{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:46:45Z","timestamp":1790048805675,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Chicago Biomedical Consortium"}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.yjmcc.2015.08.009","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T02:30:21Z","timestamp":1440383421000},"page":"171-179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis"],"prefix":"10.1016","volume":"87","author":[{"given":"Shuang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yi","family":"Yeap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubov","family":"Grigoryeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Dehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"DeBerge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Rostlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorien","family":"Schrijvers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng Jenny","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronen","family":"Sumagin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren G.","family":"Tourtellotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Lomasney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Morrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Thorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.yjmcc.2015.08.009_bb0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0092-8674(02)00819-X","article-title":"How to eat something bigger than your head","volume":"110","author":"Aderem","year":"2002","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.yjmcc.2015.08.009_bb0010","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1161\/CIRCRESAHA.109.213629","article-title":"Role of the urokinase plasminogen activator receptor in mediating impaired efferocytosis of anti-SSA\/Ro-bound apoptotic cardiocytes: implications in the pathogenesis of congenital heart block","volume":"107","author":"Briassouli","year":"2010","journal-title":"Circ. Res."},{"issue":"14","key":"10.1016\/j.yjmcc.2015.08.009_bb0015","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jacc.2008.01.011","article-title":"Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction","volume":"51","author":"Bujak","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.yjmcc.2015.08.009_bb0020","doi-asserted-by":"crossref","first-page":"3498","DOI":"10.4049\/jimmunol.162.6.3498","article-title":"A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha production and lipopolysaccharide-induced endotoxic shock","volume":"162","author":"Camenisch","year":"1999","journal-title":"J. Immunol."},{"issue":"Pt 4","key":"10.1016\/j.yjmcc.2015.08.009_bb0025","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1242\/jcs.101.4.907","article-title":"The macrophage capacity for phagocytosis","volume":"101","author":"Cannon","year":"1992","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.yjmcc.2015.08.009_bb0030","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1189\/jlb.1MR0114-021R","article-title":"Phagosome maturation in polarized macrophages","volume":"96","author":"Canton","year":"2014","journal-title":"J. Leukoc. Biol."},{"issue":"13","key":"10.1016\/j.yjmcc.2015.08.009_bb0035","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1073\/pnas.0600997103","article-title":"Role of target geometry in phagocytosis","volume":"103","author":"Champion","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7261","key":"10.1016\/j.yjmcc.2015.08.009_bb0040","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nature08296","article-title":"Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance","volume":"461","author":"Elliott","year":"2009","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.yjmcc.2015.08.009_bb0045","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1083\/jcb.201004096","article-title":"Clearance of apoptotic cells: implications in health and disease","volume":"189","author":"Elliott","year":"2010","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.yjmcc.2015.08.009_bb0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.immuni.2013.11.019","article-title":"Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation","volume":"40","author":"Epelman","year":"2014","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.yjmcc.2015.08.009_bb0055","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1172\/JCI1112","article-title":"Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine\/paracrine mechanisms involving TGF-beta, PGE2, and PAF","volume":"101","author":"Fadok","year":"1998","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.yjmcc.2015.08.009_bb0060","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0008-6363(01)00434-5","article-title":"The inflammatory response in myocardial infarction","volume":"53","author":"Frangogiannis","year":"2002","journal-title":"Cardiovasc. Res."},{"issue":"1\u20132","key":"10.1016\/j.yjmcc.2015.08.009_bb0065","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000331392","article-title":"Optimizing dynamic interactions between a cardiac patch and inflammatory host cells","volume":"195","author":"Freytes","year":"2012","journal-title":"Cells Tissues Organs"},{"issue":"11","key":"10.1016\/j.yjmcc.2015.08.009_bb0070","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ni.2419","article-title":"Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages","volume":"13","author":"Gautier","year":"2012","journal-title":"Nat. Immunol."},{"issue":"19","key":"10.1016\/j.yjmcc.2015.08.009_bb0075","doi-asserted-by":"crossref","first-page":"R795","DOI":"10.1016\/S0960-9822(01)00474-2","article-title":"Apoptotic cell removal","volume":"11","author":"Henson","year":"2001","journal-title":"Curr. Biol."},{"issue":"4","key":"10.1016\/j.yjmcc.2015.08.009_bb0080","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.200601030","article-title":"ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages","volume":"174","author":"Jehle","year":"2006","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.yjmcc.2015.08.009_bb0085","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijcard.2008.04.059","article-title":"Macrophage roles following myocardial infarction","volume":"130","author":"Lambert","year":"2008","journal-title":"Int. J. Cardiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2015.08.009_bb0090","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0002-9440(10)61739-7","article-title":"Dynamic process of apoptosis in adult rat cardiomyocytes analyzed using 48-hour videomicroscopy and electron microscopy: beating and rate are associated with the apoptotic process","volume":"159","author":"Maruyama","year":"2001","journal-title":"Am. J. Pathol."},{"issue":"1\u20132","key":"10.1016\/j.yjmcc.2015.08.009_bb0095","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0165-0270(92)90140-9","article-title":"Immunocytochemical staining of neuropeptides in terminal arborization of primary afferent fibers anterogradely labeled and identified at light and electron microscopic levels","volume":"42","author":"Merighi","year":"1992","journal-title":"J. Neurosci. Methods"},{"issue":"12","key":"10.1016\/j.yjmcc.2015.08.009_bb0100","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"Nahrendorf","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.yjmcc.2015.08.009_bb0105","first-page":"271","article-title":"Isolation and culture of adult mouse cardiac myocytes","volume":"357","author":"O'Connell","year":"2007","journal-title":"Methods Mol. Biol."},{"issue":"4","key":"10.1016\/j.yjmcc.2015.08.009_bb0110","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.immuni.2011.09.004","article-title":"Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways","volume":"35","author":"Ravichandran","year":"2011","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.yjmcc.2015.08.009_bb0115","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1182\/blood-2006-05-021634","article-title":"A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation","volume":"109","author":"Sather","year":"2007","journal-title":"Blood"},{"issue":"6834","key":"10.1016\/j.yjmcc.2015.08.009_bb0120","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/35075603","article-title":"Phagocytosis and clearance of apoptotic cells is mediated by MER","volume":"411","author":"Scott","year":"2001","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.yjmcc.2015.08.009_bb0125","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ni1276","article-title":"Resolution of inflammation: the beginning programs the end","volume":"6","author":"Serhan","year":"2005","journal-title":"Nat. Immunol."},{"issue":"6116","key":"10.1016\/j.yjmcc.2015.08.009_bb0130","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1126\/science.1230719","article-title":"Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure","volume":"339","author":"Swirski","year":"2013","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.yjmcc.2015.08.009_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117787","article-title":"MERTK deficiency affects macrophage directional migration via disruption of cytoskeletal organization","volume":"10","author":"Tang","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.yjmcc.2015.08.009_bb0140","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/ATVBAHA.108.167197","article-title":"MERTK receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of Apoe\u2212\/\u2212 mice","volume":"28","author":"Thorp","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"38","key":"10.1016\/j.yjmcc.2015.08.009_bb0145","doi-asserted-by":"crossref","first-page":"33335","DOI":"10.1074\/jbc.M111.263020","article-title":"Shedding of the Mer tyrosine kinase receptor is mediated by ADAM17 protein through a pathway involving reactive oxygen species, protein kinase Cdelta, and p38 mitogen-activated protein kinase (MAPK)","volume":"286","author":"Thorp","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.08.009_bb0150","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/B978-0-12-385116-1.00016-9","article-title":"Methods and models for monitoring UPR-associated macrophage death during advanced atherosclerosis","volume":"489","author":"Thorp","year":"2011","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.yjmcc.2015.08.009_bb0155","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/1752-0509-4-149","article-title":"The zipper mechanism in phagocytosis: energetic requirements and variability in phagocytic cup shape","volume":"4","author":"Tollis","year":"2010","journal-title":"BMC Syst. Biol."},{"issue":"7","key":"10.1016\/j.yjmcc.2015.08.009_bb0160","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nri3244","article-title":"Information processing during phagocytosis","volume":"12","author":"Underhill","year":"2012","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.yjmcc.2015.08.009_bb0165","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1378\/chest.129.6.1673","article-title":"Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease","volume":"129","author":"Vandivier","year":"2006","journal-title":"Chest"},{"issue":"8","key":"10.1016\/j.yjmcc.2015.08.009_bb0170","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCRESAHA.113.301198","article-title":"Enhanced efferocytosis of apoptotic cardiomyocytes through myeloid\u2013epithelial\u2013reproductive tyrosine kinase links acute inflammation resolution to cardiac repair after infarction","volume":"113","author":"Wan","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.08.009_bb0175","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.physiol.010908.163111","article-title":"Cell death in the pathogenesis of heart disease: mechanisms and significance","volume":"72","author":"Whelan","year":"2010","journal-title":"Annu. Rev. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.yjmcc.2015.08.009_bb0180","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cellimm.2014.04.006","article-title":"Phagocyte\u2013myocyte interactions and consequences during hypoxic wound healing","volume":"291","author":"Zhang","year":"2014","journal-title":"Cell. Immunol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815300420?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815300420?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T06:26:18Z","timestamp":1691907978000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282815300420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":36,"alternative-id":["S0022282815300420"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.08.009","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiomyocytes induce macrophage receptor shedding to suppress phagocytosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}