{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:00:35Z","timestamp":1792342835351,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570292"],"award-info":[{"award-number":["81570292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500248"],"award-info":[{"award-number":["81500248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.yjmcc.2019.03.007","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T11:59:42Z","timestamp":1552391982000},"page":"10-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":129,"special_numbering":"C","title":["Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b"],"prefix":"10.1016","volume":"130","author":[{"given":"Lidong","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baozhen","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6492-5702","authenticated-orcid":false,"given":"Songwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0351-6868","authenticated-orcid":false,"given":"Shaowen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2019.03.007_bb0005","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1093\/eurheartj\/ehw334","article-title":"Cardiovascular disease in Europe 2016: an epidemiological update","volume":"37","author":"Townsend","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.disamonth.2012.12.004","article-title":"Acute myocardial infarction","volume":"59","author":"Boateng","year":"2013","journal-title":"Disease-a-Month"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0015","series-title":"Apoptosis in Ischemic Heart Disease","first-page":"87","volume":"15","author":"Teringova","year":"2017"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0020","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0025","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.yjmcc.2013.11.015","article-title":"Fibroblasts in myocardial infarction: a role in inflammation and repair","author":"Shinde","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0030","series-title":"A review of the molecular mechanisms underlying the development and progression of cardiac remodeling","first-page":"3920195","volume":"vol. 2017","author":"Schirone","year":"2017"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0035","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pathophys.2018.04.003","article-title":"The pathophysiology of myocardial infarction-induced heart failure","volume":"25","author":"Gabriel-Costa","year":"2018","journal-title":"Pathophysiology"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0040","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/eurheartj\/eht453","article-title":"Incidence of sudden cardiac death after ventricular fibrillation complicating acute myocardial infarction: a 5-year cause-of-death analysis of the FAST-MI 2005 registry","volume":"35","author":"Bougouin","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0045","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1177\/1535370217708978","article-title":"Circular RNA \u2013 new member of noncoding RNA with novel functions","volume":"242","author":"Hsiao","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0050","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jbiotec.2016.09.011","article-title":"Circular RNAs are miRNA sponges and can be used as a new class of biomarker","volume":"238","author":"Kulcheski","year":"2016","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0055","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/febs.14191","article-title":"Biogenesis of circular RNAs and their roles in cardiovascular development and pathology","volume":"285","author":"Li","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0060","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/ejhf.801","article-title":"Circular RNAs in heart failure","volume":"19","author":"Devaux","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0151753","article-title":"The circular RNA Cdr1as promotes myocardial infarction by mediating the regulation of miR-7a on its target genes expression","volume":"11","author":"Geng","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12429","article-title":"Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans","volume":"7","author":"Holdt","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0075","first-page":"298","article-title":"A landscape of circular RNA expression in the human heart","volume":"113","author":"Tan","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0080","first-page":"1291","article-title":"Modification of the method for establishing myocardial infarction model in rats","volume":"26","author":"Ren","year":"2009","journal-title":"Sheng Wu Yi Xue Gong Cheng Xue Za Zhi"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0085","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/CIRCRESAHA.109.209809","article-title":"Cardiac fibroblast: the renaissance cell","volume":"105","author":"Souders","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0090","first-page":"41","article-title":"Study of non-muscle cells of the adult mammalian heart: a fine structural analysis and distribution","volume":"28","author":"Nag","year":"1980","journal-title":"Cytobios"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0095","first-page":"17","article-title":"Development and proliferative capacity of cardiac muscle cells","volume":"35","author":"Zak","year":"1974","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0100","doi-asserted-by":"crossref","first-page":"73271","DOI":"10.18632\/oncotarget.19154","article-title":"An emerging function of circRNA-miRNAs-mRNA axis in human diseases","volume":"8","author":"Rong","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3724\/SP.J.1263.2012.00028","article-title":"MicroRNA-15a\/b are up-regulated in response to myocardial ischemia\/reperfusion injury","volume":"9","author":"Liu","year":"2012","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0110","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-14-S2-S4","article-title":"An enhanced computational platform for investigating the roles of regulatory RNA and for identifying functional RNA motifs","volume":"14","author":"Chang","year":"2013","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0115","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/nar\/9.1.133","article-title":"Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information","volume":"9","author":"Zuker","year":"1981","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0120","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1038\/emboj.2011.359","article-title":"miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA","volume":"30","author":"Hansen","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0125","first-page":"15677","article-title":"MiR-15b mediates liver cancer cells proliferation through targeting BCL-2","volume":"8","author":"Zhang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0130","doi-asserted-by":"crossref","first-page":"26406","DOI":"10.1074\/jbc.M114.573592","article-title":"miR-15b\/16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung","volume":"289","author":"Rahman","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0135","doi-asserted-by":"crossref","first-page":"687826","DOI":"10.1155\/2014\/687826","article-title":"MiR-15b targets cyclin D1 to regulate proliferation and apoptosis in glioma cells","volume":"2014","author":"Sun","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0140","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.pan.2012.02.008","article-title":"miR-15b and miR-16 induce the apoptosis of rat activated pancreatic stellate cells by targeting Bcl-2 in vitro","volume":"12","author":"Shen","year":"2012","journal-title":"Pancreatology"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0145","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10495-013-0899-2","article-title":"MicroRNA-15b enhances hypoxia\/reoxygenation-induced apoptosis of cardiomyocytes via a mitochondrial apoptotic pathway","volume":"19","author":"Liu","year":"2014","journal-title":"Apoptosis"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0150","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1159\/000484507","article-title":"LncRNA UCA1 promotes mitochondrial function of bladder cancer via the MiR-195\/ARL2 signaling pathway","volume":"43","author":"Li","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/CIRCRESAHA.111.244442","article-title":"Inhibition of miR-15 protects against cardiac ischemic injury","volume":"110","author":"Hullinger","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0160","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/cdd.2017.61","article-title":"Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression","volume":"24","author":"Wang","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0165","first-page":"1402","article-title":"Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses","volume":"38","author":"Du","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0170","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1093\/eurheartj\/ehv713","article-title":"A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223","volume":"37","author":"Wang","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/genes8120353","article-title":"Circular RNAs (circRNAs) in health and disease","volume":"8","author":"Haque","year":"2017","journal-title":"Genes"},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0180","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1074\/jbc.M109.082610","article-title":"MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes","volume":"285","author":"Nishi","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0185","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbrc.2017.01.152","article-title":"miR-214 down-regulates ARL2 and suppresses growth and invasion of cervical cancer cells","volume":"484","author":"Peng","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0190","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1073\/pnas.1208863110","article-title":"Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family","volume":"110","author":"Porrello","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0195","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/cvr\/cvu184","article-title":"The microRNA-15 family inhibits the TGF\u03b2-pathway in the heart","volume":"104","author":"Tijsen","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0200","doi-asserted-by":"crossref","first-page":"979","DOI":"10.7150\/ijbs.15071","article-title":"BDNF-mediates Down-regulation of MicroRNA-195 inhibits ischemic cardiac apoptosis in rats","volume":"12","author":"Hang","year":"2016","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.yjmcc.2019.03.007_bb0205","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/cvr\/cvr145","article-title":"MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1","volume":"92","author":"Zhu","year":"2011","journal-title":"Cardiovasc. Res."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281831068X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281831068X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:26:20Z","timestamp":1758313580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228281831068X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":41,"alternative-id":["S002228281831068X"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2019.03.007","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2019.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}