{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,22]],"date-time":"2026-02-22T10:51:34Z","timestamp":1771757494556,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670044"],"award-info":[{"award-number":["81670044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.yjmcc.2020.09.008","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T22:12:56Z","timestamp":1600726376000},"page":"31-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway"],"prefix":"10.1016","volume":"151","author":[{"given":"Xuejun","family":"Hui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shangzhi","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peipei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2020.09.008_bb0005","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"7","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.12659\/MSMBR.900437","article-title":"Cardiac hypertrophy: an introduction to molecular and cellular basis","author":"Samak","year":"2016","journal-title":"Med. Sci. Monit. Basic Res."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0015","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0020","article-title":"The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling","volume":"11267","author":"Ji","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0025","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.yjmcc.2016.08.018","article-title":"Regulation of cardiac hypertrophy and remodeling through the dual-specificity MAPK phosphatases (DUSPs)","author":"Liu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0030","first-page":"H552","article-title":"Differential cardiac hypertrophy and signaling pathways in pressure versus volume overload","volume":"3","author":"You","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0035","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1161\/CIRCRESAHA.113.300536","article-title":"Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging","volume":"2","author":"Pillai","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0040","article-title":"Cardiac fibroblast p38 MAPK: a critical regulator of myocardial remodeling","volume":"3","author":"Turner","year":"2019","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0045","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00535-013-0931-x","article-title":"TAK1 regulates hepatic cell survival and carcinogenesis","volume":"2","author":"Roh","year":"2014","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0050","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/cdd.2014.123","article-title":"TAK1 control of cell death","volume":"11","author":"Mihaly","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0055","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ncb1823","article-title":"Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point","volume":"2","author":"Liu","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0060","article-title":"TAK1 regulates myocardial response to pathological stress via NFAT, NFkappaB, and Bnip3 pathways","volume":"16626","author":"Li","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0065","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4155\/fmc.14.138","article-title":"TAK1 selective inhibition: state of the art and future opportunities","volume":"1","author":"Kilty","year":"2015","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0070","first-page":"795","article-title":"Tomoregulin-1 prevents cardiac hypertrophy after pressure overload in mice by inhibiting TAK1-JNK pathways","volume":"8","author":"Bao","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00395-016-0536-7","article-title":"Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK\/-JNK1\/2 signaling pathway","volume":"2","author":"Li","year":"2016","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0080","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1161\/HYPERTENSIONAHA.116.07392","article-title":"Ubiquitin-specific protease 4 is an endogenous negative regulator of pathological cardiac hypertrophy","volume":"6","author":"He","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0085","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1113\/JP273129","article-title":"Non-coding RNAs in cardiac hypertrophy","volume":"12","author":"Ottaviani","year":"2017","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0090","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1101\/gad.1255304","article-title":"Systematic analysis and nomenclature of mammalian F-box proteins","volume":"21","author":"Jin","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0095","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.bbrc.2013.10.123","article-title":"Ubiquitin E3 ligase SCF(beta-TRCP) regulates TRIB2 stability in liver cancer cells","volume":"3","author":"Qiao","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0100","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1172\/JCI200422220","article-title":"Atrogin-1\/muscle atrophy F-box inhibits calcineurin-dependent cardiac hypertrophy by participating in an SCF ubiquitin ligase complex","volume":"8","author":"Li","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0105","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/ncb2282","article-title":"The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication","volume":"8","author":"Puklowski","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0110","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1159\/000329967","article-title":"Stability of F-box protein atrogin-1 is regulated by p38 mitogen-activated protein kinase pathway in cardiac H9c2 cells","volume":"5","author":"Li","year":"2011","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0115","article-title":"FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy","volume":"2","author":"Al-Yacoub","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0120","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.bbrc.2009.02.052","article-title":"An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1\u03b2 signaling pathway","volume":"3","author":"Minoda","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0125","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ncb2661","article-title":"SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression","volume":"2","author":"Werner","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0130","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.12643","article-title":"Tnfaip8l1\/Oxi-beta binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson\u2019s disease model","author":"Ha","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0135","doi-asserted-by":"crossref","first-page":"e42253","DOI":"10.7554\/eLife.42253","article-title":"The ULK1-FBXW5-SEC23B nexus controls autophagy","volume":"7","author":"Jeong","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0140","doi-asserted-by":"crossref","first-page":"16868","DOI":"10.1073\/pnas.1306358110","article-title":"CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth","volume":"42","author":"Kim","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0145","article-title":"Production of knockout mice by DNA microinjection of various CRISPR\/Cas9 vectors into freeze-thawed fertilized oocytes","volume":"33","author":"Nakagawa","year":"2015","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0150","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/cr.2013.46","article-title":"Generation of gene-modified mice via Cas9\/RNA-mediated gene targeting","volume":"5","author":"Shen","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0155","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.yjmcc.2019.01.027","article-title":"The protective effect of high mobility group protein HMGA2 in pressure overload-induced cardiac remodeling","author":"Wu","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0160","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1111\/bph.14164","article-title":"Aucubin protects against pressure overload-induced cardiac remodelling via the beta3 -adrenoceptor-neuronal NOS cascades","volume":"9","author":"Wu","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0165","article-title":"Suppressor of IKKvarepsilon is an essential negative regulator of pathological cardiac hypertrophy","volume":"11432","author":"Deng","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0170","article-title":"Carboxyl-terminal modulator protein ameliorates pathological cardiac hypertrophy by suppressing the protein kinase B signaling pathway","volume":"13","author":"Liu","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0175","article-title":"Hepatocyte TRAF3 promotes liver steatosis and systemic insulin resistance through targeting TAK1-dependent signalling","volume":"10592","author":"Wang","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0180","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1161\/HYPERTENSIONAHA.113.02653","article-title":"Interferon regulatory factor 7 functions as a novel negative regulator of pathological cardiac hypertrophy","volume":"4","author":"Jiang","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0185","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1002\/hep.30537","article-title":"F-box\/WD repeat-containing protein 5 mediates the ubiquitination of apoptosis signal-regulating kinase 1 and exacerbates nonalcoholic steatohepatitis in mice","volume":"6","author":"Bai","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0190","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/hep.29616","article-title":"Hepatocyte DUSP14 maintains metabolic homeostasis and suppresses inflammation in the liver","volume":"4","author":"Wang","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0195","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nm.4453","article-title":"The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis","volume":"1","author":"Zhang","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0200","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10495-018-1498-z","article-title":"NG25, a novel inhibitor of TAK1, suppresses KRAS-mutant colorectal cancer growth in vitro and in vivo","volume":"1\u20132","author":"Ma","year":"2019","journal-title":"Apoptosis"},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0205","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1161\/HYPERTENSIONAHA.116.07562","article-title":"Novel protective role for ubiquitin-specific protease 18 in pathological cardiac remodeling","volume":"5","author":"Ying","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0210","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1161\/HYPERTENSIONAHA.116.08728","article-title":"Control of pathological cardiac hypertrophy by transcriptional corepressor IRF2BP2 (interferon regulatory factor-2 binding protein 2)","volume":"3","author":"Fang","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0215","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jfda.2018.08.002","article-title":"Ubiquitin-protein ligase E3a (UBE3A) as a new biomarker of cardiac hypertrophy in cell models","volume":"1","author":"Cheng","year":"2019","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0220","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1152\/physrev.00054.2009","article-title":"Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale","volume":"4","author":"Rose","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0225","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/gt.2017.97","article-title":"AAV-9 mediated phosphatase-1 inhibitor-1 overexpression improves cardiac contractility in unchallenged mice but is deleterious in pressure-overload","volume":"1","author":"Schwab","year":"2018","journal-title":"Gene Ther."},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0230","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1126\/science.1072682","article-title":"Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases","volume":"5600","author":"Johnson","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0235","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.devcel.2009.01.021","article-title":"A new G-initiated MAPK signaling pathway in the heart","volume":"2","author":"Gutkind","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.yjmcc.2020.09.008_bb0240","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.biocel.2009.12.023","article-title":"The TAK1-TRAF6 signalling pathway","volume":"5","author":"Landstr\u00f6m","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820302881?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820302881?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:31:59Z","timestamp":1758313919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282820302881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":48,"alternative-id":["S0022282820302881"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.09.008","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.09.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}