{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:47:43Z","timestamp":1781765263965,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011699","name":"Siemens Healthineers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010447","name":"Deutsches Zentrum f\u00fcr Herz-Kreislaufforschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010447","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.yjmcc.2020.04.014","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T21:20:34Z","timestamp":1587072034000},"page":"155-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["microRNA neural networks improve diagnosis of acute coronary syndrome (ACS)"],"prefix":"10.1016","volume":"151","author":[{"given":"Elham","family":"Kayvanpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weng-Tein","family":"Gi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farbod","family":"Sedaghat-Hamedani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen S.","family":"Frese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rewati","family":"Tappu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid Shirvani","family":"Samani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouven","family":"Nietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Kahraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Fehlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"M\u00fcller-Hennessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Giannitsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Niederdr\u00e4nk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo A.","family":"Katus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Meder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2020.04.014_bb0005","article-title":"Prognostic value, clinical effectiveness and cost-effectiveness of high sensitivity C-reactive protein as a marker in primary prevention of major cardiac events","volume":"5","author":"Schnell-Inderst","year":"2009","journal-title":"GMS Health Technol Assess"},{"issue":"9","key":"10.1016\/j.yjmcc.2020.04.014_bb0010","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1164\/rccm.201109-1745CI","article-title":"Unstable angina and non-ST elevation myocardial infarction","volume":"185","author":"Braunwald","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"9","key":"10.1016\/j.yjmcc.2020.04.014_bb0015","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1093\/eurheartj\/eht530","article-title":"Biomarkers and acute coronary syndromes: an update","volume":"35","author":"Mueller","year":"2014","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.04.014_bb0020","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ahj.2012.11.010","article-title":"Risk stratification in patients with unstable angina using absolute serial changes of 3 high-sensitive troponin assays","volume":"165","author":"Reichlin","year":"2013","journal-title":"Am. Heart J."},{"issue":"30","key":"10.1016\/j.yjmcc.2020.04.014_bb0025","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1093\/eurheartj\/ehw029","article-title":"Consequences of implementing a cardiac troponin assay with improved sensitivity at Swedish coronary care units: an analysis from the SWEDEHEART registry","volume":"37","author":"Eggers","year":"2016","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.04.014_bb0030","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1373\/clinchem.2009.132654","article-title":"Analytical validation of a high-sensitivity cardiac troponin T assay","volume":"56","author":"Giannitsis","year":"2010","journal-title":"Clin. Chem."},{"issue":"20","key":"10.1016\/j.yjmcc.2020.04.014_bb0035","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1093\/eurheartj\/ehs184","article-title":"Third universal definition of myocardial infarction","volume":"33","author":"Thygesen","year":"2012","journal-title":"Eur. Heart J."},{"issue":"10","key":"10.1016\/j.yjmcc.2020.04.014_bb0040","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1373\/clinchem.2015.240796","article-title":"Biomarker changes after strenuous exercise can mimic pulmonary embolism and cardiac injury--a metaanalysis of 45 studies","volume":"61","author":"Sedaghat-Hamedani","year":"2015","journal-title":"Clin. Chem."},{"issue":"8","key":"10.1016\/j.yjmcc.2020.04.014_bb0045","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/CIRCULATIONAHA.109.889048","article-title":"MicroRNAs add a new dimension to cardiovascular disease","volume":"121","author":"Small","year":"2010","journal-title":"Circulation."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.04.014_bb0050","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00395-010-0123-2","article-title":"MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction","volume":"106","author":"Meder","year":"2011","journal-title":"Basic Res. Cardiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.04.014_bb0055","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1373\/clinchem.2011.181370","article-title":"Refining diagnostic microRNA signatures by whole-miRNome kinetic analysis in acute myocardial infarction","volume":"59","author":"Vogel","year":"2013","journal-title":"Clin. Chem."},{"issue":"5","key":"10.1016\/j.yjmcc.2020.04.014_bb0060","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/CIRCRESAHA.109.215566","article-title":"Circulating microRNAs in patients with coronary artery disease","volume":"107","author":"Fichtlscherer","year":"2010","journal-title":"Circ. Res."},{"issue":"48","key":"10.1016\/j.yjmcc.2020.04.014_bb0065","doi-asserted-by":"crossref","first-page":"18255","DOI":"10.1073\/pnas.0608791103","article-title":"A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure","volume":"103","author":"van Rooij","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"31","key":"10.1016\/j.yjmcc.2020.04.014_bb0070","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1093\/eurheartj\/ehu151","article-title":"Assessment of microRNAs in patients with unstable angina pectoris","volume":"35","author":"Zeller","year":"2014","journal-title":"Eur. Heart J."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.04.014_bb0075","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1093\/eurheartj\/ehq013","article-title":"Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans","volume":"31","author":"Wang","year":"2010","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.yjmcc.2020.04.014_bb0080","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.yjmcc.2011.07.011","article-title":"Diagnostic and prognostic impact of six circulating microRNAs in acute coronary syndrome","volume":"51","author":"Widera","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.04.014_bb0085","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/eurheartj\/ehv320","volume":"37","author":"Roffi","year":"2016","journal-title":"Eur. Heart J."},{"issue":"20","key":"10.1016\/j.yjmcc.2020.04.014_bb0090","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1093\/eurheartj\/ehs215","article-title":"ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"33","author":"Task Force on the management of STseamiotESoC","year":"2012","journal-title":"Eur. Heart J."},{"issue":"15","key":"10.1016\/j.yjmcc.2020.04.014_bb0095","doi-asserted-by":"crossref","first-page":"8731","DOI":"10.1093\/nar\/gkx595","article-title":"Web-based NGS data analysis using miRMaster: a large-scale meta-analysis of human miRNAs","volume":"45","author":"Fehlmann","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.yjmcc.2020.04.014_bb0100","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/bioinformatics\/btx019","article-title":"miRmine: a database of human miRNA expression profiles","volume":"33","author":"Panwar","year":"2017","journal-title":"Bioinformatics."},{"issue":"46","key":"10.1016\/j.yjmcc.2020.04.014_bb0105","doi-asserted-by":"crossref","first-page":"27911","DOI":"10.18632\/oncotarget.25575","article-title":"Next generation sequencing identifies miRNA-based biomarker panel for lupus nephritis","volume":"9","author":"Su","year":"2018","journal-title":"Oncotarget."},{"key":"10.1016\/j.yjmcc.2020.04.014_bb0110","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fgene.2013.00150","article-title":"The detection of microRNA associated with Alzheimer\u2019s disease in biological fluids using next-generation sequencing technologies","volume":"4","author":"Cheng","year":"2013","journal-title":"Front. Genet."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.04.014_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057800","article-title":"A deep sequencing approach to uncover the miRNOME in the human heart","volume":"8","author":"Leptidis","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.yjmcc.2020.04.014_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034394","article-title":"Discovery of novel microRNAs in rat kidney using next generation sequencing and microarray validation","volume":"7","author":"Meng","year":"2012","journal-title":"PLoS One"},{"issue":"30","key":"10.1016\/j.yjmcc.2020.04.014_bb0125","doi-asserted-by":"crossref","first-page":"49191","DOI":"10.18632\/oncotarget.16788","article-title":"Next-generation sequencing reveals microRNA markers of adrenocortical tumors malignancy","volume":"8","author":"Koperski","year":"2017","journal-title":"Oncotarget."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.04.014_bb0130","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/labinvest.2013.157","article-title":"Robust global microRNA expression profiling using next-generation sequencing technologies","volume":"94","author":"Tam","year":"2014","journal-title":"Lab. Investig."},{"key":"10.1016\/j.yjmcc.2020.04.014_bb0135","series-title":"MicroRNAs in Cardiovascular Disease: From Pathogenesis to Treatment","first-page":"231","author":"Barb","year":"2015"},{"issue":"5","key":"10.1016\/j.yjmcc.2020.04.014_bb0140","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1261\/rna.1947110","article-title":"Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression","volume":"16","author":"Git","year":"2010","journal-title":"RNA."},{"key":"10.1016\/j.yjmcc.2020.04.014_bb0145","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13148-016-0287-1","article-title":"cPAS-based sequencing on the BGISEQ-500 to explore small non-coding RNAs","volume":"8","author":"Fehlmann","year":"2016","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.yjmcc.2020.04.014_bb0150","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12867-016-0057-9","article-title":"What is normal? Next generation sequencing-driven analysis of the human circulating miRNAOme","volume":"17","author":"Tonge","year":"2016","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.yjmcc.2020.04.014_bb0155","doi-asserted-by":"crossref","first-page":"11106","DOI":"10.1038\/ncomms11106","article-title":"Diverse human extracellular RNAs are widely detected in human plasma","volume":"7","author":"Freedman","year":"2016","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.yjmcc.2020.04.014_bb0160","first-page":"1133","article-title":"Evaluation of methodologies for microRNA biomarker detection by next generation sequencing","volume":"15","author":"Coenen-Stass","year":"2018","journal-title":"RNA Biol."},{"issue":"5","key":"10.1016\/j.yjmcc.2020.04.014_bb0165","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1261\/rna.036863.112","article-title":"Identification of extracellular miRNA in human cerebrospinal fluid by next-generation sequencing","volume":"19","author":"Burgos","year":"2013","journal-title":"RNA."},{"issue":"4","key":"10.1016\/j.yjmcc.2020.04.014_bb0170","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1021\/acs.analchem.5b03376","article-title":"Bias in high-throughput analysis of miRNAs and implications for biomarker studies","volume":"88","author":"Backes","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.yjmcc.2020.04.014_bb0175","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/1471-2164-14-319","article-title":"Characterization of human plasma-derived exosomal RNAs by deep sequencing","volume":"14","author":"Huang","year":"2013","journal-title":"BMC Genomics"},{"issue":"22","key":"10.1016\/j.yjmcc.2020.04.014_bb0180","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1093\/eurheartj\/ehq167","article-title":"Circulating microRNAs are new and sensitive biomarkers of myocardial infarction","volume":"31","author":"D\u2019Alessandra","year":"2010","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.yjmcc.2020.04.014_bb0185","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1161\/CIRCGENETICS.110.958975","article-title":"Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage","volume":"4","author":"Kuwabara","year":"2011","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.yjmcc.2020.04.014_bb0190","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2261-13-12","article-title":"Circulating cardio-enriched microRNAs are associated with long-term prognosis following myocardial infarction","volume":"13","author":"Gidlof","year":"2013","journal-title":"BMC Cardiovasc. Disord."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.04.014_bb0195","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/CIRCGENETICS.110.957415","article-title":"Circulating MicroRNA-208b and MicroRNA-499 reflect myocardial damage in cardiovascular disease","volume":"3","author":"Corsten","year":"2010","journal-title":"Circ. Cardiovasc. Genet."},{"issue":"24","key":"10.1016\/j.yjmcc.2020.04.014_bb0200","doi-asserted-by":"crossref","first-page":"12104","DOI":"10.1021\/acs.analchem.5b02850","article-title":"Double-stranded ligation assay for the rapid multiplex quantification of MicroRNAs","volume":"87","author":"Hofmann","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.yjmcc.2020.04.014_bb0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.21105\/joss.00747","article-title":"NN-SVG: publication-ready neural network architecture schematics","volume":"4","author":"LeNail","year":"2019","journal-title":"J. Open Source Software."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820300973?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820300973?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:34:30Z","timestamp":1758314070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282820300973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":41,"alternative-id":["S0022282820300973"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.04.014","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"microRNA neural networks improve diagnosis of acute coronary syndrome (ACS)","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}