{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:13:51Z","timestamp":1793142831269,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["10057"],"award-info":[{"award-number":["10057"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000312","name":"Joseph Rowntree Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SRG\/2019\/000274"],"award-info":[{"award-number":["SRG\/2019\/000274"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.yjmcc.2020.03.015","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T10:59:34Z","timestamp":1585825174000},"page":"14-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Non-coding RNAs: Regulators of valvular calcification"],"prefix":"10.1016","volume":"142","author":[{"given":"Shashi Kumar","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunaina","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Barthwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Thum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9540","key":"10.1016\/j.yjmcc.2020.03.015_bb0005","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: a population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.yjmcc.2020.03.015_bb0010","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000354221","article-title":"Etiology of valvular heart disease in the 21st century","volume":"126","author":"Boudoulas","year":"2013","journal-title":"Cardiology"},{"issue":"12","key":"10.1016\/j.yjmcc.2020.03.015_bb0015","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.jacc.2018.06.063","article-title":"Rheumatic heart disease worldwide: JACC scientific expert panel","volume":"72","author":"Watkins","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"issue":"10159","key":"10.1016\/j.yjmcc.2020.03.015_bb0020","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(18)32203-7","article-title":"Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","year":"2018","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.yjmcc.2020.03.015_bb0025","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.3892\/etm.2016.3048","article-title":"Pathophysiology of valvular heart disease","volume":"11","author":"Zeng","year":"2016","journal-title":"Exp. Ther. Med."},{"issue":"12","key":"10.1016\/j.yjmcc.2020.03.015_bb0030","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1007\/s00726-017-2432-3","article-title":"Human interstitial cellular model in therapeutics of heart valve calcification","volume":"49","author":"He","year":"2017","journal-title":"Amino Acids"},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0035","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fcvm.2018.00021","article-title":"Advances in pathophysiology of calcific aortic valve disease propose novel molecular therapeutic targets","volume":"5","author":"Hulin","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0040","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00100.2019","article-title":"Adaptive immune cells in calcific aortic valve disease","volume":"317","author":"Raddatz","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.03.015_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2017.01.052","article-title":"The shift of macrophages toward M1 phenotype promotes aortic valvular calcification","volume":"153","author":"Li","year":"2017","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carpath.2018.03.004","article-title":"Lymphocyte and monocyte subpopulations in severe aortic stenosis at the time of surgical intervention","volume":"35","author":"Mazur","year":"2018","journal-title":"Cardiovasc. Pathol."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0055","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jjcc.2015.05.002","article-title":"Presence of B cells within aortic valves in patients with aortic stenosis: relation to severity of the disease","volume":"67","author":"Natorska","year":"2016","journal-title":"J. Cardiol."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.03.015_bb0060","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.ajpath.2017.02.012","article-title":"Interferon-gamma released by activated CD8(+) T lymphocytes impairs the calcium resorption potential of osteoclasts in calcified human aortic valves","volume":"187","author":"Nagy","year":"2017","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0065","article-title":"Besides pathology: long non-coding RNA in cell and tissue homeostasis","volume":"4","author":"Salviano-Silva","year":"2018","journal-title":"Noncoding RNA"},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0070","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/164_2016_99","article-title":"Noncoding RNAs in heart failure","volume":"243","author":"Dangwal","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"issue":"11","key":"10.1016\/j.yjmcc.2020.03.015_bb0075","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/ATVBAHA.114.302523","article-title":"Calcific aortic valve disease: a consensus summary from the Alliance of investigators on calcific aortic valve disease","volume":"34","author":"Yutzey","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"21","key":"10.1016\/j.yjmcc.2020.03.015_bb0080","doi-asserted-by":"crossref","first-page":"8657","DOI":"10.1074\/jbc.M117.783308","article-title":"An epigenetic regulatory loop controls pro-osteogenic activation by TGF-beta1 or bone morphogenetic protein 2 in human aortic valve interstitial cells","volume":"292","author":"Song","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0085","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1097\/FJC.0000000000000244","article-title":"MicroRNA-204 targets Runx2 to attenuate BMP-2-induced osteoblast differentiation of human aortic valve interstitial cells","volume":"66","author":"Wang","year":"2015","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0090","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ijcard.2017.05.037","article-title":"LncRNA MALAT1 sponges miR-204 to promote osteoblast differentiation of human aortic valve interstitial cells through up-regulating Smad4","volume":"243","author":"Xiao","year":"2017","journal-title":"Int J Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0095","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1093\/cvr\/cvx180","article-title":"LncRNA TUG1 sponges miR-204-5p to promote osteoblast differentiation through upregulating Runx2 in aortic valve calcification","volume":"114","author":"Yu","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2020.03.015_bb0100","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005364","article-title":"Altered MicroRNA expression is responsible for the pro-osteogenic phenotype of interstitial cells in calcified human aortic valves","volume":"6","author":"Song","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0105","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.celrep.2012.06.003","article-title":"The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult","volume":"2","author":"Zhang","year":"2012","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.yjmcc.2020.03.015_bb0110","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1261\/rna.033217.112","article-title":"Malat1 is not an essential component of nuclear speckles in mice","volume":"18","author":"Nakagawa","year":"2012","journal-title":"RNA"},{"issue":"3","key":"10.1016\/j.yjmcc.2020.03.015_bb0115","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.molcel.2016.09.027","article-title":"Impact of MicroRNA levels, target-site complementarity, and cooperativity on competing endogenous RNA-regulated gene expression","volume":"64","author":"Denzler","year":"2016","journal-title":"Mol. Cell"},{"issue":"4","key":"10.1016\/j.yjmcc.2020.03.015_bb0120","article-title":"Myxomatous degeneration of the mitral valve","volume":"8","author":"Neto","year":"2018","journal-title":"Autopsy Case Rep."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0125","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1038\/s41467-019-10753-5","article-title":"The microRNAs miR-204 and miR-211 maintain joint homeostasis and protect against osteoarthritis progression","volume":"10","author":"Huang","year":"2019","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.03.015_bb0130","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/cvr\/cvs258","article-title":"MicroRNA-204 regulates vascular smooth muscle cell calcification in vitro and in vivo","volume":"96","author":"Cui","year":"2012","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0135","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/s41467-019-09174-1","article-title":"Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.03.015_bb0140","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1253\/circj.CJ-11-0395","article-title":"Cardiovascular calcification: an inflammatory disease","volume":"75","author":"New","year":"2011","journal-title":"Circ. J."},{"issue":"12","key":"10.1016\/j.yjmcc.2020.03.015_bb0145","first-page":"5773","article-title":"M1 macrophages promote aortic valve calcification mediated by microRNA-214\/TWIST1 pathway in valvular interstitial cells","volume":"8","author":"Li","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0150","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00392-018-1398-9","article-title":"MicroRNA-214 promotes the calcification of human aortic valve interstitial cells through the acceleration of inflammatory reactions with activated MyD88\/NF-kappaB signaling","volume":"108","author":"Zheng","year":"2019","journal-title":"Clin. Res. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0155","doi-asserted-by":"crossref","first-page":"25397","DOI":"10.1038\/srep25397","article-title":"Identification of side- and shear-dependent microRNAs regulating porcine aortic valve pathogenesis","volume":"6","author":"Rathan","year":"2016","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.yjmcc.2020.03.015_bb0160","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1007\/s10439-019-02206-3","article-title":"miR-214 is stretch-sensitive in aortic valve and inhibits aortic valve calcification","volume":"47","author":"Salim","year":"2019","journal-title":"Ann. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0165","doi-asserted-by":"crossref","first-page":"8740","DOI":"10.1038\/s41598-017-09390-z","article-title":"MicroRNA-449c-5p inhibits osteogenic differentiation of human VICs through Smad4-mediated pathway","volume":"7","author":"Xu","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0170","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1536\/ihj.18-086","article-title":"MicroRNA-138 suppresses osteoblastic differentiation of valvular interstitial cells in degenerative calcific aortic valve disease","volume":"60","author":"Lu","year":"2019","journal-title":"Int. Heart J."},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0175","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s12265-019-09880-7","article-title":"Identification of miR-143 as a major contributor for human stenotic aortic valve disease","volume":"12","author":"Fiedler","year":"2019","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"5","key":"10.1016\/j.yjmcc.2020.03.015_bb0180","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/07853890.2015.1059955","article-title":"MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease","volume":"47","author":"Ohukainen","year":"2015","journal-title":"Ann. Med."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.03.015_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtcvs.2013.05.011","article-title":"MicroRNA-30b is a multifunctional regulator of aortic valve interstitial cells","volume":"147","author":"Zhang","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"7","key":"10.1016\/j.yjmcc.2020.03.015_bb0190","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1002\/jcb.26545","article-title":"Mir-29b promotes human aortic valve interstitial cell calcification via inhibiting TGF-beta3 through activation of wnt3\/beta-catenin\/Smad3 signaling","volume":"119","author":"Fang","year":"2018","journal-title":"J. Cell. Biochem."},{"issue":"1 Suppl","key":"10.1016\/j.yjmcc.2020.03.015_bb0195","first-page":"I547","article-title":"Role of human valve interstitial cells in valve calcification and their response to atorvastatin","volume":"114","author":"Osman","year":"2006","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2020.03.015_bb0200","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s13239-017-0296-z","article-title":"Mechanosensitive microRNA-181b regulates aortic valve endothelial matrix degradation by targeting TIMP3","volume":"9","author":"Heath","year":"2018","journal-title":"Cardiovasc. Eng. Technol."},{"issue":"12","key":"10.1016\/j.yjmcc.2020.03.015_bb0205","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/CIRCRESAHA.110.234237","article-title":"Cell-matrix interactions in the pathobiology of calcific aortic valve disease: critical roles for matricellular, matricrine, and matrix mechanics cues","volume":"108","author":"Chen","year":"2011","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.03.015_bb0210","doi-asserted-by":"crossref","first-page":"H856","DOI":"10.1152\/ajpheart.00117.2011","article-title":"Discovery of shear- and side-specific mRNAs and miRNAs in human aortic valvular endothelial cells","volume":"301","author":"Holliday","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.03.015_bb0215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091812","article-title":"Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis","volume":"9","author":"Rosjo","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.yjmcc.2020.03.015_bb0220","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00432.2017","article-title":"microRNA-206 correlates with left ventricular function after transcatheter aortic valve implantation","volume":"313","author":"Kleeberger","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"23","key":"10.1016\/j.yjmcc.2020.03.015_bb0225","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1161\/CIRCULATIONAHA.116.023116","article-title":"Altered DNA methylation of long noncoding RNA H19 in calcific aortic valve disease promotes mineralization by silencing NOTCH1","volume":"134","author":"Hadji","year":"2016","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.yjmcc.2020.03.015_bb0230","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.yjmcc.2009.08.008","article-title":"Notch1 represses osteogenic pathways in aortic valve cells","volume":"47","author":"Nigam","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"19","key":"10.1016\/j.yjmcc.2020.03.015_bb0235","article-title":"H19 is not hypomethylated or upregulated with age or sex in the aortic valves of mice","volume":"7","author":"Vander Roest","year":"2019","journal-title":"Phys. Rep."},{"issue":"4","key":"10.1016\/j.yjmcc.2020.03.015_bb0240","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.bbrc.2019.02.109","article-title":"LncRNA OIP5-AS1 inhibits osteoblast differentiation of valve interstitial cells via miR-137\/TWIST11 axis","volume":"511","author":"Zheng","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.yjmcc.2020.03.015_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096577","article-title":"The long non-coding HOTAIR is modulated by cyclic stretch and WNT\/beta-CATENIN in human aortic valve cells and is a novel repressor of calcification genes","volume":"9","author":"Carrion","year":"2014","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.yjmcc.2020.03.015_bb0250","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.ymthe.2019.07.001","article-title":"Circular RNAs: a novel class of functional RNA molecules with a therapeutic perspective","volume":"27","author":"Santer","year":"2019","journal-title":"Mol. Ther."},{"issue":"7441","key":"10.1016\/j.yjmcc.2020.03.015_bb0255","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature11928","article-title":"Circular RNAs are a large class of animal RNAs with regulatory potency","volume":"495","author":"Memczak","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0260","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yjmcc.2016.07.007","article-title":"Characterization of circular RNAs in human, mouse and rat hearts","volume":"98","author":"Werfel","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0265","doi-asserted-by":"crossref","first-page":"196037","DOI":"10.1155\/2012\/196037","article-title":"Bicuspid aortic valve disease: a comprehensive review","volume":"2012","author":"Mordi","year":"2012","journal-title":"Cardiol. Res. Pract."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.03.015_bb0270","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jtcvs.2011.10.097","article-title":"miRNA-141 is a novel regulator of BMP-2-mediated calcification in aortic stenosis","volume":"144","author":"Yanagawa","year":"2012","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.03.015_bb0275","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1159\/000485356","article-title":"Downregulated MicroRNA-195 in the bicuspid aortic valve promotes calcification of valve interstitial cells via targeting SMAD7","volume":"44","author":"Du","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"10","key":"10.1016\/j.yjmcc.2020.03.015_bb0280","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1161\/CIRCRESAHA.115.304361","article-title":"Role of miR-195 in aortic aneurysmal disease","volume":"115","author":"Zampetaki","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0285","doi-asserted-by":"crossref","first-page":"16003","DOI":"10.1038\/ncomms16003","article-title":"MiR-497 approximately 195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial notch and HIF-1alpha activity","volume":"8","author":"Yang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0290","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.yjmcc.2019.03.013","article-title":"Chronic inflammation: a key role in degeneration of bicuspid aortic valve","volume":"130","author":"Manno","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5","key":"10.1016\/j.yjmcc.2020.03.015_bb0295","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1096\/fj.14-257808","article-title":"The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-kappaB signaling, and inflammatory gene expression in human aortic valve cells","volume":"29","author":"Patel","year":"2015","journal-title":"FASEB J."},{"issue":"31","key":"10.1016\/j.yjmcc.2020.03.015_bb0300","doi-asserted-by":"crossref","first-page":"9698","DOI":"10.1073\/pnas.1508399112","article-title":"Spontaneous retrotransposon insertion into TNF 3\u2019UTR causes heart valve disease and chronic polyarthritis","volume":"112","author":"Lacey","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.03.015_bb0305","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20186997","article-title":"miR-27a protects human mitral valve interstitial cell from TNF-alpha-induced inflammatory injury via up-regulation of NELL-1","volume":"51","author":"Chen","year":"2018","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"40","key":"10.1016\/j.yjmcc.2020.03.015_bb0310","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/eurheartj\/ehv343","article-title":"Management and outcomes in patients with moderate or severe functional mitral regurgitation and severe left ventricular dysfunction","volume":"36","author":"Samad","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2020.03.015_bb0315","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ijcard.2016.04.018","article-title":"Circulating exosomal microRNAs predict functional recovery after MitraClip repair of severe mitral regurgitation","volume":"215","author":"Kasner","year":"2016","journal-title":"Int. J. Cardiol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820300808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820300808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:25:06Z","timestamp":1777418706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282820300808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":63,"alternative-id":["S0022282820300808"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.03.015","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-coding RNAs: Regulators of valvular calcification","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}