{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:33:41Z","timestamp":1789065221033,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600283"],"award-info":[{"award-number":["81600283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Natural Science Foundation","award":["2017GXNSFAA198069"],"award-info":[{"award-number":["2017GXNSFAA198069"]}]}],"content-domain":{"domain":["jmmc-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.yjmcc.2019.05.021","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:35:55Z","timestamp":1559003755000},"page":"12-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":113,"special_numbering":"C","title":["Inhibition of lncRNA TUG1 upregulates miR-142-3p to ameliorate myocardial injury during ischemia and reperfusion via targeting HMGB1- and Rac1-induced autophagy"],"prefix":"10.1016","volume":"133","author":[{"given":"Qiang","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Wei","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Liang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Han","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Hui","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Bai","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2019.05.021_bb0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijcard.2016.11.130","article-title":"Mortality due to acute myocardial infarction in China from 1987 to 2014: secular trends and age-period-cohort effects","volume":"227","author":"Chang","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0010","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.acvd.2008.06.013","article-title":"Reperfusion injury in acute myocardial infarction: from bench to cath lab. Part II: clinical issues and therapeutic options","volume":"101","author":"Monassier","year":"2008","journal-title":"Arch. Cardiovasc. Dis."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0015","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.acvd.2008.06.014","article-title":"Reperfusion injury in acute myocardial infarction. From bench to cath lab. Part I: basic considerations","volume":"101","author":"Monassier","year":"2008","journal-title":"Arch. Cardiovasc. Dis."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.physiol.010908.163111","article-title":"Cell death in the pathogenesis of heart disease: mechanisms and significance","volume":"72","author":"Whelan","year":"2010","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0025","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/path.2697","article-title":"Autophagy: cellular and molecular mechanisms","volume":"221","author":"Glick","year":"2010","journal-title":"J. Pathol."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0030","doi-asserted-by":"crossref","first-page":"H2261","DOI":"10.1152\/ajpheart.01056.2010","article-title":"Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion","volume":"300","author":"Kanamori","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0035","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1582-4934.2011.01323.x","article-title":"STAT1 deficiency in the heart protects against myocardial infarction by enhancing autophagy","volume":"16","author":"McCormick","year":"2012","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0040","doi-asserted-by":"crossref","first-page":"6779","DOI":"10.1038\/ncomms7779","article-title":"APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p","volume":"6","author":"Wang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0045","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1534\/genetics.112.146704","article-title":"Long noncoding RNAs: past, present, and future","volume":"193","author":"Kung","year":"2013","journal-title":"Genetics"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0050","first-page":"2422","article-title":"LncRNA TUG1 serves an important role in hypoxia-induced myocardial cell injury by regulating the miR1455pBinp3 axis","volume":"17","author":"Wu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0055","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbrc.2017.02.043","article-title":"LncRNA TUG1 sponges microRNA-9 to promote neurons apoptosis by up-regulated Bcl2l11 under ischemia","volume":"485","author":"Chen","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0060","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.2147\/OTT.S124595","article-title":"Downregulation of long noncoding RNA TUG1 inhibits proliferation and induces apoptosis through the TUG1\/miR-142\/ZEB2 axis in bladder cancer cells","volume":"10","author":"Liu","year":"2017","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0065","article-title":"MiR-142-3p attenuates the migration of CD4(+) T cells through regulating actin cytoskeleton via RAC1 and ROCK2 in arteriosclerosis obliterans","volume":"9","author":"Liu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11010-012-1546-x","article-title":"Circulating miRNA as novel markers for diastolic dysfunction","volume":"376","author":"Nair","year":"2013","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0075","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1093\/eurjhf\/hft078","article-title":"Circulating microRNAs as candidate markers to distinguish heart failure in breathless patients","volume":"15","author":"Ellis","year":"2013","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0080","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3892\/ijmm.2016.2756","article-title":"MicroRNA-142-3p inhibits hypoxia\/reoxygenationinduced apoptosis and fibrosis of cardiomyocytes by targeting high mobility group box 1","volume":"38","author":"Wang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0085","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/jcp.25576","article-title":"HMGB1 inhibits apoptosis following MI and induces autophagy via mTORC1 inhibition","volume":"232","author":"Foglio","year":"2017","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0090","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1159\/000350111","article-title":"Enhancement of autophagy by simvastatin through inhibition of Rac1-mTOR signaling pathway in coronary arterial myocytes","volume":"31","author":"Wei","year":"2013","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0095","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-1-4939-7714-7_7","article-title":"Embryonary mouse cardiac fibroblast isolation","volume":"1752","author":"Garate-Carrillo","year":"2018","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41467-017-02280-y","article-title":"LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription","volume":"9","author":"Liu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0105","article-title":"A murine model of myocardial ischemia-reperfusion injury through ligation of the left anterior descending artery","volume":"86","author":"Xu","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0110","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0115","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1038\/s41419-017-0047-y","article-title":"Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21\/PDCD4 signaling pathway","volume":"8","author":"Yan","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0120","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.febslet.2011.03.067","article-title":"MicroRNA-142-3p, a new regulator of RAC1, suppresses the migration and invasion of hepatocellular carcinoma cells","volume":"585","author":"Wu","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0125","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI76344","article-title":"Cytosolic HMGB1 controls the cellular autophagy\/apoptosis checkpoint during inflammation","volume":"125","author":"Zhu","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0130","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1161\/ATVBAHA.111.224915","article-title":"Mechanisms of cell death in heart disease","volume":"32","author":"Konstantinidis","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0135","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/ncb1192","article-title":"Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes","volume":"6","author":"Shimizu","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0140","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1038\/onc.2009.487","article-title":"Involvement of JNK in the regulation of autophagic cell death","volume":"29","author":"Shimizu","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0145","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41419-017-0229-7","article-title":"bFGF plays a neuroprotective role by suppressing excessive autophagy and apoptosis after transient global cerebral ischemia in rats","volume":"9","author":"Sun","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0150","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12395","article-title":"Pre-ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting endoplasmic reticulum stress-dependent autophagy via PERK and IRE1 signalings","volume":"62","author":"Feng","year":"2017","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0155","doi-asserted-by":"crossref","first-page":"e2983","DOI":"10.1038\/cddis.2017.386","article-title":"The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2\/HO-1 pathway enhanced autophagy","volume":"8","author":"Xu","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0160","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41419-018-0518-9","article-title":"Targeting the miR-665-3p-ATG4B-autophagy axis relieves inflammation and apoptosis in intestinal ischemia\/reperfusion","volume":"9","author":"Li","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0165","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.0000261924.76669.36","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy","volume":"100","author":"Matsui","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0170","doi-asserted-by":"crossref","first-page":"855","DOI":"10.4161\/auto.6.7.13005","article-title":"Bnip3-mediated mitochondrial autophagy is independent of the mitochondrial permeability transition pore","volume":"6","author":"Quinsay","year":"2010","journal-title":"Autophagy"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0175","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1161\/CIRCULATIONAHA.107.763870","article-title":"Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy","volume":"117","author":"Tannous","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0180","first-page":"336","article-title":"The HMGB1IL17A axis contributes to hypoxia\/reoxygenation injury via regulation of cardiomyocyte apoptosis and autophagy","volume":"17","author":"Hu","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0185","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1007\/s00253-018-9058-6","article-title":"Deacetylmycoepoxydiene is an agonist of Rac1, and simultaneously induces autophagy and apoptosis","volume":"102","author":"Xie","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0190","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/cpr.12235","article-title":"miR-142-3p inhibits cancer cell proliferation by targeting CDC25C","volume":"49","author":"Cao","year":"2016","journal-title":"Cell Prolif."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143993","article-title":"microRNA miR-142-3p inhibits breast cancer cell invasiveness by synchronous targeting of WASL, integrin alpha V, and additional cytoskeletal elements","volume":"10","author":"Schwickert","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0200","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s00109-013-1037-x","article-title":"MiR-142-3p functions as a tumor suppressor by targeting CD133, ABCG2, and Lgr5 in colon cancer cells","volume":"91","author":"Shen","year":"2013","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0205","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.3892\/ol.2015.4021","article-title":"Oncogenic microRNA-142-3p is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma","volume":"11","author":"Li","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0210","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1159\/000373999","article-title":"Downregulation of lncRNA TUG1 affects apoptosis and insulin secretion in mouse pancreatic beta cells","volume":"35","author":"Yin","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0215","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12943-015-0431-0","article-title":"Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2","volume":"14","author":"Huang","year":"2015","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0220","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yexcr.2017.04.002","article-title":"TUG1 promotes lens epithelial cell apoptosis by regulating miR-421\/caspase-3 axis in age-related cataract","volume":"356","author":"Li","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0225","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1177\/1535370215622708","article-title":"LncRNA TUG1 acts as a tumor suppressor in human glioma by promoting cell apoptosis","volume":"241","author":"Li","year":"2016","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0230","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopha.2018.02.129","article-title":"Long non-coding RNA TUG1 inhibits apoptosis and inflammatory response in LPS-treated H9c2 cells by down-regulation of miR-29b","volume":"101","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0235","first-page":"779","article-title":"Long non-coding RNA TUG1 promotes osteosarcoma cell proliferation and invasion through inhibition of microRNA-212-3p expression","volume":"16","author":"Li","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0240","doi-asserted-by":"crossref","first-page":"31386","DOI":"10.18632\/oncotarget.15607","article-title":"Long non-coding RNA TUG1 promotes endometrial cancer development via inhibiting miR-299 and miR-34a-5p","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.yjmcc.2019.05.021_bb0245","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1080\/15384101.2017.1288324","article-title":"MALAT1 promotes osteosarcoma development by regulation of HMGB1 via miR-142-3p and miR-129-5p","volume":"16","author":"Liu","year":"2017","journal-title":"Cell Cycle"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282818310320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282818310320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,15]],"date-time":"2020-12-15T21:55:05Z","timestamp":1608069305000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282818310320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":49,"alternative-id":["S0022282818310320"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2019.05.021","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of lncRNA TUG1 upregulates miR-142-3p to ameliorate myocardial injury during ischemia and reperfusion via targeting HMGB1- and Rac1-induced autophagy","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2019.05.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}