{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:58:08Z","timestamp":1790704688024,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Butcher Foundation","award":["CU3167H"],"award-info":[{"award-number":["CU3167H"]}]},{"name":"Bioscience Discovery Evaluation"},{"name":"NIH","award":["HL116848"],"award-info":[{"award-number":["HL116848"]}]},{"name":"NIH","award":["HL127240"],"award-info":[{"award-number":["HL127240"]}]},{"name":"NIH","award":["AG043822"],"award-info":[{"award-number":["AG043822"]}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["14510001"],"award-info":[{"award-number":["14510001"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH","award":["5T32HL007822"],"award-info":[{"award-number":["5T32HL007822"]}]},{"name":"NIH","award":["5T32HL007171"],"award-info":[{"award-number":["5T32HL007171"]}]},{"name":"NIH","award":["F32HL126354"],"award-info":[{"award-number":["F32HL126354"]}]}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.yjmcc.2016.04.015","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T20:21:30Z","timestamp":1461961290000},"page":"106-113","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Discovery of novel small molecule inhibitors of cardiac hypertrophy using high throughput, high content imaging"],"prefix":"10.1016","volume":"97","author":[{"given":"Brian G.","family":"Reid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S.","family":"Stratton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Bowers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Cavasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley M.","family":"Demos-Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidro","family":"Susano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"McKinsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2016.04.015_bb0005","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/j.1476-5381.2010.01127.x","article-title":"Principles of early drug discovery","volume":"162","author":"Hughes","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/sj.bjp.0707373","article-title":"Origin and evolution of high throughput screening","volume":"152","author":"Pereira","year":"2007","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0015","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.coph.2009.08.004","article-title":"Novel trends in high-throughput screening","volume":"9","author":"Mayr","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0020","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/CIR.0b013e31823ac046","article-title":"Heart disease and stroke statistics\u20132012 update: a report from the American Heart Association","volume":"125","author":"Roger","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0025","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1001\/jama.292.19.2350","article-title":"Prognostic significance of left ventricular mass change during treatment of hypertension","volume":"292","author":"Devereux","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0030","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1001\/jama.292.19.2396","article-title":"Left ventricular hypertrophy: the next treatable, silent killer?","volume":"292","author":"Gardin","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0035","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0040","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1161\/CIRCRESAHA.113.302254","article-title":"Research advances in heart failure: a compendium","volume":"113","author":"Braunwald","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0045","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrd2193","article-title":"Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface","volume":"6","author":"McKinsey","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0050","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1091\/mbc.2.12.1081","article-title":"A growth factor for cardiac myocytes is produced by cardiac nonmyocytes","volume":"2","author":"Long","year":"1991","journal-title":"Cell. Regul."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0055","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.yjmcc.2013.07.017","article-title":"BET acetyl-lysine binding proteins control pathological cardiac hypertrophy","volume":"63","author":"Spiltoir","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1177\/108705719900400206","article-title":"A simple statistical parameter for use in evaluation and validation of high throughput screening assays","volume":"4","author":"Zhang","year":"1999","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0065","doi-asserted-by":"crossref","first-page":"28930","DOI":"10.1074\/jbc.M303113200","article-title":"Dose-dependent blockade to cardiomyocyte hypertrophy by histone deacetylase inhibitors","volume":"278","author":"Antos","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0070","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1345\/aph.1M732","article-title":"Intravenous artesunate for the treatment of severe malaria","volume":"44","author":"Hess","year":"2010","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0075","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1093\/eurheartj\/ehv186","article-title":"Effect of the angiotensin-receptor-neprilysin inhibitor LCZ696 compared with enalapril on mode of death in heart failure patients","volume":"36","author":"Desai","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0080","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1056\/NEJMoa1409077","article-title":"Angiotensin-neprilysin inhibition versus enalapril in heart failure","volume":"371","author":"McMurray","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0085","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/CIRCULATIONAHA.114.013748","article-title":"Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure","volume":"131","author":"Packer","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0090","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1161\/01.CIR.94.9.2285","article-title":"Medical therapy can improve the biological properties of the chronically failing heart. A new era in the treatment of heart failure","volume":"94","author":"Eichhorn","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0095","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.yjmcc.2011.07.010","article-title":"A phenotypic screen to identify hypertrophy-modulating microRNAs in primary cardiomyocytes","volume":"52","author":"Jentzsch","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.yjmcc.2014.02.013","article-title":"Phenotypic screen quantifying differential regulation of cardiac myocyte hypertrophy identifies CITED4 regulation of myocyte elongation","volume":"72","author":"Ryall","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0105","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1177\/1087057113500812","article-title":"Phenotypic screening with human iPS cell-derived cardiomyocytes: HTS-compatible assays for interrogating cardiac hypertrophy","volume":"18","author":"Carlson","year":"2013","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0110","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.stemcr.2014.09.002","article-title":"Aberrant \u03b1-adrenergic hypertrophic response in cardiomyocytes from human induced pluripotent cells","volume":"3","author":"Foldes","year":"2014","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0115","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nrd3252","article-title":"Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes","volume":"10","author":"Force","year":"2011","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0120","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1161\/01.CIR.0000030181.63741.56","article-title":"Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense","volume":"106","author":"Kagiyama","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0125","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1161\/01.CIR.0000130641.08705.45","article-title":"Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload","volume":"109","author":"McMullen","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0130","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/07853890310001294","article-title":"A novel pleiotropic effect of statins: prevention of cardiac hypertrophy by cholesterol-independent mechanisms","volume":"35","author":"Nakagami","year":"2003","journal-title":"Ann. Med."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0135","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.0000057979.36322.88","article-title":"Rapamycin attenuates load-induced cardiac hypertrophy in mice","volume":"107","author":"Shioi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0140","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.cell.2015.11.031","article-title":"A new golden age of natural products drug discovery","volume":"163","author":"Shen","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0145","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1620\/tjem.227.161","article-title":"Artemisinin attenuates post-infarct myocardial remodeling by down-regulating the NF-\u03baB pathway","volume":"227","author":"Gu","year":"2012","journal-title":"Tohoku J. Exp. Med."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0150","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ejphar.2010.09.018","article-title":"Artemisinin, an anti-malarial agent, inhibits rat cardiac hypertrophy via inhibition of NF-\u03baB signaling","volume":"649","author":"Xiong","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0155","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.apsb.2016.01.008","article-title":"Artemisinin anti-malarial drugs in China","volume":"6","author":"Guo","year":"2016","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0160","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2011.12.034","article-title":"Artesunate activates Nrf2 pathway-driven anti-inflammatory potential through ERK signaling in microglial BV2 cells","volume":"509","author":"Lee","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0165","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.trsl.2012.06.001","article-title":"Inhibitory effect of the antimalarial agent artesunate on collagen-induced arthritis in rats through nuclear factor \u03ba B and mitogen-activated protein kinase signaling pathway","volume":"161","author":"Li","year":"2013","journal-title":"Transl. Res."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0170","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.freeradbiomed.2015.05.027","article-title":"Endoplasmic reticulum stress and Nrf2 signaling in cardiovascular diseases","volume":"88","author":"Cominacini","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0175","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1161\/CIRCULATIONAHA.110.942268","article-title":"Molecular pathways underlying cardiac remodeling during pathophysiological stimulation","volume":"122","author":"Kehat","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0180","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1007\/s00109-007-0183-4","article-title":"Natriuretic peptide receptor B signaling in the cardiovascular system: protection from cardiac hypertrophy","volume":"85","author":"Pagel-Langenickel","year":"2007","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.yjmcc.2016.04.015_bb0185","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1517\/14656566.2015.1000300","article-title":"LCZ696: a new paradigm for the treatment of heart failure?","volume":"16","author":"Minguet","year":"2015","journal-title":"Expert. Opin. Pharmacother."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282816300815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282816300815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T01:13:55Z","timestamp":1567818835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282816300815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":37,"alternative-id":["S0022282816300815"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.04.015","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery of novel small molecule inhibitors of cardiac hypertrophy using high throughput, high content imaging","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.04.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}