{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T10:16:45Z","timestamp":1758363405190,"version":"3.44.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.yjmcc.2020.08.012","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T11:10:15Z","timestamp":1598872215000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The CnB1 p.D102A variant is linked to dilated cardiomyopathy via impaired Calcineurin activity"],"prefix":"10.1016","volume":"148","author":[{"given":"M.D.","family":"Jinqiang Zhuang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Ruijun Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Yizeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Congliang Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Dandan Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Anli Na","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Xinying Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.D.","family":"Hui Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2020.08.012_bb0005","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1161\/CIRCULATIONAHA.119.040037","article-title":"Dilated cardiomyopathy","volume":"139","author":"Knowlton","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0010","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.118.005418","article-title":"Metformin enhances autophagy and provides cardioprotection in delta-sarcoglycan deficiency-induced dilated cardiomyopathy","volume":"12","author":"Kanamori","year":"2019","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI62862","article-title":"Genetic mutations and mechanisms in dilated cardiomyopathy","volume":"123","author":"McNally","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0020","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/humu.21603","article-title":"Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes","volume":"32","author":"Arimura","year":"2011","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0025","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0092-8674(00)81878-4","article-title":"MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure","volume":"88","author":"Arber","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0030","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0092-8674(02)01226-6","article-title":"The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy","volume":"111","author":"Knoll","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0035","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1161\/CIRCRESAHA.107.165985","article-title":"PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling","volume":"102","author":"Jeong","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0040","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.yjmcc.2009.10.012","article-title":"Calcineurin protects the heart in a murine model of dilated cardiomyopathy","volume":"48","author":"Heineke","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.yjmcc.2016.12.006","article-title":"Calcineurin signaling in the heart: the importance of time and place","volume":"103","author":"Parra","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0050","doi-asserted-by":"crossref","first-page":"6270","DOI":"10.1073\/pnas.76.12.6270","article-title":"Calcineurin: a calcium- and calmodulin-binding protein of the nervous system","volume":"76","author":"Klee","year":"1979","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0055","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.bbrc.2008.12.094","article-title":"Calcineurin regulates phosphorylation status of transcription factor osterix","volume":"379","author":"Okamura","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0060","doi-asserted-by":"crossref","first-page":"91","DOI":"10.5115\/acb.2014.47.2.91","article-title":"FK506 reduces calpain-regulated calcineurin activity in both the cytoplasm and the nucleus","volume":"47","author":"Lee","year":"2014","journal-title":"Anat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0065","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/S0008-6363(01)00493-X","article-title":"Calcineurin and hypertrophic heart disease: novel insights and remaining questions","volume":"53","author":"Bueno","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0070","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1161\/01.CIR.0000017141.01845.FA","article-title":"Calcineurin signaling in human cardiac hypertrophy","volume":"105","author":"Williams","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0075","unstructured":"H.Y. Wu, K. Tomizawa, H. Matsui, Calpain-calcineurin signaling in the pathogenesis of calcium-dependent disorder, Acta Med. Okayama 61 (2007) 123\u2013137. doi:10.18926\/AMO\/32905."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0080","doi-asserted-by":"crossref","first-page":"6716","DOI":"10.1074\/jbc.M109.056143","article-title":"Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function","volume":"285","author":"Maillet","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0085","doi-asserted-by":"crossref","DOI":"10.1161\/01.CIR.101.25.e239","article-title":"Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy","volume":"101","author":"Pulkki","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0090","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1023\/B:NERE.0000042218.27842.79","article-title":"In vitro proteolytic degradation of bovine brain calcineurin by m-calpain","volume":"29","author":"Lakshmikuttyamma","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0095","unstructured":"Kingsbury et al."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0100","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1534\/genetics.118.300911","article-title":"Calcineurin regulatory subunit calcium-binding domains differentially contribute to calcineurin signaling in saccharomyces cerevisiae","volume":"209","author":"Connolly","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0105","article-title":"Protein purification-free method of binding affinity determination by microscale thermophoresis","volume":"50541","author":"Khavrutskii","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0110","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ebiom.2019.09.043","article-title":"Genetic determinants of responsiveness to mesenchymal stem cell injections in non-ischemic dilated cardiomyopathy","volume":"48","author":"Rieger","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0115","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/01.CIR.0000078641.19365.4C","article-title":"Differentiation of heart failure related to dilated cardiomyopathy and coronary artery disease using gadolinium-enhanced cardiovascular magnetic resonance","volume":"108","author":"McCrohon","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0120","unstructured":"Y. Zhao, H. Zhang, X.S. Xia, Application of next-generation semiconductor sequencing technologies in genetic diagnosis of inherited cardiomyopathies, Yi Chuan 37 (2015) 635\u2013644. doi:10.16288\/j.yczz.14-326."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0125","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jacbts.2019.08.005","article-title":"DNA damage prediction tool in dilated cardiomyopathy: don't go breaking my heart","volume":"4","author":"Jimenez","year":"2019","journal-title":"JACC Basic Transl. Sci."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0130","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/eurheartj\/ehq507","article-title":"Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy","volume":"32","author":"Sibbing","year":"2011","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0135","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1136\/hrt.2003.023390","article-title":"Multiple pathogenetic mechanisms in X linked dilated cardiomyopathy","volume":"90","author":"Cohen","year":"2004","journal-title":"Heart"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0140","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1161\/01.CIR.87.6.1854","article-title":"X-linked dilated cardiomyopathy. Molecular genetic evidence of linkage to the Duchenne muscular dystrophy (dystrophin) gene at the Xp21 locus","volume":"87","author":"Towbin","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0145","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/j.1939-1676.2012.00987.x","article-title":"Screening for dilated cardiomyopathy in great Danes in the United Kingdom","volume":"26","author":"Stephenson","year":"2012","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0150","doi-asserted-by":"crossref","first-page":"639250","DOI":"10.1155\/2012\/639250","article-title":"The mutations associated with dilated cardiomyopathy","volume":"2012","author":"Parvari","year":"2012","journal-title":"Biochem. Res. Int."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0155","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1089\/gtmb.2011.0214","article-title":"Identification of novel mutations in LMNA associated with familial forms of dilated cardiomyopathy","volume":"16","author":"Stallmeyer","year":"2012","journal-title":"Genet. Test. Mol. Biomarkers"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0160","doi-asserted-by":"crossref","unstructured":"N. Norton, P.D. Robertson, M.J. Rieder, S. Zuchner, E. Rampersaud, E. Martin, D. Li, NHLBI GO Exome Sequencing Project, D.A. Nickerson, R.E. Hershberger, Evaluating pathogenicity of rare variants from dilated cardiomyopathy in the exome era, Circ. Cardiovasc. Genet. 5 (2012) 167\u2013174. doi:https:\/\/doi.org\/10.1161\/CIRCGENETICS.111.961805.","DOI":"10.1161\/CIRCGENETICS.111.961805"},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0165","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1161\/01.RES.0000077045.84609.9F","article-title":"NFATc3 and NFATc4 are required for cardiac development and mitochondrial function","volume":"92","author":"Bushdid","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0170","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1083\/jcb.200301058","article-title":"Requirement of transcription factor NFAT in developing atrial myocardium","volume":"161","author":"Schubert","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2003.10.008","article-title":"Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development","volume":"266","author":"Schulz","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0180","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.yjmcc.2012.01.013","article-title":"The secondary heart field is a new site of calcineurin\/Nfatc1 signaling for semilunar valve development","volume":"52","author":"Lin","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.08.012_bb0185","unstructured":"S. Gachet, J. Ghysdael, Calcineurin\/NFAT signaling in lymphoid malignancies, Gen. Physiol. Biophys. 28 Spec No Focus (2009) F47\u2013F54."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820302704?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820302704?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:31:33Z","timestamp":1758313893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282820302704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":37,"alternative-id":["S0022282820302704"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.08.012","relation":{},"ISSN":["0022-2828"],"issn-type":[{"type":"print","value":"0022-2828"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The CnB1 p.D102A variant is linked to dilated cardiomyopathy via impaired Calcineurin activity","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}