{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:28:11Z","timestamp":1792672091559,"version":"4.5.0"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2P20RR016467-09A1 INBRE II"],"award-info":[{"award-number":["2P20RR016467-09A1 INBRE II"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.yjmcc.2015.12.010","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T18:27:01Z","timestamp":1450290421000},"page":"129-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["The TGF-\u03b2 pathway mediates doxorubicin effects on cardiac endothelial cells"],"prefix":"10.1016","volume":"90","author":[{"given":"Zuyue","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Schriewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Marlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph V.","family":"Shohet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene A.","family":"Konorev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2015.12.010_bb0005","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/S0140-6736(14)60107-0","article-title":"Cardiovascular remodelling in coronary artery disease and heart failure","volume":"383","author":"Heusch","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027901","article-title":"A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure","volume":"6","author":"Fukushima","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0015","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1161\/CIRCULATIONAHA.109.872200","article-title":"Activin A and follistatin-like 3 determine the susceptibility of heart to ischemic injury","volume":"120","author":"Oshima","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-014-0365-0","article-title":"Myostatin and IGF-I signaling in end-stage human heart failure: a qRT-PCR study","volume":"13","author":"Baan","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0025","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cardfail.2008.05.003","article-title":"Activin-A, transforming growth factor-beta, and myostatin signaling pathway in experimental dilated cardiomyopathy","volume":"14","author":"Mahmoudabady","year":"2008","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0030","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1253\/circj.CJ-14-0511","article-title":"Enhanced bioactive myocardial transforming growth factor-beta in advanced human heart failure","volume":"78","author":"Khan","year":"2014","journal-title":"Circ. J."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0035","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/eurjhf\/hfr024","article-title":"Increased plasma myostatin in heart failure","volume":"13","author":"Gruson","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0040","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1161\/01.CIR.0000120704.97934.41","article-title":"Elevated levels of activin A in heart failure: potential role in myocardial remodeling","volume":"109","author":"Yndestad","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0045","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1101\/gad.1350705","article-title":"Smad transcription factors","volume":"19","author":"Massague","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0050","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1093\/emboj\/17.11.3091","article-title":"Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene","volume":"17","author":"Dennler","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0055","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.yjmcc.2013.07.014","article-title":"Coronary adventitial cells are linked to perivascular cardiac fibrosis via TGFbeta1 signaling in the mdx mouse model of Duchenne muscular dystrophy","volume":"63","author":"Ieronimakis","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0060","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1161\/CIRCHEARTFAILURE.109.931451","article-title":"Cardiac inflammation contributes to changes in the extracellular matrix in patients with heart failure and normal ejection fraction","volume":"4","author":"Westermann","year":"2011","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0065","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1161\/CIRCRESAHA.111.256776","article-title":"Interplay between heart and skeletal muscle disease in heart failure: the 2011 George E. Brown Memorial Lecture","volume":"110","author":"McNally","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0070","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1161\/CIRCULATIONAHA.111.080002","article-title":"Reduced endoglin activity limits cardiac fibrosis and improves survival in heart failure","volume":"125","author":"Kapur","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0075","first-page":"323","article-title":"BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF-beta signaling","volume":"2013","author":"Villar","year":"1832","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0080","doi-asserted-by":"crossref","first-page":"H1415","DOI":"10.1152\/ajpheart.01048.2009","article-title":"Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction","volume":"298","author":"Tan","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0085","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/01.CIR.0000020689.12472.E0","article-title":"Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats","volume":"106","author":"Kuwahara","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0090","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1523-1755.2004.00780.x","article-title":"TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways","volume":"66","author":"Nakagawa","year":"2004","journal-title":"Kidney Int."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0095","doi-asserted-by":"crossref","first-page":"23066","DOI":"10.1016\/S0021-9258(19)49426-X","article-title":"Inhibition of vascular endothelial cell growth by activin-A","volume":"268","author":"McCarthy","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0100","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1242\/jcs.084558","article-title":"TGFB1 disrupts the angiogenic potential of microvascular endothelial cells of the corpus luteum","volume":"124","author":"Maroni","year":"2011","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035460","article-title":"Premature senescence and increased TGFbeta signaling in the absence of Tgif1","volume":"7","author":"Zerlanko","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0110","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1093\/emboj\/21.7.1743","article-title":"Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors","volume":"21","author":"Goumans","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0115","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1242\/dev.107193","article-title":"Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking alphaVbeta8-TGFbeta signaling in the brain","volume":"141","author":"Arnold","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0120","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1242\/jcs.03419","article-title":"Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferation","volume":"120","author":"Castanares","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0125","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1038\/bjc.2011.348","article-title":"Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer","volume":"105","author":"Kaneda","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0130","first-page":"4596","article-title":"The N-myc oncogene in human neuroblastoma cells: down-regulation of an angiogenesis inhibitor identified as activin A","volume":"60","author":"Breit","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0135","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/RES.0b013e3182582523","article-title":"Animal models of heart failure: a scientific statement from the American Heart Association","volume":"111","author":"Houser","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0140","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/CIRCULATIONAHA.109.902221","article-title":"Juvenile exposure to anthracyclines impairs cardiac progenitor cell function and vascularization resulting in greater susceptibility to stress-induced myocardial injury in adult mice","volume":"121","author":"Huang","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0145","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0008-6363(98)00009-1","article-title":"A small animal model of non-ischemic cardiomyopathy and its evaluation by transthoracic echocardiography","volume":"39","author":"Schwarz","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0150","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/1097-0142(197308)32:2<302::AID-CNCR2820320205>3.0.CO;2-2","article-title":"A clinicopathologic analysis of adriamycin cardiotoxicity","volume":"32","author":"Lefrak","year":"1973","journal-title":"Cancer"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0155","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/pbc.20352","article-title":"Pathophysiology of anthracycline- and radiation-associated cardiomyopathies: implications for screening and prevention","volume":"44","author":"Adams","year":"2005","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0160","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1161\/01.CIR.0000133187.74800.B9","article-title":"Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management","volume":"109","author":"Yeh","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0165","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1200\/JCO.2009.26.5751","article-title":"Cardiotoxicity after childhood cancer: beginning with the end in mind","volume":"28","author":"Lipshultz","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0170","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/jnci\/djp440","article-title":"Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention","volume":"102","author":"Albini","year":"2010","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0175","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1161\/01.RES.84.3.257","article-title":"Daunorubicin-induced apoptosis in rat cardiac myocytes is inhibited by dexrazoxane","volume":"84","author":"Sawyer","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0180","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1161\/01.CIR.0000160359.49478.C2","article-title":"Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity","volume":"111","author":"Fisher","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0185","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.freeradbiomed.2008.09.006","article-title":"Differences in doxorubicin-induced apoptotic signaling in adult and immature cardiomyocytes","volume":"45","author":"Konorev","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0190","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.yjmcc.2004.04.016","article-title":"Apoptosome formation and caspase activation: is it different in the heart?","volume":"37","author":"Czerski","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0195","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1023\/A:1012218401036","article-title":"Comparison of three in vitro human \u2018angiogenesis\u2019 assays with capillaries formed in vivo","volume":"4","author":"Donovan","year":"2001","journal-title":"Angiogenesis"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0200","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1161\/ATVBAHA.112.248674","article-title":"Vascular endothelial growth factor-induced neovascularization rescues cardiac function but not adverse remodeling at advanced ischemic heart disease","volume":"32","author":"Gordon","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0205","doi-asserted-by":"crossref","first-page":"F198","DOI":"10.1152\/ajprenal.00244.2003","article-title":"HIF-1alpha expression follows microvascular loss in advanced murine adriamycin nephrosis","volume":"288","author":"Kairaitis","year":"2005","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0210","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.2337\/db09-0136","article-title":"Vascular endothelial growth factor inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt\/eNOS axis in db\/db mice","volume":"58","author":"Whee","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0215","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1161\/01.CIR.0000162472.52990.36","volume":"111","author":"Yoon","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0220","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1161\/01.HYP.0000215207.54689.31","article-title":"Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload","volume":"47","author":"Izumiya","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0225","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1172\/JCI24682","article-title":"Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure","volume":"115","author":"Shiojima","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0230","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"Sano","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0235","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1161\/CIRCULATIONAHA.109.895771","article-title":"Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function","volume":"121","author":"De Angelis","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0240","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.jid.5700486","article-title":"Chemotherapy targets the hair-follicle vascular network but not the stem cells","volume":"127","author":"Amoh","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0245","doi-asserted-by":"crossref","first-page":"10883","DOI":"10.1074\/jbc.M107442200","article-title":"Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism","volume":"277","author":"Lorenzo","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0250","first-page":"2034","article-title":"Combined anti-fetal liver kinase 1 monoclonal antibody and continuous low-dose doxorubicin inhibits angiogenesis and growth of human soft tissue sarcoma xenografts by induction of endothelial cell apoptosis","volume":"62","author":"Zhang","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0255","doi-asserted-by":"crossref","first-page":"33585","DOI":"10.1074\/jbc.M003890200","article-title":"Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen. Role of reactive oxygen and nitrogen species","volume":"275","author":"Kotamraju","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0260","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nrclinonc.2012.99","article-title":"Reducing the toxicity of cancer therapy: recognizing needs, taking action","volume":"9","author":"Cleeland","year":"2012","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0265","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fphar.2013.00019","article-title":"Cardiotoxicity of cancer therapeutics: current issues in screening, prevention, and therapy","volume":"4","author":"Sheppard","year":"2013","journal-title":"Front Pharmacol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0270","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1002\/pbc.24610","article-title":"Pilot study of vascular health in survivors of osteosarcoma","volume":"60","author":"Mulrooney","year":"2013","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0275","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/pbc.24082","article-title":"Pilot study of vascular health in survivors of Hodgkin lymphoma","volume":"59","author":"Mulrooney","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0280","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00264199","article-title":"The influence of ranitidine on the pharmacokinetics and toxicity of doxorubicin in rabbits","volume":"21","author":"Harris","year":"1988","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0285","doi-asserted-by":"crossref","first-page":"H2424","DOI":"10.1152\/ajpheart.2000.279.5.H2424","article-title":"Bicarbonate exacerbates oxidative injury induced by antitumor antibiotic doxorubicin in cardiomyocytes","volume":"279","author":"Konorev","year":"2000","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0290","first-page":"H2079","article-title":"Visualization of doxorubicin-induced oxidative stress in isolated cardiac myocytes","volume":"271","author":"Sarvazyan","year":"1996","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0295","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/sj.bjc.6690019","article-title":"Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein","volume":"79","author":"van Asperen","year":"1999","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0300","first-page":"2295","article-title":"Comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes","volume":"46","author":"Rahman","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0305","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/mpo.2950100306","article-title":"Tissue disposition of doxorubicin in experimental animals","volume":"10","author":"Lee","year":"1982","journal-title":"Med. Pediatr. Oncol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0310","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bcp.2007.04.003","article-title":"Cisplatin and doxorubicin repress Vascular Endothelial Growth Factor expression and differentially down-regulate Hypoxia-inducible Factor I activity in human ovarian cancer cells","volume":"74","author":"Duyndam","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0315","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1073\/pnas.0812801106","article-title":"Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells","volume":"106","author":"Lee","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0320","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.yjmcc.2012.01.022","article-title":"Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes","volume":"52","author":"Chiusa","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0325","doi-asserted-by":"crossref","first-page":"25535","DOI":"10.1074\/jbc.M400944200","article-title":"Doxorubicin induces apoptosis in normal and tumor cells via distinctly different mechanisms. Intermediacy of H(2)O(2)- and p53-dependent pathways","volume":"279","author":"Wang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0330","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1128\/MCB.24.6.2546-2559.2004","article-title":"Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element","volume":"24","author":"Frederick","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0335","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nrc1208","article-title":"Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer","volume":"3","author":"Siegel","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0340","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1124\/mol.62.1.65","article-title":"SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7","volume":"62","author":"Inman","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0345","doi-asserted-by":"crossref","first-page":"3294","DOI":"10.1242\/jcs.048942","article-title":"VEGF and inhibitors of TGFbeta type-I receptor kinase synergistically promote blood-vessel formation by inducing alpha5-integrin expression","volume":"122","author":"Liu","year":"2009","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011084","article-title":"Radiotherapy suppresses angiogenesis in mice through TGF-betaRI\/ALK5-dependent inhibition of endothelial cell sprouting","volume":"5","author":"Imaizumi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0355","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1681\/ASN.2013101137","article-title":"Curtailing endothelial TGF-beta signaling is sufficient to reduce endothelial\u2013mesenchymal transition and fibrosis in CKD","volume":"26","author":"Xavier","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0360","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nbt.1605","article-title":"Expansion and maintenance of human embryonic stem cell-derived endothelial cells by TGFbeta inhibition is Id1 dependent","volume":"28","author":"James","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0365","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1083\/jcb.200305147","article-title":"TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells","volume":"163","author":"Watabe","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0370","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0089678","article-title":"Inhibition of TGFbeta signaling increases direct conversion of fibroblasts to induced cardiomyocytes","volume":"9","author":"Ifkovits","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0375","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/bj2980275","article-title":"Autoinduction of activin genes in early Xenopus embryos. A carboxyl-terminal truncated version of the activin receptor mediates activin signals in early Xenopus embryos","volume":"298","author":"Suzuki","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0380","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1128\/MCB.10.4.1492","article-title":"Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex","volume":"10","author":"Kim","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0385","doi-asserted-by":"crossref","first-page":"30765","DOI":"10.1074\/jbc.M000039200","article-title":"Requirement of Ras\/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway","volume":"275","author":"Yue","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0390","doi-asserted-by":"crossref","first-page":"19945","DOI":"10.1074\/jbc.M102382200","article-title":"Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts","volume":"276","author":"Piek","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0395","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1523-1755.2001.059002579.x","article-title":"TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)","volume":"59","author":"Strutz","year":"2001","journal-title":"Kidney Int."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0400","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/(SICI)1097-4652(199701)170:1<69::AID-JCP8>3.0.CO;2-J","article-title":"TGF-beta 1 stimulates cultured human fibroblasts to proliferate and produce tissue-like fibroplasia: a fibronectin matrix-dependent event","volume":"170","author":"Clark","year":"1997","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0405","first-page":"5545","article-title":"A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability","volume":"55","author":"Myeroff","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0410","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/(SICI)1097-0215(19990611)81:6<851::AID-IJC2>3.0.CO;2-D","article-title":"Gene mutation of transforming growth factor beta1 type II receptor in hepatocellular carcinoma","volume":"81","author":"Furuta","year":"1999","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0415","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1158\/0008-5472.CAN-14-0243","article-title":"Transforming growth factor-beta as a therapeutic target in hepatocellular carcinoma","volume":"74","author":"Giannelli","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0420","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/carcin\/bgv067","article-title":"miR-27 is associated with chemoresistance in esophageal cancer through transformation of normal fibroblasts to cancer-associated fibroblasts","volume":"36","author":"Tanaka","year":"2015","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0425","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.1242\/jcs.115.15.3193","article-title":"p38 mitogen-activated protein kinase is required for TGFbeta-mediated fibroblastic transdifferentiation and cell migration","volume":"115","author":"Bakin","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0430","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/bcr3573","article-title":"Transforming growth factor-beta signalling controls human breast cancer metastasis in a zebrafish xenograft model","volume":"15","author":"Drabsch","year":"2013","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0435","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1158\/1535-7163.737.3.6","article-title":"SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility","volume":"3","author":"Hjelmeland","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0440","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.2353\/ajpath.2006.060169","article-title":"Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-beta1\/Smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy","volume":"169","author":"Li","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0445","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1681\/ASN.2006020130","article-title":"Blockade of p38 mitogen-activated protein kinase and TGF-beta1\/Smad signaling pathways rescues bone marrow-derived peritubular capillary endothelial cells in adriamycin-induced nephrosis","volume":"17","author":"Li","year":"2006","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yjmcc.2015.12.010_bb0450","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.jacc.2008.05.064","article-title":"Depressed coronary flow reserve is associated with decreased myocardial capillary density in patients with heart failure due to idiopathic dilated cardiomyopathy","volume":"52","author":"Tsagalou","year":"2008","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815301486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282815301486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T03:45:54Z","timestamp":1718250354000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282815301486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":90,"alternative-id":["S0022282815301486"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.12.010","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The TGF-\u03b2 pathway mediates doxorubicin effects on cardiac endothelial cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2015.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}