{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:29:51Z","timestamp":1784921391430,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700342"],"award-info":[{"award-number":["81700342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670449"],"award-info":[{"award-number":["81670449"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870280"],"award-info":[{"award-number":["81870280"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31600938"],"award-info":[{"award-number":["31600938"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008250","name":"Shaanxi University of Science and Technology","doi-asserted-by":"publisher","award":["20180302"],"award-info":[{"award-number":["20180302"]}],"id":[{"id":"10.13039\/501100008250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFF0301603"],"award-info":[{"award-number":["2019YFF0301603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007547","name":"Fourth Military Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.yjmcc.2020.03.002","type":"journal-article","created":{"date-parts":[[2020,3,8]],"date-time":"2020-03-08T22:39:25Z","timestamp":1583707165000},"page":"163-172","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Upregulated hepatokine fetuin B aggravates myocardial ischemia\/reperfusion injury through inhibiting insulin signaling in diabetic mice"],"prefix":"10.1016","volume":"151","author":[{"given":"Wenjuan","family":"Xing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanzhen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaifeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2020.03.002_bb0005","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","article-title":"IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040","volume":"128","author":"Ogurtsova","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"10","key":"10.1016\/j.yjmcc.2020.03.002_bb0010","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.yjmcc.2020.03.002_bb0015","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1124\/pr.113.008300","article-title":"Interaction of risk factors, comorbidities, and comedications with ischemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning","volume":"66","author":"Ferdinandy","year":"2014","journal-title":"Pharmacol. Rev."},{"issue":"Pt 1","key":"10.1016\/j.yjmcc.2020.03.002_bb0020","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/bj20030676","article-title":"Tissue distribution and activity testing suggest a similar but not identical function of fetuin-B and fetuin-A","volume":"376","author":"Denecke","year":"2003","journal-title":"Biochem. J."},{"issue":"Pt 2","key":"10.1016\/j.yjmcc.2020.03.002_bb0025","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1042\/bj3500589","article-title":"Fetuin-B, a second member of the fetuin family in mammals","volume":"350","author":"Olivier","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.yjmcc.2020.03.002_bb0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.metabol.2016.11.017","article-title":"Regulation of the novel adipokines\/hepatokines fetuin A and fetuin B in gestational diabetes mellitus","volume":"68","author":"Kralisch","year":"2017","journal-title":"Metab. Clin. Exp."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.03.002_bb0035","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cmet.2015.09.023","article-title":"Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism","volume":"22","author":"Meex","year":"2015","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.002_bb0040","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12020-017-1387-1","article-title":"Increased serum levels of fetuin B in patients with coronary artery disease","volume":"58","author":"Zhu","year":"2017","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.002_bb0045","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1042\/CS20140462","article-title":"The serum protein fetuin-B is involved in the development of acute myocardial infarction","volume":"129","author":"Jung","year":"2015","journal-title":"Clin. Sci."},{"issue":"8","key":"10.1016\/j.yjmcc.2020.03.002_bb0050","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/nm.2851","article-title":"Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance","volume":"18","author":"Pal","year":"2012","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.yjmcc.2020.03.002_bb0055","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0092-8674(89)90098-6","article-title":"Characterization of a natural inhibitor of the insulin receptor tyrosine kinase: cDNA cloning, purification, and anti-mitogenic activity","volume":"58","author":"Auberger","year":"1989","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.yjmcc.2020.03.002_bb0060","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.15252\/embj.201696179","article-title":"OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance","volume":"36","author":"Pereira","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.yjmcc.2020.03.002_bb0065","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.gene.2017.06.024","article-title":"MicroRNA-21 regulates hepatic glucose metabolism by targeting FOXO1","volume":"627","author":"Luo","year":"2017","journal-title":"Gene"},{"issue":"6B","key":"10.1016\/j.yjmcc.2020.03.002_bb0070","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1111\/j.1582-4934.2009.00795.x","article-title":"Inhibition of IGF-IR tyrosine kinase induces apoptosis and cell cycle arrest in imatinib-resistant chronic myeloid leukaemia cells","volume":"14","author":"Shi","year":"2010","journal-title":"J. Cell. Mol. Med."},{"issue":"9","key":"10.1016\/j.yjmcc.2020.03.002_bb0075","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1161\/CIRCRESAHA.118.314635","article-title":"Longterm exercise-derived exosomal miR-342-5p","volume":"124","author":"Hou","year":"2019","journal-title":"Circ. Res."},{"issue":"9081","key":"10.1016\/j.yjmcc.2020.03.002_bb0080","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0140-6736(05)62030-2","article-title":"Fetuin protects the fetus from TNF","volume":"350","author":"Wang","year":"1997","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.yjmcc.2020.03.002_bb0085","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/bies.950141105","article-title":"Fetuin\u2014an old friend revisited","volume":"14","author":"Brown","year":"1992","journal-title":"BioEssays"},{"issue":"2","key":"10.1016\/j.yjmcc.2020.03.002_bb0090","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1001\/jama.300.2.182","article-title":"Fetuin-A and incident diabetes mellitus in older persons","volume":"300","author":"Ix","year":"2008","journal-title":"Jama"},{"issue":"10","key":"10.1016\/j.yjmcc.2020.03.002_bb0095","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.2337\/db08-0538","article-title":"Plasma fetuin-A levels and the risk of type 2 diabetes","volume":"57","author":"Stefan","year":"2008","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.002_bb0100","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbadis.2016.10.002","article-title":"Fetuin-A downregulates adiponectin through Wnt-PPARgamma pathway in lipid induced inflamed adipocyte","volume":"1863","author":"Agarwal","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.002_bb0105","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2337\/db12-0372","article-title":"Plasma levels of fetuin-A and hepatic enzymes and risk of type 2 diabetes in women in the U.S","volume":"62","author":"Sun","year":"2013","journal-title":"Diabetes"},{"issue":"24","key":"10.1016\/j.yjmcc.2020.03.002_bb0110","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1161\/CIRCULATIONAHA.108.814418","article-title":"Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke","volume":"118","author":"Weikert","year":"2008","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.yjmcc.2020.03.002_bb0115","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1161\/CIRCRESAHA.116.306819","article-title":"Epigenetic changes in diabetes and cardiovascular risk","volume":"118","author":"Keating","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.03.002_bb0120","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12933-015-0313-1","article-title":"Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning","volume":"14","author":"Baranyai","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.002_bb0125","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1582-4934.2012.01661.x","article-title":"Acute hyperglycaemia enhances oxidative stress and aggravates myocardial ischaemia\/reperfusion injury: role of thioredoxin-interacting protein","volume":"17","author":"Su","year":"2013","journal-title":"J. Cell. Mol. Med."},{"issue":"5","key":"10.1016\/j.yjmcc.2020.03.002_bb0130","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00395-014-0415-z","article-title":"TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia\/reperfusion injury","volume":"109","author":"Liu","year":"2014","journal-title":"Basic Res. Cardiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.03.002_bb0135","doi-asserted-by":"crossref","first-page":"H813","DOI":"10.1152\/ajpheart.00092.2005","article-title":"Insulin resistance in spontaneously hypertensive rats is associated with endothelial dysfunction characterized by imbalance between NO and ET-1 production","volume":"289","author":"Potenza","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"7","key":"10.1016\/j.yjmcc.2020.03.002_bb0140","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/CIRCRESAHA.116.306206","article-title":"Insulin signaling and heart failure","volume":"118","author":"Riehle","year":"2016","journal-title":"Circ. Res."},{"issue":"18","key":"10.1016\/j.yjmcc.2020.03.002_bb0145","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1161\/CIRCULATIONAHA.110.988642","article-title":"G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia","volume":"123","author":"Ciccarelli","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.002_bb0150","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s12350-016-0586-0","article-title":"Heart failure, whole-body insulin resistance and myocardial insulin resistance: an intriguing puzzle","volume":"25","author":"Gargiulo","year":"2018","journal-title":"J. Nucl. Cardiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.03.002_bb0155","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/cvr\/cvq349","article-title":"Insulin says NO to cardiovascular disease","volume":"89","author":"Yu","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.yjmcc.2020.03.002_bb0160","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1161\/HYPERTENSIONAHA.111.00728","article-title":"A novel mechanism for vascular insulin resistance in normotensive young SHRs: hypoadiponectinemia and resultant APPL1 downregulation","volume":"61","author":"Xing","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2020.03.002_bb0165","doi-asserted-by":"crossref","first-page":"17927","DOI":"10.1038\/srep17927","article-title":"Direct evidence that myocardial insulin resistance following myocardial ischemia contributes to post-ischemic heart failure","volume":"5","author":"Fu","year":"2015","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.yjmcc.2020.03.002_bb0170","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.2337\/diabetes.53.9.2366","article-title":"Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob\/ob mouse hearts","volume":"53","author":"Mazumder","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2020.03.002_bb0175","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.yjmcc.2015.05.012","article-title":"Antioxidant treatment normalizes mitochondrial energetics and myocardial insulin sensitivity independently of changes in systemic metabolic homeostasis in a mouse model of the metabolic syndrome","volume":"85","author":"Ilkun","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"9","key":"10.1016\/j.yjmcc.2020.03.002_bb0180","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1007\/s10495-009-0378-y","article-title":"Insulin inhibits myocardial ischemia-induced apoptosis and alleviates chronic adverse changes in post-ischemic cardiac structure and function","volume":"14","author":"Xing","year":"2009","journal-title":"Apoptosis"},{"issue":"8","key":"10.1016\/j.yjmcc.2020.03.002_bb0185","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/eurjhf\/hfr080","article-title":"AKT signalling in the failing heart","volume":"13","author":"Chaanine","year":"2011","journal-title":"Eur. J. Heart Fail."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.03.002_bb0190","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/cvr\/cvs426","article-title":"FoxO1 is crucial for sustaining cardiomyocyte metabolism and cell survival","volume":"97","author":"Puthanveetil","year":"2013","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.03.002_bb0195","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/jdi.12651","article-title":"Forkhead box class O family member proteins: the biology and pathophysiological roles in diabetes","volume":"8","author":"Tsuchiya","year":"2017","journal-title":"J. Diabetes Investig."},{"issue":"12","key":"10.1016\/j.yjmcc.2020.03.002_bb0200","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.18632\/aging.102042","article-title":"Altered FoxO1 and PPARgamma interaction in age-related ER stress-induced hepatic steatosis","volume":"11","author":"Kim","year":"2019","journal-title":"Aging"},{"key":"10.1016\/j.yjmcc.2020.03.002_bb0205","doi-asserted-by":"crossref","first-page":"153074","DOI":"10.1016\/j.phymed.2019.153074","article-title":"Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK\/PGC-1alpha pathway","volume":"64","author":"Fang","year":"2019","journal-title":"Phytomedicine"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820300572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820300572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:22:35Z","timestamp":1777418555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282820300572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":41,"alternative-id":["S0022282820300572"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.03.002","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulated hepatokine fetuin B aggravates myocardial ischemia\/reperfusion injury through inhibiting insulin signaling in diabetic mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}