{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:06:46Z","timestamp":1790467606826,"version":"4.1.0"},"reference-count":200,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL115933"],"award-info":[{"award-number":["HL115933"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL103566"],"award-info":[{"award-number":["HL103566"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL066941"],"award-info":[{"award-number":["HL066941"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["HL127806"],"award-info":[{"award-number":["HL127806"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.yjmcc.2015.11.010","type":"journal-article","created":{"date-parts":[[2015,11,10]],"date-time":"2015-11-10T04:42:05Z","timestamp":1447130525000},"page":"162-174","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":149,"special_numbering":"C","title":["Integrins and integrin-related proteins in cardiac fibrosis"],"prefix":"10.1016","volume":"93","author":[{"given":"Chao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Manso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2015.11.010_bb0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4065\/81.1.71","article-title":"A look between the cardiomyocytes: the extracellular matrix in heart failure","volume":"81","author":"Miner","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0010","doi-asserted-by":"crossref","DOI":"10.1038\/nrd4592","article-title":"Dissecting fibrosis: therapeutic insights from the small-molecule toolbox","author":"Nanthakumar","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrcardio.2012.158","article-title":"Myofibroblast-mediated mechanisms of pathological remodelling of the heart","volume":"10","author":"Weber","year":"2013","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nrcardio.2014.159","article-title":"Cardiac MRI: a central prognostic tool in myocardial fibrosis","volume":"12","author":"Ambale-Venkatesh","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0025","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/ni.2109","article-title":"Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils","volume":"12","author":"Galli","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/CS20060242","article-title":"Liver fibrosis: cellular mechanisms of progression and resolution","volume":"112","author":"Henderson","year":"2007","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0035","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1172\/JCI31139","article-title":"Systemic sclerosis: a prototypic multisystem fibrotic disorder","volume":"117","author":"Varga","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0040","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrcardio.2009.199","article-title":"Myocardial remodeling after infarction: the role of myofibroblasts","volume":"7","author":"van den Borne","year":"2010","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0045","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ceb.2014.09.001","article-title":"Signaling pathway cooperation in TGF-beta-induced epithelial-mesenchymal transition","volume":"31","author":"Derynck","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0050","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40169-015-0055-4","article-title":"Epithelial mesenchymal transition: a double-edged sword","volume":"4","author":"Barriere","year":"2015","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ceb.2015.06.009","article-title":"Regulation of integrin-mediated adhesions","volume":"36","author":"Iwamoto","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0060","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/CIRCRESAHA.114.301275","article-title":"Integrins and integrin-associated proteins in the cardiac myocyte","volume":"114","author":"Israeli-Rosenberg","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0065","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fphar.2014.00131","article-title":"Integrins and cadherins as therapeutic targets in fibrosis","volume":"5","author":"Agarwal","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0075","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1152\/physrev.00008.2011","article-title":"Matricellular proteins in cardiac adaptation and disease","volume":"92","author":"Frangogiannis","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0080","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1242\/jcs.03098","article-title":"Integrin ligands at a glance","volume":"119","author":"Humphries","year":"2006","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0085","doi-asserted-by":"crossref","first-page":"4093","DOI":"10.1002\/j.1460-2075.1988.tb03303.x","article-title":"Electron microscopy and structural model of human fibronectin receptor","volume":"7","author":"Nermut","year":"1988","journal-title":"EMBO J."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0090","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrm2594","article-title":"Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus","volume":"10","author":"Wang","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0095","doi-asserted-by":"crossref","first-page":"E65","DOI":"10.1038\/ncb0402-e65","article-title":"Networks and crosstalk: integrin signalling spreads","volume":"4","author":"Schwartz","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0100","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.7716514","article-title":"Integrins and signal transduction pathways: the road taken","volume":"268","author":"Clark","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0105","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/FJC.0b013e3181d9f5d4","article-title":"Lack of beta3 integrin signaling contributes to calpain-mediated myocardial cell loss in pressure-overloaded myocardium","volume":"55","author":"Suryakumar","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0110","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1096\/fj.08-127480","article-title":"Beta3 integrin-mediated ubiquitination activates survival signaling during myocardial hypertrophy","volume":"23","author":"Johnston","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/15419060109080710","article-title":"Prominent beta-5 gene expression in the cardiovascular system and in the cartilaginous primordiae of the skeleton during mouse development","volume":"8","author":"Le Gat","year":"2001","journal-title":"Cell Commun. Adhes."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0120","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1083\/jcb.129.3.867","article-title":"Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin","volume":"129","author":"Huhtala","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0125","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0092-8674(00)81235-0","article-title":"Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3","volume":"85","author":"Brooks","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0130","doi-asserted-by":"crossref","first-page":"C254","DOI":"10.1152\/ajpcell.00235.2005","article-title":"Beta-adrenergic receptor-stimulated apoptosis in adult cardiac myocytes involves MMP-2-mediated disruption of beta1 integrin signaling and mitochondrial pathway","volume":"290","author":"Menon","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0135","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1074\/mcp.M800449-MCP200","article-title":"MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages","volume":"8","author":"Vaisar","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0140","doi-asserted-by":"crossref","first-page":"36556","DOI":"10.1074\/jbc.M112.384909","article-title":"Matrix metalloproteinase-2 cleavage of the beta1 integrin ectodomain facilitates colon cancer cell motility","volume":"287","author":"Kryczka","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0145","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1146\/annurev.biophys.050708.133744","article-title":"Biochemical and structural properties of the integrin-associated cytoskeletal protein talin","volume":"38","author":"Critchley","year":"2009","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0150","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/ni1548","article-title":"\u2018Tuning\u2019 of type I interferon-induced JAK\u2013STAT1 signaling by calcium-dependent kinases in macrophages","volume":"9","author":"Wang","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0155","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/0092-8674(87)90126-7","article-title":"Colocalization of calcium-dependent protease II and one of its substrates at sites of cell adhesion","volume":"51","author":"Beckerle","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0160","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1242\/jcs.00166","article-title":"Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell\u2013matrix adhesion sites","volume":"115","author":"Zhang","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0165","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal adhesion kinase: in command and control of cell motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0170","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1128\/MCB.19.9.6120","article-title":"Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase","volume":"19","author":"Nolan","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0175","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/01.RES.0000081595.25297.1B","article-title":"Focal adhesion kinase is activated and mediates the early hypertrophic response to stretch in cardiac myocytes","volume":"93","author":"Torsoni","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0180","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00418-002-0476-1","article-title":"Modulation of integrins and integrin signaling molecules in the pressure-loaded murine ventricle","volume":"118","author":"Babbitt","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0185","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2466\/pms.1975.41.1.185","article-title":"Generation of different numbers of button presses under supplementary feedback conditions by educable retardates","volume":"41","author":"Holden","year":"1975","journal-title":"Percept. Mot. Skills"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0190","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1517\/14728220903473194","article-title":"Targeting Pyk2 for therapeutic intervention","volume":"14","author":"Lipinski","year":"2010","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0195","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/embor.2008.202","article-title":"Kindlins: essential regulators of integrin signalling and cell\u2013matrix adhesion","volume":"9","author":"Larjava","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0200","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/cvr\/cvs290","article-title":"Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms","volume":"97","author":"Askar","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0205","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0955-0674(97)80124-X","article-title":"Integrins and anoikis","volume":"9","author":"Frisch","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0210","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/path.3000","article-title":"Anoikis: an emerging hallmark in health and diseases","volume":"226","author":"Taddei","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0215","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1161\/01.ATV.0000099882.52647.E4","article-title":"Anoikis in the cardiovascular system: known and unknown extracellular mediators","volume":"23","author":"Michel","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0220","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1161\/01.CIR.101.24.2854","article-title":"Left ventricular hypertrophy in ascending aortic stenosis mice: anoikis and the progression to early failure","volume":"101","author":"Ding","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0225","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yjmcc.2015.11.028","article-title":"Modifying the mechanics of healing infarcts: is better the enemy of good?","volume":"93","author":"Holmes","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0230","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yjmcc.2015.12.024","article-title":"The crossroads of inflammation, fibrosis, and arrhythmia following myocardial infarction","volume":"91","author":"Stuart","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0235","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.yjmcc.2013.11.015","article-title":"Fibroblasts in myocardial infarction: a role in inflammation and repair","volume":"70","author":"Shinde","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0240","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.yjmcc.2009.07.015","article-title":"The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction","volume":"48","author":"Dobaczewski","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0245","doi-asserted-by":"crossref","first-page":"18954","DOI":"10.1074\/jbc.271.31.18954","article-title":"Fibronectin mRNA splice variant in articular cartilage lacks bases encoding the V, III-15, and I-10 protein segments","volume":"271","author":"MacLeod","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0250","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0008-6363(99)00212-6","article-title":"The infarcted myocardium: simply dead tissue, or a lively target for therapeutic interventions","volume":"44","author":"Cleutjens","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0255","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/01.CIR.89.1.151","article-title":"Structural basis of end-stage failure in ischemic cardiomyopathy in humans","volume":"89","author":"Beltrami","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0260","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0008-6363(99)00117-0","article-title":"Differential expression of alpha 1, alpha 3 and alpha 5 integrin subunits in acute and chronic stages of myocardial infarction in rats","volume":"43","author":"Nawata","year":"1999","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0265","first-page":"768720","article-title":"Allosteric modulation of beta1 integrin function induces lung tissue repair","volume":"2012","author":"Aljamal-Naylor","year":"2012","journal-title":"Adv. Pharmacol. Sci."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0270","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1083\/jcb.133.4.921","article-title":"Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin","volume":"133","author":"Huang","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0275","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1172\/JCI115794","article-title":"Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis","volume":"89","author":"Hertle","year":"1992","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0280","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/01.CIR.0000051363.86009.3C","article-title":"Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines","volume":"107","author":"Sun","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0285","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/hrt.2005.071001","article-title":"Deficiency of beta1 integrins results in increased myocardial dysfunction after myocardial infarction","volume":"92","author":"Krishnamurthy","year":"2006","journal-title":"Heart"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0290","first-page":"124","article-title":"Gender-based differences in cardiac remodeling and ILK expression after myocardial infarction","volume":"103","author":"Sofia","year":"2014","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0295","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/CIRCULATIONAHA.109.870725","article-title":"Increased expression of integrin-linked kinase attenuates left ventricular remodeling and improves cardiac function after myocardial infarction","volume":"120","author":"Ding","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0300","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1161\/01.RES.0000265233.40455.62","article-title":"Integrin-linked kinase at the heart of cardiac contractility, repair, and disease","volume":"100","author":"Hannigan","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0305","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-014-2188-y","article-title":"Mesenchymal stem cells overexpressing integrin-linked kinase attenuate left ventricular remodeling and improve cardiac function after myocardial infarction","volume":"397","author":"Mao","year":"2014","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0310","article-title":"Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction?","author":"Nahrendorf","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0315","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1161\/CIRCRESAHA.115.303567","article-title":"Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction","volume":"115","author":"Heidt","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0320","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s12265-012-9410-7","article-title":"Communication in the heart: the role of the innate immune system in coordinating cellular responses to ischemic injury","volume":"5","author":"Epelman","year":"2012","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0325","first-page":"305","article-title":"Systemic inflammatory response following acute myocardial infarction","volume":"12","author":"Fang","year":"2015","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0330","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ijcard.2014.11.006","article-title":"The cellular immune system in the post-myocardial infarction repair process","volume":"179","author":"Latet","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0335","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/eci.12118","article-title":"Targeting inflammatory pathways in myocardial infarction","volume":"43","author":"Christia","year":"2013","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0340","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1365-2362.2012.02677.x","article-title":"Leucocyte recruitment in inflammation and novel endogenous negative regulators thereof","volume":"42","author":"Chavakis","year":"2012","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0345","doi-asserted-by":"crossref","first-page":"359","DOI":"10.4049\/jimmunol.0803388","article-title":"Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1","volume":"183","author":"Hyun","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0350","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1126\/science.1163865","article-title":"The tail of integrins, talin, and kindlins","volume":"324","author":"Moser","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0355","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1084\/jem.193.10.1149","article-title":"Chemoattractants induce a rapid and transient upregulation of monocyte alpha4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigration","volume":"193","author":"Chan","year":"2001","journal-title":"J Exp Med."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0360","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1161\/CIRCULATIONAHA.108.823740","article-title":"Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia","volume":"119","author":"Wu","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0365","first-page":"487","article-title":"Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature","volume":"82","author":"O'Doherty","year":"1994","journal-title":"Immunology"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0370","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1189\/jlb.0804460","article-title":"Targeting leukocyte integrins in human diseases","volume":"77","author":"Yonekawa","year":"2005","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0375","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/1074-7613(95)90058-6","article-title":"A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3","volume":"3","author":"Van der Vieren","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0380","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1172\/JCI113364","article-title":"Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion","volume":"81","author":"Simpson","year":"1988","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0385","first-page":"H2300","article-title":"Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice","volume":"275","author":"Palazzo","year":"1998","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0390","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/jama.297.1.43","article-title":"Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial","volume":"297","author":"Investigators","year":"2007","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0395","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0735-1097(02)02136-8","article-title":"The effect of blockade of the CD11\/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI study","volume":"40","author":"Faxon","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0400","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1161\/hc4801.100236","volume":"104","author":"Baran","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0405","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0002-9149(01)01723-4","article-title":"An anti-CD11\/CD18 monoclonal antibody in patients with acute myocardial infarction having percutaneous transluminal coronary angioplasty (the FESTIVAL study)","volume":"88","author":"Rusnak","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0410","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.001932","article-title":"Anti-alpha4 integrin antibody blocks monocyte\/macrophage traffic to the heart and decreases cardiac pathology in a SIV infection model of AIDS","volume":"4","author":"Walker","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0415","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1172\/JCI31044","article-title":"ECM remodeling in hypertensive heart disease","volume":"117","author":"Berk","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0420","doi-asserted-by":"crossref","first-page":"H627","DOI":"10.1152\/ajpheart.00444.2008","article-title":"Cardiac fibroblasts require focal adhesion kinase for normal proliferation and migration","volume":"296","author":"Manso","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0425","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1054-8807(01)00104-1","article-title":"Differential integrin expression by cardiac fibroblasts from hypertensive and exercise-trained rat hearts","volume":"11","author":"Burgess","year":"2002","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0430","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/cvr\/cvp416","article-title":"FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex","volume":"86","author":"Dalla Costa","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0435","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1161\/CIRCRESAHA.107.160978","article-title":"Targeting focal adhesion kinase with small interfering RNA prevents and reverses load-induced cardiac hypertrophy in mice","volume":"101","author":"Clemente","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0440","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045076","article-title":"beta3 integrin in cardiac fibroblast is critical for extracellular matrix accumulation during pressure overload hypertrophy in mouse","volume":"7","author":"Balasubramanian","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0445","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/j.1532-5415.1997.tb02968.x","article-title":"Epidemiology, pathophysiology, and etiology of congestive heart failure in older adults","volume":"45","author":"Rich","year":"1997","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0450","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1111\/j.1755-5922.2010.00228.x","article-title":"Targeting fibrosis for the treatment of heart failure: a role for transforming growth factor-beta","volume":"30","author":"Edgley","year":"2012","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0455","article-title":"Aging and the cardiac extracellular matrix: novel mediators of fibrotic remodeling","author":"Horn","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0460","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/S0047-6374(01)00296-2","article-title":"Age-associated changes in cardiac matrix and integrins","volume":"122","author":"Burgess","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0465","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1161\/01.RES.71.6.1341","article-title":"Age-related changes in fibronectin expression in spontaneously hypertensive, Wistar-Kyoto, and Wistar rat hearts","volume":"71","author":"Mamuya","year":"1992","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0470","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1017\/S1431927611000390","article-title":"Age-dependent expression of collagen receptors and deformation of type I collagen substrates by rat cardiac fibroblasts","volume":"17","author":"Wilson","year":"2011","journal-title":"Microsc. Microanal."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0475","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1161\/01.CIR.0000051467.31874.29","article-title":"Decreased efficiency of adenovirus-mediated gene transfer in aging cardiomyocytes","volume":"107","author":"Communal","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0480","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/hh0402.105790","article-title":"Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure","volume":"90","author":"Shai","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0485","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.yjmcc.2015.12.011","article-title":"Diabetes-associated cardiac fibrosis: cellular effectors, molecular mechanisms and therapeutic opportunities","volume":"90","author":"Russo","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0490","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.pharmthera.2014.01.003","article-title":"Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways","volume":"142","author":"Huynh","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0495","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1177\/0960327112450885","article-title":"Diabetic cardiomyopathy: pathophysiological mechanisms and cardiac dysfunction","volume":"32","author":"Goyal","year":"2013","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0500","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.lfs.2012.10.028","article-title":"Molecular and metabolic mechanisms of cardiac dysfunction in diabetes","volume":"92","author":"Mandavia","year":"2013","journal-title":"Life Sci."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0505","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s12265-012-9405-4","article-title":"Crosstalk between the renin-angiotensin system and the advance glycation end product axis in the heart: role of the cardiac fibroblast","volume":"5","author":"Yamazaki","year":"2012","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0510","doi-asserted-by":"crossref","first-page":"H2860","DOI":"10.1152\/ajpheart.01167.2006","article-title":"Tranilast attenuates diastolic dysfunction and structural injury in experimental diabetic cardiomyopathy","volume":"293","author":"Kelly","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0515","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11010-006-9401-6","article-title":"High glucose promotes the production of collagen types I and III by cardiac fibroblasts through a pathway dependent on extracellular-signal-regulated kinase 1\/2","volume":"301","author":"Tang","year":"2007","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0520","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.cardiores.2004.10.041","article-title":"Tranilast attenuates cardiac matrix deposition in experimental diabetes: role of transforming growth factor-beta","volume":"65","author":"Martin","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0525","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/cvr\/cvs259","article-title":"alpha11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy","volume":"96","author":"Talior-Volodarsky","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0530","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1161\/CIRCRESAHA.110.217737","article-title":"Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activation","volume":"106","author":"Leask","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0535","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1093\/cvr\/28.11.1623","article-title":"Angiotensin II receptor binding following myocardial infarction in the rat","volume":"28","author":"Sun","year":"1994","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0540","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1006\/jmcc.1997.0435","article-title":"Angiotensin II stimulated expression of transforming growth factor-beta1 in cardiac fibroblasts and myofibroblasts","volume":"29","author":"Campbell","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0545","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI0214190","article-title":"TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II","volume":"109","author":"Schultz Jel","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0550","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3317\/jraas.2006.038","article-title":"Chronic blockade of angiotensin II AT1-receptors increased cell-to-cell communication, reduced fibrosis and improved impulse propagation in the failing heart","volume":"7","author":"De Mello","year":"2006","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0555","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1291\/hypres.28.787","article-title":"Impact of the angiotensin II receptor antagonist, losartan, on myocardial fibrosis in patients with end-stage renal disease: assessment by ultrasonic integrated backscatter and biochemical markers","volume":"28","author":"Shibasaki","year":"2005","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0560","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s12885-015-1471-y","article-title":"TIF1gamma interferes with TGFbeta1\/SMAD4 signaling to promote poor outcome in operable breast cancer patients","volume":"15","author":"Kassem","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0565","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1161\/01.HYP.35.4.978","article-title":"Angiotensin II and alpha(v)beta(3) integrin expression in rat neonatal cardiac fibroblasts","volume":"35","author":"Graf","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0570","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1161\/01.HYP.35.1.273","article-title":"Angiotensin II enhances integrin and alpha-actinin expression in adult rat cardiac fibroblasts","volume":"35","author":"Kawano","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0575","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.yjmcc.2003.11.007","article-title":"Alpha8beta1 integrin is upregulated in myofibroblasts of fibrotic and scarring myocardium","volume":"36","author":"Bouzeghrane","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0580","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/jcp.1041650224","article-title":"Role of the alpha 1 beta 1 integrin complex in collagen gel contraction in vitro by fibroblasts","volume":"165","author":"Carver","year":"1995","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0585","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/ajh.2008.309","article-title":"Deletion of the alpha8 integrin gene does not protect mice from myocardial fibrosis in DOCA hypertension","volume":"22","author":"Hartner","year":"2009","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0590","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/cvr\/cvq385","article-title":"Rac1 and RhoA differentially regulate angiotensinogen gene expression in stretched cardiac fibroblasts","volume":"90","author":"Verma","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0595","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","article-title":"Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system","volume":"292","author":"Mehta","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0600","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1161\/HYPERTENSIONAHA.115.06004","article-title":"Tenascin-C may accelerate cardiac fibrosis by activating macrophages via the integrin alphaVbeta3\/nuclear factor-kappaB\/interleukin-6 axis","volume":"66","author":"Shimojo","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0605","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1007\/s00018-011-0783-6","article-title":"Advances in tenascin-C biology","volume":"68","author":"Midwood","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0610","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089307","article-title":"Induction of atrial fibrillation by neutrophils critically depends on CD11b\/CD18 integrins","volume":"9","author":"Friedrichs","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0615","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1161\/01.HYP.0000148458.03202.48","article-title":"Osteopontin modulates myocardial hypertrophy in response to chronic pressure overload in mice","volume":"44","author":"Xie","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0620","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cytogfr.2008.08.001","article-title":"Osteopontin: role in immune regulation and stress responses","volume":"19","author":"Wang","year":"2008","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0625","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.jbiomech.2009.05.039","article-title":"RGD-dependent integrins are mechanotransducers in dynamically compressed tissue-engineered cartilage constructs","volume":"42","author":"Kock","year":"2009","journal-title":"J. Biomech."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0630","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.matbio.2005.05.005","article-title":"Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin","volume":"24","author":"Yokosaki","year":"2005","journal-title":"Matrix Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0635","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/01.HYP.0000128621.68160.dd","article-title":"Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy","volume":"43","author":"Matsui","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0640","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.jacc.2003.11.058","article-title":"Osteopontin modulates angiotensin II-induced fibrosis in the intact murine heart","volume":"43","author":"Collins","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0645","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1161\/01.HYP.33.2.663","article-title":"Myocardial osteopontin expression coincides with the development of heart failure","volume":"33","author":"Singh","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0650","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1172\/JCI119031","article-title":"Osteopontin is produced by rat cardiac fibroblasts and mediates a(II)-induced DNA synthesis and collagen gel contraction","volume":"98","author":"Ashizawa","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0655","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0660","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1006\/jmcc.1998.0721","article-title":"Angiotensin II, transforming growth factor-beta1 and repair in the infarcted heart","volume":"30","author":"Sun","year":"1998","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0665","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.cardiores.2004.07.017","article-title":"Inhibition of TGF-beta signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction","volume":"64","author":"Ikeuchi","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0670","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1172\/JCI44824","article-title":"Pivotal role of cardiomyocyte TGF-beta signaling in the murine pathological response to sustained pressure overload","volume":"121","author":"Koitabashi","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0675","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1006\/jmcc.1999.1065","article-title":"Myocardial fibrosis in transforming growth factor beta(1)heterozygous mice","volume":"32","author":"Brooks","year":"2000","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0680","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1091\/mbc.9.9.2627","article-title":"Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1","volume":"9","author":"Munger","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0685","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/stem.150190","article-title":"TGF-beta latency: biological significance and mechanisms of activation","volume":"15","author":"Gleizes","year":"1997","journal-title":"Stem Cells"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0690","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ejcb.2008.01.012","article-title":"Integrins and the activation of latent transforming growth factor beta1 \u2014 an intimate relationship","volume":"87","author":"Wipff","year":"2008","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0695","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/bj20020809","article-title":"The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3","volume":"369","author":"Ludbrook","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0700","doi-asserted-by":"crossref","first-page":"7708","DOI":"10.4049\/jimmunol.175.11.7708","article-title":"Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts","volume":"175","author":"Asano","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0705","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.200109100","article-title":"The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1","volume":"157","author":"Mu","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0710","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)80545-0","article-title":"The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis","volume":"96","author":"Munger","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0715","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1083\/jcb.200704042","article-title":"Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix","volume":"179","author":"Wipff","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0720","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2353\/ajpath.2006.041306","article-title":"Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts","volume":"168","author":"Asano","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0725","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1177\/41.10.8245410","article-title":"Restricted distribution of integrin beta 6 mRNA in primate epithelial tissues","volume":"41","author":"Breuss","year":"1993","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0730","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2353\/ajpath.2007.060158","article-title":"Alphav beta6 integrin regulates renal fibrosis and inflammation in alport mouse","volume":"170","author":"Hahm","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0735","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jhep.2007.11.021","article-title":"Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies","volume":"48","author":"Popov","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0740","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/jcb.21071","article-title":"Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721","volume":"100","author":"Wang","year":"2007","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0745","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0002-9440(10)63486-4","article-title":"Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(\u2212\/\u2212) mice","volume":"163","author":"Ma","year":"2003","journal-title":"Am J Pathol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0750","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1053\/j.gastro.2008.04.009","article-title":"Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression","volume":"135","author":"Patsenker","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0755","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0014-5793(01)03280-X","article-title":"The integrin alphaVbeta6 binds and activates latent TGFbeta3","volume":"511","author":"Annes","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0760","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1172\/JCI27183","article-title":"Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury","volume":"116","author":"Jenkins","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0765","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nature10152","article-title":"Latent TGF-beta structure and activation","volume":"474","author":"Shi","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0770","doi-asserted-by":"crossref","first-page":"F271","DOI":"10.1152\/ajprenal.00499.2013","article-title":"Kindlin-2 regulates renal tubular cell plasticity by activation of ras and its downstream signaling","volume":"306","author":"Wei","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0775","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1172\/JCI32526","article-title":"Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients","volume":"117","author":"Araya","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0780","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1172\/JCI45589","article-title":"Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin alphavbeta8-mediated activation of TGF-beta","volume":"121","author":"Kitamura","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0785","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ajpath.2010.10.031","article-title":"Mesangial cell integrin alphavbeta8 provides glomerular endothelial cell cytoprotection by sequestering TGF-beta and regulating PECAM-1","volume":"178","author":"Khan","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0790","doi-asserted-by":"crossref","first-page":"23996","DOI":"10.1074\/jbc.M311668200","article-title":"Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells","volume":"279","author":"Zhou","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0795","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/hep.23144","article-title":"Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis","volume":"50","author":"Patsenker","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0800","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1038\/sj.jid.5700331","article-title":"Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma","volume":"126","author":"Asano","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0805","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1002\/art.21246","article-title":"Involvement of alphavbeta5 integrin-mediated activation of latent transforming growth factor beta1 in autocrine transforming growth factor beta signaling in systemic sclerosis fibroblasts","volume":"52","author":"Asano","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0810","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1038\/nm.3282","article-title":"Targeting of alphav integrin identifies a core molecular pathway that regulates fibrosis in several organs","volume":"19","author":"Henderson","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0815","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa5094","article-title":"The alphavbeta1 integrin plays a critical in vivo role in tissue fibrosis","volume":"7","author":"Reed","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0820","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/art.33482","article-title":"Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation","volume":"64","author":"Lagares","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0825","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1089\/wound.2012.0363","article-title":"A key mediator of transforming growth factor beta signaling in fibroblasts","volume":"2","author":"Focal","year":"2013","journal-title":"Adv. Wound Care (New Rochelle)"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0830","doi-asserted-by":"crossref","first-page":"12384","DOI":"10.1074\/jbc.M208544200","article-title":"Myofibroblast differentiation by transforming growth factor-beta1 is dependent on cell adhesion and integrin signaling via focal adhesion kinase","volume":"278","author":"Thannickal","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0835","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/cvr\/cvu053","article-title":"Integrins alphavbeta5 and alphavbeta3 promote latent TGF-beta1 activation by human cardiac fibroblast contraction","volume":"102","author":"Sarrazy","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0840","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0845","doi-asserted-by":"crossref","first-page":"13180","DOI":"10.1073\/pnas.0605669103","article-title":"Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix","volume":"103","author":"Kim","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0850","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1681\/ASN.2008090930","article-title":"Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis","volume":"20","author":"Li","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0855","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1681\/ASN.2007030315","article-title":"PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase","volume":"18","author":"Li","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0860","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1172\/JCI200317913","article-title":"Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis","volume":"112","author":"Li","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0865","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1089\/hum.2009.160","article-title":"ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction","volume":"21","author":"Zhao","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0870","doi-asserted-by":"crossref","first-page":"E1475","DOI":"10.1073\/pnas.1117988108","article-title":"Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition","volume":"108","author":"Rock","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0875","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2353\/ajpath.2010.090517","article-title":"Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis","volume":"176","author":"Humphreys","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0880","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis","volume":"21","author":"Lovisa","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0885","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nm.3901","article-title":"Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease","volume":"21","author":"Grande","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0890","doi-asserted-by":"crossref","first-page":"724080","DOI":"10.4061\/2011\/724080","article-title":"Roles of TGF-beta signals in endothelial-mesenchymal transition during cardiac fibrosis","volume":"2011","author":"Yoshimatsu","year":"2011","journal-title":"Int. J. Inflamm."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0895","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1161\/CIRCULATIONAHA.110.938217","article-title":"Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition","volume":"121","author":"Widyantoro","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0900","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0905","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1016\/j.jacc.2015.03.520","article-title":"Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar","volume":"65","author":"Ruiz-Villalba","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0910","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1172\/JCI74783","article-title":"Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis","volume":"124","author":"Moore-Morris","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0915","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1083\/jcb.201004082","article-title":"Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression","volume":"190","author":"Liu","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0920","doi-asserted-by":"crossref","first-page":"G110","DOI":"10.1152\/ajpgi.00412.2010","article-title":"Hepatic stellate cells require a stiff environment for myofibroblastic differentiation","volume":"301","author":"Olsen","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0925","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biomaterials.2009.09.025","article-title":"In situ elasticity modulation with dynamic substrates to direct cell phenotype","volume":"31","author":"Kloxin","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0930","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.carpath.2012.10.003","article-title":"Substrate stiffness affects sarcomere and costamere structure and electrophysiological function of isolated adult cardiomyocytes","volume":"22","author":"Galie","year":"2013","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0935","doi-asserted-by":"crossref","first-page":"045009","DOI":"10.1088\/1758-5082\/6\/4\/045009","article-title":"Microengineered in vitro model of cardiac fibrosis through modulating myofibroblast mechanotransduction","volume":"6","author":"Zhao","year":"2014","journal-title":"Biofabrication"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0940","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.carpath.2010.10.001","article-title":"Reduced serum content and increased matrix stiffness promote the cardiac myofibroblast transition in 3D collagen matrices","volume":"20","author":"Galie","year":"2011","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0945","first-page":"884","article-title":"Tissue mechanics and fibrosis","volume":"2013","author":"Wells","year":"1832","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0950","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1172\/JCI1026","article-title":"Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts","volume":"101","author":"MacKenna","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0955","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.yexcr.2014.09.007","article-title":"Beta 1 integrin binding plays a role in the constant traction force generation in response to varying stiffness for cells grown on mature cardiac extracellular matrix","volume":"330","author":"Gershlak","year":"2015","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0960","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1365-2184.2005.00350.x","article-title":"Enhanced matrix degradation after withdrawal of TGF-beta1 triggers hepatocytes from apoptosis to proliferation and regeneration","volume":"38","author":"Arendt","year":"2005","journal-title":"Cell Prolif."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0965","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1073\/pnas.90.2.770","article-title":"Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death","volume":"90","author":"Kulkarni","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0970","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/359693a0","article-title":"Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease","volume":"359","author":"Shull","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0975","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1476-5381.2011.01247.x","article-title":"Novel therapeutic approaches for pulmonary fibrosis","volume":"163","author":"Datta","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0980","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s40259-012-0003-4","article-title":"Targeting focal adhesion kinase in fibrotic diseases","volume":"27","author":"Lagares","year":"2013","journal-title":"BioDrugs"},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0985","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1517\/13543784.2010.489548","article-title":"Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer","volume":"19","author":"Schultze","year":"2010","journal-title":"Expert Opin. Investig. Drugs."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0990","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2174\/187152011796817727","article-title":"Clinical importance and potential use of small molecule inhibitors of focal adhesion kinase","volume":"11","author":"Schultze","year":"2011","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb0995","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nm.2574","article-title":"Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling","volume":"18","author":"Wong","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2015.11.010_bb1000","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1084\/jem.20071297","article-title":"Periostin is essential for cardiac healing after acute myocardial infarction","volume":"205","author":"Shimazaki","year":"2008","journal-title":"J. Exp. Med."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815301152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815301152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T01:12:29Z","timestamp":1599786749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282815301152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":200,"alternative-id":["S0022282815301152"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.11.010","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrins and integrin-related proteins in cardiac fibrosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}