{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:48:22Z","timestamp":1790696902498,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institutes of Health National Heart Lung and Blood Institute","award":["5R01HL098481-05"],"award-info":[{"award-number":["5R01HL098481-05"]}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["15POST25610016"],"award-info":[{"award-number":["15POST25610016"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Carlyle Fraser Heart Center of Emory University Hospital Midtown"}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.yjmcc.2016.04.008","type":"journal-article","created":{"date-parts":[[2016,4,30]],"date-time":"2016-04-30T06:41:19Z","timestamp":1461998479000},"page":"56-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"special_numbering":"C","title":["DJ-1 protects the heart against ischemia\u2013reperfusion injury by regulating mitochondrial fission"],"prefix":"10.1016","volume":"97","author":[{"given":"Yuuki","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan P.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad K.","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Wolfson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Cheol","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan","family":"Husain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawazish","family":"Naqvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Shen","family":"Chin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Calvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2016.04.008_bb0005","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1093\/hmg\/ddq113","article-title":"Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage","volume":"19","author":"Chen","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0010","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1006\/bbrc.1997.6132","article-title":"DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras","volume":"231","author":"Nagakubo","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10072-003-0108-0","article-title":"DJ-1(PARK7), a novel gene for autosomal recessive, early onset parkinsonism","volume":"24","author":"Bonifati","year":"2003","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0020","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/sj.jcbfm.9600553","article-title":"DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats","volume":"28","author":"Yanagisawa","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0025","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.embor.7400074","article-title":"DJ-1 has a role in antioxidative stress to prevent cell death","volume":"5","author":"Taira","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0030","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1111\/j.1471-4159.2012.07734.x","article-title":"Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction","volume":"121","author":"Wang","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0035","doi-asserted-by":"crossref","first-page":"8506","DOI":"10.1074\/jbc.M311017200","article-title":"Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function","volume":"279","author":"Olzmann","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0040","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1073\/pnas.1303444110","article-title":"Parkinson-susceptibility gene DJ-1\/PARK7 protects the murine heart from oxidative damage in vivo","volume":"110","author":"Billia","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0045","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.41","article-title":"DJ-1 protects against cell death following acute cardiac ischemia\u2013reperfusion injury","volume":"5","author":"Dongworth","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0050","doi-asserted-by":"crossref","first-page":"20940","DOI":"10.1074\/jbc.M601935200","article-title":"DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor","volume":"281","author":"Zhong","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0055","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrm3011","article-title":"The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition","volume":"11","author":"Gareau","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0060","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-biochem-061909-093311","article-title":"Sumoylation: a regulatory protein modification in health and disease","volume":"82","author":"Flotho","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0065","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.yjmcc.2014.08.003","article-title":"SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy","volume":"78","author":"Kim","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0070","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.yjmcc.2014.11.014","article-title":"Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy","volume":"79","author":"Cai","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0075","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.yjmcc.2011.11.011","article-title":"Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction","volume":"52","author":"Kim","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1161\/CIRCRESAHA.110.220491","article-title":"Sumoylation and regulation of cardiac gene expression","volume":"107","author":"Wang","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0085","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1074\/mcp.M400149-MCP200","article-title":"A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers","volume":"4","author":"Rosas-Acosta","year":"2005","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0090","doi-asserted-by":"crossref","first-page":"8223","DOI":"10.1074\/jbc.R800050200","article-title":"SUMOylation and de-SUMOylation: wrestling with life's processes","volume":"284","author":"Yeh","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0095","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.tcb.2007.08.002","article-title":"SUMO-specific proteases: a twist in the tail","volume":"17","author":"Hay","year":"2007","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2013.08.002","article-title":"Chronic exercise downregulates myocardial myoglobin and attenuates nitrite reductase capacity during ischemia-reperfusion","volume":"64","author":"Nicholson","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0105","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1161\/ATVBAHA.112.300484","article-title":"Thioredoxin 1 is essential for sodium sulfide-mediated cardioprotection in the setting of heart failure","volume":"33","author":"Nicholson","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0110","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2014.03.035","article-title":"A proliferative burst during preadolescence establishes the final cardiomyocyte number","volume":"157","author":"Naqvi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0115","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nbt.2465","article-title":"Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18","volume":"31","author":"Kapoor","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0120","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/cvr\/cvt224","article-title":"Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia\/reperfusion","volume":"101","author":"Kamga Pride","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0125","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1083\/jcb.200610042","article-title":"Bax\/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death","volume":"177","author":"Wasiak","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0130","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.135","article-title":"Regulation of the tumor suppressor PTEN by SUMO","volume":"3","author":"Gonzalez-Santamaria","year":"2012","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0135","doi-asserted-by":"crossref","first-page":"95","DOI":"10.18632\/oncoscience.12","article-title":"Cross talk between two antioxidant systems, thioredoxin and DJ-1: consequences for cancer","volume":"1","author":"Raninga","year":"2014","journal-title":"Oncoscience"},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0140","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1534-5807(01)00055-7","article-title":"The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis","volume":"1","author":"Frank","year":"2001","journal-title":"Dev. Cell"},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0145","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1096\/fj.09-136630","article-title":"SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle","volume":"23","author":"Figueroa-Romero","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0150","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/emboj.2013.65","article-title":"SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia","volume":"32","author":"Guo","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/nm.2282","article-title":"miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1","volume":"17","author":"Wang","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0160","doi-asserted-by":"crossref","first-page":"5969","DOI":"10.1073\/pnas.1213294110","article-title":"Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation","volume":"110","author":"Din","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0165","doi-asserted-by":"crossref","first-page":"35308","DOI":"10.1074\/jbc.M110.207134","article-title":"Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL","volume":"286","author":"Ren","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0020362","article-title":"DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation","volume":"2","author":"Shendelman","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0175","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.200712124","article-title":"Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies","volume":"182","author":"Zhang","year":"2008","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0180","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/bdra.20816","article-title":"Defective sumoylation pathway directs congenital heart disease","volume":"91","author":"Wang","year":"2011","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0185","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.4161\/cc.10.18.17436","article-title":"MDM2 promotes SUMO-2\/3 modification of p53 to modulate transcriptional activity","volume":"10","author":"Stindt","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0190","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/sj.jcbfm.9600523","article-title":"Transient global cerebral ischemia induces a massive increase in protein sumoylation","volume":"28","author":"Yang","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0195","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1038\/jcbfm.2011.112","article-title":"SUMO2\/3 conjugation is an endogenous neuroprotective mechanism","volume":"31","author":"Datwyler","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0200","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1253\/circj.CJ-14-0240","article-title":"Regulation of mitochondrial dynamics and cell fate","volume":"78","author":"Dhingra","year":"2014","journal-title":"Circ. J."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0205","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1161\/CIRCULATIONAHA.109.906610","article-title":"Inhibiting mitochondrial fission protects the heart against ischemia\/reperfusion injury","volume":"121","author":"Ong","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0210","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrn2417","article-title":"Mitochondrial fragmentation in neurodegeneration","volume":"9","author":"Knott","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0215","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1242\/jcs.02537","article-title":"Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1","volume":"118","author":"Yu","year":"2005","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yjmcc.2016.04.008_bb0220","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbrc.2010.03.093","article-title":"Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2","volume":"395","author":"Mishra","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282816300748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282816300748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,12]],"date-time":"2018-09-12T13:57:36Z","timestamp":1536760656000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282816300748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":44,"alternative-id":["S0022282816300748"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.04.008","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DJ-1 protects the heart against ischemia\u2013reperfusion injury by regulating mitochondrial fission","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}