{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:38:34Z","timestamp":1790836714911,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T00:00:00Z","timestamp":1513123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Physiological Genomics Fellowship-APS"},{"name":"UNAM-PAPIIT","award":["IA 209016"],"award-info":[{"award-number":["IA 209016"]}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR062554"],"award-info":[{"award-number":["R01 AR062554"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL105239"],"award-info":[{"award-number":["R01 HL105239"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL116321"],"award-info":[{"award-number":["U01 HL116321"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR 055928"],"award-info":[{"award-number":["R01 AR 055928"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.yjmcc.2017.12.005","type":"journal-article","created":{"date-parts":[[2017,12,14]],"date-time":"2017-12-14T08:11:01Z","timestamp":1513239061000},"page":"354-363","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Absence of synemin in mice causes structural and functional abnormalities in heart"],"prefix":"10.1016","volume":"114","author":[{"given":"Karla P.","family":"Garc\u00eda-Pelagio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto C.","family":"Joca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Jonathan Lederer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Bloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2017.12.005_bb0005","author":"World Health Organization Cardiovascular diseases (CVDs) Fact sheet 317"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0010","unstructured":"CDC, NCHS. Underlying Cause of Death 1999\u20132013 on CDC WONDER Online Database, released 2015. Data are from the Multiple Cause of Death Files, 1999\u20132013, as compiled from data provided by the 57 vital statistics jurisdictions through the Vital Statistics Cooperative Program. Accessed May 15, 2016."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0015","series-title":"Hurst's the Heart Manual of Cardiology","author":"Walsh","year":"2012"},{"issue":"23","key":"10.1016\/j.yjmcc.2017.12.005_bb0020","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1056\/NEJM200012073432304","article-title":"Mutations in sarcomere protein genes as a cause of dilated cardiomyopathy","volume":"343","author":"Kamisago","year":"2000","journal-title":"The New England J. Med."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0025","series-title":"Gene Reviews [Internet]","article-title":"Dilated cardiomyopathy overview","author":"Hershberger","year":"2015"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0030","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1161\/01.CIR.0000034170.83171.0B","article-title":"Hypertrophic cardiomyopathy","volume":"106","author":"Maron","year":"2002","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.yjmcc.2017.12.005_bb0035","doi-asserted-by":"crossref","DOI":"10.7326\/0003-4819-152-8-201004200-00008","article-title":"Harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy","volume":"152","author":"Wang","year":"2010","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.yjmcc.2017.12.005_bb0040","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000346146","article-title":"Progress in the molecular genetics of hypertrophic cardiomyopathy: a mini-review","volume":"59","author":"Tian","year":"2013","journal-title":"Gerontology"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0045","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1161\/CIRCRESAHA.111.242974","article-title":"Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy","volume":"109","author":"Ashrafian","year":"2011","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.yjmcc.2017.12.005_bb0050","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/bies.10140","article-title":"Beyond structure: do intermediate filaments modulate cell signaling?","volume":"24","author":"Paramio","year":"2002","journal-title":"Bioassays"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0055","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1101\/gad.1552107","article-title":"Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm","volume":"21","author":"Kim","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0060","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1172\/JCI38214","article-title":"Intermediate filaments: primary determinants of cell architecture and plasticity","volume":"119","author":"Herrmann","year":"2009","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0065","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1242\/jcs.009241","article-title":"Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization","volume":"120","author":"Stone","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0070","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1091\/mbc.01-12-0576","article-title":"Sarcolemmal organization in skeletal muscle lacking desmin: evidence for cytokeratins associated with membrane skeleton at costameres","volume":"13","author":"O'Neill","year":"2002","journal-title":"Mol. Biol. Cell"},{"issue":"10","key":"10.1016\/j.yjmcc.2017.12.005_bb0075","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.yexcr.2007.03.033","article-title":"Muscle intermediate filaments and their links to membranes and membranous organelles","volume":"313","author":"Capetanaki","year":"2007","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0080","series-title":"Methods in Enzymology. Intermediate Filament Proteins","author":"Omary","year":"2016"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0085","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1006\/bbrc.1995.2200","article-title":"Synemin contains the rod domain of intermediate filaments","volume":"213","author":"Becker","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0090","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/abbi.1998.0702","article-title":"Properties of the novel intermediate filament protein synemin and its identification in mammalian muscle","volume":"355","author":"Bilak","year":"1998","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0095","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1042\/BJ20071188","article-title":"Human alpha-synemin interacts directly with vinculin and metavinculin","volume":"409","author":"Sun","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0100","first-page":"137","article-title":"Synemin isoforms differentially organize cell junctions and desmin filaments in neonatal cardiomyocytes","volume":"1","author":"Lund","year":"2011","journal-title":"FASEB"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0105","doi-asserted-by":"crossref","first-page":"32330","DOI":"10.1074\/jbc.M104005200","article-title":"Synemin may function to directly link muscle cell intermediate filaments to both myofibrillar Z-lines and costameres","volume":"276","author":"Bellin","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.yjmcc.2017.12.005_bb0110","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1016\/S0021-9258(18)32964-8","article-title":"Purification of the intermediate filament-associated protein, synemin, from chicken smooth muscle. Studies on its physicochemical properties, interaction with desmin, and phosphorylation","volume":"258","author":"Sandoval","year":"1983","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0115","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.abb.2006.06.010","article-title":"The intermediate filament protein, synemin, is an AKAP in the heart","volume":"456","author":"Russell","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0120","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1091\/mbc.e11-08-0685","article-title":"Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A","volume":"23","author":"Pitre","year":"2012","journal-title":"Mol. Biol. Cell"},{"issue":"6","key":"10.1016\/j.yjmcc.2017.12.005_bb0125","doi-asserted-by":"crossref","first-page":"C448","DOI":"10.1152\/ajpcell.00331.2014","article-title":"Myopathic changes in murine skeletal muscle lacking synemin","volume":"308","author":"Garc\u00eda-Pelagio","year":"2015","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0130","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1152\/japplphysiol.01372.2009","article-title":"The Na+\/Ca+ exchanger-1 mediates left ventricular dysfunction in mice with chronic intermittent hypoxia","volume":"109","author":"Chen","year":"2010","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0135","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/nprot.2008.138","article-title":"Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats","volume":"3","author":"Pacher","year":"2008","journal-title":"Nat. Protoc."},{"issue":"6","key":"10.1016\/j.yjmcc.2017.12.005_bb0140","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2170\/physiolsci.RP010107","article-title":"A Simple technique for isolating healthy heart cells from mouse models","volume":"57","author":"Shioya","year":"2007","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0145","doi-asserted-by":"crossref","first-page":"41830","DOI":"10.1074\/jbc.M400128200","article-title":"Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex","volume":"279","author":"Ursitti","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0150","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1091\/mbc.e02-07-0411","article-title":"Obscurin is a ligand for small ankyrin 1 in skeletal muscle","volume":"14","author":"Kontrogianni-Konstantopoulos","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0155","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.nmd.2004.06.008","article-title":"Histological parameters for the quantitative assessment of muscular dystrophy in the mdx mouse","volume":"14","author":"Briguet","year":"2004","journal-title":"Neuromuscul. Disord."},{"issue":"2","key":"10.1016\/j.yjmcc.2017.12.005_bb0160","doi-asserted-by":"crossref","first-page":"H501","DOI":"10.1152\/ajpheart.00138.2005","article-title":"Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers","volume":"289","author":"Burkhoff","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0165","doi-asserted-by":"crossref","first-page":"S203","DOI":"10.1097\/00003086-200210001-00024","article-title":"Costameres: repeating structures at the sarcolemma of skeletal muscle","volume":"403","author":"Bloch","year":"2002","journal-title":"Clin. Orthop. Relat. Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2017.12.005_bb0170","doi-asserted-by":"crossref","first-page":"C803","DOI":"10.1152\/ajpcell.00394.2010","article-title":"Physiology, structure, and susceptibility to injury of skeletal muscle in mice lacking keratin 19-based and desmin-based intermediate filaments","volume":"300","author":"Lovering","year":"2011","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0175","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1242\/jcs.143164","article-title":"Synemin acts as a regulator of signaling molecules in skeletal muscle hypertrophy","volume":"127","author":"Zhenlin","year":"2014","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.yjmcc.2017.12.005_bb0180","doi-asserted-by":"crossref","first-page":"C839","DOI":"10.1152\/ajpcell.00218.2016","article-title":"Deficiency of the intermediate filament synemin reduces bone mass in vivo","volume":"11","author":"Moorer","year":"2016","journal-title":"Am. J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0185","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0092-8674(80)90549-8","article-title":"Synemin: a new high molecular weight protein associated with desmin and vimentin filaments in muscle","volume":"22","author":"Granger","year":"1980","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0190","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1161\/01.CIR.83.2.504","article-title":"Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy","volume":"83","author":"Schaper","year":"1991","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.yjmcc.2017.12.005_bb0195","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/01.CIR.100.5.461","article-title":"Desmin mutation responsible for idiopathic dilated cardiomyopathy","volume":"100","author":"Li","year":"1999","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.yjmcc.2017.12.005_bb0200","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.CIR.101.5.473","article-title":"C gene mutation associated with dilated cardiomyopathy with variable skeletal muscle involvement","volume":"101","author":"Brodsky","year":"2000","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.yjmcc.2017.12.005_bb0205","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0735-1097(02)02954-6","article-title":"Natural history of dilated cardiomyopathy due to lamin A\/C gene mutations","volume":"41","author":"Taylor","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.yjmcc.2017.12.005_bb0210","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1620\/tjem.218.309","article-title":"C gene mutations in familial cardiomyopathy with advanced atrioventricular block and arrhythmia","volume":"218","author":"Saga","year":"2009","journal-title":"Tohoku J. Exp. Med."},{"issue":"2","key":"10.1016\/j.yjmcc.2017.12.005_bb0215","first-page":"269","article-title":"Histological changes and immunohistochemical changes of the myocardium in dilated cardiomyopathy","volume":"53","author":"Radu","year":"2012","journal-title":"Romanian J. Morphol. Embryol."},{"issue":"8","key":"10.1016\/j.yjmcc.2017.12.005_bb0220","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1006\/jmcc.1997.0446","article-title":"Null mutation in the desmin gene gives rise to a cardiomyopathy","volume":"29","author":"Thornell","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"11","key":"10.1016\/j.yjmcc.2017.12.005_bb0225","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1006\/jmcc.1999.1037","article-title":"The absence of desmin leads to cardiomyocyte hypertrophy and cardiac dilation with compromised systolic function","volume":"31","author":"Milner","year":"1999","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2017.12.005_bb0230","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0008-6363(01)00500-4","article-title":"Hearts from mice lacking desmin have a myopathy with impaired active force generation and unaltered wall compliance","volume":"53","author":"Balogh","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0235","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/heart.84.6.659","article-title":"Changes in myocardial cytoskeletal intermediate filaments and myocyte contractile dysfunction in dilated cardiomyopathy: an in vivo study in humans","volume":"84","author":"Di Somma","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2017.00162","article-title":"Contribution of autonomic reflexes to the hyperadrenergic state in heart failure","volume":"11","author":"Toschi-Dias","year":"2017","journal-title":"Front. Neurosci."},{"issue":"23","key":"10.1016\/j.yjmcc.2017.12.005_bb0245","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1093\/hmg\/ddq387","article-title":"De novo desmin-mutation N116S is associated with arrhythmogenic right ventricular cardiomyopathy","volume":"19","author":"Klauke","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0250","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.cr.7290146","article-title":"Hypertrophic cardiomyopathy: from gene defect to clinical disease","volume":"13","author":"Chung","year":"2003","journal-title":"Cell Res."},{"issue":"3","key":"10.1016\/j.yjmcc.2017.12.005_bb0255","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.yjmcc.2004.04.017","article-title":"A-kinase anchoring protein targeting of protein kinase A in the heart","volume":"37","author":"Ruehr","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0260","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrm1983","article-title":"Regulation of cardiac hypertrophy by intracellular signaling pathways","volume":"7","author":"Heineke","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.yjmcc.2017.12.005_bb0265","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1083\/jcb.201101100","article-title":"Cellular mechanisms of cardiomyopathy","volume":"194","author":"Harvey","year":"2011","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.yjmcc.2017.12.005_bb0270","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbamcr.2012.07.014","article-title":"A-kinase anchoring proteins: molecular regulators of the cardiac stress response","volume":"1833","author":"Diviani","year":"2013","journal-title":"Biochem. Biophys Acta"},{"issue":"1","key":"10.1016\/j.yjmcc.2017.12.005_bb0275","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/02699050500284218","article-title":"The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions","volume":"24","author":"Yoon","year":"2006","journal-title":"Growth Factors"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0280","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/01.RES.0000038488.38975.1A","article-title":"Involvement of extracellular signal-regulated kinases \u00bd in cardiac hypertrophy and cell death","volume":"91","author":"Bueno","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0285","doi-asserted-by":"crossref","first-page":"7783","DOI":"10.1073\/pnas.141224398","article-title":"Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1through a MEK-ERK independent mechanism","volume":"98","author":"Chen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0290","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1161\/hc4401.099449","article-title":"Differential regulation of mitogen-activated protein kinases in the failing human heart in response to mechanical unloading","volume":"104","author":"Flesch","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0295","doi-asserted-by":"crossref","first-page":"14074","DOI":"10.1073\/pnas.0610906104","article-title":"Genetic inhibition of cardiac ERK1\/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo","volume":"104","author":"Purcell","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.yjmcc.2017.12.005_bb0300","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1152\/physrev.00054.2009","article-title":"Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale","volume":"90","author":"Rose","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yjmcc.2017.12.005_bb0305","doi-asserted-by":"crossref","DOI":"10.1063\/1.4954099","article-title":"Absence of synemin causes hypertrophy in murine heart","volume":"1747","author":"Garcia-Pelagio","year":"2016","journal-title":"AIP Conf Proc"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282817303619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282817303619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T13:36:41Z","timestamp":1660138601000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282817303619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":61,"alternative-id":["S0022282817303619"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2017.12.005","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Absence of synemin in mice causes structural and functional abnormalities in heart","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2017.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}