{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:09:19Z","timestamp":1792030159500,"version":"4.4.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.yjmcc.2015.10.022","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T14:06:10Z","timestamp":1445695570000},"page":"268-279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":198,"special_numbering":"PB","title":["A critical role of cardiac fibroblast-derived exosomes in activating renin angiotensin system in cardiomyocytes"],"prefix":"10.1016","volume":"89","author":[{"given":"Linmao","family":"Lyu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitzi","family":"Nagarkatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakash","family":"Nagarkatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Janicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-7299","authenticated-orcid":false,"given":"Taixing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2015.10.022_bb0005","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0008-6363(99)00145-5","article-title":"The renin\u2013angiotensin system and experimental heart failure","volume":"43","author":"Wollert","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0010","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1016\/j.cellsig.2014.06.011","article-title":"A century old renin\u2013angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology","volume":"26","author":"Balakumar","year":"2014","journal-title":"Cell. Signal."},{"issue":"Pt 1","key":"10.1016\/j.yjmcc.2015.10.022_bb0015","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/bj3470275","article-title":"Specific role of the extracellular signal-regulated kinase pathway in angiotensin II-induced cardiac hypertrophy in vitro","volume":"347","author":"Aoki","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0020","doi-asserted-by":"crossref","first-page":"H901","DOI":"10.1152\/ajpheart.00250.2011","article-title":"Cooperative interaction between reactive oxygen species and Ca2+ signals contributes to angiotensin II-induced hypertrophy in adult rat cardiomyocytes","volume":"302","author":"Gul","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0025","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jprot.2010.06.006","article-title":"Exosomes: extracellular organelles important in intercellular communication","volume":"73","author":"Mathivanan","year":"2010","journal-title":"J. Proteomics"},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0030","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/j.bcp.2011.02.011","article-title":"Exosomes as intercellular signalosomes and pharmacological effectors","volume":"81","author":"Record","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0035","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1038\/labinvest.2010.152","article-title":"Role of extracellular membrane vesicles in the pathogenesis of various diseases, including cancer, renal diseases, atherosclerosis, and arthritis","volume":"90","author":"Anderson","year":"2010","journal-title":"Lab. Investig."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0040","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1172\/JCI70577","article-title":"Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy","volume":"124","author":"Bang","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0045","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1161\/ATVBAHA.109.189480","article-title":"Nrf2 protects against maladaptive cardiac responses to hemodynamic stress","volume":"29","author":"Li","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0050","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/cvr\/cvr010","article-title":"Up-regulation of p27(kip1) contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy","volume":"90","author":"Li","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0055","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.yjmcc.2013.04.004","article-title":"Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success","volume":"60","author":"Addis","year":"2013","journal-title":"J. Mol. Cell Cardiol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0060","doi-asserted-by":"crossref","unstructured":"Thery C, Amigorena S, Raposo G, Clayton A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr. Protoc. Cell Biol. 2006;Chapter 3:Unit 3 22.","DOI":"10.1002\/0471143030.cb0322s30"},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0065","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/nm.2753","article-title":"Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET","volume":"18","author":"Peinado","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0070","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1007\/s00018-011-0689-3","article-title":"Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles","volume":"68","author":"Gyorgy","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0075","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ceb.2009.03.007","article-title":"Exosomes\u2013vesicular carriers for intercellular communication","volume":"21","author":"Simons","year":"2009","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0080","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/jcp.22322","article-title":"The origin of fibroblasts and mechanism of cardiac fibrosis","volume":"225","author":"Krenning","year":"2010","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0085","doi-asserted-by":"crossref","first-page":"5238","DOI":"10.1158\/0008-5472.CAN-04-3804","article-title":"Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells","volume":"65","author":"Gastpar","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0090","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/jcp.20197","article-title":"Interactions between cardiac cells enhance cardiomyocyte hypertrophy and increase fibroblast proliferation","volume":"202","author":"Fredj","year":"2005","journal-title":"J. Cell Physiol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0095","doi-asserted-by":"crossref","first-page":"C1799","DOI":"10.1152\/ajpcell.00166.2006","article-title":"Cardiac fibroblasts influence cardiomyocyte phenotype in vitro","volume":"292","author":"LaFramboise","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0100","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/cvr\/cvm056","article-title":"Regulation of sarcoplasmic reticulum Ca2+ ATPase pump expression and its relevance to cardiac muscle physiology and pathology","volume":"77","author":"Periasamy","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0105","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1172\/JCI24144","article-title":"Toward transcriptional therapies for the failing heart: chemical screens to modulate genes","volume":"115","author":"McKinsey","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0110","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2337\/db10-1164","article-title":"Diabetic downregulation of Nrf2 activity via ERK contributes to oxidative stress-induced insulin resistance in cardiac cells in vitro and in vivo","volume":"60","author":"Tan","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0115","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.bbrc.2014.01.101","article-title":"Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2","volume":"444","author":"Li","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0120","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jep.2010.03.040","article-title":"An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytes","volume":"130","author":"Li","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0125","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1476-5381.2012.02195.x","article-title":"The role of the paracrine\/autocrine mediator endothelin-1 in regulation of cardiac contractility and growth","volume":"168","author":"Drawnel","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0130","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cardiores.2004.04.030","article-title":"TGF-beta1 and angiotensin networking in cardiac remodeling","volume":"63","author":"Rosenkranz","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0135","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1242\/jcs.115.12.2505","article-title":"The exosome pathway in K562 cells is regulated by Rab11","volume":"115","author":"Savina","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0140","doi-asserted-by":"crossref","first-page":"17442","DOI":"10.1074\/jbc.M110.107821","article-title":"Secretory mechanisms and intercellular transfer of microRNAs in living cells","volume":"285","author":"Kosaka","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0145","first-page":"457","article-title":"Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells","volume":"120","author":"Chalmin","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0150","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.2353\/ajpath.2008.070762","article-title":"Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK\/p38 MAP kinase pathway","volume":"172","author":"Koka","year":"2008","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0155","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3109\/10715762.2011.560149","article-title":"Telmisartan attenuates oxidative stress and renal fibrosis in streptozotocin induced diabetic mice with the alteration of angiotensin-(1\u20137) mas receptor expression associated with its PPAR-gamma agonist action","volume":"45","author":"Lakshmanan","year":"2011","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0160","article-title":"The microRNA-132\/212 family fine-tunes multiple targets in angiotensin II signalling in cardiac fibroblasts","author":"Eskildsen","year":"2014","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0165","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/01.HYP.0000128621.68160.dd","article-title":"Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy","volume":"43","author":"Matsui","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0030156","article-title":"The epidermal growth factor receptor is involved in angiotensin II but not aldosterone\/salt-induced cardiac remodelling","volume":"7","author":"Messaoudi","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0175","doi-asserted-by":"crossref","first-page":"29661","DOI":"10.1074\/jbc.M411694200","article-title":"Androgen receptor gene knockout male mice exhibit impaired cardiac growth and exacerbation of angiotensin II-induced cardiac fibrosis","volume":"280","author":"Ikeda","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0180","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.neurobiolaging.2014.02.012","article-title":"Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease","volume":"35","author":"Dinkins","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1177\/1074248413501018","article-title":"Renin\u2013angiotensin system blocking drugs","volume":"19","author":"Robles","year":"2014","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0190","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/000155501317140007","article-title":"Angiotensin-converting enzyme inhibitors as inducers of adverse cutaneous reactions","volume":"81","author":"Steckelings","year":"2001","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0195","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.0906-6705.2004.0139.x","article-title":"Human skin: source of and target organ for angiotensin II","volume":"13","author":"Steckelings","year":"2004","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.yjmcc.2015.10.022_bb0200","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1093\/nar\/gkq601","article-title":"Export of microRNAs and microRNA-protective protein by mammalian cells","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815300924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815300924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T22:39:13Z","timestamp":1653345553000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282815300924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":40,"alternative-id":["S0022282815300924"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.10.022","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A critical role of cardiac fibroblast-derived exosomes in activating renin angiotensin system in cardiomyocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.10.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}