{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:48:59Z","timestamp":1791946139676,"version":"4.3.4"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19CDA34760284"],"award-info":[{"award-number":["19CDA34760284"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL115148"],"award-info":[{"award-number":["HL115148"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U1601219"],"award-info":[{"award-number":["U1601219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970420"],"award-info":[{"award-number":["81970420"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["91939109"],"award-info":[{"award-number":["91939109"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.yjmcc.2019.10.009","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T16:21:52Z","timestamp":1574094112000},"page":"291-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome"],"prefix":"10.1016","volume":"138","author":[{"given":"Bicheng","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanrui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanjiao Jenny","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.yjmcc.2019.10.009_bb0005","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1161\/CIRCULATIONAHA.106.616011","article-title":"New insights into pacemaker activity: promoting understanding of sick sinus syndrome","volume":"115","author":"Dobrzynski","year":"2007","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.yjmcc.2019.10.009_bb0010","doi-asserted-by":"crossref","first-page":"e269","DOI":"10.1161\/CIR.0b013e318214876d","volume":"123","author":"Fuster","year":"2011","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.yjmcc.2019.10.009_bb0015","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1253\/circj.CJ-14-1255","article-title":"Development of Atrioventricular block and diagnostic value of stored Electrograms in patients with sick sinus syndrome and implanted pacemaker","volume":"79","author":"Hosoda","year":"2015","journal-title":"Circ. J."},{"issue":"24","key":"10.1016\/j.yjmcc.2019.10.009_bb0020","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1056\/NEJMoa013040","article-title":"Mode selection trial in sinus-node, ventricular pacing or dual-chamber pacing for sinus-node dysfunction","volume":"346","author":"Lamas","year":"2002","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.yjmcc.2019.10.009_bb0025","first-page":"1725","article-title":"Diagnosis and treatment of sick sinus syndrome","volume":"67","author":"Adan","year":"2003","journal-title":"Am. Fam. Physician"},{"issue":"12","key":"10.1016\/j.yjmcc.2019.10.009_bb0030","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1136\/hrt.40.12.1384","article-title":"Histopathological correlates of sinoatrial disease","volume":"40","author":"Demoulin","year":"1978","journal-title":"Br. Heart J."},{"issue":"11","key":"10.1016\/j.yjmcc.2019.10.009_bb0035","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1161\/01.CIR.94.11.2953","article-title":"Pacing-induced chronic atrial fibrillation impairs sinus node function in dogs. Electrophysiological remodeling","volume":"94","author":"Elvan","year":"1996","journal-title":"Circulation"},{"issue":"15","key":"10.1016\/j.yjmcc.2019.10.009_bb0040","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1161\/01.CIR.102.15.1807","article-title":"Electrical remodeling of the atria associated with paroxysmal and chronic atrial flutter","volume":"102","author":"Sparks","year":"2000","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.yjmcc.2019.10.009_bb0045","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/ng.781","article-title":"A rare variant in MYH6 is associated with high risk of sick sinus syndrome","volume":"43","author":"Holm","year":"2011","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.yjmcc.2019.10.009_bb0050","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI200318062","article-title":"Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)","volume":"112","author":"Benson","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.yjmcc.2019.10.009_bb0055","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/CIRCULATIONAHA.106.663070","article-title":"Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node","volume":"115","author":"Jones","year":"2007","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.yjmcc.2019.10.009_bb0060","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1161\/CIRCULATIONAHA.108.789677","article-title":"Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome","volume":"119","author":"Yeh","year":"2009","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2019.10.009_bb0065","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJMoa052475","article-title":"Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel","volume":"354","author":"Milanesi","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.yjmcc.2019.10.009_bb0070","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1172\/JCI200316387","article-title":"Pacemaker channel dysfunction in a patient with sinus node disease","volume":"111","author":"Schulze-Bahr","year":"2003","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.yjmcc.2019.10.009_bb0075","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/jhg.2008.16","article-title":"Role of HCN4 channel in preventing ventricular arrhythmia","volume":"54","author":"Ueda","year":"2009","journal-title":"J. Hum. Genet."},{"issue":"1\u20133","key":"10.1016\/j.yjmcc.2019.10.009_bb0080","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.pbiomolbio.2007.07.009","article-title":"Role of pacemaking current in cardiac nodes: insights from a comparative study of sinoatrial node and atrioventricular node","volume":"96","author":"Liu","year":"2008","journal-title":"Prog. Biophys. Mol. Biol."},{"issue":"4","key":"10.1016\/j.yjmcc.2019.10.009_bb0085","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/emboj.2008.3","article-title":"Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP","volume":"27","author":"Harzheim","year":"2008","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.yjmcc.2019.10.009_bb0090","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1073\/pnas.1010122108","article-title":"Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4","volume":"108","author":"Baruscotti","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.yjmcc.2019.10.009_bb0095","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1152\/physrev.00029.2008","article-title":"Hyperpolarization-activated cation channels: from genes to function","volume":"89","author":"Biel","year":"2009","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.yjmcc.2019.10.009_bb0100","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1476-5381.2011.01798.x","article-title":"HCN channels in the heart: lessons from mouse mutants","volume":"166","author":"Herrmann","year":"2012","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.yjmcc.2019.10.009_bb0105","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/CIRCRESAHA.113.301588","article-title":"HCN4 dynamically marks the first heart field and conduction system precursors","volume":"113","author":"Liang","year":"2013","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2019.10.009_bb0110","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/cvr\/cvq033","article-title":"The sinus venosus progenitors separate and diversify from the first and second heart fields early in development","volume":"87","author":"Mommersteeg","year":"2010","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.yjmcc.2019.10.009_bb0115","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/CIRCRESAHA.108.187062","article-title":"Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3","volume":"104","author":"Wiese","year":"2009","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.yjmcc.2019.10.009_bb0120","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1101\/gad.416007","article-title":"Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria","volume":"21","author":"Hoogaars","year":"2007","journal-title":"Genes Dev."},{"issue":"3","key":"10.1016\/j.yjmcc.2019.10.009_bb0125","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.cardiores.2004.01.030","article-title":"The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart","volume":"62","author":"Hoogaars","year":"2004","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.yjmcc.2019.10.009_bb0130","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/CIRCRESAHA.107.169565","article-title":"Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system","volume":"102","author":"Bakker","year":"2008","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2019.10.009_bb0135","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbrc.2006.11.119","article-title":"NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes","volume":"353","author":"Kuratomi","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.yjmcc.2019.10.009_bb0140","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/cvr\/cvp171","article-title":"The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2","volume":"83","author":"Kuratomi","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.yjmcc.2019.10.009_bb0145","first-page":"774","article-title":"MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1","volume":"143","author":"Barnes","year":"2016","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.yjmcc.2019.10.009_bb0150","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1083\/jcb.201105063","article-title":"Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4","volume":"195","author":"Backs","year":"2011","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.yjmcc.2019.10.009_bb0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.0000197782.21444.8f","article-title":"Control of cardiac growth by histone acetylation\/deacetylation","volume":"98","author":"Backs","year":"2006","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2019.10.009_bb0160","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.cell.2008.04.041","article-title":"A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy","volume":"133","author":"Ago","year":"2008","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.yjmcc.2019.10.009_bb0165","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.cell.2007.06.044","article-title":"Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice","volume":"130","author":"Rajasekaran","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.yjmcc.2019.10.009_bb0170","doi-asserted-by":"crossref","first-page":"H1227","DOI":"10.1152\/ajpheart.01162.2006","article-title":"Thiol-based mechanisms of the thioredoxin and glutaredoxin systems: implications for diseases in the cardiovascular system","volume":"292","author":"Berndt","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"21","key":"10.1016\/j.yjmcc.2019.10.009_bb0175","doi-asserted-by":"crossref","first-page":"9414","DOI":"10.1128\/MCB.24.21.9414-9423.2004","article-title":"Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function","volume":"24","author":"Conrad","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.yjmcc.2019.10.009_bb0180","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1128\/MCB.23.3.916-922.2003","article-title":"The absence of mitochondrial thioredoxin 2 causes massive apoptosis, exencephaly, and early embryonic lethality in homozygous mice","volume":"23","author":"Nonn","year":"2003","journal-title":"Mol. Cell. Biol."},{"issue":"7","key":"10.1016\/j.yjmcc.2019.10.009_bb0185","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1093\/emboj\/21.7.1695","article-title":"Thioredoxin-2 (TRX-2) is an essential gene regulating mitochondria- dependent apoptosis","volume":"21","author":"Tanaka","year":"2002","journal-title":"EMBO J."},{"issue":"5","key":"10.1016\/j.yjmcc.2019.10.009_bb0190","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1128\/MCB.25.5.1980-1988.2005","article-title":"Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development","volume":"25","author":"Jakupoglu","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.yjmcc.2019.10.009_bb0195","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.cmet.2013.12.013","article-title":"A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation","volume":"19","author":"Shao","year":"2014","journal-title":"Cell Metab."},{"issue":"10","key":"10.1016\/j.yjmcc.2019.10.009_bb0200","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1161\/CIRCULATIONAHA.109.872481","article-title":"Thioredoxin-1 gene therapy enhances angiogenic signaling and reduces ventricular remodeling in infarcted myocardium of diabetic rats","volume":"121","author":"Samuel","year":"2010","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.yjmcc.2019.10.009_bb0205","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1161\/01.RES.0000100665.67510.F5","article-title":"Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II-induced cardiac hypertrophy and remodeling","volume":"93","author":"Izumiya","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2019.10.009_bb0210","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/978-3-319-55330-6_14","article-title":"Mechanistic role of Thioredoxin 2 in heart failure","volume":"982","author":"Chen","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"issue":"12","key":"10.1016\/j.yjmcc.2019.10.009_bb0215","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1161\/CIRCULATIONAHA.114.012725","article-title":"Thioredoxin-2 inhibits mitochondrial ROS generation and ASK1 activity to maintain cardiac function","volume":"131","author":"Huang","year":"2015","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.yjmcc.2019.10.009_bb0220","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/eurheartj\/ehq507","article-title":"Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy","volume":"32","author":"Sibbing","year":"2011","journal-title":"Eur. Heart J."},{"issue":"6 Pt 1","key":"10.1016\/j.yjmcc.2019.10.009_bb0225","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1083\/jcb.111.6.2427","article-title":"Developmental regulation of myosin gene expression in mouse cardiac muscle","volume":"111","author":"Lyons","year":"1990","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.yjmcc.2019.10.009_bb0230","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCRESAHA.116.310396","article-title":"Transient notch activation induces long-term gene expression changes leading to sick sinus syndrome in mice","volume":"121","author":"Qiao","year":"2017","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.yjmcc.2019.10.009_bb0235","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1038\/cr.2014.113","article-title":"Baf250a orchestrates an epigenetic pathway to repress the Nkx2.5-directed contractile cardiomyocyte program in the sinoatrial node","volume":"24","author":"Wu","year":"2014","journal-title":"Cell Res."},{"issue":"2","key":"10.1016\/j.yjmcc.2019.10.009_bb0240","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/dvg.22730","article-title":"Inducible gene deletion in the entire cardiac conduction system using Hcn4-CreERT2 BAC transgenic mice","volume":"52","author":"Wu","year":"2014","journal-title":"Genesis"},{"issue":"9","key":"10.1016\/j.yjmcc.2019.10.009_bb0245","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/nm.4169","article-title":"Augmented endothelial exocytosis of angiopoietin-2 resulting from CCM3-deficiency contributes to the progression of cerebral cavernous malformation","volume":"22","author":"Zhou","year":"2016","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.yjmcc.2019.10.009_bb0250","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/nrg2485","article-title":"The many roles of histone deacetylases in development and physiology: implications for disease and therapy","volume":"10","author":"Haberland","year":"2009","journal-title":"Nat. Rev. Genet."},{"issue":"1","key":"10.1016\/j.yjmcc.2019.10.009_bb0255","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ydbio.2012.10.017","article-title":"Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning","volume":"373","author":"Vedantham","year":"2013","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.yjmcc.2019.10.009_bb0260","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/dbio.1996.0208","article-title":"Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene","volume":"178","author":"Matsui","year":"1996","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.yjmcc.2019.10.009_bb0265","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1172\/JCI44927","article-title":"Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury","volume":"122","author":"Yoshioka","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"Suppl. 1","key":"10.1016\/j.yjmcc.2019.10.009_bb0270","first-page":"S70","article-title":"Model mice for tissue-specific deletion of the manganese superoxide dismutase gene","volume":"10","author":"Shimizu","year":"2010","journal-title":"Geriatr Gerontol Int"},{"issue":"8","key":"10.1016\/j.yjmcc.2019.10.009_bb0275","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1161\/hc0802.104502","article-title":"Postischemic recovery of contractile function is impaired in SOD2(+\/\u2212) but not SOD1(+\/\u2212) mouse hearts","volume":"105","author":"Asimakis","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2019.10.009_bb0280","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3389\/fphys.2019.01089","article-title":"A unique SUMO-interacting motif of Trx2 is critical for its mitochondrial Presequence processing and anti-oxidant activity","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Physiol."},{"issue":"4","key":"10.1016\/j.yjmcc.2019.10.009_bb0285","first-page":"77","article-title":"Ev, [the sick sinus syndrome and lipid peroxidation: its possible role in the pathogenesis of the disease]","volume":"63","author":"Tuev","year":"1991","journal-title":"Ter. Arkh."},{"issue":"16","key":"10.1016\/j.yjmcc.2019.10.009_bb0290","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.jacc.2013.03.061","article-title":"Mitochondrial dysfunction as an arrhythmogenic substrate: a translational proof-of-concept study in patients with metabolic syndrome in whom post-operative atrial fibrillation develops","volume":"62","author":"Montaigne","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2019.10.009_bb0295","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/5089","article-title":"Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression","volume":"21","author":"Wang","year":"1999","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.yjmcc.2019.10.009_bb0300","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.yjmcc.2011.07.018","article-title":"Ca2+\u2212regulated-cAMP\/PKA signaling in cardiac pacemaker cells links ATP supply to demand","volume":"51","author":"Yaniv","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"10","key":"10.1016\/j.yjmcc.2019.10.009_bb0305","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1161\/01.RES.0000148632.35500.d9","article-title":"The mitochondrial death pathway and cardiac myocyte apoptosis","volume":"95","author":"Crow","year":"2004","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.yjmcc.2019.10.009_bb0310","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1083\/jcb.201101100","article-title":"The cell biology of disease: cellular mechanisms of cardiomyopathy","volume":"194","author":"Harvey","year":"2011","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.yjmcc.2019.10.009_bb0315","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.yjmcc.2011.09.018","article-title":"Metabolic stress, reactive oxygen species, and arrhythmia","volume":"52","author":"Jeong","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"Pt 3","key":"10.1016\/j.yjmcc.2019.10.009_bb0320","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1042\/bj20021321","article-title":"Histone deacetylases (HDACs): characterization of the classical HDAC family","volume":"370","author":"de Ruijter","year":"2003","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.yjmcc.2019.10.009_bb0325","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0959-437X(00)00224-0","article-title":"Control of muscle development by dueling HATs and HDACs","volume":"11","author":"McKinsey","year":"2001","journal-title":"Curr. Opin. Genet. Dev."},{"issue":"8","key":"10.1016\/j.yjmcc.2019.10.009_bb0330","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00109-009-0471-2","article-title":"The role of redox modulation of class II histone deacetylases in mediating pathological cardiac hypertrophy","volume":"87","author":"Oka","year":"2009","journal-title":"J Mol Med (Berl)"}],"updated-by":[{"DOI":"10.1016\/j.yjmcc.2025.06.007","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000}}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281930375X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228281930375X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T02:20:24Z","timestamp":1751682024000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228281930375X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":66,"alternative-id":["S002228281930375X"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2019.10.009","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial thioredoxin-2 maintains HCN4 expression and prevents oxidative stress-mediated sick sinus syndrome","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2019.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}