{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T21:47:21Z","timestamp":1776980841651,"version":"3.51.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Heart, Lung and Blood Institute, National Institutes of Health, USA","award":["R01 HL104516"],"award-info":[{"award-number":["R01 HL104516"]}]},{"name":"National Heart, Lung and Blood Institute, National Institutes of Health, USA","award":["R01HL116042"],"award-info":[{"award-number":["R01HL116042"]}]},{"name":"National Heart, Lung and Blood Institute, National Institutes of Health, USA","award":["R01 HL120659"],"award-info":[{"award-number":["R01 HL120659"]}]}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.yjmcc.2016.06.067","type":"journal-article","created":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T20:53:22Z","timestamp":1467492802000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation"],"prefix":"10.1016","volume":"98","author":[{"given":"Christopher J.","family":"Pelham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth M.","family":"Drews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-0013","authenticated-orcid":false,"given":"Devendra K.","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2016.06.067_bb0005","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev-nutr-071812-161156","article-title":"Hypoxia and adipocyte physiology: implications for adipose tissue dysfunction in obesity","volume":"34","author":"Trayhurn","year":"2014","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.yjmcc.2016.06.067_bb0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/VHRM.S33760","article-title":"The influence of perivascular adipose tissue on vascular homeostasis","volume":"9","author":"Szasz","year":"2013","journal-title":"Vasc. Health Risk Manag."},{"issue":"12","key":"10.1016\/j.yjmcc.2016.06.067_bb0015","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1161\/CIRCULATIONAHA.108.821181","article-title":"Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients","volume":"119","author":"Greenstein","year":"2009","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2016.06.067_bb0020","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jacc.2013.04.027","article-title":"Effects of bariatric surgery on human small artery function: evidence for reduction in perivascular adipocyte inflammation, and the restoration of normal anticontractile activity despite persistent obesity","volume":"62","author":"Aghamohammadzadeh","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"7","key":"10.1016\/j.yjmcc.2016.06.067_bb0025","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/oby.2011.404","article-title":"Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity","volume":"20","author":"Drincic","year":"2012","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.yjmcc.2016.06.067_bb0030","first-page":"69","article-title":"Vitamin D and inflammatory diseases","volume":"7","author":"Yin","year":"2014","journal-title":"J. Inflamm. Res."},{"issue":"7","key":"10.1016\/j.yjmcc.2016.06.067_bb0035","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.amjcard.2010.05.027","article-title":"Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population","volume":"106","author":"Anderson","year":"2010","journal-title":"Am. J. Cardiol."},{"issue":"11","key":"10.1016\/j.yjmcc.2016.06.067_bb0040","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1017\/S0007114512003285","article-title":"Vitamin D signalling in adipose tissue","volume":"108","author":"Ding","year":"2012","journal-title":"Br. J. Nutr."},{"issue":"1","key":"10.1016\/j.yjmcc.2016.06.067_bb0045","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.yexmp.2012.04.006","article-title":"Vitamin D deficiency induces cardiac hypertrophy and inflammation in epicardial adipose tissue in hypercholesterolemic swine","volume":"93","author":"Gupta","year":"2012","journal-title":"Exp. Mol. Pathol."},{"issue":"6","key":"10.1016\/j.yjmcc.2016.06.067_bb0050","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/cea.12102","article-title":"Vitamin D supplementation reduces airway hyperresponsiveness and allergic airway inflammation in a murine model","volume":"43","author":"Agrawal","year":"2013","journal-title":"Clin. Exp. Allergy"},{"issue":"6","key":"10.1016\/j.yjmcc.2016.06.067_bb0055","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0022-2275(20)30474-0","article-title":"Determination of adipocyte size by computer image analysis","volume":"43","author":"Chen","year":"2002","journal-title":"J. Lipid Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2016.06.067_bb0060","doi-asserted-by":"crossref","first-page":"H1425","DOI":"10.1152\/ajpheart.00376.2011","article-title":"Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation","volume":"301","author":"Fitzgibbons","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"7088","key":"10.1016\/j.yjmcc.2016.06.067_bb0065","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nature04695","article-title":"Lysyl oxidase is essential for hypoxia-induced metastasis","volume":"440","author":"Erler","year":"2006","journal-title":"Nature"},{"issue":"17","key":"10.1016\/j.yjmcc.2016.06.067_bb0070","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1161\/CIRCULATIONAHA.111.032680","article-title":"Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy","volume":"124","author":"Chen","year":"2011","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.yjmcc.2016.06.067_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035316","article-title":"Vitamin D receptor deficiency and low vitamin D diet stimulate aortic calcification and osteogenic key factor expression in mice","volume":"7","author":"Schmidt","year":"2012","journal-title":"PLoS One"},{"issue":"Pt 19","key":"10.1016\/j.yjmcc.2016.06.067_bb0080","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1113\/jphysiol.2011.214726","article-title":"Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats","volume":"589","author":"Tare","year":"2011","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.yjmcc.2016.06.067_bb0085","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/HYPERTENSIONAHA.114.03971","article-title":"Elimination of vitamin D receptor in vascular endothelial cells alters vascular function","volume":"64","author":"Ni","year":"2014","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.yjmcc.2016.06.067_bb0090","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI0215219","article-title":"1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin\u2013angiotensin system","volume":"110","author":"Li","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.yjmcc.2016.06.067_bb0095","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.atherosclerosis.2014.05.911","article-title":"Lack of vitamin D receptor causes stress-induced premature senescence in vascular smooth muscle cells through enhanced local angiotensin-II signals","volume":"235","author":"Valcheva","year":"2014","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.yjmcc.2016.06.067_bb0100","doi-asserted-by":"crossref","DOI":"10.1007\/s11906-014-0521-1","article-title":"Dysregulation of T cell subsets in the pathogenesis of hypertension","volume":"17","author":"Chen","year":"2015","journal-title":"Curr. Hypertens. Rep."},{"issue":"20","key":"10.1016\/j.yjmcc.2016.06.067_bb0105","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1161\/01.CIR.0000099542.57313.C5","article-title":"Human epicardial adipose tissue is a source of inflammatory mediators","volume":"108","author":"Mazurek","year":"2003","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.yjmcc.2016.06.067_bb0110","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/CIRCULATIONAHA.111.027375","article-title":"Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension","volume":"124","author":"Lee","year":"2011","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.yjmcc.2016.06.067_bb0115","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.ijcard.2013.01.158","article-title":"C-reactive protein promotes vascular endothelial dysfunction partly via activating adipose tissue inflammation in hyperlipidemic rabbits","volume":"168","author":"Chen","year":"2013","journal-title":"Int. J. Cardiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2016.06.067_bb0120","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.numecd.2014.08.012","article-title":"Epicardial adipose tissue inflammation is related to vitamin D deficiency in patients affected by coronary artery disease","volume":"25","author":"Dozio","year":"2015","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"issue":"5","key":"10.1016\/j.yjmcc.2016.06.067_bb0125","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s10875-012-9696-x","article-title":"Calcitriol decreases expression of importin alpha3 and attenuates RelA translocation in human bronchial smooth muscle cells","volume":"32","author":"Agrawal","year":"2012","journal-title":"J. Clin. Immunol."},{"issue":"7","key":"10.1016\/j.yjmcc.2016.06.067_bb0130","first-page":"1","article-title":"Vitamin D deficiency accelerates coronary artery disease progression in swine","volume":"36","author":"Chen","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"16","key":"10.1016\/j.yjmcc.2016.06.067_bb0135","doi-asserted-by":"crossref","first-page":"11205","DOI":"10.1074\/jbc.M510343200","article-title":"Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells","volume":"281","author":"Blumberg","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.06.067_bb0140","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3389\/fphys.2014.00228","article-title":"Vitamin D and adipose tissue-more than storage","volume":"5","author":"Mutt","year":"2014","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2016.06.067_bb0145","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1210\/en.2008-1118","article-title":"Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue","volume":"150","author":"Narvaez","year":"2009","journal-title":"Endocrinology"},{"issue":"39","key":"10.1016\/j.yjmcc.2016.06.067_bb0150","doi-asserted-by":"crossref","first-page":"33804","DOI":"10.1074\/jbc.M111.257568","article-title":"Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice","volume":"286","author":"Wong","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.yjmcc.2016.06.067_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079245","article-title":"Regulation of vascular smooth muscle tone by adipose-derived contracting factor","volume":"8","author":"Meyer","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.yjmcc.2016.06.067_bb0160","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1253\/circj.CJ-09-0661","article-title":"Periadventitial adipose tissue promotes endothelial dysfunction via oxidative stress in diet-induced obese C57Bl\/6 mice","volume":"74","author":"Ketonen","year":"2010","journal-title":"Circ. J."},{"issue":"1","key":"10.1016\/j.yjmcc.2016.06.067_bb0165","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/cvr\/cvt229","article-title":"cGMP-dependent protein kinase (PKG) mediates the anticontractile capacity of perivascular adipose tissue","volume":"101","author":"Withers","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2016.06.067_bb0170","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1158\/1535-7163.MCT-06-0677","article-title":"1alpha,25-Dihydroxyvitamin D3 (calcitriol) inhibits hypoxia-inducible factor-1\/vascular endothelial growth factor pathway in human cancer cells","volume":"6","author":"Ben-Shoshan","year":"2007","journal-title":"Mol. Cancer Ther."},{"issue":"5","key":"10.1016\/j.yjmcc.2016.06.067_bb0175","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbamcr.2007.10.012","article-title":"VDUP1 mediates nuclear export of HIF1alpha via CRM1-dependent pathway","volume":"1783","author":"Shin","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.yjmcc.2016.06.067_bb0180","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1128\/MCB.00951-12","article-title":"Selective inhibition of hypoxia-inducible factor 1alpha ameliorates adipose tissue dysfunction","volume":"33","author":"Sun","year":"2013","journal-title":"Mol. Cell. Biol."},{"issue":"16","key":"10.1016\/j.yjmcc.2016.06.067_bb0185","doi-asserted-by":"crossref","first-page":"4467","DOI":"10.1128\/MCB.00192-09","article-title":"Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue","volume":"29","author":"Halberg","year":"2009","journal-title":"Mol. Cell. Biol."},{"issue":"1","key":"10.1016\/j.yjmcc.2016.06.067_bb0190","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/cvr\/cvn102","article-title":"Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases","volume":"79","author":"Rodriguez","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2016.06.067_bb0195","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0021-9150(98)00130-0","article-title":"Inhibition of cross-links in collagen is associated with reduced stiffness of the aorta in young rats","volume":"140","author":"Bruel","year":"1998","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.yjmcc.2016.06.067_bb0200","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001383","article-title":"Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts","volume":"10","author":"Vimaleswaran","year":"2013","journal-title":"PLoS Med."},{"issue":"9","key":"10.1016\/j.yjmcc.2016.06.067_bb0205","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S2213-8587(14)70113-5","article-title":"LifeLines Cohort Study investigators, Jorde R, Dieffenbach AK, et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study","volume":"2","author":"Vimaleswaran","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"4","key":"10.1016\/j.yjmcc.2016.06.067_bb0210","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S2213-8587(13)70212-2","article-title":"The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis","volume":"2","author":"Bolland","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"10","key":"10.1016\/j.yjmcc.2016.06.067_bb0215","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1210\/jc.2014-2136","article-title":"Clinical review: effect of vitamin D3 supplementation on improving glucose homeostasis and preventing diabetes: a systematic review and meta-analysis","volume":"99","author":"Seida","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.yjmcc.2016.06.067_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071042","article-title":"Primary vitamin D target genes allow a categorization of possible benefits of vitamin D(3) supplementation","volume":"8","author":"Carlberg","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.yjmcc.2016.06.067_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124339","article-title":"Relevance of vitamin D receptor target genes for monitoring the vitamin D responsiveness of primary human cells","volume":"10","author":"Vukic","year":"2015","journal-title":"PLoS One"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281630219X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281630219X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T01:49:50Z","timestamp":1718675390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228281630219X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":45,"alternative-id":["S002228281630219X"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.06.067","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D controls resistance artery function through regulation of perivascular adipose tissue hypoxia and inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.06.067","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}