{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:09:47Z","timestamp":1760425787465,"version":"3.44.0"},"reference-count":145,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100008522","name":"University of Illinois at Chicago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008522","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.yjmcc.2020.05.010","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T02:20:06Z","timestamp":1589854806000},"page":"145-158","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Implications of the complex biology and micro-environment of cardiac sarcomeres in the use of high affinity troponin antibodies as serum biomarkers for cardiac disorders"],"prefix":"10.1016","volume":"143","author":[{"given":"Christopher R.","family":"Solaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. John","family":"Solaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2020.05.010_bb0005","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/271031a0","article-title":"Comparison of amino acid sequence of troponin I from different striated muscles","volume":"271","author":"Wilkinson","year":"1978","journal-title":"Nature."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0010","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/0002-8703(87)90645-4","article-title":"Cardiac-specific troponin-I radioimmunoassay in the diagnosis of acute myocardial infarction","volume":"113","author":"Cummins","year":"1987","journal-title":"Am. Heart J."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0015","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/0022-2828(89)90680-9","article-title":"Enzyme linked immuno assay of cardiac troponin T for the detection of acute myocardial infarction in patients","volume":"21","author":"Katus","year":"1989","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0020","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1093\/clinchem\/38.11.2203","article-title":"Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected cases of myocardial infarction","volume":"38","author":"Bodor","year":"1992","journal-title":"Clin. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0025","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/262615a0","article-title":"Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart","volume":"262","author":"Solaro","year":"1976","journal-title":"Nature."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0030","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/CIRCRESAHA.112.268672","article-title":"Integration of troponin I phosphorylation with cardiac regulatory networks","volume":"112","author":"Solaro","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0035","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1161\/01.RES.0000111522.02730.56","article-title":"Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes","volume":"94","author":"Ke","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0040","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41467-019-14008-1","article-title":"Cardiac muscle thin filament structures reveal calcium regulatory mechanism","volume":"11","author":"Yamada","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0045","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.120.047008","article-title":"High-sensitivity cardiac troponin can be an ally in the fight against COVID-19","author":"Chapman","year":"2020","journal-title":"Circulation."},{"year":"2020","series-title":"Association of Cardiac Injury with Mortality in Hospitalized Patients with COVID-19 in Wuhan","author":"Shi","key":"10.1016\/j.yjmcc.2020.05.010_bb0050"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0055","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/01.RES.0000116143.74830.A9","article-title":"At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function","volume":"94","author":"Pyle","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0060","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/1535370219868960","article-title":"Cardiac microtubules in health and heart disease","volume":"244","author":"Caporizzo","year":"2019","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0065","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1242\/jeb.124941","article-title":"The sarcomeric cytoskeleton: from molecules to motion","volume":"219","author":"Gautel","year":"2016","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0070","doi-asserted-by":"crossref","first-page":"849","DOI":"10.2310\/JIM.0b013e3181c5e074","article-title":"Vinculin and Talin: focus on the myocardium","volume":"57","author":"Zemljic-Harpf","year":"2009","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0075","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/CIRCRESAHA.114.301275","article-title":"Integrins and integrin-associated proteins in the cardiac myocyte","volume":"114","author":"Israeli-Rosenberg","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0080","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00246-019-02167-3","article-title":"Talin and Kindlin as Integrin-Activating Proteins: Focus on the Heart","volume":"40","author":"Chen","year":"2019","journal-title":"Pediatr. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0085","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1161\/CIRCGENETICS.109.862128","article-title":"Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy","volume":"2","author":"Ho","year":"2009","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0090","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1161\/01.CIR.103.16.2035","article-title":"Preload induces troponin I degradation independently of myocardial ischemia","volume":"103","author":"Feng","year":"2001","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0095","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev.physiol.67.040403.114025","article-title":"Calcium, thin filaments, and the integrative biology of cardiac contractility","volume":"67","author":"Kobayashi","year":"2005","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0100","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcm.2012.10.005","article-title":"Tuning the molecular giant titin through phosphorylation: role in health and disease","volume":"23","author":"Hidalgo","year":"2013","journal-title":"Trends Cardiovas. Med."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.abb.2011.02.013","article-title":"The significance of regulatory light chain phosphorylation in cardiac physiology","volume":"510","author":"Scruggs","year":"2011","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0110","doi-asserted-by":"crossref","first-page":"E1355","DOI":"10.1073\/pnas.1614020114","article-title":"Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments","volume":"114","author":"Kensler","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0115","first-page":"73","article-title":"A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation","volume":"22","author":"Hinken","year":"2007","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.str.2018.08.007","article-title":"N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament","volume":"26","author":"Risi","year":"2018","journal-title":"Structure"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0125","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/S0021-9258(19)70073-8","article-title":"Turnover of cardiac troponin subunits. Kinetic evidence for a precursor pool of troponin-I","volume":"256","author":"Martin","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0130","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1093\/clinchem\/44.9.1912","article-title":"Different intracellular compartmentations of cardiac troponins and myosin heavy chains: a causal connection to their different early release after myocardial damage","volume":"44","author":"Bleier","year":"1998","journal-title":"Clin. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0135","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.me.42.020191.001301","article-title":"The cell biology of acute myocardial ischemia","volume":"42","author":"Jennings","year":"1991","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0140","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0022-2828(95)90086-1","article-title":"Intracellular compartmentation of troponin T: release kinetics after global ischemia and calcium paradox in the isolated perfused rat heart","volume":"27","author":"Remppis","year":"1995","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0145","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.jacbts.2016.04.001","article-title":"Intracoronary Poloxamer 188 prevents reperfusion injury in a porcine model of ST-segment elevation myocardial infarction","volume":"1","author":"Bartos","year":"2016","journal-title":"JACC Basic Transl Sci."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0150","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jacbts.2019.01.009","article-title":"Cardiac muscle membrane stabilization in myocardial reperfusion injury","volume":"4","author":"Houang","year":"2019","journal-title":"JACC Basic Transl Sci."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0155","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1056\/NEJMoa0900428","article-title":"Early diagnosis of myocardial infarction with sensitive cardiac troponin assays","volume":"361","author":"Reichlin","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0160","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1056\/NEJMoa1803377","article-title":"Application of high-sensitivity troponin in suspected myocardial infarction","volume":"380","author":"Neumann","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0165","doi-asserted-by":"crossref","first-page":"e618","DOI":"10.1161\/CIR.0000000000000617","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"138","author":"Thygesen","year":"2018","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0170","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1016\/j.annemergmed.2018.07.045","article-title":"Clinical policy: critical issues in the evaluation and Management of Emergency Department Patients with Suspected non-ST-elevation acute coronary syndromes","volume":"72","author":"Tomaszewski","year":"2018","journal-title":"Ann. Emerg. Med."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0175","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/CRD.0000000000000275","article-title":"Using high sensitivity troponins to rule out acute coronary syndrome and lower admission rates","volume":"27","author":"Potomac","year":"2019","journal-title":"Cardiol. Rev."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0180","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1161\/01.RES.0000173849.68636.1e","article-title":"Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia","volume":"97","author":"Urboniene","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0185","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1161\/01.RES.69.5.1409","article-title":"Troponin I isoform expression in human heart","volume":"69","author":"Hunkeler","year":"1991","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0190","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1515\/cclm-2018-1211","article-title":"High sensitivity, contemporary and point-of-care cardiac troponin assays: educational aids developed by the IFCC committee on clinical application of cardiac bio-markers","volume":"57","author":"Collinson","year":"2019","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0195","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1053\/j.semtcvs.2018.08.010","article-title":"Postoperative serum troponin trends in infants undergoing cardiac surgery","volume":"31","author":"Su","year":"2019","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0200","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1038\/s41372-018-0192-x","article-title":"High-sensitivity troponin T in preterm infants with a hemodynamically significant patent ductus arteriosus","volume":"38","author":"Asrani","year":"2018","journal-title":"J Perinatol: Official Journal of the California Perinatal Association"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0205","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1373\/clinchem.2017.286211","article-title":"Full-size cardiac troponin I and its Proteolytic fragments in blood of patients with acute myocardial infarction: antibody selection for assay development","volume":"64","author":"Katrukha","year":"2018","journal-title":"Clin. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0210","doi-asserted-by":"crossref","first-page":"C397","DOI":"10.1152\/ajpcell.00358.2014","article-title":"NH2-terminal truncations of cardiac troponin I and cardiac troponin T produce distinct effects on contractility and calcium homeostasis in adult cardiomyocytes","volume":"308","author":"Wei","year":"2015","journal-title":"Am J Physiol Cell Physiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0215","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbrc.2016.10.149","article-title":"Cardiac troponin T degradation in serum is catalysed by human thrombin","volume":"481","author":"Streng","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0220","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1073\/pnas.092022999","article-title":"Functional consequences of caspase activation in cardiac myocytes","volume":"99","author":"Communal","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0225","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1161\/01.CIR.102.11.1221","article-title":"Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction","volume":"102","author":"Labugger","year":"2000","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0230","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.clinbiochem.2019.06.012","article-title":"Cardiac troponin I is present in plasma of type 1 myocardial infarction patients and patients with troponin I elevations due to other etiologies as complex with little free I","volume":"73","author":"van Wijk","year":"2019","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0235","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1093\/clinchem\/44.12.2433","article-title":"Degradation of cardiac troponin I: implication for reliable immunodetection","volume":"44","author":"Katrukha","year":"1998","journal-title":"Clin. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0240","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/acel.12453","article-title":"Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice","volume":"15","author":"Zhang","year":"2016","journal-title":"Aging Cell"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0245","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1373\/clinchem.2016.261511","article-title":"Identification and characterization of cardiac troponin T fragments in serum of patients suffering from acute myocardial infarction","volume":"63","author":"Streng","year":"2017","journal-title":"Clin. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0250","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1007\/s00216-018-0960-7","article-title":"Quantification of cardiac troponin I in human plasma by immunoaffinity enrichment and targeted mass spectrometry","volume":"410","author":"Schneck","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0255","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1080\/14789450.2017.1387054","article-title":"The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform","volume":"14","author":"Soetkamp","year":"2017","journal-title":"Expert Rev Proteomics."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0260","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cca.2009.12.009","article-title":"Cardiac troponin may be released by ischemia alone, without necrosis","volume":"411","author":"Hickman","year":"2010","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0265","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1373\/clinchem.2009.133546","article-title":"Circulating immunoreactive cardiac troponin forms determined by gel filtration chromatography after acute myocardial infarction","volume":"56","author":"Bates","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0270","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.stem.2015.04.020","article-title":"Epigenetic regulation of Phosphodiesterases 2A and 3A underlies compromised beta-adrenergic Signaling in an iPSC model of dilated cardiomyopathy","volume":"17","author":"Wu","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0275","first-page":"327","article-title":"Cytoskeletal injury and subsarcolemmal bleb formation in dog heart during in vitro total ischemia","volume":"133","author":"Sage","year":"1988","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0280","first-page":"477","article-title":"Myocyte swelling and plasmalemmal integrity during early experimental myocardial ischemia in vivo","volume":"2","author":"Sage","year":"1988","journal-title":"Scanning Microsc."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0285","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.RES.57.6.864","article-title":"Volume regulation and plasma membrane injury in aerobic, anaerobic, and ischemic myocardium in vitro. Effects of osmotic cell swelling on plasma membrane integrity","volume":"57","author":"Steenbergen","year":"1985","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0290","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1006\/jmcc.2001.1380","article-title":"Ischemic loss of sarcolemmal dystrophin and spectrin: correlation with myocardial injury","volume":"33","author":"Armstrong","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0295","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1161\/01.RES.82.2.261","article-title":"Breakdown and release of myofilament proteins during ischemia and ischemia\/reperfusion in rat hearts: identification of degradation products and effects on the pCa-force relation","volume":"82","author":"Van Eyk","year":"1998","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0300","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11010-011-1172-z","article-title":"Myocardial infarction in mice alters sarcomeric function via post-translational protein modification","volume":"363","author":"Avner","year":"2012","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0305","doi-asserted-by":"crossref","first-page":"32170","DOI":"10.1074\/jbc.M111.248088","article-title":"Calpain protects the heart from hemodynamic stress","volume":"286","author":"Taneike","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0310","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/FJC.0b013e3181d9f5d4","article-title":"Lack of beta3 integrin signaling contributes to calpain-mediated myocardial cell loss in pressure-overloaded myocardium","volume":"55","author":"Suryakumar","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0315","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jacbts.2017.03.008","article-title":"Troponin release following brief myocardial ischemia: apoptosis versus necrosis","volume":"2","author":"Amgalan","year":"2017","journal-title":"JACC Basic Transl Sci."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0320","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1152\/physrev.00022.2018","article-title":"Fundamental mechanisms of regulated cell death and implications for heart disease","volume":"99","author":"Del Re","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0325","doi-asserted-by":"crossref","first-page":"E6250","DOI":"10.1073\/pnas.1701416114","article-title":"Loss of mouse cardiomyocyte Talin-1 and Talin-2 leads to beta-1 integrin reduction, costameric instability, and dilated cardiomyopathy","volume":"114","author":"Manso","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0330","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1172\/JCI64216","article-title":"Integrins protect cardiomyocytes from ischemia\/reperfusion injury","volume":"123","author":"Okada","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0335","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s00424-007-0354-8","article-title":"Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation","volume":"455","author":"Hessel","year":"2008","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0340","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1159\/000324013","article-title":"Integrin stimulation favors uptake of macromolecules by cardiomyocytes in vitro","volume":"26","author":"Swildens","year":"2010","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0345","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1083\/jcb.201609037","article-title":"Integrin-mediated mechanotransduction","volume":"215","author":"Sun","year":"2016","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0350","doi-asserted-by":"crossref","first-page":"H510","DOI":"10.1152\/ajpheart.00517.2009","article-title":"Proliferating cardiac microtubules","volume":"297","author":"Cooper","year":"2009","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0355","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1073\/pnas.1323842111","article-title":"Microtubule binding distinguishes dystrophin from utrophin","volume":"111","author":"Belanto","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0360","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1083\/jcb.139.4.963","article-title":"Microtubule stabilization in pressure overload cardiac hypertrophy","volume":"139","author":"Sato","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0365","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.yjmcc.2016.02.012","article-title":"Oxidative stress decreases microtubule growth and stability in ventricular myocytes","volume":"93","author":"Drum","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0370","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.jacc.2019.01.061","article-title":"Moving beyond the sarcomere to explain heterogeneity in hypertrophic cardiomyopathy: JACC review topic of the week","volume":"73","author":"Maron","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0375","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1161\/01.RES.85.1.47","article-title":"Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction","volume":"85","author":"Muthuchamy","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0380","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00424-019-02269-0","article-title":"Moving beyond simple answers to complex disorders in sarcomeric cardiomyopathies: the role of integrated systems","volume":"471","author":"Deranek","year":"2019","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0385","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1002\/1873-3468.13496","article-title":"Energetic drain driving hypertrophic cardiomyopathy","volume":"593","author":"Sequeira","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0390","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1161\/CIRCULATIONAHA.116.024482","article-title":"Long-term biased beta-Arrestin Signaling improves cardiac structure and function in dilated cardiomyopathy","volume":"135","author":"Ryba","year":"2017","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0395","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00424-018-2224-y","article-title":"Coronary arterial vasculature in the pathophysiology of hypertrophic cardiomyopathy","volume":"471","author":"Marszalek","year":"2019","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0400","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/heart.89.6.659","article-title":"Measurements of cardiac troponin T in patients with hypertrophic cardiomyopathy","volume":"89","author":"Sato","year":"2003","journal-title":"Heart."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0405","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.amjcard.2013.12.033","article-title":"Relation of highly sensitive cardiac troponin T in hypertrophic cardiomyopathy to left ventricular mass and cardiovascular risk","volume":"113","author":"Cramer","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0410","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1111\/echo.13645","article-title":"Relationship of cardiac troponin to systolic global longitudinal strain in hypertrophic cardiomyopathy","volume":"34","author":"Agarwal","year":"2017","journal-title":"Echocardiography."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0415","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1136\/heartjnl-2015-308576","article-title":"Global longitudinal strain is associated with heart failure outcomes in hypertrophic cardiomyopathy","volume":"102","author":"Reant","year":"2016","journal-title":"Heart."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0420","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s11596-014-1329-6","article-title":"Age-related changes in familial hypertrophic cardiomyopathy phenotype in transgenic mice and humans","volume":"34","author":"Luo","year":"2014","journal-title":"J Huazhong Univ Sci Technolog Med Sci."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0425","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.jacc.2010.11.066","article-title":"Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study","volume":"57","author":"Turer","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0430","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1373\/clinchem.2012.187682","article-title":"Cardiac biomarker responses to dobutamine stress echocardiography in healthy volunteers and patients with coronary artery disease","volume":"58","author":"Siriwardena","year":"2012","journal-title":"Clin. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0435","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tvjl.2017.08.001","article-title":"Right ventricular function during pharmacological and exercise stress testing in horses","volume":"227","author":"Decloedt","year":"2017","journal-title":"Vet. J."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0440","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1517\/13543780902922660","article-title":"Current drugs and medical treatment algorithms in the management of acute decompensated heart failure","volume":"18","author":"Triposkiadis","year":"2009","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0445","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1016\/S0140-6736(16)32049-9","article-title":"Chronic Oral study of myosin activation to increase contractility in heart failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial","volume":"388","author":"Teerlink","year":"2016","journal-title":"Lancet."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0450","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/CIRCULATIONAHA.114.013748","article-title":"Angiotensin receptor neprilysin inhibition compared with enalapril on the risk of clinical progression in surviving patients with heart failure","volume":"131","author":"Packer","year":"2015","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1536\/ihj.19-231","article-title":"The impact of Sacrubitril\/valsartan on clinical treatment and hs-cTnT and NT-ProBNP serum levels and the left ventricular function in patients with chronic heart failure","volume":"61","author":"Gao","year":"2020","journal-title":"Int. Heart J."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0460","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jchf.2019.12.001","article-title":"Omecamtiv Mecarbil in chronic heart failure with reduced ejection fraction: rationale and design of GALACTIC-HF","volume":"8","author":"Teerlink","year":"2020","journal-title":"JACC Heart Fail."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0465","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1001\/jama.2010.1768","article-title":"Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population","volume":"304","author":"de Lemos","year":"2010","journal-title":"Jama."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0470","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1161\/CIRCULATIONAHA.118.038529","article-title":"Cardiac troponin T and troponin I in the general population","volume":"139","author":"Welsh","year":"2019","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0475","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1161\/CIRCULATIONAHA.118.038772","article-title":"High-sensitivity troponin I and incident coronary events, stroke, heart failure hospitalization, and mortality in the ARIC study","volume":"139","author":"Jia","year":"2019","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0480","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1002\/jnr.21558","article-title":"Bradykinin increases blood-tumor barrier permeability by down-regulating the expression levels of ZO-1, occludin, and claudin-5 and rearranging actin cytoskeleton","volume":"86","author":"Liu","year":"2008","journal-title":"J. Neurosci. Res."},{"year":"1993","series-title":"ANO5 Muscle Disease","author":"Penttila","key":"10.1016\/j.yjmcc.2020.05.010_bb0485"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0490","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1091\/mbc.e16-06-0455","article-title":"Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes","volume":"28","author":"Loveless","year":"2017","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0495","doi-asserted-by":"crossref","first-page":"17542","DOI":"10.1074\/jbc.272.28.17542","article-title":"ArgBP2, a multiple Src homology 3 domain-containing, Arg\/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks","volume":"272","author":"Wang","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0500","doi-asserted-by":"crossref","first-page":"H936","DOI":"10.1152\/ajpheart.00519.2004","article-title":"Integrin mechanotransduction stimulates caveolin-1 phosphorylation and recruitment of Csk to mediate actin reorganization","volume":"288","author":"Radel","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0505","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1373\/clinchem.2018.292086","article-title":"Comparison between high-sensitivity cardiac troponin T and cardiac troponin I in a large general population cohort","volume":"64","author":"Welsh","year":"2018","journal-title":"Clin. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0510","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1161\/CIRCULATIONAHA.119.041627","article-title":"Exercise-induced cardiac troponin I increase and incident mortality and cardiovascular events","volume":"140","author":"Aengevaeren","year":"2019","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0515","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1161\/CIRCULATIONAHA.119.042131","article-title":"Cardiac troponin increase after endurance exercise","volume":"140","author":"Omland","year":"2019","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0520","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1161\/CIRCULATIONAHA.116.025711","article-title":"Fire simulation and cardiovascular health in firefighters","volume":"135","author":"Hunter","year":"2017","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0525","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-069X-2-14","article-title":"Firefighters and on-duty deaths from coronary heart disease: a case control study","volume":"2","author":"Kales","year":"2003","journal-title":"Environ. Health"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0530","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11886-019-1147-3","article-title":"The Cardiorenal Axis: myocardial perfusion, metabolism, and innervation","volume":"21","author":"Shirani","year":"2019","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0535","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.advms.2018.08.016","article-title":"Cardiac troponins in chronic kidney disease patients with special emphasis on their importance in acute coronary syndrome","volume":"64","author":"Szczykowska","year":"2019","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0540","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1001\/jamacardio.2017.0363","article-title":"Coronary artery calcification and risk of cardiovascular disease and death among patients with chronic kidney disease","volume":"2","author":"Chen","year":"2017","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0545","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1161\/01.HYP.0000102971.85504.7c","article-title":"Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention","volume":"42","author":"Sarnak","year":"2003","journal-title":"Hypertension (Dallas, Tex\u202f: 1979)"},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0550","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1161\/CIRCULATIONAHA.117.030320","article-title":"High-sensitivity cardiac troponin and the risk stratification of patients with renal impairment presenting with suspected acute coronary syndrome","volume":"137","author":"Miller-Hodges","year":"2018","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0555","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1161\/CIRCULATIONAHA.117.029986","article-title":"Origin of cardiac troponin T elevations in chronic kidney disease","volume":"136","author":"van der Linden","year":"2017","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0560","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1373\/clinchem.2016.257485","article-title":"Diurnal rhythm of cardiac troponin: consequences for the diagnosis of acute myocardial infarction","volume":"62","author":"Klinkenberg","year":"2016","journal-title":"Clin. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0565","doi-asserted-by":"crossref","first-page":"H891","DOI":"10.1152\/ajpheart.00259.2019","article-title":"Guidelines for evaluating myocardial cell death","volume":"317","author":"Mishra","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0570","first-page":"100366","article-title":"PTEN gene & TNF-alpha in acute myocardial infarction","volume":"23","author":"Mahmoud","year":"2019","journal-title":"Int J Cardiol Heart Vasc."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0575","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/eurheartj\/eht367","article-title":"Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis","volume":"35","author":"Kaptoge","year":"2014","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0580","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.yjmcc.2016.12.007","article-title":"CaMKII is a nodal signal for multiple programmed cell death pathways in heart","volume":"103","author":"Feng","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0585","doi-asserted-by":"crossref","first-page":"9291","DOI":"10.1038\/s41598-019-45743-6","article-title":"Myocardial death and dysfunction after ischemia-reperfusion injury require CaMKIIdelta oxidation","volume":"9","author":"Wu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0590","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10557-007-6035-1","article-title":"Necrostatin: a potentially novel cardioprotective agent?","volume":"21","author":"Smith","year":"2007","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0595","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1161\/CIRCULATIONAHA.116.026240","article-title":"Cardioprotective role of tumor necrosis factor receptor-associated factor 2 by suppressing apoptosis and Necroptosis","volume":"136","author":"Guo","year":"2017","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0600","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11010-017-3188-5","article-title":"Necroptosis may be a novel mechanism for cardiomyocyte death in acute myocarditis","volume":"442","author":"Zhou","year":"2018","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0605","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jacbts.2017.01.006","article-title":"Brief myocardial ischemia produces cardiac troponin I release and focal Myocyte apoptosis in the absence of pathological infarction in swine","volume":"2","author":"Weil","year":"2017","journal-title":"JACC Basic Transl Sci."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0610","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/CIRCRESAHA.117.312482","article-title":"Network analysis to risk stratify patients with exercise intolerance","volume":"122","author":"Oldham","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0615","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/CIRCRESAHA.117.310782","article-title":"Emerging role of precision medicine in cardiovascular disease","volume":"122","author":"Leopold","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0620","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1016\/j.jacc.2019.08.1057","article-title":"Distinct subgroups in hypertrophic cardiomyopathy in the NHLBI HCM registry","volume":"74","author":"Neubauer","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0625","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.jacc.2013.03.055","article-title":"Significance of high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy","volume":"62","author":"Kubo","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0630","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1253\/circj.CJ-10-0782","article-title":"Combined measurements of cardiac troponin I and brain natriuretic peptide are useful for predicting adverse outcomes in hypertrophic cardiomyopathy","volume":"75","author":"Kubo","year":"2011","journal-title":"Circ. J."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0635","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1536\/ihj.14-335","article-title":"Clinical significance of high-sensitivity cardiac troponin T in patients with dilated cardiomyopathy","volume":"56","author":"Baba","year":"2015","journal-title":"Int. Heart J."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0640","doi-asserted-by":"crossref","first-page":"H1140","DOI":"10.1152\/ajpheart.00521.2015","article-title":"Dilated cardiomyopathy mutations in delta-sarcoglycan exert a dominant-negative effect on cardiac myocyte mechanical stability","volume":"310","author":"Campbell","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0645","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI30848","article-title":"Dysferlin-mediated membrane repair protects the heart from stress-induced left ventricular injury","volume":"117","author":"Han","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0650","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ceb.2007.07.001","article-title":"Dysferlin and muscle membrane repair","volume":"19","author":"Han","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0655","first-page":"375","article-title":"A patient with limb girdle muscular dystrophy type 2B (LGMD2B) manifesting cardiomyopathy","volume":"44","author":"Kuru","year":"2004","journal-title":"Clin. Neurol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0660","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1113\/JP271225","article-title":"Dysferlin deficiency blunts beta-adrenergic-dependent lusitropic function of mouse heart","volume":"593","author":"Wei","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0665","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10974-013-9356-7","article-title":"Nuclear tropomyosin and troponin in striated muscle: new roles in a new locale?","volume":"34","author":"Chase","year":"2013","journal-title":"J. Muscle Res. Cell Motil."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0670","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.exger.2018.03.012","article-title":"Troponin T3 associates with DNA consensus sequence that overlaps with p53 binding motifs","volume":"108","author":"Nunez Lopez","year":"2018","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0675","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2013.07.004","article-title":"Posttranslational modifications of cardiac troponin T: an overview","volume":"63","author":"Streng","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0680","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/prca.201400034","article-title":"Targeted proteomics of myofilament phosphorylation and other protein posttranslational modifications","volume":"8","author":"Ramirez-Correa","year":"2014","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0685","doi-asserted-by":"crossref","first-page":"35135","DOI":"10.1074\/jbc.M306325200","article-title":"Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T","volume":"278","author":"Sumandea","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0690","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1152\/physrev.00040.2017","article-title":"Cardiac disorders and pathophysiology of Sarcomeric proteins","volume":"99","author":"van der Velden","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0695","doi-asserted-by":"crossref","first-page":"16084","DOI":"10.1038\/s41598-018-33886-x","article-title":"Cardiac troponins may be irreversibly modified by glycation: novel potential mechanisms of cardiac performance modulation","volume":"8","author":"Janssens","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0700","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1161\/CIRCULATIONAHA.112.096388","article-title":"Multiple reaction monitoring to identify site-specific troponin I phosphorylated residues in the failing human heart","volume":"126","author":"Zhang","year":"2012","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0705","doi-asserted-by":"crossref","first-page":"e1647","DOI":"10.1212\/WNL.0000000000008081","article-title":"High-precision plasma \u03b2-amyloid 42\/40 predicts current and future brain amyloidosis","volume":"93","author":"Schindler","year":"2019","journal-title":"Neurology."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0710","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1016\/j.bios.2011.05.019","article-title":"Functionalized SnO(2) nanobelt field-effect transistor sensors for label-free detection of cardiac troponin","volume":"26","author":"Cheng","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0715","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1915922","article-title":"Initial invasive or conservative strategy for stable coronary disease","volume":"382","author":"Maron","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0720","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12872-019-1152-x","article-title":"Prognostic implications of statin intolerance in stable coronary artery disease patients with different levels of high-sensitive troponin","volume":"19","author":"Hai","year":"2019","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.yjmcc.2020.05.010_bb0725","doi-asserted-by":"crossref","first-page":"17167","DOI":"10.1038\/s41598-019-53603-6","article-title":"PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820301929?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820301929?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:30:47Z","timestamp":1758313847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282820301929"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":145,"alternative-id":["S0022282820301929"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.05.010","relation":{},"ISSN":["0022-2828"],"issn-type":[{"type":"print","value":"0022-2828"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implications of the complex biology and micro-environment of cardiac sarcomeres in the use of high affinity troponin antibodies as serum biomarkers for cardiac disorders","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}