{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:44:55Z","timestamp":1791398695847,"version":"4.3.3"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.yjmcc.2016.08.009","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T16:42:18Z","timestamp":1471279338000},"page":"100-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Loss of myocardial retinoic acid receptor \u03b1 induces diastolic dysfunction by promoting intracellular oxidative stress and calcium mishandling in adult mice"],"prefix":"10.1016","volume":"99","author":[{"given":"Sen","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakeshwar S.","family":"Guleria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice M.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fnu","family":"Gerilechaogetu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Dostal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth M.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2016.08.009_bb0005","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1161\/CIRCULATIONAHA.111.080770","article-title":"Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes","volume":"126","author":"Steinberg","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1056\/NEJMoa052256","article-title":"Trends in prevalence and outcome of heart failure with preserved ejection fraction","volume":"355","author":"Owan","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0015","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.amjcard.2003.12.026","article-title":"Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus","volume":"93","author":"Boyer","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0020","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1093\/eurheartj\/ehv305","article-title":"Pathophysiological role of oxidative stress in systolic and diastolic heart failure and its therapeutic implications","volume":"36","author":"Munzel","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0025","doi-asserted-by":"crossref","first-page":"H2181","DOI":"10.1152\/ajpheart.00554.2011","article-title":"Oxidative stress and heart failure","volume":"301","author":"Tsutsui","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0030","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1161\/01.RES.86.2.152","article-title":"Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium","volume":"86","author":"Ide","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0035","doi-asserted-by":"crossref","first-page":"f10","DOI":"10.1136\/bmj.f10","article-title":"Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials","volume":"346","author":"Myung","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0040","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1096\/fasebj.10.9.8801176","article-title":"A decade of molecular biology of retinoic acid receptors","volume":"10","author":"Chambon","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0045","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1002\/jcp.22457","article-title":"Retinoic acid receptor-mediated signaling protects cardiomyocytes from hyperglycemia induced apoptosis: role of the renin-angiotensin system","volume":"226","author":"Guleria","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0050","doi-asserted-by":"crossref","first-page":"54905","DOI":"10.1074\/jbc.M407383200","article-title":"Mitogen-activated protein kinases and mitogen-activated protein kinase phosphatases mediate the inhibitory effects of all-trans retinoic acid on the hypertrophic growth of cardiomyocytes","volume":"279","author":"Palm-Leis","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0055","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1073\/pnas.92.16.7391","article-title":"Retinoid-dependent pathways suppress myocardial cell hypertrophy","volume":"92","author":"Zhou","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0060","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1172\/JCI118582","article-title":"1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes","volume":"97","author":"Wu","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0065","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1152\/japplphysiol.01192.2001","article-title":"Effects of all-trans retinoic acid on angiotensin II-induced myocyte hypertrophy","volume":"92","author":"Wang","year":"2002","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0070","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/jcp.21297","article-title":"All-trans retinoic acid prevents angiotensin II- and mechanical stretch-induced reactive oxygen species generation and cardiomyocyte apoptosis","volume":"215","author":"Choudhary","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0075","doi-asserted-by":"crossref","first-page":"H633","DOI":"10.1152\/ajpheart.01301.2007","article-title":"All-trans retinoic acid prevents development of cardiac remodeling in aortic banded rats by inhibiting the renin-angiotensin system","volume":"294","author":"Choudhary","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0080","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/jcp.24142","article-title":"Retinoic acid protects cardiomyocytes from high glucose-induced apoptosis via inhibition of sustained activation of NF-kappaB signaling","volume":"228","author":"Nizamutdinova","year":"2013","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0085","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.yjmcc.2013.01.017","article-title":"Activation of retinoid receptor-mediated signaling ameliorates diabetes-induced cardiac dysfunction in Zucker diabetic rats","volume":"57C","author":"Guleria","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0090","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1042\/CS20120448","article-title":"Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor","volume":"124","author":"Thomas","year":"2013","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0095","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1161\/CIRCHEARTFAILURE.114.001550","article-title":"Phosphorylation of cardiac myosin-binding protein-C is a critical mediator of diastolic function","volume":"8","author":"Rosas","year":"2015","journal-title":"Circ Heart Fail."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0100","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11626-007-9079-4","article-title":"An improved protocol for primary culture of cardiomyocyte from neonatal mice","volume":"44","author":"Sreejit","year":"2008","journal-title":"In Vitro Cell Dev Biol Anim."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0105","first-page":"271","article-title":"Isolation and culture of adult mouse cardiac myocytes","volume":"357","author":"O'Connell","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0110","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1161\/01.RES.87.4.275","article-title":"Calcium fluxes involved in control of cardiac myocyte contraction","volume":"87","author":"Bers","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0115","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1139\/cjpp-2014-0463","article-title":"The regulation of sarco(endo)plasmic reticulum calcium-ATPases (SERCA)","volume":"93","author":"Stammers","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0120","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yjmcc.2014.10.005","article-title":"Phospholamban interactome in cardiac contractility and survival: a new vision of an old friend","volume":"77","author":"Haghighi","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0125","doi-asserted-by":"crossref","first-page":"28180","DOI":"10.1074\/jbc.M109.036566","article-title":"Akt increases sarcoplasmic reticulum Ca2+ cycling by direct phosphorylation of phospholamban at Thr17","volume":"284","author":"Catalucci","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0130","doi-asserted-by":"crossref","first-page":"13333","DOI":"10.1016\/S0021-9258(18)69309-3","article-title":"Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains","volume":"261","author":"Simmerman","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0135","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1050-1738(98)00032-2","article-title":"Molecular regulation of phospholamban function and expression","volume":"8","author":"Tada","year":"1998","journal-title":"Trends in cardiovascular medicine."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0140","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yjmcc.2014.12.020","article-title":"Phospholamban pentamers attenuate PKA-dependent phosphorylation of monomers","volume":"80","author":"Wittmann","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0145","doi-asserted-by":"crossref","first-page":"30181","DOI":"10.1074\/jbc.M113.501585","article-title":"The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum","volume":"288","author":"Akin","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0150","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1073\/pnas.0237326100","article-title":"Modeling of the inhibitory interaction of phospholamban with the Ca2+ ATPase","volume":"100","author":"Toyoshima","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0155","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/0092-8674(94)90274-7","article-title":"Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis","volume":"78","author":"Kastner","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0160","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1172\/JCI118920","article-title":"RXR alpha deficiency confers genetic susceptibility for aortic sac, conotruncal, atrioventricular cushion, and ventricular muscle defects in mice","volume":"98","author":"Gruber","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0165","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1161\/01.RES.80.6.757","article-title":"Compartment-selective sensitivity of cardiovascular morphogenesis to combinations of retinoic acid receptor gene mutations","volume":"80","author":"Lee","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0170","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/0968-0004(92)90014-Z","article-title":"Multiplicity generates diversity in the retinoic acid signalling pathways","volume":"17","author":"Leid","year":"1992","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0175","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1002\/jcp.23005","article-title":"High glucose-induced repression of RAR\/RXR in cardiomyocytes is mediated through oxidative stress\/JNK signaling","volume":"227","author":"Singh","year":"2012","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0180","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jacc.2013.09.052","article-title":"Impaired systolic function by strain imaging in heart failure with preserved ejection fraction","volume":"63","author":"Kraigher-Krainer","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0185","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jacc.2009.05.012","article-title":"Heart failure with preserved ejection fraction is characterized by dynamic impairment of active relaxation and contraction of the left ventricle on exercise and associated with myocardial energy deficiency","volume":"54","author":"Phan","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0190","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1161\/01.RES.0000129254.25507.d6","article-title":"What mechanisms underlie diastolic dysfunction in heart failure?","volume":"94","author":"Kass","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0195","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1161\/CIRCULATIONAHA.110.011031","article-title":"Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction","volume":"124","author":"Zile","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0200","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jacc.2009.05.013","article-title":"Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction","volume":"54","author":"Borlaug","year":"2009","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0205","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jcmg.2014.04.022","article-title":"CMR-verified diffuse myocardial fibrosis is associated with diastolic dysfunction in HFpEF","volume":"7","author":"Su","year":"2014","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0210","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.jacc.2010.10.024","article-title":"Diastolic tissue Doppler indexes correlate with the degree of collagen expression and cross-linking in heart failure and normal ejection fraction","volume":"57","author":"Kasner","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0215","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1126\/science.1223602","article-title":"Molecular mechanics of cardiac myosin-binding protein C in native thick filaments","volume":"337","author":"Previs","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0220","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1161\/01.CIR.104.2.128","article-title":"Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy","volume":"104","author":"Nagueh","year":"2001","journal-title":"Circulation"},{"issue":"725","key":"10.1016\/j.yjmcc.2016.08.009_bb0225","first-page":"e1","article-title":"Diastolic dysfunction without left ventricular hypertrophy is an early finding in children with hypertrophic cardiomyopathy-causing mutations in the beta-myosin heavy chain, alpha-tropomyosin, and myosin-binding protein C genes","volume":"151","author":"Poutanen","year":"2006","journal-title":"Am. Heart J."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0230","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/01.RES.0000012222.70819.64","article-title":"Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice","volume":"90","author":"Harris","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0235","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1161\/CIRCULATIONAHA.111.089219","article-title":"Dissociation of structural and functional phenotypes in cardiac myosin-binding protein C conditional knockout mice","volume":"126","author":"Chen","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0240","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.yjmcc.2012.03.009","article-title":"Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice","volume":"52","author":"Fraysse","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0245","doi-asserted-by":"crossref","first-page":"H1720","DOI":"10.1152\/ajpheart.00339.2015","article-title":"N-acetylcysteine reverses diastolic dysfunction and hypertrophy in familial hypertrophic cardiomyopathy","volume":"309","author":"Wilder","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0250","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1089\/ars.2015.6275","article-title":"S-Nitrosylation of sarcomeric proteins depresses myofilament Ca2(+)sensitivity in intact cardiomyocytes","volume":"23","author":"Figueiredo-Freitas","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0255","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1021\/pr901006h","article-title":"Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysis","volume":"9","author":"Jia","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0260","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1161\/CIRCRESAHA.111.242560","article-title":"A critical function for Ser-282 in cardiac myosin binding protein-C phosphorylation and cardiac function","volume":"109","author":"Sadayappan","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0265","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/S0021-9258(18)49919-X","article-title":"Phosphorylation of chicken cardiac C-protein by calcium\/calmodulin-dependent protein kinase II","volume":"266","author":"Schlender","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0270","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/CIRCRESAHA.108.177683","article-title":"Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function","volume":"103","author":"Tong","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0275","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1006\/jmcc.1998.0748","article-title":"Contribution of abnormal sarcoplasmic reticulum ATPase activity to systolic and diastolic dysfunction in human heart failure","volume":"30","author":"Schmidt","year":"1998","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0280","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1161\/CIRCRESAHA.111.259754","article-title":"Modulation of cardiac contractility by the phospholamban\/SERCA2a regulatome","volume":"110","author":"Kranias","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0285","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.yjmcc.2005.03.014","article-title":"Impaired SERCA function contributes to cardiomyocyte dysfunction in insulin resistant rats","volume":"39","author":"Wold","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0290","doi-asserted-by":"crossref","first-page":"H1454","DOI":"10.1152\/ajpheart.00812.2011","article-title":"CaMKII inhibition in heart failure, beneficial, harmful, or both","volume":"302","author":"Cheng","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0295","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.yjmcc.2013.02.014","article-title":"While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKIIdelta-KO mice","volume":"59","author":"Neef","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0300","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1161\/CIRCRESAHA.111.300105","article-title":"Crucial role for Ca2(+)\/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation","volume":"112","author":"Hamdani","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0305","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1161\/01.RES.0000069686.31472.C5","article-title":"The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure","volume":"92","author":"Zhang","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0310","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1172\/JCI38022","article-title":"Requirement for Ca2+\/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice","volume":"119","author":"Ling","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0315","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1089\/ars.2012.4550","article-title":"NADPH oxidases in heart failure: poachers or gamekeepers?","volume":"18","author":"Zhang","year":"2013","journal-title":"Antioxid. Redox Signal."},{"issue":"127","key":"10.1016\/j.yjmcc.2016.08.009_bb0320","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1042\/CS20130787","article-title":"Loss of NOX2 (gp91phox) prevents oxidative stress and progression to advanced heart failure","author":"Parajuli","year":"2014","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0325","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/CIRCULATIONAHA.114.011079","article-title":"NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt\/mTOR and NFkappaB signaling pathways","volume":"131","author":"Zhao","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0330","doi-asserted-by":"crossref","first-page":"18121","DOI":"10.1073\/pnas.1009700107","article-title":"NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis","volume":"107","author":"Zhang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0335","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1527-5299.2002.00717.x","article-title":"Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure","volume":"8","author":"Sorescu","year":"2002","journal-title":"Congest. Heart Fail."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0340","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1161\/CIRCRESAHA.108.184457","article-title":"Redox modification of ryanodine receptors contributes to sarcoplasmic reticulum Ca2+ leak in chronic heart failure","volume":"103","author":"Terentyev","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0345","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","article-title":"A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation","volume":"133","author":"Erickson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0350","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.109.204172","article-title":"Angiotensin II-induced oxidative stress resets the Ca2+ dependence of Ca2+-calmodulin protein kinase II and promotes a death pathway conserved across different species","volume":"105","author":"Palomeque","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0355","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000184","article-title":"Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart","volume":"2","author":"Qin","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0360","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.jnutbio.2013.08.002","article-title":"Cardioprotective effect of selenium via modulation of cardiac ryanodine receptor calcium release channels in diabetic rat cardiomyocytes through thioredoxin system","volume":"24","author":"Okatan","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0365","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0370","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jchf.2015.10.007","article-title":"Myocardial microvascular inflammatory endothelial activation in heart failure with preserved ejection fraction","volume":"4","author":"Franssen","year":"2016","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.yjmcc.2016.08.009_bb0375","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/CIRCRESAHA.108.184408","article-title":"Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs","volume":"104","author":"Kruger","year":"2009","journal-title":"Circ. Res."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282816302826?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282816302826?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:32:36Z","timestamp":1657067556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282816302826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":75,"alternative-id":["S0022282816302826"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.08.009","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of myocardial retinoic acid receptor \u03b1 induces diastolic dysfunction by promoting intracellular oxidative stress and calcium mishandling in adult mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}