{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:27:13Z","timestamp":1788794833897,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007292","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007292","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.yjmcc.2019.12.013","type":"journal-article","created":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T19:20:15Z","timestamp":1579807215000},"page":"47-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"special_numbering":"C","title":["LncRNA-Mhrt regulates cardiac hypertrophy by modulating the miR-145a-5p\/KLF4\/myocardin axis"],"prefix":"10.1016","volume":"139","author":[{"given":"Yao","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongcun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5740","key":"10.1016\/j.yjmcc.2019.12.013_bb0005","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1126\/science.1112014","article-title":"The transcriptional landscape of the mammalian genome","volume":"309","author":"Carninci","year":"2005","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.yjmcc.2019.12.013_bb0010","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1093\/hmg\/ddq362","article-title":"Transcribed dark matter: meaning or myth?","volume":"19","author":"Ponting","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.yjmcc.2019.12.013_bb0015","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1056\/NEJM199910213411706","article-title":"Signaling pathways for cardiac hypertrophy and failure","volume":"341","author":"Hunter","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yjmcc.2019.12.013_bb0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.physiol.65.092101.142243","article-title":"Cardiac hypertrophy: the good, the bad, and the ugly","volume":"65","author":"Frey","year":"2003","journal-title":"Annu. Rev. Physiol."},{"issue":"33","key":"10.1016\/j.yjmcc.2019.12.013_bb0025","doi-asserted-by":"crossref","first-page":"12264","DOI":"10.1073\/pnas.1410622111","article-title":"Epigenetic coordination of embryonic heart transcription by dynamically regulated long noncoding RNAs","volume":"111","author":"Matkovich","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"7520","key":"10.1016\/j.yjmcc.2019.12.013_bb0030","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nature13596","article-title":"A long noncoding RNA protects the heart from pathological hypertrophy","volume":"514","author":"Han","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2019.12.013_bb0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cellsig.2017.11.007","article-title":"The mechanism of myocardial hypertrophy regulated by the interaction between Mhrt and myocardin","volume":"43","author":"Luo","year":"2018","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.yjmcc.2019.12.013_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1097-2765(01)00297-0","article-title":"Myocardin: a novel potentiator of SRF-mediated transcription in cardiac muscle","volume":"8","author":"Hauschka","year":"2001","journal-title":"Mol. Cell"},{"issue":"28","key":"10.1016\/j.yjmcc.2019.12.013_bb0045","doi-asserted-by":"crossref","first-page":"19585","DOI":"10.1074\/jbc.M113.540559","article-title":"Co-activation of nuclear factor-\u03bab and myocardin\/serum response factor conveys the hypertrophy signal of high insulin levels in cardiac myoblasts","volume":"289","author":"Madonna","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.yjmcc.2019.12.013_bb0050","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1161\/01.RES.0000267856.00713.0a","article-title":"Role of kr\u00fcppel-like transcription factors in endothelial biology","volume":"100","author":"Atkins","year":"2009","journal-title":"Circulat. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2019.12.013_bb0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2007.04.005","article-title":"Kruppel-like factors (klfs) in muscle biology","volume":"43","author":"Haldar","year":"2007","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"7","key":"10.1016\/j.yjmcc.2019.12.013_bb0060","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1161\/CIRCRESAHA.108.184663","article-title":"Hemizygous deficiency of kr\u00fcppel-like factor 2 augments experimental atherosclerosis","volume":"103","author":"Atkins","year":"2008","journal-title":"Circ. Res."},{"issue":"18","key":"10.1016\/j.yjmcc.2019.12.013_bb0065","doi-asserted-by":"crossref","first-page":"13769","DOI":"10.1074\/jbc.M700078200","article-title":"Kruppel-like factor 4 regulates endothelial inflammation","volume":"282","author":"Hamik","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.yjmcc.2019.12.013_bb0070","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1161\/CIRCRESAHA.108.176974","article-title":"Conditional deletion of kr\u00fcppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury","volume":"102","author":"Yoshida","year":"2008","journal-title":"Circ. Res."},{"issue":"38","key":"10.1016\/j.yjmcc.2019.12.013_bb0075","doi-asserted-by":"crossref","first-page":"26107","DOI":"10.1074\/jbc.M114.582809","article-title":"Kruppel-like factor 4 protein regulates isoproterenol-induced cardiac hypertrophy by modulating myocardin expression and activity","volume":"289","author":"Yoshida","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2019.12.013_bb0080","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1126\/science.131.3414.1674","article-title":"In vitro studies of single isolated beating heart cells","volume":"131","author":"Harary","year":"1960","journal-title":"Science"},{"issue":"30","key":"10.1016\/j.yjmcc.2019.12.013_bb0085","doi-asserted-by":"crossref","first-page":"15841","DOI":"10.1074\/jbc.M115.684118","article-title":"Loss of mouse p2y6 nucleotide receptor is associated with physiological macrocardia and amplified pathological cardiac hypertrophy","volume":"291","author":"Clouet","year":"2016","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.yjmcc.2019.12.013_bb0090","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1158\/0008-5472.CAN-10-4460","article-title":"The melanoma-upregulated long noncoding RNA SPRY4-IT1 modulates apoptosis and invasion","volume":"71","author":"Khaitan","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.yjmcc.2019.12.013_bb0095","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1002\/hep.24563","article-title":"Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans","volume":"54","author":"Yang","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.yjmcc.2019.12.013_bb0100","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ccr.2014.03.010","article-title":"A long noncoding RNA activated by TGF-b promotes the invasion-metastasis cascade in hepatocellular carcinoma","volume":"25","author":"Yuan","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.yjmcc.2019.12.013_bb0105","doi-asserted-by":"crossref","first-page":"12103","DOI":"10.1073\/pnas.0811371106","article-title":"MiR-23a functions downstream of NFATC3 to regulate cardiac hypertrophy","volume":"106","author":"Lin","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.yjmcc.2019.12.013_bb0110","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1152\/japplphysiol.00033.2007","article-title":"Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches","volume":"102","author":"Takagawa","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.yjmcc.2019.12.013_bb0115","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fphar.2016.00471","article-title":"Triptolide upregulates myocardial forkhead helix transcription factor p3 expression and attenuates cardiac hypertrophy","volume":"7","author":"Ding","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"13","key":"10.1016\/j.yjmcc.2019.12.013_bb0120","doi-asserted-by":"crossref","first-page":"9261","DOI":"10.1074\/jbc.M112.433730","article-title":"Mir-145 and mir-143 regulate odontoblast differentiation through targeting Klf4 and Osx genes in a feedback loop","volume":"288","author":"Liu","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"32","key":"10.1016\/j.yjmcc.2019.12.013_bb0125","doi-asserted-by":"crossref","first-page":"28097","DOI":"10.1074\/jbc.M111.236950","article-title":"Down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143\/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4","volume":"286","author":"Davis-Dusenbery","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.yjmcc.2019.12.013_bb0130","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cell.2009.02.038","article-title":"MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells","volume":"137","author":"Na","year":"2009","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.yjmcc.2019.12.013_bb0135","doi-asserted-by":"crossref","first-page":"19987","DOI":"10.3390\/ijms141019987","article-title":"Non-coding RNAs: the \u201cdark matter\u201dof cardiovascular pathophysiology","volume":"14","author":"Iaconetti","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.yjmcc.2019.12.013_bb0140","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cell.2013.01.003","article-title":"Braveheart, a long noncoding RNA required for cardiovascular lineage commitment","volume":"152","author":"Klattenhoff","year":"2013","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.yjmcc.2019.12.013_bb0145","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/nar\/gkq833","article-title":"Steroid receptor RNA activator protein binds to and counteracts sra rna-mediated activation of myod and muscle differentiation","volume":"39","author":"Hub\u00e9","year":"2011","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.yjmcc.2019.12.013_bb0150","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1161\/CIRCRESAHA.110.227058","article-title":"Mesp1 a key regulator of cardiovascular lineage commitment","volume":"107","author":"Bondue","year":"2010","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.yjmcc.2019.12.013_bb0155","doi-asserted-by":"crossref","first-page":"3512","DOI":"10.1002\/cam4.900","article-title":"LncRNA PVT1 regulates prostate cancer cell growth by inducing the methylation of miR-146a","volume":"5","author":"Hong-tao","year":"2016","journal-title":"Cancer Med."},{"issue":"12","key":"10.1016\/j.yjmcc.2019.12.013_bb0160","doi-asserted-by":"crossref","first-page":"e3175","DOI":"10.1038\/cddis.2017.392","article-title":"H19 lncRNA alters methylation and expression of HNF4\u03b1 in the liver of metformin-exposed fetuses","volume":"8","author":"Deng","year":"2017","journal-title":"Cell Death and Disease"},{"key":"10.1016\/j.yjmcc.2019.12.013_bb0165","doi-asserted-by":"crossref","first-page":"10221","DOI":"10.1038\/ncomms10221","article-title":"H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase","volume":"6","author":"Zhou","year":"2015","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.yjmcc.2019.12.013_bb0170","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nsmb.2217","article-title":"ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of KLF4","volume":"19","author":"Kim","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"4","key":"10.1016\/j.yjmcc.2019.12.013_bb0175","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.stemcr.2018.02.007","article-title":"KLF4 nuclear export requires ERK activation and initiates exit from naive pluripotency","volume":"10","author":"Dhaliwal","year":"2018","journal-title":"Stem Cell Reports"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820300079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820300079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:29:39Z","timestamp":1758313779000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282820300079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":35,"alternative-id":["S0022282820300079"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2019.12.013","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA-Mhrt regulates cardiac hypertrophy by modulating the miR-145a-5p\/KLF4\/myocardin axis","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2019.12.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}