{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:11:42Z","timestamp":1790255502897,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100017325","name":"Engineering Research Centers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001774","name":"New Jersey Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.yjmcc.2018.12.017","type":"journal-article","created":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T03:08:54Z","timestamp":1546744134000},"page":"38-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":90,"special_numbering":"C","title":["Mitochondrial LonP1 protects cardiomyocytes from ischemia\/reperfusion injury in vivo"],"prefix":"10.1016","volume":"128","author":[{"given":"Sundararajan","family":"Venkatesh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Rashed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satvik","family":"Mareedu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyong","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clea","family":"B\u00e1rcena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"L\u00f3pez-Ot\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9834-6012","authenticated-orcid":false,"given":"Ghassan","family":"Yehia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Sadoshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn K.","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.yjmcc.2018.12.017_bb0005","first-page":"1121","article-title":"Myocardial reperfusion injury","volume":"357","author":"Yellon","year":"2007","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.yjmcc.2018.12.017_bb0010","first-page":"92","article-title":"Myocardial ischemia-reperfusion injury: a neglected therapeutic target","volume":"123","author":"Hausenloy","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"7527","key":"10.1016\/j.yjmcc.2018.12.017_bb0015","first-page":"431","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.yjmcc.2018.12.017_bb0020","first-page":"193","article-title":"Ischaemic conditioning and reperfusion injury","volume":"13","author":"Hausenloy","year":"2016","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2018.12.017_bb0025","first-page":"56","article-title":"Multitasking in the mitochondrion by the ATP-dependent Lon protease","volume":"1823","author":"Venkatesh","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.yjmcc.2018.12.017_bb0030","first-page":"121","article-title":"Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease","volume":"49","author":"Lu","year":"2013","journal-title":"Mol. Cell"},{"issue":"30","key":"10.1016\/j.yjmcc.2018.12.017_bb0035","first-page":"26424","article-title":"Lon peptidase 1 (LONP1)-dependent breakdown of mitochondrial 5-aminolevulinic acid synthase protein by heme in human liver cells","volume":"286","author":"Tian","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.yjmcc.2018.12.017_bb0040","first-page":"305","article-title":"Regulation of pyruvate dehydrogenase kinase 4 in the heart through degradation by the lon protease in response to mitochondrial substrate availability","volume":"292","author":"Crewe","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.yjmcc.2018.12.017_bb0045","first-page":"1151","article-title":"Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease","volume":"157","author":"Hori","year":"2002","journal-title":"J. Cell Biol."},{"issue":"8","key":"10.1016\/j.yjmcc.2018.12.017_bb0050","first-page":"1042","article-title":"Mitochondrial Lon protease is a human stress protein","volume":"46","author":"Ngo","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.yjmcc.2018.12.017_bb0055","first-page":"111","article-title":"HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells","volume":"129","author":"Fukuda","year":"2007","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.yjmcc.2018.12.017_bb0060","first-page":"519","article-title":"Mitochondrial LON protease-dependent degradation of cytochrome c oxidase subunits under hypoxia and myocardial ischemia","volume":"1858","author":"Sepuri","year":"2017","journal-title":"BBA-Bioenergetics"},{"issue":"14","key":"10.1016\/j.yjmcc.2018.12.017_bb0065","first-page":"3321","article-title":"The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives","volume":"119","author":"Bernstein","year":"2012","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.yjmcc.2018.12.017_bb0070","first-page":"542","article-title":"ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity","volume":"8","author":"Quiros","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.yjmcc.2018.12.017_bb0075","article-title":"Overexpression of Lon contributes to survival and aggressive phenotype of cancer cells through mitochondrial complex I-mediated generation of reactive oxygen species","volume":"4","author":"Cheng","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yjmcc.2018.12.017_bb0080","first-page":"7","article-title":"Mitochondrial Lon protease controls ROS-dependent apoptosis in cardiomyocyte under hypoxia","volume":"23","author":"Kuo","year":"2015","journal-title":"Mitochondrion"},{"issue":"11","key":"10.1016\/j.yjmcc.2018.12.017_bb0085","article-title":"Down-regulating overexpressed human Lon in cervical cancer suppresses cell proliferation and bioenergetics","volume":"8","author":"Nie","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.yjmcc.2018.12.017_bb0090","first-page":"121","article-title":"CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease","volume":"96","author":"Strauss","year":"2015","journal-title":"Am. J. Hum. Genet."},{"issue":"7","key":"10.1016\/j.yjmcc.2018.12.017_bb0095","first-page":"1501","article-title":"Mutations in LONP1, a mitochondrial matrix protease, cause CODAS syndrome","volume":"167","author":"Dikoglu","year":"2015","journal-title":"Am. J. Med. Genet. A"},{"issue":"2","key":"10.1016\/j.yjmcc.2018.12.017_bb0100","first-page":"71","article-title":"In for the long run: focus on \"Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart\"","volume":"12","author":"Welle","year":"2003","journal-title":"Physiol. Genomics"},{"issue":"23","key":"10.1016\/j.yjmcc.2018.12.017_bb0105","first-page":"11247","article-title":"A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease","volume":"90","author":"Wang","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5432","key":"10.1016\/j.yjmcc.2018.12.017_bb0110","first-page":"1390","article-title":"Gene expression profile of aging and its retardation by caloric restriction","volume":"285","author":"Lee","year":"1999","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.yjmcc.2018.12.017_bb0115","first-page":"852","article-title":"Increasing organismal healthspan by enhancing mitochondrial protein quality control","volume":"11","author":"Luce","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.yjmcc.2018.12.017_bb0120","first-page":"199","article-title":"Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis","volume":"3","author":"Tong","year":"2006","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.yjmcc.2018.12.017_bb0125","first-page":"106","article-title":"Ischaemic preconditioning protects against ischaemia\/reperfusion injury: emerging concepts","volume":"29","author":"Pasupathy","year":"2005","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"issue":"5","key":"10.1016\/j.yjmcc.2018.12.017_bb0130","first-page":"1124","article-title":"Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium","volume":"74","author":"Murry","year":"1986","journal-title":"Circulation"},{"issue":"17","key":"10.1016\/j.yjmcc.2018.12.017_bb0135","first-page":"5987","article-title":"Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during in vivo cardiac ischemia\/reperfusion","volume":"102","author":"Bulteau","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.yjmcc.2018.12.017_bb0140","first-page":"510","article-title":"Cardiac reperfusion injury: aging, lipid peroxidation, and mitochondrial dysfunction","volume":"95","author":"Lucas","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"9","key":"10.1016\/j.yjmcc.2018.12.017_bb0145","article-title":"Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures","volume":"4","author":"Cantu","year":"2009","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.yjmcc.2018.12.017_bb0150","first-page":"946","article-title":"Ischemic A\/D transition of mitochondrial complex I and its role in ROS generation","volume":"1857","author":"Drose","year":"2016","journal-title":"BBA-Bioenergetics"},{"issue":"2","key":"10.1016\/j.yjmcc.2018.12.017_bb0155","first-page":"254","article-title":"A unifying mechanism for mitochondrial superoxide production during ischemia-reperfusion injury","volume":"23","author":"Chouchani","year":"2016","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.yjmcc.2018.12.017_bb0160","first-page":"421","article-title":"Addition of 2-deoxyglucose enhances growth inhibition but reverses acidification in colon cancer cells treated with phenformin","volume":"31","author":"Lea","year":"2011","journal-title":"Anticancer Res."},{"issue":"2","key":"10.1016\/j.yjmcc.2018.12.017_bb0165","first-page":"297","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.yjmcc.2018.12.017_bb0170","first-page":"700","article-title":"The role of mitochondrial membrane potential in ischemic heart failure","volume":"11","author":"Kadenbach","year":"2011","journal-title":"Mitochondrion"},{"issue":"1","key":"10.1016\/j.yjmcc.2018.12.017_bb0175","first-page":"216","article-title":"Targeted modification of mitochondrial ROS production converts high glucose-induced cytotoxicity to cytoprotection: effects on anesthetic preconditioning","volume":"232","author":"Sedlic","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.yjmcc.2018.12.017_bb0180","first-page":"598","article-title":"Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia\/reperfusion injury and inflammation","volume":"1817","author":"Huttemann","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.yjmcc.2018.12.017_bb0185","first-page":"665","article-title":"Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death","volume":"38","author":"Bota","year":"2005","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.yjmcc.2018.12.017_bb0190","first-page":"629","article-title":"Ischemic preconditioning: protection against myocardial necrosis and apoptosis","volume":"3","author":"Iliodromitis","year":"2007","journal-title":"Vasc. Health Risk Manag."},{"issue":"4","key":"10.1016\/j.yjmcc.2018.12.017_bb0195","first-page":"H1107","article-title":"Ischemic preconditioning protects against infarction in rat-heart","volume":"263","author":"Liu","year":"1992","journal-title":"Am. J. Physiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2018.12.017_bb0200","first-page":"463","article-title":"Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha","volume":"77","author":"Cai","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"2","key":"10.1016\/j.yjmcc.2018.12.017_bb0205","first-page":"449","article-title":"Reactive oxygen species as mediators of signal transduction in ischemic preconditioning","volume":"6","author":"Otani","year":"2004","journal-title":"Antioxid. Redox Signal."},{"issue":"9","key":"10.1016\/j.yjmcc.2018.12.017_bb0210","first-page":"674","article-title":"Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism","volume":"4","author":"Bota","year":"2002","journal-title":"Nat. Cell Biol."},{"issue":"25","key":"10.1016\/j.yjmcc.2018.12.017_bb0215","first-page":"12248","article-title":"Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs","volume":"91","author":"Gardner","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1\u20132","key":"10.1016\/j.yjmcc.2018.12.017_bb0220","first-page":"81","article-title":"Labile iron pool: the main determinant of cellular response to oxidative stress","volume":"531","author":"Kruszewski","year":"2003","journal-title":"Mutat. Res."},{"issue":"2","key":"10.1016\/j.yjmcc.2018.12.017_bb0225","first-page":"286","article-title":"Compartmentation of citrate in relation to the regulation of glycolysis and the mitochondrial transmembrane proton electrochemical potential gradient in isolated perfused rat heart","volume":"681","author":"Kauppinen","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"issue":"38","key":"10.1016\/j.yjmcc.2018.12.017_bb0230","first-page":"36027","article-title":"Production of reactive oxygen species by mitochondria: central role of complex III","volume":"278","author":"Chen","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.yjmcc.2018.12.017_bb0235","first-page":"2522","article-title":"A LON-ClpP proteolytic axis degrades complex I to extinguish ROS production in depolarized mitochondria","volume":"17","author":"Pryde","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.yjmcc.2018.12.017_bb0240","first-page":"38","article-title":"Heart specific knockout of Ndufs4 ameliorates ischemia reperfusion injury","volume":"123","author":"Zhang","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2018.12.017_bb0250","first-page":"976","article-title":"The production of reactive oxygen species by complex I","volume":"36","author":"Hirst","year":"2008","journal-title":"Biochem. Soc. Trans."},{"issue":"46","key":"10.1016\/j.yjmcc.2018.12.017_bb0255","first-page":"47961","article-title":"Blockade of electron transport during ischemia protects cardiac mitochondria","volume":"279","author":"Lesnefsky","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.yjmcc.2018.12.017_bb0260","first-page":"696","article-title":"Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling","volume":"57","author":"Calvert","year":"2008","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.yjmcc.2018.12.017_bb0265","first-page":"1405","article-title":"Reversible blockade of electron transport during ischemia protects mitochondria and decreases myocardial injury following reperfusion","volume":"319","author":"Chen","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.yjmcc.2018.12.017_bb0270","first-page":"188","article-title":"Mitochondrial Lon protease in human disease and aging: including an etiologic classification of Lon-related diseases and disorders","volume":"100","author":"Bota","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2018.12.017_bb0275","first-page":"258","article-title":"Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging","volume":"1","author":"Ngo","year":"2013","journal-title":"Redox Biol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282818309180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282818309180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:25:21Z","timestamp":1758313521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282818309180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":54,"alternative-id":["S0022282818309180"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2018.12.017","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial LonP1 protects cardiomyocytes from ischemia\/reperfusion injury in vivo","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2018.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}