{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:39:32Z","timestamp":1788255572756,"version":"build-2803163510"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Hannover Biomedical Research School"},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Clinical Research Group","award":["KFO136"],"award-info":[{"award-number":["KFO136"]}]}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.yjmcc.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T02:16:03Z","timestamp":1462932963000},"page":"140-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature"],"prefix":"10.1016","volume":"97","author":[{"given":"Franziska","family":"Greulich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark-Oliver","family":"Trowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Leffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Stoetzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henner F.","family":"Farin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kispert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2016.05.004_bb0005","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12265-012-9433-0","article-title":"The anatomy of the conduction system: implications for the clinical cardiologist","volume":"6","author":"Anderson","year":"2013","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0010","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1161\/01.CIR.24.2.458","article-title":"Differentiation of the atrioventricular conducting system of the heart","volume":"24","author":"Dehaan","year":"1961","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0015","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.0000018627.89528.6F","article-title":"Differential distribution of cardiac ion channel expression as a basis for regional specialization in electrical function","volume":"90","author":"Schram","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0020","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1073\/pnas.0508512103","article-title":"Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node","volume":"103","author":"Kreuzberg","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1113\/jphysiol.2004.074047","article-title":"Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart","volume":"562","author":"Marionneau","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0030","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1080\/19336950.2015.1076597","article-title":"Cardiac ion channels","volume":"9","author":"Priest","year":"2015","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0035","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/419132b","article-title":"Biological pacemaker created by gene transfer","volume":"419","author":"Miake","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0040","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1161\/01.CIR.0000059939.97249.2C","article-title":"Expression and function of a biological pacemaker in canine heart","volume":"107","author":"Qu","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcm.2015.02.005","article-title":"The past, present, and future of pacemaker therapies","author":"Boink","year":"2015","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0050","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1242\/dev.124883","article-title":"The formation and function of the cardiac conduction system","volume":"143","author":"van Weerd","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0055","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.cardiores.2004.01.030","article-title":"The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart","volume":"62","author":"Hoogaars","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0060","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1101\/gad.416007","article-title":"Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria","volume":"21","author":"Hoogaars","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0065","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/cvr\/cvs120","article-title":"T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells","volume":"94","author":"Bakker","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0070","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1161\/01.RES.0000227571.84189.65","article-title":"Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18","volume":"98","author":"Christoffels","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0075","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCRESAHA.108.187062","article-title":"Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3","volume":"104","author":"Wiese","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0080","doi-asserted-by":"crossref","first-page":"14073","DOI":"10.1074\/jbc.M110.185298","article-title":"Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes","volume":"286","author":"Kapoor","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0085","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nbt.2465","article-title":"Direct conversion of quiescent cardiomyocytes to pacemaker cells by expression of Tbx18","volume":"31","author":"Kapoor","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0090","doi-asserted-by":"crossref","first-page":"245ra94","DOI":"10.1126\/scitranslmed.3008681","article-title":"Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block","volume":"6","author":"Hu","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0095","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/cvr\/cvs277","article-title":"Tbx18 function in epicardial development","volume":"96","author":"Greulich","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0100","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI119509","article-title":"Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo","volume":"100","author":"Agah","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0105","doi-asserted-by":"crossref","first-page":"7142","DOI":"10.1073\/pnas.102650499","article-title":"Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure","volume":"99","author":"Holtwick","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0110","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/002215540104900101","article-title":"Sensitive nonradioactive detection of mRNA in tissue sections: novel application of the whole-mount in situ hybridization protocol","volume":"49","author":"Moorman","year":"2001","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0120","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0125","doi-asserted-by":"crossref","first-page":"W169","DOI":"10.1093\/nar\/gkm415","article-title":"DAVID bioinformatics resources: expanded annotation database and novel algorithms to better extract biology from large gene lists","volume":"35","author":"Huang","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0130","doi-asserted-by":"crossref","first-page":"W305","DOI":"10.1093\/nar\/gkp427","article-title":"ToppGene suite for gene list enrichment analysis and candidate gene prioritization","volume":"37","author":"Chen","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0135","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1471-2105-6-232","article-title":"EXPANDER\u2013an integrative program suite for microarray data analysis","volume":"6","author":"Shamir","year":"2005","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0140","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1172\/JCI62613","article-title":"Genetic variation in T-box binding element functionally affects SCN5A\/SCN10A enhancer","volume":"122","author":"van den Boogaard","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099844","article-title":"OccuPeak: ChIP-Seq peak calling based on internal background modelling","volume":"9","author":"de Boer","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0150","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1534\/g3.112.003202","article-title":"oPOSSUM-3: advanced analysis of regulatory motif over-representation across genes or ChIP-Seq datasets","volume":"2","author":"Kwon","year":"2012","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0155","doi-asserted-by":"crossref","first-page":"R86","DOI":"10.1186\/gb-2010-11-8-r86","article-title":"Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences","volume":"11","author":"Goecks","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0160","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.1038\/nature07916","article-title":"Tbx18 and the fate of epicardial progenitors","volume":"458","author":"Christoffels","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0165","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1161\/CIRCULATIONAHA.106.637819","article-title":"Targeted mutation reveals essential functions of the homeodomain transcription factor Shox2 in sinoatrial and pacemaking development","volume":"115","author":"Blaschke","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0170","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/FJC.0b013e3181e775d3","article-title":"The cardiac pacemaker and conduction system develops from embryonic myocardium that retains its primitive phenotype","volume":"56","author":"Bakker","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0175","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1006\/dbio.2001.0225","article-title":"Identification and characterization of Lbh, a novel conserved nuclear protein expressed during early limb and heart development","volume":"233","author":"Briegel","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0180","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1096\/fasebj.5.15.1835945","article-title":"Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response","volume":"5","author":"Chien","year":"1991","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0185","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.bi.60.070191.001305","article-title":"Atrial natriuretic factor and related peptide hormones","volume":"60","author":"Rosenzweig","year":"1991","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0190","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1161\/CIRCRESAHA.107.163188","article-title":"Myocardial Pitx2 differentially regulates the left atrial identity and ventricular asymmetric remodeling programs","volume":"102","author":"Tessari","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0195","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/CIRCRESAHA.107.161059","article-title":"Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling","volume":"102","author":"El-Bizri","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0200","doi-asserted-by":"crossref","first-page":"25748","DOI":"10.1074\/jbc.M703724200","article-title":"Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors","volume":"282","author":"Farin","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0205","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/cvr\/cvr112","article-title":"Mechanisms of T-box gene function in the developing heart","volume":"91","author":"Greulich","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0210","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s00018-011-0884-2","article-title":"Tbx2 and Tbx3 induce atrioventricular myocardial development and endocardial cushion formation","volume":"69","author":"Singh","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0215","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.devcel.2006.12.011","article-title":"Notch signaling is essential for ventricular chamber development","volume":"12","author":"Grego-Bessa","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0220","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1242\/dev.01094","article-title":"BMP10 is essential for maintaining cardiac growth during murine cardiogenesis","volume":"131","author":"Chen","year":"2004","journal-title":"Development"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0225","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1161\/01.RES.0000084852.65396.70","article-title":"High incidence of cardiac malformations in connexin40-deficient mice","volume":"93","author":"Gu","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0230","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00109-008-0380-9","article-title":"Thin filament proteins mutations associated with skeletal myopathies: defective regulation of muscle contraction","volume":"86","author":"Ochala","year":"2008","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0235","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.gene.2015.08.062","article-title":"The cardiac sodium channel gene SCN5A and its gene product NaV1.5: role in physiology and pathophysiology","volume":"573","author":"Veerman","year":"2015","journal-title":"Gene"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0240","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1002\/j.1460-2075.1993.tb05990.x","article-title":"The Brachyury gene encodes a novel DNA binding protein","volume":"12","author":"Kispert","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0245","doi-asserted-by":"crossref","first-page":"3819","DOI":"10.1242\/dev.104471","article-title":"The T-box gene family: emerging roles in development, stem cells and cancer","volume":"141","author":"Papaioannou","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0250","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1101\/gad.222902","article-title":"Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation","volume":"16","author":"Habets","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0255","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1073\/pnas.1016959108","article-title":"Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart","volume":"108","author":"He","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0260","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1172\/JCI62617","article-title":"TBX5 drives Scn5a expression to regulate cardiac conduction system function","volume":"122","author":"Arnolds","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0265","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cardiores.2004.09.021","article-title":"Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5, GATA4 and Tbx5","volume":"64","author":"Linhares","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2016.05.004_bb0270","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1242\/dev.02309","article-title":"Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field","volume":"133","author":"Nowotschin","year":"2006","journal-title":"Development"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281630116X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281630116X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,7]],"date-time":"2019-09-07T10:16:30Z","timestamp":1567851390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228281630116X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":54,"alternative-id":["S002228281630116X"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.05.004","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}