{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:32:49Z","timestamp":1772890369470,"version":"3.50.1"},"reference-count":10,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["90663"],"award-info":[{"award-number":["90663"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BBS\/E\/B\/000C0400-403"],"award-info":[{"award-number":["BBS\/E\/B\/000C0400-403"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007491","name":"Zentrum f\u00fcr Regenerative Therapien Dresden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["107715\/Z\/15\/Z"],"award-info":[{"award-number":["107715\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003043","name":"EMBO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.yjmcc.2020.08.009","type":"journal-article","created":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T21:46:24Z","timestamp":1597700784000},"page":"88-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes"],"prefix":"10.1016","volume":"147","author":[{"given":"Emma L.","family":"Robinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanar","family":"Alkass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet J.","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. Llewelyn","family":"Roderick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony P.","family":"Davenport","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2020.08.009_bb0005","article-title":"Preventing a covid-19 pandemic: ACE inhibitors as a potential risk factor for fatal Covid-19","volume":"368","author":"Sommerstein","year":"2020","journal-title":"BMJ."},{"key":"10.1016\/j.yjmcc.2020.08.009_bb0010","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1161\/CIRCULATIONAHA.120.047549","article-title":"The science underlying COVID-19: implications for the cardiovascular system","volume":"142","author":"Liu","year":"2020","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2020.08.009_bb0015","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell."},{"key":"10.1016\/j.yjmcc.2020.08.009_bb0020","first-page":"1","article-title":"A rational roadmap for SARS-CoV-2\/COVID-19 pharmacotherapeutic research and development. IUPHAR review 29","author":"Alexander","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2020.08.009_bb0025","doi-asserted-by":"crossref","unstructured":"Hikmet F, M\u00e9ar L, Edvinsson A, Micke P, Uhl\u00e9n M, Lindskog C. The protein expression profile of ACE2 in human tissues bioRxiv 2020.03.31.016048; Doi: doi:https:\/\/doi.org\/10.1101\/2020.03.31.016048.","DOI":"10.1101\/2020.03.31.016048"},{"key":"10.1016\/j.yjmcc.2020.08.009_bb0030","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.120.047911","article-title":"Myocyte specific upregulation of ACE2 in cardiovascular disease: implications for SARS-CoV-2 mediated myocarditis","author":"Tucker","year":"2020","journal-title":"Circ."},{"key":"10.1016\/j.yjmcc.2020.08.009_bb0035","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1161\/CIRCRESAHA.116.310509","article-title":"Clinical relevance and role of neuronal AT1 receptors in ADAM17-mediated ACE2 shedding in neurogenic hypertension","volume":"121","author":"Xu","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.08.009_bb0040","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1126\/science.abb2762","article-title":"Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2","volume":"367","author":"Yan","year":"2020","journal-title":"Science."},{"key":"10.1016\/j.yjmcc.2020.08.009_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102568","article-title":"Tocilizumab for the treatment of severe COVID-19 pneumonia with hyperinflammatory syndrome and acute respiratory failure: a single center study of 100 patients in Brescia, Italy","volume":"19","author":"Toniati","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.yjmcc.2020.08.009_bb0050","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1172\/JCI88353","article-title":"The H3K9 dimethyltransferases EHMT1\/2 protect against pathological cardiac hypertrophy","volume":"127","author":"Thienpont","year":"2017","journal-title":"J. Clin. Invest."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820302571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820302571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T05:59:40Z","timestamp":1762667980000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282820302571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":10,"alternative-id":["S0022282820302571"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.08.009","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.07.07.191429","asserted-by":"object"}]},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}