{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:18:58Z","timestamp":1793949538041,"version":"4.8.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571527"],"award-info":[{"award-number":["31571527"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81322003"],"award-info":[{"award-number":["81322003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["17XD1400300"],"award-info":[{"award-number":["17XD1400300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2016YFC1000500"],"award-info":[{"award-number":["2016YFC1000500"]}]},{"name":"National Key R&D Program of China","award":["2016YFC1305100"],"award-info":[{"award-number":["2016YFC1305100"]}]},{"name":"National Key Scientific Research Projects","award":["2014CBA02003"],"award-info":[{"award-number":["2014CBA02003"]}]}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.yjmcc.2018.02.007","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T17:31:28Z","timestamp":1518543088000},"page":"49-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Establishment of a PRKAG2 cardiac syndrome disease model and mechanism study using human induced pluripotent stem cells"],"prefix":"10.1016","volume":"117","author":[{"given":"Yongkun","family":"Zhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhe","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sifeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhua","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7861-3646","authenticated-orcid":false,"given":"Ning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.yjmcc.2018.02.007_bb0005","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0968-0004(98)01340-1","article-title":"Dealing with energy demand: the AMP-activated protein kinase","volume":"24","author":"Kemp","year":"1999","journal-title":"Trends Biochem. Sci."},{"issue":"3","key":"10.1016\/j.yjmcc.2018.02.007_bb0010","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1161\/CIRCRESAHA.108.190918","article-title":"Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure","volume":"104","author":"Gundewar","year":"2009","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.yjmcc.2018.02.007_bb0015","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.108.114702","article-title":"AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice","volume":"52","author":"Zhang","year":"2008","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.yjmcc.2018.02.007_bb0020","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1172\/JCI19297","article-title":"AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury","volume":"114","author":"Russell","year":"2004","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.yjmcc.2018.02.007_bb0025","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1748-1716.2009.01978.x","article-title":"AMP-activated protein kinase: a core signalling pathway in the heart","volume":"196","author":"Kim","year":"2009","journal-title":"Acta Physiol (Oxford)"},{"issue":"3","key":"10.1016\/j.yjmcc.2018.02.007_bb0030","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1172\/JCI0214571","article-title":"Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy","volume":"109","author":"Arad","year":"2002","journal-title":"J. Clin. Investig."},{"issue":"24","key":"10.1016\/j.yjmcc.2018.02.007_bb0035","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1056\/NEJM200106143442403","article-title":"Identification of a gene responsible for familial Wolff-Parkinson-White syndrome","volume":"344","author":"Gollob","year":"2001","journal-title":"N. Engl. J. Med."},{"issue":"11","key":"10.1016\/j.yjmcc.2018.02.007_bb0040","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/hmg\/10.11.1215","article-title":"Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis","volume":"10","author":"Blair","year":"2001","journal-title":"Hum. Mol. Genet."},{"issue":"25","key":"10.1016\/j.yjmcc.2018.02.007_bb0045","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1161\/hc5001.102111","article-title":"Novel PRKAG2 mutation responsible for the genetic syndrome of ventricular preexcitation and conduction system disease with childhood onset and absence of cardiac hypertrophy","volume":"104","author":"Gollob","year":"2001","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.yjmcc.2018.02.007_bb0050","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00001573-200205000-00004","article-title":"PRKAG2 cardiac syndrome: familial ventricular preexcitation, conduction system disease, and cardiac hypertrophy","volume":"17","author":"Gollob","year":"2002","journal-title":"Curr. Opin. Cardiol."},{"issue":"6","key":"10.1016\/j.yjmcc.2018.02.007_bb0055","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.jacc.2004.11.053","article-title":"Adenosine monophosphate-activated protein kinase disease mimicks hypertrophic cardiomyopathy and Wolff-Parkinson-White syndrome: natural history","volume":"45","author":"Murphy","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2018.02.007_bb0060","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.hrthm.2010.09.081","article-title":"Clinical, electrocardiographic, and electrophysiologic characteristics of patients with a fasciculoventricular pathway: the role of PRKAG2 mutation","volume":"8","author":"Sternick","year":"2011","journal-title":"Heart Rhythm."},{"issue":"Pt 1","key":"10.1016\/j.yjmcc.2018.02.007_bb0065","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1042\/bst0310228","article-title":"Glycogen storage disease as a unifying mechanism of disease in the PRKAG2 cardiac syndrome","volume":"31","author":"Gollob","year":"2003","journal-title":"Biochem. Soc. Trans."},{"issue":"5","key":"10.1016\/j.yjmcc.2018.02.007_bb0070","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1172\/JCI30658","article-title":"Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage","volume":"117","author":"Luptak","year":"2007","journal-title":"J. Clin. Investig."},{"issue":"4","key":"10.1016\/j.yjmcc.2018.02.007_bb0075","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1161\/01.RES.0000179035.20319.c2","article-title":"N488I mutation of the gamma2-subunit results in bidirectional changes in AMP-activated protein kinase activity","volume":"97","author":"Zou","year":"2005","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.yjmcc.2018.02.007_bb0080","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1161\/CIRCGENETICS.108.834564","article-title":"Distinct early signaling events resulting from the expression of the PRKAG2 R302Q mutant of AMPK contribute to increased myocardial glycogen","volume":"2","author":"Folmes","year":"2009","journal-title":"Circ. Cardiovasc. Genet."},{"issue":"22","key":"10.1016\/j.yjmcc.2018.02.007_bb0085","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1161\/01.CIR.0000075270.13497.2B","article-title":"Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-white syndrome in glycogen storage cardiomyopathy","volume":"107","author":"Arad","year":"2003","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.yjmcc.2018.02.007_bb0090","doi-asserted-by":"crossref","first-page":"H1942","DOI":"10.1152\/ajpheart.01020.2005","article-title":"Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome","volume":"290","author":"Davies","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.yjmcc.2018.02.007_bb0095","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.yjmcc.2018.02.007_bb0100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.stem.2012.10.010","article-title":"Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells","volume":"12","author":"Lan","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"130","key":"10.1016\/j.yjmcc.2018.02.007_bb0105","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003552","article-title":"Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy","volume":"4","author":"Sun","year":"2012","journal-title":"Sci. Transl. Med."},{"issue":"15","key":"10.1016\/j.yjmcc.2018.02.007_bb0110","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1056\/NEJMoa0908679","article-title":"Patient-specific induced pluripotent stem-cell models for long-QT syndrome","volume":"363","author":"Moretti","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"7299","key":"10.1016\/j.yjmcc.2018.02.007_bb0115","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature09005","article-title":"Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome","volume":"465","author":"Carvajal-Vergara","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2018.02.007_bb0120","unstructured":"\u5218\u6e58\u73ae, \u738b\u806a, \u5b59\u7231\u519b, \u738b\u9e4f, \u7ba1\u4e3d\u534e, \u7a0b\u857e\u857e, \u845b\u5747\u6ce2. PRKAG2\u57fa\u56e0R302Q\u7a81\u53d8\u81f4\u540c\u80de\u5144\u5f1f\u4e0d\u540c\u4e34\u5e8a\u8868\u73b0\u7684\u7814\u7a76. \u4e2d\u56fd\u5206\u5b50\u5fc3\u810f\u75c5\u5b66\u6742\u5fd7 2013(02): 486\u2013488."},{"issue":"27","key":"10.1016\/j.yjmcc.2018.02.007_bb0125","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1200250109","article-title":"Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling","volume":"109","author":"Lian","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.yjmcc.2018.02.007_bb0130","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/cvr\/cvu205","article-title":"Study familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cells","volume":"104","author":"Han","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"15","key":"10.1016\/j.yjmcc.2018.02.007_bb0135","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1161\/01.CIR.0000069269.60167.02","article-title":"Constitutively active adenosine monophosphate-activated protein kinase regulates voltage-gated sodium channels in ventricular myocytes","volume":"107","author":"Light","year":"2003","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2018.02.007_bb0140","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/CIRCGENETICS.111.959973","article-title":"Long-term outcomes in hypertrophic cardiomyopathy caused by mutations in the cardiac troponin T gene","volume":"5","author":"Pasquale","year":"2012","journal-title":"Circ. Cardiovasc. Genet."},{"issue":"11","key":"10.1016\/j.yjmcc.2018.02.007_bb0145","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1016\/j.celrep.2016.11.040","article-title":"Early-onset hypertrophic cardiomyopathy mutations significantly increase the velocity, force, and actin-activated atpase activity of human beta-cardiac myosin","volume":"17","author":"Adhikari","year":"2016","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.yjmcc.2018.02.007_bb0150","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.celrep.2015.09.025","article-title":"Contractile defect caused by mutation in MYBPC3 revealed under conditions optimized for human PSC-cardiomyocyte function","volume":"13","author":"Birket","year":"2015","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.yjmcc.2018.02.007_bb0155","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1161\/01.CIR.0000151291.32974.D5","article-title":"Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome","volume":"111","author":"Sidhu","year":"2005","journal-title":"Circulation"},{"issue":"22","key":"10.1016\/j.yjmcc.2018.02.007_bb0160","doi-asserted-by":"crossref","first-page":"12953","DOI":"10.1074\/jbc.270.22.12953","article-title":"An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)","volume":"270","author":"Lehmann","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"Pt 1","key":"10.1016\/j.yjmcc.2018.02.007_bb0165","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/bj2950287","article-title":"Glucose transporters and in vivo glucose uptake in skeletal and cardiac muscle: fasting, insulin stimulation and immunoisolation studies of GLUT1 and GLUT4","volume":"295","author":"Kraegen","year":"1993","journal-title":"Biochem. J."},{"issue":"3","key":"10.1016\/j.yjmcc.2018.02.007_bb0170","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.yjmcc.2012.06.015","article-title":"Transcript variant dictates Prkag2 cardiomyopathy?","volume":"53","author":"Kim","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.yjmcc.2018.02.007_bb0175","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.yjmcc.2010.06.003","article-title":"SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy","volume":"49","author":"Banerjee","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"4","key":"10.1016\/j.yjmcc.2018.02.007_bb0180","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nmeth.2857","article-title":"Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects","volume":"11","author":"Shen","year":"2014","journal-title":"Nat. Methods"},{"issue":"5469","key":"10.1016\/j.yjmcc.2018.02.007_bb0185","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1126\/science.288.5469.1248","article-title":"A mutation in PRKAG3 associated with excess glycogen content in pig skeletal muscle","volume":"288","author":"Milan","year":"2000","journal-title":"Science"},{"issue":"Pt 3","key":"10.1016\/j.yjmcc.2018.02.007_bb0190","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1042\/bj3460659","article-title":"Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding","volume":"346","author":"Cheung","year":"2000","journal-title":"Biochem. J."},{"issue":"52","key":"10.1016\/j.yjmcc.2018.02.007_bb0195","doi-asserted-by":"crossref","first-page":"51017","DOI":"10.1074\/jbc.M207093200","article-title":"Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-white syndrome","volume":"277","author":"Daniel","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.yjmcc.2018.02.007_bb0200","doi-asserted-by":"crossref","DOI":"10.1152\/ajpendo.00073.2006","article-title":"Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation","volume":"291","author":"Yu","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.yjmcc.2018.02.007_bb0205","doi-asserted-by":"crossref","unstructured":"Arad M, Seidman CE, Seidman JG. AMP-activated protein kinase in the heart: role during health and disease. Circ. Res. 2007; 100(4): 474\u2013488. https:\/\/doi.org\/10.1161\/01.RES.0000258446.23525.37.","DOI":"10.1161\/01.RES.0000258446.23525.37"},{"issue":"4","key":"10.1016\/j.yjmcc.2018.02.007_bb0210","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1203\/PDR.0b013e3181462b86","article-title":"Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase","volume":"62","author":"Akman","year":"2007","journal-title":"Pediatr. Res."},{"issue":"10","key":"10.1016\/j.yjmcc.2018.02.007_bb0215","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1111\/j.1540-8159.2008.01192.x","article-title":"Focal AF-ablation after pulmonary vein isolation in a patient with hypertrophic cardiomyopathy using cryothermal energy","volume":"31","author":"Van Belle","year":"2008","journal-title":"Pacing Clin. Electrophysiol."},{"issue":"8","key":"10.1016\/j.yjmcc.2018.02.007_bb0220","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1007\/s00246-009-9521-3","article-title":"Severe hypertrophic cardiomyopathy in an infant with a novel PRKAG2 gene mutation: potential differences between infantile and adult onset presentation","volume":"30","author":"Kelly","year":"2009","journal-title":"Pediatr. Cardiol."},{"issue":"18","key":"10.1016\/j.yjmcc.2018.02.007_bb0225","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1056\/NEJMoa075463","article-title":"Shared genetic causes of cardiac hypertrophy in children and adults","volume":"358","author":"Morita","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.yjmcc.2018.02.007_bb0230","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/europace\/eum071","article-title":"A familial form of conduction defect related to a mutation in the PRKAG2 gene","volume":"9","author":"Charron","year":"2007","journal-title":"Europace"},{"issue":"11","key":"10.1016\/j.yjmcc.2018.02.007_bb0235","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1016\/j.celrep.2017.05.038","article-title":"Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis","volume":"19","author":"Hinson","year":"2017","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.yjmcc.2018.02.007_bb0240","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCRESAHA.113.300376","article-title":"Cardiac metabolism in heart failure: implications beyond ATP production","volume":"113","author":"Doenst","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2018.02.007_bb0245","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biomaterials.2016.07.035","article-title":"Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction","volume":"105","author":"Wang","year":"2016","journal-title":"Biomaterials"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282818300415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282818300415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T23:53:43Z","timestamp":1574985223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282818300415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":49,"alternative-id":["S0022282818300415"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2018.02.007","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Establishment of a PRKAG2 cardiac syndrome disease model and mechanism study using human induced pluripotent stem cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2018.02.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}