{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:12:06Z","timestamp":1787314326988,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.yjmcc.2016.08.016","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T14:32:32Z","timestamp":1472135552000},"page":"207-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"special_numbering":"C","title":["miR-106a promotes cardiac hypertrophy by targeting mitofusin 2"],"prefix":"10.1016","volume":"99","author":[{"given":"Xiaoxiang","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2016.08.016_bb0005","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMra072139","article-title":"Cardiac plasticity","volume":"358","author":"Hill","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0010","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1172\/JCI31044","article-title":"ECM remodeling in hypertensive heart disease","volume":"117","author":"Berk","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0015","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signalling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0020","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0025","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nsmb.1552","article-title":"Biological basis for restriction of microRNA targets to the 3\u2032 untranslated region in mammalian mRNAs","volume":"16","author":"Gu","year":"2009","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0030","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/cvr\/cvp015","article-title":"MicroRNA expression in response to murine myocardial infarction: mir-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue","volume":"82","author":"Roy","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0035","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nm1569","article-title":"The muscle-specific microRNA mir-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2","volume":"13","author":"Yang","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0040","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ijcard.2014.02.035","article-title":"MicroRNA-328 as a regulator of cardiac hypertrophy","volume":"173","author":"Li","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0045","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mehy.2013.03.043","article-title":"mir-17-92 cluster is a novel regulatory gene of cardiac ischemic\/reperfusion injury","volume":"81","author":"Zhou","year":"2013","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0050","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1096\/fj.12-221994","article-title":"Cardiovascular dysregulation of mir-17-92 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis","volume":"27","author":"Danielson","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0055","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1161\/CIRCRESAHA.112.300658","article-title":"mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts","volume":"112","author":"Chen","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0060","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1016\/j.lfs.2007.04.003","article-title":"Down-regulation of mitofusin-2 expression in cardiac hypertrophy in vitro and in vivo","volume":"80","author":"Fang","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/1074248410385683","article-title":"Mitofusin 2 inhibits angiotensin II-induced myocardial hypertrophy","volume":"16","author":"Yu","year":"2011","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0070","doi-asserted-by":"crossref","first-page":"20321","DOI":"10.1074\/jbc.M112.359174","article-title":"Loss of mitofusin 2 promotes endoplasmic reticulum stress","volume":"287","author":"Ngoh","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0075","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ncb1161","article-title":"Dysregulation of HSG triggers vascular proliferative disorders","volume":"6","author":"Chen","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0080","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1242\/dmm.016162","article-title":"Contribution of neural cell death to depressive phenotypes of streptozotocin-induced diabetic mice","volume":"7","author":"Chen","year":"2014","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0085","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1161\/CIRCRESAHA.115.304384","article-title":"Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy","volume":"115","author":"Song","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0090","doi-asserted-by":"crossref","first-page":"4314","DOI":"10.2337\/db13-1256","article-title":"IHG-1 increases mitochondrial fusion and bioenergetic function","volume":"63","author":"Hickey","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0095","doi-asserted-by":"crossref","first-page":"16017","DOI":"10.1073\/pnas.1408061111","article-title":"A mitofusin-2-dependent inactivating cleavage of OPA1 links changes in mitochondria cristae and ER contacts in the postprandial liver","volume":"111","author":"Sood","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0100","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1128\/MCB.00911-10","article-title":"Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes","volume":"31","author":"Papanicolaou","year":"2011","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0105","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1161\/CIRCRESAHA.112.266585","article-title":"Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk","volume":"111","author":"Chen","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0110","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1161\/CIRCRESAHA.107.157644","article-title":"Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway","volume":"101","author":"Guo","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0115","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1161\/CIRCRESAHA.112.274142","article-title":"Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart","volume":"111","author":"Papanicolaou","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0120","doi-asserted-by":"crossref","first-page":"23615","DOI":"10.1074\/jbc.M112.379164","article-title":"Central role of mitofusin 2 in autophagosome-lysosome fusion in cardiomyocytes","volume":"287","author":"Zhao","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0125","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1111\/j.1476-5381.2010.01070.x","article-title":"Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting tgfbeta1 expression and activation of p38-mapk and erk1\/2","volume":"162","author":"Pan","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0130","doi-asserted-by":"crossref","first-page":"383","DOI":"10.7150\/ijbs.7.383","article-title":"Tanshinone IIa protects against cardiac hypertrophy via inhibiting calcineurin\/NFATc3 pathway","volume":"7","author":"Tan","year":"2011","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0135","doi-asserted-by":"crossref","first-page":"e72985","DOI":"10.1371\/journal.pone.0072985","article-title":"Downregulation of mir-151-5p contributes to increased susceptibility to arrhythmogenesis during myocardial infarction with estrogen deprivation","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0140","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00210-013-0929-1","article-title":"Downregulation of mir-133 via MAPK\/ERK signaling pathway involved in nicotine-induced cardiomyocyte apoptosis","volume":"387","author":"Wang","year":"2014","journal-title":"Naunyn Schmiedeberg's Arch. Pharmacol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0145","doi-asserted-by":"crossref","first-page":"6535","DOI":"10.1242\/jcs.01565","article-title":"Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity","volume":"117","author":"Ishihara","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0150","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1152\/physiolgenomics.00042.2014","article-title":"Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation","volume":"46","author":"Slagsvold","year":"2014","journal-title":"Physiol. Genomics"},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0155","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1158\/1541-7786.MCR-13-0131","article-title":"mir-106a represses the Rb tumor suppressor p130 to regulate cellular proliferation and differentiation in high-grade serous ovarian carcinoma","volume":"11","author":"Liu","year":"2013","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0160","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1016\/j.febslet.2013.06.058","article-title":"MicroRNA-106a induces multidrug resistance in gastric cancer by targeting runx3","volume":"587","author":"Zhang","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0165","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cca.2008.10.021","article-title":"Detection of mir-106a in gastric carcinoma and its clinical significance","volume":"400","author":"Xiao","year":"2009","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0170","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1158\/1078-0432.CCR-12-3302","article-title":"The prognostic value of microRNAs varies with patient race\/ethnicity and stage of colorectal cancer","volume":"19","author":"Bovell","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0175","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1182\/blood-2011-07-370122","article-title":"Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis","volume":"119","author":"Iqbal","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0180","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1172\/JCI36154","article-title":"MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice","volume":"119","author":"Callis","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0185","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1126\/science.1139089","article-title":"Control of stress-dependent cardiac growth and gene expression by a microRNA","volume":"316","author":"van Rooij","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0190","doi-asserted-by":"crossref","first-page":"18255","DOI":"10.1073\/pnas.0608791103","article-title":"A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure","volume":"103","author":"van Rooij","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0195","doi-asserted-by":"crossref","first-page":"12103","DOI":"10.1073\/pnas.0811371106","article-title":"mir-23a functions downstream of NFATc3 to regulate cardiac hypertrophy","volume":"106","author":"Lin","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0200","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/cr.2011.132","article-title":"Cardiomyocyte overexpression of mir-27b induces cardiac hypertrophy and dysfunction in mice","volume":"22","author":"Wang","year":"2012","journal-title":"Cell Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0205","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/ncb2126","article-title":"MicroRNA-199b targets the nuclear kinase DYRK1A in an auto-amplification loop promoting calcineurin\/NFAT signalling","volume":"12","author":"da Costa Martins","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0210","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nm1582","article-title":"MicroRNA-133 controls cardiac hypertrophy","volume":"13","author":"Care","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0215","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1161\/CIRCRESAHA.114.302476","article-title":"The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting mir-489","volume":"114","author":"Wang","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0220","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.4877","article-title":"Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer","volume":"6","author":"Dhar","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0225","first-page":"3827","article-title":"miR-106a promotes growth and metastasis of non-small cell lung cancer by targeting PTEN","volume":"8","author":"Xie","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0230","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00395-010-0122-3","article-title":"Expression of mitochondrial fusion-fission proteins during post-infarction remodeling: the effect of NHE-1 inhibition","volume":"106","author":"Javadov","year":"2011","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0235","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/cvr\/cvs117","article-title":"Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload","volume":"94","author":"Piquereau","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0240","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1089\/ars.2012.4777","article-title":"Mitochondrial dynamics in cardiovascular health and disease","volume":"19","author":"Ong","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0245","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCRESAHA.110.232306","article-title":"Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure","volume":"108","author":"Dai","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0250","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.cell.2012.02.035","article-title":"Mitochondria: in sickness and in health","volume":"148","author":"Nunnari","year":"2012","journal-title":"Cell"},{"issue":"PtA","key":"10.1016\/j.yjmcc.2016.08.016_bb0255","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.ejphar.2015.04.056","article-title":"Mitochondrial fusion and fission proteins as novel therapeutic targets for treating cardiovascular disease","volume":"763","author":"Ong","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2016.08.016_bb0260","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1139\/cjpp-2014-0060","article-title":"Dysregulation of Mfn2 and Drp-1 proteins in heart failure","volume":"92","author":"Givvimani","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282816303169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282816303169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T21:21:35Z","timestamp":1536441695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282816303169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":52,"alternative-id":["S0022282816303169"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.08.016","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-106a promotes cardiac hypertrophy by targeting mitofusin 2","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2016.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}