06.005","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic variants associated with risk of atrial fibrillation regulate expression of PITX2, CAV1, MYOZ1, C9orf3 and FANCC","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}