{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:55:11Z","timestamp":1791910511757,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.yjmcc.2020.05.016","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T02:28:15Z","timestamp":1590460095000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"special_numbering":"C","title":["Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages"],"prefix":"10.1016","volume":"145","author":[{"given":"Qin","family":"Fei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenmei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sipin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huali","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangkai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2020.05.016_bb0005","first-page":"305","article-title":"Systemic inflammatory response following acute myocardial infarction","volume":"12","author":"Fang","year":"2015","journal-title":"J. Geriatr. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0010","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.12659\/MSM.910930","article-title":"Metformin increases cardiac rupture after myocardial infarction via the AMPK-MTOR\/PGC-1alpha signaling pathway in rats with acute myocardial infarction","volume":"24","author":"Hua","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0015","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/imcb.1019","article-title":"Beta-catenin promotes macrophage-mediated acute inflammatory response after myocardial infarction","volume":"96","author":"Huang","year":"2018","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0020","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0025","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0030","doi-asserted-by":"crossref","first-page":"10555","DOI":"10.1038\/ncomms10555","article-title":"Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1beta secretion in response to ATP","volume":"7","author":"Karmakar","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0035","doi-asserted-by":"crossref","first-page":"2183026","DOI":"10.1155\/2016\/2183026","article-title":"ROS-mediated NLRP3 inflammasome activation in brain, heart, kidney, and testis ischemia\/reperfusion injury","volume":"2016","author":"Minutoli","year":"2016","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0040","first-page":"4235","article-title":"Muscone improves cardiac function in mice after myocardial infarction by alleviating cardiac macrophage-mediated chronic inflammation through inhibition of NF-kappaB and NLRP3 inflammasome","volume":"10","author":"Du","year":"2018","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0045","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature09204","article-title":"Network organization of the human autophagy system","volume":"466","author":"Behrends","year":"2010","journal-title":"Nature."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1159\/000480367","article-title":"Autophagy inhibition contributes to ROS-producing NLRP3-dependent Inflammasome activation and cytokine secretion in high glucose-induced macrophages","volume":"43","author":"Dai","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0055","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.yexcr.2016.01.014","article-title":"The role of resveratrol-induced mitophagy\/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS","volume":"341","author":"Wu","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0060","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12933-019-0860-y","article-title":"Metformin in patients with and without diabetes: A paradigm shift in cardiovascular disease management","volume":"18","author":"Luo","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0065","doi-asserted-by":"crossref","first-page":"7045","DOI":"10.1002\/jcp.26505","article-title":"Metformin attenuates folic-acid induced renal fibrosis in mice","volume":"233","author":"Yi","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0070","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1136\/bmj.38415.708634.F7","article-title":"Metformin and reduced risk of cancer in diabetic patients","volume":"330","author":"Evans","year":"2005","journal-title":"BMJ."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0075","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4049\/jimmunol.1800006","article-title":"Metformin augments anti-inflammatory and chondroprotective properties of mesenchymal stem cells in experimental osteoarthritis","volume":"203","author":"Park","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0080","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ajog.2013.05.001","article-title":"Maternal metformin treatment decreases fetal inflammation in a rat model of obesity and metabolic syndrome","volume":"209","author":"Desai","year":"2013","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0085","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12933-019-0900-7","article-title":"Effect of metformin on all-cause and cardiovascular mortality in patients with coronary artery diseases: A systematic review and an updated meta-analysis","volume":"18","author":"Han","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0090","doi-asserted-by":"crossref","first-page":"107511","DOI":"10.1016\/j.jdiacomp.2019.107511","article-title":"Recurrent cardiovascular events in patients with newly diagnosed acute coronary syndrome: Influence of diabetes and its management with medication","volume":"34","author":"Komaru","year":"2020","journal-title":"J. Diab. Complicat"},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0095","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10059-013-0169-8","article-title":"Metabolic roles of AMPK and metformin in cancer cells","volume":"36","author":"Choi","year":"2013","journal-title":"Mol Cells."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0100","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1161\/CIRCRESAHA.108.190918","article-title":"Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure","volume":"104","author":"Gundewar","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0105","doi-asserted-by":"crossref","first-page":"696","DOI":"10.2337\/db07-1098","article-title":"Acute metformin therapy confers cardioprotection against myocardial infarction via AMPK-eNOS-mediated signaling","volume":"57","author":"Calvert","year":"2008","journal-title":"Diabetes."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0110","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.7150\/ijbs.29680","article-title":"Metformin inhibits the NLRP3 Inflammasome via AMPK\/mTOR-dependent effects in diabetic cardiomyopathy","volume":"15","author":"Yang","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0115","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tem.2017.10.009","article-title":"AMP-activated protein kinase regulation of the NLRP3 inflammasome during aging","volume":"29","author":"Cordero","year":"2018","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0120","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41420-020-0245-8","article-title":"Metformin inhibits IL-1beta secretion via impairment of NLRP3 inflammasome in keratinocytes: Implications for preventing the development of psoriasis","volume":"6","author":"Tsuji","year":"2020","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0125","doi-asserted-by":"crossref","first-page":"e183664","DOI":"10.1371\/journal.pone.0183664","article-title":"A systematic review and meta-analysis of the protective effects of metformin in experimental myocardial infarction","volume":"12","author":"Hesen","year":"2017","journal-title":"PLos One"},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0130","doi-asserted-by":"crossref","first-page":"e2314","DOI":"10.1161\/JAHA.115.002314","article-title":"Metformin and myocardial injury in patients with diabetes and ST-segment elevation myocardial infarction: A propensity score matched analysis","volume":"4","author":"Basnet","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0135","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1111\/jcmm.13552","article-title":"Nucleolin mediated pro-angiogenic role of Hydroxysafflor Yellow A in ischaemic cardiac dysfunction: Post-transcriptional regulation of VEGF-A and MMP-9","volume":"22","author":"Zou","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0140","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mce.2009.03.001","article-title":"Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes","volume":"307","author":"Wang","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0145","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.pharmthera.2018.01.001","article-title":"Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities","volume":"186","author":"Ong","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0150","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: Molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0155","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrcardio.2017.161","article-title":"The NLRP3 inflammasome in acute myocardial infarction","volume":"15","author":"Toldo","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0160","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbadis.2018.08.017","article-title":"Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy","volume":"1865","author":"Ren","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0165","doi-asserted-by":"crossref","first-page":"e13050","DOI":"10.1111\/acel.13050","article-title":"NLRP3 inflammasome suppression improves longevity and prevents cardiac aging in male mice","volume":"19","author":"Marin-Aguilar","year":"2020","journal-title":"Aging Cell"},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0170","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/eji.200940168","article-title":"Signaling by ROS drives inflammasome activation","volume":"40","author":"Martinon","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0175","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s10571-015-0166-x","article-title":"ROS and autophagy: Interactions and molecular regulatory mechanisms","volume":"35","author":"Li","year":"2015","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0180","first-page":"224","article-title":"Release of mitochondrial DNA correlates with peak inflammatory cytokines in patients with acute myocardial infarction","volume":"17","author":"Qin","year":"2017","journal-title":"Anatol. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0185","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mvr.2015.11.005","article-title":"Ischemia triggered ATP release through Pannexin-1 channel by myocardial cells activates sympathetic fibers","volume":"104","author":"Dong","year":"2016","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0190","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12933-019-0972-4","article-title":"Metformin use and cardiovascular outcomes after acute myocardial infarction in patients with type 2 diabetes: A cohort study","volume":"18","author":"Bromage","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0195","doi-asserted-by":"crossref","first-page":"e2975","DOI":"10.1002\/dmrr.2975","article-title":"Is metformin poised for a second career as an antimicrobial?","volume":"34","author":"Malik","year":"2018","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0200","doi-asserted-by":"crossref","DOI":"10.1002\/JLB.3MA0320-358RR","article-title":"Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS","author":"Liu","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0205","doi-asserted-by":"crossref","first-page":"101583","DOI":"10.1016\/j.mcp.2020.101583","article-title":"Insulin-like growth factor-I activates NFkappaB and NLRP3 inflammatory signalling via ROS in cancer cells","author":"Wang","year":"2020","journal-title":"Mol. Cell Probes"},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0210","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/s41418-018-0086-7","article-title":"Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2alpha-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy","volume":"25","author":"Zhou","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0215","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/j.bbadis.2019.05.007","article-title":"Mitophagy and mitochondrial integrity in cardiac ischemia-reperfusion injury","volume":"1865","author":"Yang","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0220","doi-asserted-by":"crossref","first-page":"605","DOI":"10.5582\/bst.2018.01263","article-title":"Protective effects of metformin against osteoarthritis through upregulation of SIRT3-mediated PINK1\/Parkin-dependent mitophagy in primary chondrocytes","volume":"12","author":"Wang","year":"2019","journal-title":"Biosci. Trends."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0225","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jss.2014.05.005","article-title":"Metformin mitigates apoptosis in ischemic myocardium","volume":"192","author":"Elmadhun","year":"2014","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0230","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s12933-016-0344-2","article-title":"Metformin improves the angiogenic potential of human CD34(+) cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction","volume":"15","author":"Bakhashab","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0235","doi-asserted-by":"crossref","first-page":"3","DOI":"10.15171\/bi.2015.02","article-title":"Metformin attenuates myocardial remodeling and neutrophil recruitment after myocardial infarction in rat","volume":"5","author":"Soraya","year":"2015","journal-title":"Bioimpacts."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0240","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/CIRCRESAHA.113.300987","article-title":"Historical perspective on the pathology of myocardial ischemia\/reperfusion injury","volume":"113","author":"Jennings","year":"2013","journal-title":"Circ. Res."},{"issue":"Suppl. 1","key":"10.1016\/j.yjmcc.2020.05.016_bb0245","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.amjcard.2019.10.028","article-title":"Potential mechanisms of sodium-glucose co-transporter 2 inhibitor-related cardiovascular benefits","volume":"124","author":"Verma","year":"2019","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0250","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1038\/s41467-020-15983-6","article-title":"SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with cardiovascular disease","volume":"11","author":"Kim","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0255","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.tips.2018.10.005","article-title":"Targeting autophagy in aging and aging-related cardiovascular diseases","volume":"39","author":"Ren","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.yjmcc.2020.05.016_bb0260","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/j.1474-9726.2010.00586.x","article-title":"AMP-activated protein kinase deficiency exacerbates aging-induced myocardial contractile dysfunction","volume":"9","author":"Turdi","year":"2010","journal-title":"Aging Cell"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228282030198X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002228282030198X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:29:50Z","timestamp":1758313790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002228282030198X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":52,"alternative-id":["S002228282030198X"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.05.016","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.05.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}