{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T19:23:58Z","timestamp":1772133838683,"version":"3.50.1"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.yjmcc.2020.03.016","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T20:25:52Z","timestamp":1585945552000},"page":"53-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Human induced pluripotent stem cell-derived cardiomyocytes reveal abnormal TGF\u03b2 signaling in type 2 diabetes mellitus"],"prefix":"10.1016","volume":"142","author":[{"given":"Ling","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongkun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danni","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengfeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingqian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingyu","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo-Xian","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianye","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2020.03.016_bb0005","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12916-017-0901-x","article-title":"Environmental\/lifestyle factors in the pathogenesis and prevention of type 2 diabetes","volume":"15","author":"Kolb","year":"2017","journal-title":"BMC Med."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabres.2016.11.006","article-title":"Incidence of complications in young-onset diabetes: comparing type 2 with type 1 (the young diab study)","volume":"123","author":"Amutha","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0020","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.jacc.2017.07.001","article-title":"Primary prevention of cardiovascular disease in diabetes mellitus","volume":"70","author":"Newman","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0025","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1136\/bmj.320.7241.1062","article-title":"ABC of arterial and venous disease: vascular complications of diabetes","volume":"320","author":"Donnelly","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0030","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nrendo.2009.266","article-title":"Diabetic angiopathy, the complement system and the tumor necrosis factor superfamily","volume":"6","author":"Flyvbjerg","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrendo.2015.216","article-title":"Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy","volume":"12","author":"Jia","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0040","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1161\/CIRCULATIONAHA.106.634949","article-title":"Diabetic cardiovascular autonomic neuropathy","volume":"115","author":"Vinik","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2840-2-1","article-title":"Influence of diabetes mellitus on heart failure risk and outcome","volume":"2","author":"Bauters","year":"2003","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0050","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1161\/01.HYP.37.4.1053","article-title":"Diabetes, hypertension, and cardiovascular disease: an update","volume":"37","author":"Sowers","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0055","first-page":"e29","article-title":"Heart disease and stroke statistics--2015 update: a report from the American Heart Association","volume":"131","author":"Mozaffarian","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0060","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1152\/ajpendo.00029.2008","article-title":"Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level","volume":"294","author":"Feng","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0065","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/dmrr.964","article-title":"Leptin and endothelin-1 mediated increased extracellular matrix protein production and cardiomyocyte hypertrophy in diabetic heart disease","volume":"25","author":"Majumdar","year":"2009","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0070","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1007\/s00125-012-2495-3","article-title":"Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in the db\/db mouse model of type 2 diabetes","volume":"55","author":"Huynh","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0075","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/dmrr.1054","article-title":"miR133a regulates cardiomyocyte hypertrophy in diabetes","volume":"26","author":"Feng","year":"2010","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0080","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1172\/JCI60329","article-title":"Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice","volume":"122","author":"Battiprolu","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0085","first-page":"2929","article-title":"Effect of genistein on myocardial fibrosis in diabetic rats and its mechanism","volume":"17","author":"Yang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0090","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.2337\/db08-0805","article-title":"Intracellular angiotensin II production in diabetic rats is correlated with cardiomyocyte apoptosis, oxidative stress, and cardiac fibrosis","volume":"57","author":"Singh","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0095","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.2337\/diabetes.50.9.2105","article-title":"Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes","volume":"50","author":"Dyntar","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2008.10.007","article-title":"Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes","volume":"46","author":"He","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0105","doi-asserted-by":"crossref","first-page":"777","DOI":"10.2337\/diabetes.52.3.777","article-title":"Metallothionein prevents diabetes-induced deficits in cardiomyocytes by inhibiting reactive oxygen species production","volume":"52","author":"Ye","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0110","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1152\/ajpheart.00278.2006","article-title":"Role of changes in cardiac metabolism in development of diabetic cardiomyopathy","volume":"291","author":"An","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11154-010-9131-7","article-title":"Diabetic cardiomyopathy, causes and effects","volume":"11","author":"Boudina","year":"2010","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0120","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1586\/erc.10.17","article-title":"Diabetic cardiomyopathy: signaling defects and therapeutic approaches","volume":"8","author":"Dobrin","year":"2010","journal-title":"Expert. Rev. Cardiovasc. Ther."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0125","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/CS20040057","article-title":"Diabetic cardiomyopathy: mechanisms, diagnosis and treatment","volume":"107","author":"Hayat","year":"2004","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s12265-016-9723-z","article-title":"Molecular approaches in HFpEF: MicroRNAs and iPSC-derived cardiomyocytes","volume":"10","author":"Kriegel","year":"2017","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0135","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1021\/mp400258d","article-title":"Transplanted induced pluripotent stem cells mitigate oxidative stress and improve cardiac function through the Akt cell survival pathway in diabetic cardiomyopathy","volume":"10","author":"Yan","year":"2013","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0140","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s10741-016-9565-4","article-title":"Stem cells and diabetic cardiomyopathy: from pathology to therapy","volume":"21","author":"Liu","year":"2016","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0145","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.cell.2012.11.039","article-title":"A molecular roadmap of reprogramming somatic cells into iPS cells","volume":"151","author":"Polo","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0150","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1002\/stem.2438","article-title":"Generation of induced Cardiospheres via reprogramming of skin fibroblasts for myocardial regeneration","volume":"34","author":"Xu","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0155","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1681\/ASN.2011010106","article-title":"Generation of induced pluripotent stem cells from urine","volume":"22","author":"Zhou","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0160","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1161\/ATVBAHA.117.309962","article-title":"Differentiation, evaluation, and application of human induced pluripotent stem cell-derived endothelial cells","volume":"37","author":"Lin","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0165","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1161\/ATVBAHA.117.309195","article-title":"Human induced pluripotent stem cell-derived macrophages for unraveling human macrophage biology","volume":"37","author":"Zhang","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0170","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1172\/JCI82735","article-title":"Mesodermal iPSC-derived progenitor cells functionally regenerate cardiac and skeletal muscle","volume":"125","author":"Quattrocelli","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0175","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1002\/sctm.16-0029","article-title":"Donor-dependent and other nondefined factors have greater influence on the hepatic phenotype than the starting cell type in induced pluripotent stem cell derived hepatocyte-like cells","volume":"6","author":"Heslop","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0180","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature09747","article-title":"Modelling the long QT syndrome with induced pluripotent stem cells","volume":"471","author":"Itzhaki","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0185","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.scr.2017.02.015","article-title":"Generation of induced pluripotent stem cells (iPSCs) from a hypertrophic cardiomyopathy patient with the pathogenic variant p.Val698Ala in beta-myosin heavy chain (MYH7) gene","volume":"20","author":"Ross","year":"2017","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0190","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003552","article-title":"Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy","volume":"4","author":"Sun","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0195","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature11799","article-title":"Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs","volume":"494","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0200","doi-asserted-by":"crossref","first-page":"101509","DOI":"10.1016\/j.scr.2019.101509","article-title":"Generation of induced pluripotent stem cells (iPSCs) from an infant with catecholaminergic polymorphic ventricular tachycardia carrying the double heterozygous mutations A1855D in RyR2 and Q1362H in SCN10A","volume":"39","author":"Zhang","year":"2019","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0205","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1016\/j.jacc.2016.07.779","article-title":"Patient-specific and genome-edited induced pluripotent stem cell-derived cardiomyocytes elucidate single-cell phenotype of Brugada syndrome","volume":"68","author":"Liang","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0210","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/j.jacc.2019.02.055","article-title":"Modeling reentry in the short QT syndrome with human-induced pluripotent stem cell-derived cardiac cell sheets","volume":"73","author":"Shinnawi","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0215","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1038\/nprot.2012.115","article-title":"Generation of human induced pluripotent stem cells from urine samples","volume":"7","author":"Zhou","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0220","article-title":"Generating a non-integrating human induced pluripotent stem cell bank from urine-derived cells","volume":"8","author":"Xue","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0225","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/nmeth.2999","article-title":"Chemically defined and small molecule-based generation of human cardiomyocytes","volume":"11","author":"Burridge","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0230","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/nmeth.3448","article-title":"Chemically defined albumin-free human cardiomyocyte generation","volume":"12","author":"Lian","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0235","doi-asserted-by":"crossref","first-page":"14234","DOI":"10.1073\/pnas.1103509108","article-title":"Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors","volume":"108","author":"Ban","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0240","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.celrep.2014.09.055","article-title":"Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells","volume":"9","author":"Drawnel","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0245","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.2337\/db16-1237","article-title":"MICU1 alleviates diabetic cardiomyopathy through mitochondrial Ca2+-dependent antioxidant response","volume":"66","author":"Ji","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0250","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1161\/CIRCRESAHA.109.199810","article-title":"Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy","volume":"105","author":"St\u00f8len TO","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0255","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1475-2840-13-75","article-title":"Progressive decay of Ca2+ homeostasis in the development of diabetic cardiomyopathy","volume":"13","author":"Zhao","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0260","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.bbadis.2017.10.024","article-title":"Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca2+ leak is independent of diabetic remodeling of myocardium","volume":"1864","author":"Liu","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0265","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00109-016-1469-1","article-title":"The rho kinase inhibitor, fasudil, ameliorates diabetes-induced cardiac dysfunction by improving calcium clearance and actin remodeling","volume":"95","author":"Lai","year":"2017","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0270","doi-asserted-by":"crossref","first-page":"H353","DOI":"10.1152\/ajpheart.01198.2011","article-title":"Na+\/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4\/NF-kappaB pathway","volume":"303","author":"LaRocca","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0275","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.jnutbio.2013.08.002","article-title":"Cardioprotective effect of selenium via modulation of cardiac ryanodine receptor calcium release channels in diabetic rat cardiomyocytes through thioredoxin system","volume":"24","author":"Okatan","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0280","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1536\/ihj.48.233","article-title":"Impact of diabetes on cardiomyocyte apoptosis and connexin43 gap junction integrity: role of pharmacological modulation","volume":"48","author":"Sheu","year":"2007","journal-title":"Int. Heart J."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0285","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.diabres.2017.08.018","article-title":"Transforming growth factor beta (TGF-beta) mediates cardiac fibrosis and induces diabetic cardiomyopathy","volume":"133","author":"Yue","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0290","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.lfs.2018.09.004","article-title":"Peroxisome proliferator-activated receptor-gamma activation attenuates diabetic cardiomyopathy via regulation of the TGF-beta\/ERK pathway and epithelial-to-mesenchymal transition","volume":"213","author":"Yan","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0295","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/cbin.11079","article-title":"Silymarin ameliorates diabetic cardiomyopathy via inhibiting TGF-beta1\/Smad signaling","volume":"43","author":"Meng","year":"2019","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0300","first-page":"1775","article-title":"Matrine suppresses cardiac fibrosis by inhibiting the TGFbeta\/Smad pathway in experimental diabetic cardiomyopathy","volume":"17","author":"Zhang","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0305","doi-asserted-by":"crossref","first-page":"23010","DOI":"10.1038\/srep23010","article-title":"Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGF\u03b21 and miR-29 pathways","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0310","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrg.2017.19","article-title":"Comparative transcriptomics in human and mouse","volume":"18","author":"Breschi","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0315","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1093\/molbev\/msy056","article-title":"Divergence of noncoding regulatory elements explains gene-phenotype differences between human and mouse orthologous genes","volume":"35","author":"Han","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0320","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/humupd\/dmg043","article-title":"A comparison of placental development and endocrine functions between the human and mouse model","volume":"9","author":"Malassin\u00e9","year":"2003","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0325","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.mib.2013.03.002","article-title":"Differences in the repertoire, regulation and function of toll-like receptors and inflammasome-forming nod-like receptors between human and mouse","volume":"16","author":"Ariffin","year":"2013","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0330","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3389\/fphys.2018.01669","article-title":"Diabetes and arrhythmias: pathophysiology, mechanisms and therapeutic outcomes","volume":"9","author":"Grisanti","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0335","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.2337\/db16-1237","article-title":"MICU1 alleviates diabetic cardiomyopathy through mitochondrial Ca2+-dependent antioxidant response","volume":"66","author":"Ji","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0340","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1161\/CIRCRESAHA.109.199810","article-title":"Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy","volume":"105","author":"Stolen TO","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0345","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1475-2840-13-75","article-title":"Progressive decay of Ca2+ homeostasis in the development of diabetic cardiomyopathy","volume":"3","author":"Zhao","year":"2014","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0350","first-page":"1923","article-title":"Amylin and diabetic cardiomyopathy - amylin-induced sarcolemmal Ca2+ leak is independent of diabetic remodeling of myocardium","volume":"2018","author":"Liu","year":"1864","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0355","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.jnutbio.2013.08.002","article-title":"Cardioprotective effect of selenium via modulation of cardiac ryanodine receptor calcium release channels in diabetic rat cardiomyocytes through thioredoxin system","volume":"24","author":"Okatan","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0360","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1536\/ihj.48.233","article-title":"Impact of diabetes on cardiomyocyte apoptosis and connexin43 gap junction integrity: role of pharmacological modulation","volume":"48","author":"Sheu","year":"2007","journal-title":"Int. Heart J."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0365","article-title":"Mitochondrial dysfunction in type 2 diabetes mellitus: an organ-based analysis","volume":"361","author":"Pinti","year":"2019","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0370","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fphys.2019.00532","article-title":"Mitochondrial (Dys)function and insulin resistance: from pathophysiological molecular mechanisms to the impact of diet","volume":"10","author":"Sergi","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0375","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/j.2040-4603.2016.tb00680.x","article-title":"Glucose transporters in cardiac metabolism and hypertrophy","volume":"6","author":"Shao","year":"2015","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0380","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201891","article-title":"Cardiomyocytes cultured on mechanically compliant substrates, but not on conventional culture devices, exhibit prominent mitochondrial dysfunction due to reactive oxygen species and insulin resistance under high glucose","volume":"13","author":"Morishima","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0385","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.2337\/db13-0266","article-title":"Resveratrol prevents \u03b2-cell dedifferentiation in nonhuman primates given a high-fat\/high-sugar diet","volume":"62","author":"Fiori","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0390","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s13238-017-0442-2","article-title":"The SWI\/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control","volume":"9","author":"Wang","year":"2018","journal-title":"Protein Cell"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0395","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1042\/CS20120636","article-title":"Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factor-beta signalling","volume":"126","author":"Zhang","year":"2014","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.yjmcc.2020.03.016_bb0400","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1161\/HYPERTENSIONAHA.116.07741","article-title":"Tripartite motif 8 contributes to pathological cardiac hypertrophy through enhancing transforming growth factor beta-activated kinase 1-dependent signaling pathways","volume":"69","author":"Chen","year":"2017","journal-title":"Hypertension"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228282030081X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228282030081X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:30:18Z","timestamp":1758313818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228282030081X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":80,"alternative-id":["S002228282030081X"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.03.016","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human induced pluripotent stem cell-derived cardiomyocytes reveal abnormal TGF\u03b2 signaling in type 2 diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}