{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T19:34:46Z","timestamp":1775504086912,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL034161"],"award-info":[{"award-number":["HL034161"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL066388"],"award-info":[{"award-number":["HL066388"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL084553"],"award-info":[{"award-number":["HL084553"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.yjmcc.2017.01.006","type":"journal-article","created":{"date-parts":[[2017,1,13]],"date-time":"2017-01-13T04:47:55Z","timestamp":1484282875000},"page":"93-101","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Early remodeling of repolarizing K+ currents in the \u03b1MHC403\/+ mouse model of familial hypertrophic cardiomyopathy"],"prefix":"10.1016","volume":"103","author":[{"given":"Rocco","family":"Hueneke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Adenwala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca L.","family":"Mellor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan G.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine E.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne M.","family":"Nerbonne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2017.01.006_bb0005","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1001\/jama.1996.03540030033028","article-title":"Sudden death in young competitive athletes. Clinical, demographic, and pathological profiles","volume":"276","author":"Maron","year":"1996","journal-title":"JAMA"},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0010","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/01.RES.83.6.580","article-title":"Familial hypertrophic cardiomyopathy: from mutations to functional defects","volume":"83","author":"Bonne","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0015","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nrcardio.2011.159","article-title":"Mechanisms of disease: hypertrophic cardiomyopathy","volume":"9","author":"Frey","year":"2011","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0020","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/ncpcardio1110","article-title":"Hypertrophic cardiomyopathy: the genetic determinants of clinical disease expression","volume":"5","author":"Keren","year":"2008","journal-title":"Nat. Clin. Pract. Cardiovasc. Med."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0025","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00001573-200005000-00012","article-title":"Animal models of hypertrophic cardiomyopathy","volume":"15","author":"Maass","year":"2000","journal-title":"Curr. Opin. Cardiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0030","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1126\/science.272.5262.731","article-title":"A mouse model of familial hypertrophic cardiomyopathy","volume":"272","author":"Geisterfer-Lowrance","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0035","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1172\/JCI1940","article-title":"Diastolic dysfunction and altered energetics in the alphaMHC403\/+ mouse model of familial hypertrophic cardiomyopathy","volume":"101","author":"Spindler","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0040","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1203\/00006450-199905010-00005","article-title":"QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice","volume":"45","author":"Bevilacqua","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0045","doi-asserted-by":"crossref","first-page":"18123","DOI":"10.1073\/pnas.0509145102","article-title":"Somatic events modify hypertrophic cardiomyopathy pathology and link hypertrophy to arrhythmia","volume":"102","author":"Wolf","year":"2005","journal-title":"PNAS"},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0050","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/01.RES.88.4.383","article-title":"Comparison of two murine models of familial hypertrophic cardiomyopathy","volume":"88","author":"McConnell","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0055","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1172\/JCI119197","article-title":"Electrophysiological abnormalities and arrhythmias in alpha MHC mutant familial hypertrophic cardiomyopathy mice","volume":"99","author":"Berul","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0060","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1542-474X.2008.00275.x","article-title":"Impact of QT variables on clinical outcome of genotyped hypertrophic cardiomyopathy","volume":"14","author":"Uchiyama","year":"2009","journal-title":"Ann. Noninvasive Electrocardiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0065","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/eurheartj\/ehr021","article-title":"Prevalence and clinical correlates of QT prolongation in patients with hypertrophic cardiomyopathy","volume":"32","author":"Johnson","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0070","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/heart.88.2.153","article-title":"Relation between QT duration and maximal wall thickness in familial hypertrophic cardiomyopathy","volume":"88","author":"Jouven","year":"2002","journal-title":"Heart"},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0075","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.hrthm.2009.04.029","article-title":"Ventricular fibrillation in MYH7-related hypertrophic cardiomyopathy before onset of ventricular hypertrophy","volume":"6","author":"Christiaans","year":"2009","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0080","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1161\/CIRCRESAHA.107.170050","article-title":"Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy","volume":"102","author":"Marionneau","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0085","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/apha.12172","article-title":"Physiology and analysis of the electrocardiographic T wave in mice","volume":"209","author":"Speerschneider","year":"2013","journal-title":"Acta Physiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0090","doi-asserted-by":"crossref","first-page":"25388","DOI":"10.1038\/srep25388","article-title":"The complex QT\/RR relationship in mice","volume":"6","author":"Roussel","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0095","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1085\/jgp.113.5.661","article-title":"Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes","volume":"113","author":"Xu","year":"1999","journal-title":"J. Gen. Physiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0100","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1113\/jphysiol.2004.063347","article-title":"Heterogeneous expression of repolarizing, voltage-gated K+ currents in adult mouse ventricles","volume":"559","author":"Brunet","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0105","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/01.RES.49.2.525","article-title":"Myosin isoenzyme changes in several models of rat cardiac hypertrophy","volume":"49","author":"Mercadier","year":"1981","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0110","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1161\/01.RES.82.7.773","article-title":"Hypertrophy, pathology, and molecular markers of cardiac pathogenesis","volume":"82","author":"Vikstrom","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0115","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.RES.83.5.560","article-title":"Functional knockout of the transient outward current, long-QT synrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit","volume":"83","author":"Barry","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0120","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.RES.83.8.806","article-title":"Characterization of a slowly inactivating outward current in adult mouse ventricular myocytes","volume":"83","author":"Zhou","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0125","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1073\/pnas.95.6.2926","article-title":"Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel","volume":"95","author":"London","year":"1998","journal-title":"PNAS"},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0130","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1469-7793.1999.00587.x","article-title":"Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes","volume":"521","author":"Guo","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0135","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1161\/01.RES.85.7.623","article-title":"Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit","volume":"85","author":"Xu","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0140","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1161\/01.RES.87.1.73","article-title":"Functional consequences of elimination of i(to,f) and i(to,s): early afterdepolarizations, atrioventricular block, and ventricular arrhythmias in mice lacking Kv1.4 and expressing a dominant-negative Kv4 alpha subunit","volume":"87","author":"Guo","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0145","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0092-8674(01)00588-8","article-title":"A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of Ito and confers susceptibility to ventricular tachycardia","volume":"107","author":"Kuo","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0150","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1161\/hh0901.090929","article-title":"Targeted replacement of Kv1.5 in the mouse leads to loss of the 4-aminopyridine-sensitive component of IK,slow and resistance to drug-induced qt prolongation","volume":"88","author":"London","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0155","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1161\/01.RES.0000012664.05949.E0","article-title":"Role of heteromultimers in the generation of myocardial transient outward K+ currents","volume":"90","author":"Guo","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0160","doi-asserted-by":"crossref","first-page":"H319","DOI":"10.1152\/ajpheart.00665.2003","article-title":"Selective elimination of IK,slow1 in mouse ventricular myocytes expressing a dominant negative Kv1.5alpha subunit","volume":"286","author":"Li","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0165","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1161\/01.RES.0000196559.63223.aa","article-title":"Targeted deletion of Kv4.2 eliminates Ito,f and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction","volume":"97","author":"Guo","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0170","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yjmcc.2007.10.007","article-title":"Kv4.3 is not required for the generation of functional Ito,f channels in adult mouse ventricles","volume":"44","author":"Niwa","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0175","doi-asserted-by":"crossref","first-page":"4149","DOI":"10.1113\/jphysiol.2013.255836","article-title":"Stabilization of Kv4 protein by the accessory K+ channel interacting protein 2 (KChIP2) subunit is required for the generation of native myocardial fast transient outward K+ currents","volume":"591","author":"Foeger","year":"2013","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0180","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1469-7793.2001.t01-1-00697.x","article-title":"The consequences of disrupting cardiac inwardly rectifying K+ current (IK1) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes","volume":"533","author":"Zaritsky","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0185","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cardiores.2007.02.025","article-title":"The acid-sensitive potassium channel TASK-1 in rat cardiac muscle","volume":"75","author":"Putzke","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0190","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.yjmcc.2012.07.004","article-title":"Exercise training and P13K\u03b1-induced electrical remodeling is independent of cellular hypertrophy and Akt signaling","volume":"53","author":"Yang","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2017.01.006_bb0195","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1152\/physrev.00014.2006","article-title":"Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation","volume":"87","author":"Nattel","year":"2007","journal-title":"Physiol. Rev."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282817300068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282817300068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T20:56:17Z","timestamp":1656017777000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282817300068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":39,"alternative-id":["S0022282817300068"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2017.01.006","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early remodeling of repolarizing K+ currents in the \u03b1MHC403\/+ mouse model of familial hypertrophic cardiomyopathy","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2017.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}