{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:51:45Z","timestamp":1790358705806,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T00:00:00Z","timestamp":1636329600000},"content-version":"am","delay-in-days":311,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-16-ECVD-0007-01"],"award-info":[{"award-number":["ANR-16-ECVD-0007-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-33"],"award-info":[{"award-number":["ANR-10-LABX-33"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["PDE4HEART"],"award-info":[{"award-number":["PDE4HEART"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-IDEX-0003-01"],"award-info":[{"award-number":["ANR-11-IDEX-0003-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.yjmcc.2020.10.011","type":"journal-article","created":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T02:25:09Z","timestamp":1603592709000},"page":"109-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Selective changes in cytosolic \u03b2-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy"],"prefix":"10.1016","volume":"150","author":[{"given":"Aniella","family":"Abi-Gerges","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Leroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Domergue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolphe","family":"Fischmeister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Vandecasteele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2020.10.011_bb0005","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.physiol.70.113006.100455","article-title":"Calcium cycling and signaling in cardiac myocytes","volume":"70","author":"Bers","year":"2008","journal-title":"Annu. Rev. Physiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.10.011_bb0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10557-007-6014-6","article-title":"Myocardial phosphodiesterases and regulation of cardiac contractility in health and cardiac disease","volume":"21","author":"Osadchii","year":"2007","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.10.011_bb0015","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1161\/01.RES.0000134629.84732.11","article-title":"Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases","volume":"95","author":"Mongillo","year":"2004","journal-title":"Circ. Res."},{"issue":"36","key":"10.1016\/j.yjmcc.2020.10.011_bb0020","doi-asserted-by":"crossref","first-page":"37215","DOI":"10.1074\/jbc.C400302200","article-title":"Novel single chain cAMP sensors for receptor-induced signal propagation","volume":"279","author":"Nikolaev","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.yjmcc.2020.10.011_bb0025","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/CIRCRESAHA.107.167817","article-title":"Spatiotemporal dynamics of \u03b2-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases","volume":"102","author":"Leroy","year":"2008","journal-title":"Circ. Res."},{"issue":"7","key":"10.1016\/j.yjmcc.2020.10.011_bb0030","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1172\/JCI44747","article-title":"Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice","volume":"121","author":"Leroy","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/CIRCRESAHA.111.300003","article-title":"PDE3A regulates basal myocardial contractility through interacting with SERCA2a-signaling complexes in mouse heart","volume":"112","author":"Beca","year":"2013","journal-title":"Circ. Res."},{"issue":"9","key":"10.1016\/j.yjmcc.2020.10.011_bb0040","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/CIRCRESAHA.111.250464","article-title":"Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current","volume":"109","author":"Beca","year":"2011","journal-title":"Circ. Res."},{"issue":"11","key":"10.1016\/j.yjmcc.2020.10.011_bb0045","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1074\/jbc.M115.638585","article-title":"Regulation of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA2) activity by phosphodiesterase 3A (PDE3A) in human myocardium: phosphorylation-dependent interaction of PDE3A1 with SERCA2","volume":"290","author":"Ahmad","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.10.011_bb0050","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cell.2005.07.030","article-title":"Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias","volume":"123","author":"Lehnart","year":"2005","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.yjmcc.2020.10.011_bb0055","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1161\/01.RES.0000102042.83024.CA","article-title":"What is the role of \u03b2-adrenergic signaling in heart failure?","volume":"93","author":"Lohse","year":"2003","journal-title":"Circ. Res."},{"issue":"5973","key":"10.1016\/j.yjmcc.2020.10.011_bb0060","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.1185988","article-title":"\u03b22-adrenergic receptor redistribution in heart failure changes cAMP compartmentation","volume":"327","author":"Nikolaev","year":"2010","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.yjmcc.2020.10.011_bb0065","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1161\/01.CIR.96.9.3116","article-title":"Development of decompensated dilated cardiomyopathy is associated with decreased gene expression and activity of the milrinone-sensitive cAMP phosphodiesterase PDE3A","volume":"96","author":"Smith","year":"1997","journal-title":"Circulation"},{"issue":"5 Pt 2","key":"10.1016\/j.yjmcc.2020.10.011_bb0070","first-page":"H1699","article-title":"Mechanisms of desensitization to a PDE inhibitor (milrinone) in conscious dogs with heart failure","volume":"276","author":"Sato","year":"1999","journal-title":"Am. J. Phys."},{"issue":"19","key":"10.1016\/j.yjmcc.2020.10.011_bb0075","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1161\/01.CIR.0000165128.39715.87","article-title":"Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure","volume":"111","author":"Ding","year":"2005","journal-title":"Circulation"},{"issue":"41","key":"10.1016\/j.yjmcc.2020.10.011_bb0080","doi-asserted-by":"crossref","first-page":"14771","DOI":"10.1073\/pnas.0506489102","article-title":"A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis","volume":"102","author":"Ding","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.10.011_bb0085","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00395-010-0138-8","article-title":"Conserved expression and functions of PDE4 in rodent and human heart","volume":"106","author":"Richter","year":"2011","journal-title":"Basic Res. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.10.011_bb0090","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1172\/JCI115272","article-title":"Sarcoplasmic reticulum-associated cyclic adenosine 5\u2032-monophosphate phosphodiesterase activity in normal and failing human hearts","volume":"88","author":"Movsesian","year":"1991","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.10.011_bb0095","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF00167387","article-title":"Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations","volume":"344","author":"von der Leyen","year":"1991","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"9","key":"10.1016\/j.yjmcc.2020.10.011_bb0100","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1093\/cvr\/28.9.1360","article-title":"Milrinone, a cyclic AMP-phosphodiesterase inhibitor, has differential effects on regional myocardial work and oxygen consumption in experimental left ventricular hypertrophy","volume":"28","author":"Chiu","year":"1994","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.10.011_bb0105","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s003800200032","article-title":"Enhanced activities and gene expression of phosphodiesterase types 3 and 4 in pressure-induced congestive heart failure","volume":"16","author":"Takahashi","year":"2002","journal-title":"Heart Vessel."},{"issue":"12","key":"10.1016\/j.yjmcc.2020.10.011_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014227","article-title":"Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II","volume":"5","author":"Mokni","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0115","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.yjmcc.2019.05.025","article-title":"Synergic PDE3 and PDE4 control intracellular cAMP and cardiac excitation-contraction coupling in a porcine model","volume":"133","author":"Mika","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"10","key":"10.1016\/j.yjmcc.2020.10.011_bb0120","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.jacc.2018.12.053","article-title":"A PDE3A promoter polymorphism regulates cAMP-induced transcriptional activity in failing human myocardium","volume":"73","author":"Sucharov","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0125","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1161\/CIRCULATIONAHA.112.114074","article-title":"PI3Kgamma protects against catecholamine-induced ventricular arrhythmia through PKA-mediated regulation of distinct Phosphodiesterases","volume":"126","author":"Ghigo","year":"2012","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2020.10.011_bb0130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1093\/cvr\/cvw027","article-title":"Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+ waves induced by cAMP-phosphodiesterase inhibitors","volume":"110","author":"Bobin","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0135","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1038\/ncomms7965","article-title":"In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease","volume":"6","author":"Sprenger","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0140","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1161\/CIRCRESAHA.116.306082","article-title":"Microdomain switch of cGMP-regulated Phosphodiesterases leads to ANP-induced augmentation of \u03b2-adrenoceptor-stimulated contractility in early cardiac hypertrophy","volume":"116","author":"Perera","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0145","doi-asserted-by":"crossref","unstructured":"Z. Bastug-Ozel, P.T. Wright, A.E. Kraft, D. Pavlovic, J. Howie, A. Froese, et al., Heart failure leads to altered \u03b22-adrenoceptor\/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman\/Na,K ATPase microdomain, Cardiovasc. Res. 115(3) (2019) 546\u2013555.","DOI":"10.1093\/cvr\/cvy221"},{"issue":"8","key":"10.1016\/j.yjmcc.2020.10.011_bb0150","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1161\/CIRCRESAHA.109.197947","article-title":"Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on \u03b2-adrenergic cAMP signals","volume":"105","author":"Abi-Gerges","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0155","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1517\/13543784.4.11.1081","article-title":"Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiovascular diseases","volume":"4","author":"Stoclet","year":"1995","journal-title":"Exp Op Invest Drugs"},{"issue":"2","key":"10.1016\/j.yjmcc.2020.10.011_bb0160","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/sj.bjp.0701376","article-title":"Cyclic AMP-mediated regulation of vascular smooth muscle cell cyclic AMP phosphodiesterase activity","volume":"122","author":"Rose","year":"1997","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.10.011_bb0165","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1085\/jgp.118.1.63","article-title":"In vivo assessment of local phosphodiesterase activity using tailored cyclic nucleotide-gated channels as cAMP sensors","volume":"118","author":"Rich","year":"2001","journal-title":"J. Gen. Physiol."},{"issue":"10","key":"10.1016\/j.yjmcc.2020.10.011_bb0170","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1161\/01.RES.0000250046.69918.d5","article-title":"Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching \u03b21-adrenergic but locally confined \u03b22-adrenergic receptor-mediated signaling","volume":"99","author":"Nikolaev","year":"2006","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.10.011_bb0175","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/cvr\/cvq308","article-title":"Molecular mechanisms that control interstitial fibrosis in the pressure-overloaded heart","volume":"89","author":"Creemers","year":"2011","journal-title":"Cardiovasc. Res."},{"issue":"Pt 1","key":"10.1016\/j.yjmcc.2020.10.011_bb0180","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1469-7793.2001.0079m.x","article-title":"Simultaneous measurements of intracellular cAMP and L-type Ca2+ current in single frog ventricular myocytes","volume":"530","author":"Goaillard","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0185","doi-asserted-by":"crossref","unstructured":"B. Chevalier, P. Mansier, F. Callens-el Amrani, B. Swynghedauw, \u03b2-adrenergic system is modified in compensatory pressure cardiac overload in rats: physiological and biochemical evidence, J. Cardiovasc. Pharmacol. 13(3) (1989) 412\u201320.","DOI":"10.1097\/00005344-198903000-00009"},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0190","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.yjmcc.2019.04.020","article-title":"cAMP\/PKA signaling compartmentalization in cardiomyocytes: lessons from FRET-based biosensors","volume":"131","author":"Ghigo","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.10.011_bb0195","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.pharmthera.2009.02.009","article-title":"Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics","volume":"122","author":"Tsai","year":"2009","journal-title":"Pharmacol. Ther."},{"issue":"23","key":"10.1016\/j.yjmcc.2020.10.011_bb0200","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1111\/bph.12853","article-title":"Alteration of vascular reactivity in heart failure: role of phosphodiesterases 3 and 4","volume":"171","author":"Hubert","year":"2014","journal-title":"Br. J. Pharmacol."},{"issue":"45","key":"10.1016\/j.yjmcc.2020.10.011_bb0205","doi-asserted-by":"crossref","first-page":"E7116","DOI":"10.1073\/pnas.1607728113","article-title":"PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction","volume":"113","author":"Knight","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"18","key":"10.1016\/j.yjmcc.2020.10.011_bb0210","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1161\/CIRCULATIONAHA.117.030490","article-title":"Acute enhancement of cardiac function by phosphodiesterase type 1 inhibition","volume":"138","author":"Hashimoto","year":"2018","journal-title":"Circulation"},{"issue":"17","key":"10.1016\/j.yjmcc.2020.10.011_bb0215","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.jacc.2013.05.057","article-title":"Phosphodiesterase-2 is up-regulated in human failing hearts and blunts \u03b2-adrenergic responses in cardiomyocytes","volume":"62","author":"Mehel","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.10.011_bb1000","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1161\/CIRCULATIONAHA.119.042178","article-title":"A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction","volume":"141","author":"Chen","year":"2020","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2020.10.011_bb0220","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.yjmcc.2010.03.016","article-title":"Phosphodiesterase 8A (PDE8A) regulates excitation-contraction coupling in ventricular myocytes","volume":"49","author":"Patrucco","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.10.011_bb0225","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1073\/pnas.93.1.295","article-title":"cAMP compartmentation is responsible for a local activation of cardiac Ca2+ channels by beta-adrenergic agonists","volume":"93","author":"Jurevicius","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.yjmcc.2020.10.011_bb0230","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/CIRCRESAHA.112.300370","article-title":"Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes","volume":"112","author":"Timofeyev","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0235","doi-asserted-by":"crossref","unstructured":"F. Scamps, E. Mayoux, D. Charlemagne, G. Vassort, Calcium current in single cells isolated from normal and hypertrophied rat heart. Effects of \u03b2-adrenergic stimulation, Circ. Res. 67(1) (1990) 199\u2013208.","DOI":"10.1161\/01.RES.67.1.199"},{"issue":"10","key":"10.1016\/j.yjmcc.2020.10.011_bb0240","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1006\/jmcc.1998.0755","article-title":"L-type calcium channel abundance and function with cardiac hypertrophy and failure: a review","volume":"30","author":"Mukherjee","year":"1998","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.10.011_bb0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0050021","article-title":"Intermolecular failure of L-type Ca2+ channel and ryanodine receptor signaling in hypertrophy","volume":"5","author":"Xu","year":"2007","journal-title":"PLoS Biol."},{"issue":"10","key":"10.1016\/j.yjmcc.2020.10.011_bb0250","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/01.CIR.98.10.969","article-title":"Increased availability and open probability of single L-type calcium channels from failing compared with nonfailing human ventricle","volume":"98","author":"Schroder","year":"1998","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.yjmcc.2020.10.011_bb0255","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1161\/CIRCRESAHA.116.308698","article-title":"Microdomain-specific modulation of L-type calcium channels leads to triggered ventricular arrhythmia in heart failure","volume":"119","author":"Sanchez-Alonso","year":"2016","journal-title":"Circ. Res."},{"issue":"6 Pt 1","key":"10.1016\/j.yjmcc.2020.10.011_bb0260","first-page":"C1464","article-title":"Calcium currents in postinfarction rat cardiac myocytes","volume":"269","author":"Zhang","year":"1995","journal-title":"Am. J. Phys."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.10.011_bb0265","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0008-6363(00)00256-X","article-title":"Reduction in density of transverse tubules and L-type Ca2+ channels in canine tachycardia-induced heart failure","volume":"49","author":"He","year":"2001","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0270","doi-asserted-by":"crossref","unstructured":"X. Chen, V.r. Piacentino, S. Furukawa, B. Goldman, K.B. Margulies, S.R. Houser, L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices, Circ. Res. 91(6) (2002) 517\u201324.","DOI":"10.1161\/01.RES.0000033988.13062.7C"},{"issue":"4","key":"10.1016\/j.yjmcc.2020.10.011_bb0275","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/01.CIR.99.4.505","article-title":"Protein kinase a (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy","volume":"99","author":"Zakhary","year":"1999","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2020.10.011_bb0280","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.abb.2013.08.002","article-title":"Human heart failure is accompanied by altered protein kinase a subunit expression and post-translational state","volume":"538","author":"Han","year":"2013","journal-title":"Arch. Biochem. Biophys."},{"issue":"12","key":"10.1016\/j.yjmcc.2020.10.011_bb0285","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1161\/01.CIR.101.12.1459","article-title":"Regulation of PKA binding to AKAPs in the heart: alterations in human heart failure","volume":"101","author":"Zakhary","year":"2000","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2020.10.011_bb0290","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.yjmcc.2011.06.003","article-title":"Reorganized PKA-AKAP associations in the failing human heart","volume":"52","author":"Aye","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.10.011_bb0295","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1006\/jmcc.1996.0271","article-title":"Increased expression of cardiac phosphatases in patients with end-stage heart failure","volume":"29","author":"Neumann","year":"1997","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"8","key":"10.1016\/j.yjmcc.2020.10.011_bb0300","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1096\/fj.05-5299fje","article-title":"Inhibition of protein phosphatase 1 by inhibitor-2 gene delivery ameliorates heart failure progression in genetic cardiomyopathy","volume":"20","author":"Yamada","year":"2006","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.10.011_bb0305","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00424-005-0025-6","article-title":"Contractile responses to selective phosphodiesterase inhibitors following chronic \u03b2-adrenoreceptor activation","volume":"452","author":"Osadchii","year":"2006","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0310","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yjmcc.2015.06.012","article-title":"Altered distribution of ICa impairs ca release at the t-tubules of ventricular myocytes from failing hearts","volume":"86","author":"Bryant","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.10.011_bb0315","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/bph.12168","article-title":"PDE4 in the human heart - major player or little helper?","volume":"169","author":"Eschenhagen","year":"2013","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.10.011_bb0320","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.114.000858","article-title":"Interventricular differences in \u03b2-adrenergic responses in the canine heart: role of phosphodiesterases","volume":"3","author":"Molina","year":"2014","journal-title":"J. Am. Heart Assoc."},{"issue":"24","key":"10.1016\/j.yjmcc.2020.10.011_bb0325","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1016\/j.jacc.2012.01.060","article-title":"Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias","volume":"59","author":"Molina","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.yjmcc.2020.10.011_bb0330","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/0002-8703(85)90460-0","article-title":"Milrinone in congestive heart failure: observations on ambulatory ventricular arrhythmias","volume":"110","author":"Holmes","year":"1985","journal-title":"Am. Heart J."},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0335","doi-asserted-by":"crossref","unstructured":"M. Packer, J.R. Carver, R.J. Rodeheffer, R.J. Ivanhoe, R. DiBianco, S.M. Zeldis, et al., Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group, N. Engl. J. Med. 325(21) (1991) 1468\u201375.","DOI":"10.1056\/NEJM199111213252103"},{"key":"10.1016\/j.yjmcc.2020.10.011_bb0340","doi-asserted-by":"crossref","unstructured":"J.R. Teerlink, M. Jalaluddin, S. Anderson, M.L. Kukin, E.J. Eichhorn, G. Francis, et al., Ambulatory ventricular arrhythmias in patients with heart failure do not specifically predict an increased risk of sudden death. PROMISE (Prospective Randomized Milrinone Survival Evaluation) Investigators, Circulation 101(1) (2000) 40\u20136.","DOI":"10.1161\/01.CIR.101.1.40"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820303060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820303060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:49:35Z","timestamp":1777387775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282820303060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":69,"alternative-id":["S0022282820303060"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.10.011","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selective changes in cytosolic \u03b2-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}