{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:41:07Z","timestamp":1792795267086,"version":"4.5.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011176","name":"Peking Union Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011176","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.yjmcc.2020.11.015","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T02:52:44Z","timestamp":1607395964000},"page":"52-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation"],"prefix":"10.1016","volume":"152","author":[{"given":"Weipeng","family":"Ge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiliu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.yjmcc.2020.11.015_bb0005","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/S0002-9440(10)65037-7","article-title":"Up-regulation of AT(1) and AT(2) receptors in postinfarcted hypertrophied myocytes and stretch-mediated apoptotic cell death","volume":"156","author":"Leri","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"9A","key":"10.1016\/j.yjmcc.2020.11.015_bb0010","doi-asserted-by":"crossref","first-page":"18F","DOI":"10.1016\/S0002-9149(02)03336-2","article-title":"Pharmacologic therapy for patients with chronic heart failure and reduced systolic function: review of trials and practical considerations","volume":"91","author":"Klein","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2020.11.015_bb0015","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.11.015_bb0020","first-page":"1435","article-title":"[Regulation of the myosin heavy chain gene expression during cardiac hypertrophy induced by pressure-overload], Nihon rinsho","volume":"51","author":"Kurabayashi","year":"1993","journal-title":"Jpn. J. Clin. Med."},{"issue":"Suppl. 1","key":"10.1016\/j.yjmcc.2020.11.015_bb0025","first-page":"39","article-title":"B-type natriuretic peptide: a myocyte-specific marker for characterizing load-induced alterations in cardiac gene expression","volume":"30","author":"Magga","year":"1998","journal-title":"Ann. Med."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.11.015_bb0030","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.cardiores.2005.10.001","article-title":"The role of natriuretic peptides in cardioprotection","volume":"69","author":"Nishikimi","year":"2006","journal-title":"Cardiovasc. Res."},{"issue":"7","key":"10.1016\/j.yjmcc.2020.11.015_bb0035","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1172\/JCI74783","article-title":"Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis","volume":"124","author":"Moore-Morris","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"13","key":"10.1016\/j.yjmcc.2020.11.015_bb0040","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1161\/01.CIR.0000142607.33398.54","article-title":"Periostin as a novel factor responsible for ventricular dilation","volume":"110","author":"Katsuragi","year":"2004","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.yjmcc.2020.11.015_bb0045","doi-asserted-by":"crossref","first-page":"3201","DOI":"10.1007\/s00018-011-0784-5","article-title":"Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell","volume":"68","author":"Kudo","year":"2011","journal-title":"Cell. Mol. Life Sci.: CMLS"},{"issue":"6 Pt 2","key":"10.1016\/j.yjmcc.2020.11.015_bb0050","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1083\/jcb.103.6.2787","article-title":"A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation","volume":"103","author":"Skalli","year":"1986","journal-title":"J. Cell Biol."},{"issue":"9","key":"10.1016\/j.yjmcc.2020.11.015_bb0055","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.RES.86.9.939","article-title":"Altered patterns of gene expression in response to myocardial infarction","volume":"86","author":"Stanton","year":"2000","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.11.015_bb0060","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: the fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ. Res."},{"issue":"11","key":"10.1016\/j.yjmcc.2020.11.015_bb0065","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1161\/CIRCULATIONAHA.114.008788","article-title":"Immune cell and other noncardiomyocyte regulation of cardiac hypertrophy and remodeling","volume":"131","author":"Frieler","year":"2015","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.yjmcc.2020.11.015_bb0070","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1093\/eurjhf\/hfr122","article-title":"The role of monocytes and inflammation in the pathophysiology of heart failure","volume":"13","author":"Wrigley","year":"2011","journal-title":"Eur. J. Heart Fail."},{"issue":"5","key":"10.1016\/j.yjmcc.2020.11.015_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035144","article-title":"Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF beta\/Smad activation and cardiac fibrosis induced by angiotensin II","volume":"7","author":"Ma","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.yjmcc.2020.11.015_bb0080","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1210\/en.2013-2065","article-title":"5TNF-alpha and IL-1beta neutralization ameliorates angiotensin II-induced cardiac damage in male mice","volume":"155","author":"Wang","year":"2014","journal-title":"Endocrinology"},{"issue":"1","key":"10.1016\/j.yjmcc.2020.11.015_bb0085","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1093\/eurheartj\/ehx261","article-title":"IL-18 cleavage triggers cardiac inflammation and fibrosis upon beta-adrenergic insult","volume":"39","author":"Xiao","year":"2018","journal-title":"Eur. Heart J."},{"issue":"12","key":"10.1016\/j.yjmcc.2020.11.015_bb0090","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1161\/CIRCRESAHA.116.308688","article-title":"Deletion of Interleukin-6 attenuates pressure overload-induced left ventricular hypertrophy and dysfunction","volume":"118","author":"Zhao","year":"2016","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.yjmcc.2020.11.015_bb0095","first-page":"1787","article-title":"Asiatic acid inhibits cardiac hypertrophy by blocking interleukin-1beta-activated nuclear factor-kappaB signaling in vitro and in vivo","volume":"7","author":"Xu","year":"2015","journal-title":"J. Thora. Dis."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.11.015_bb0100","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2353\/ajpath.2007.061078","article-title":"Classic interleukin-6 receptor signaling and interleukin-6 trans-signaling differentially control angiotensin II-dependent hypertension, cardiac signal transducer and activator of transcription-3 activation, and vascular hypertrophy in vivo","volume":"171","author":"Coles","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.11.015_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033438","article-title":"Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure","volume":"7","author":"Van Tassell","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2020.11.015_bb0110","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cyto.2018.11.032","article-title":"Role of meprin metalloproteinases in cytokine processing and inflammation","volume":"114","author":"Herzog","year":"2019","journal-title":"Cytokine"},{"issue":"2","key":"10.1016\/j.yjmcc.2020.11.015_bb0115","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/BJ20121751","article-title":"The metalloproteases meprin alpha and meprin beta: unique enzymes in inflammation, neurodegeneration, cancer and fibrosis","volume":"450","author":"Broder","year":"2013","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.11.015_bb0120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/SHK.0b013e3181ec39cc","article-title":"Actinonin, a meprin a inhibitor, protects the renal microcirculation during sepsis","volume":"35","author":"Wang","year":"2011","journal-title":"Shock"},{"issue":"35","key":"10.1016\/j.yjmcc.2020.11.015_bb0125","doi-asserted-by":"crossref","first-page":"14219","DOI":"10.1073\/pnas.1305464110","article-title":"Metalloproteases meprin alpha and meprin beta are C- and N-procollagen proteinases important for collagen assembly and tensile strength","volume":"110","author":"Broder","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2020.11.015_bb0130","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.matbio.2015.01.010","article-title":"Meprin alpha and meprin beta: procollagen proteinases in health and disease","volume":"44-46","author":"Prox","year":"2015","journal-title":"Matrix Biol.: J. Intern. Soc. Matrix Biol."},{"issue":"11","key":"10.1016\/j.yjmcc.2020.11.015_bb0135","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1172\/JCI7818","article-title":"Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice","volume":"105","author":"Daugherty","year":"2000","journal-title":"J. Clin. Invest."},{"issue":"45","key":"10.1016\/j.yjmcc.2020.11.015_bb0140","doi-asserted-by":"crossref","first-page":"E7116","DOI":"10.1073\/pnas.1607728113","article-title":"PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction","volume":"113","author":"Knight","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2020.11.015_bb0145","first-page":"e52749","article-title":"Isolation of murine peritoneal macrophages to carry out gene expression analysis upon Toll-like receptors stimulation","volume":"98","author":"Layoun","year":"2015","journal-title":"J. Visual. Exper.: JoVE"},{"key":"10.1016\/j.yjmcc.2020.11.015_bb0150","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.phrs.2015.12.032","article-title":"Higenamine protects ischemia\/reperfusion induced cardiac injury and myocyte apoptosis through activation of beta2-AR\/PI3K\/AKT signaling pathway","volume":"104","author":"Wu","year":"2016","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.yjmcc.2020.11.015_bb0155","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s10557-017-6719-0","article-title":"Vinpocetine attenuates pathological cardiac remodeling by inhibiting cardiac hypertrophy and fibrosis","volume":"31","author":"Wu","year":"2017","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.yjmcc.2020.11.015_bb0160","doi-asserted-by":"crossref","first-page":"172442","DOI":"10.1016\/j.ejphar.2019.172442","article-title":"IMM-H007 improves heart function via reducing cardiac fibrosis","volume":"857","author":"Ge","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"13","key":"10.1016\/j.yjmcc.2020.11.015_bb0165","doi-asserted-by":"crossref","first-page":"18D","DOI":"10.1016\/S0002-9149(99)80487-1","article-title":"The cardiac renin-angiotensin-aldosterone system and hypertensive cardiac hypertrophy","volume":"76","author":"Raman","year":"1995","journal-title":"Am. J. Cardiol."},{"issue":"8","key":"10.1016\/j.yjmcc.2020.11.015_bb0170","doi-asserted-by":"crossref","first-page":"H1103","DOI":"10.1152\/ajpheart.00636.2012","article-title":"ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4","volume":"304","author":"Mori","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"8","key":"10.1016\/j.yjmcc.2020.11.015_bb0175","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1113\/expphysiol.2011.057612","article-title":"Angiotensin II-induced dilated cardiomyopathy in Balb\/c but not C57BL\/6J mice","volume":"96","author":"Peng","year":"2011","journal-title":"Exp. Physiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.11.015_bb0180","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/cvr\/cvs369","article-title":"Induction of oxidative stress by oxidized LDL via meprinalpha-activated epidermal growth factor receptor in macrophages","volume":"97","author":"Gao","year":"2013","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2020.11.015_bb0185","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.bbrc.2008.12.161","article-title":"Meprin a and meprin alpha generate biologically functional IL-1beta from pro-IL-1beta","volume":"379","author":"Herzog","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1\u20133","key":"10.1016\/j.yjmcc.2020.11.015_bb0190","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.regpep.2009.12.009","article-title":"Meprin-alpha metalloproteases enhance lipopolysaccharide-stimulated production of tumour necrosis factor-alpha and interleukin-1beta in peripheral blood mononuclear cells via activation of NF-kappaB","volume":"160","author":"Gao","year":"2010","journal-title":"Regul. Pept."},{"issue":"11","key":"10.1016\/j.yjmcc.2020.11.015_bb0195","doi-asserted-by":"crossref","first-page":"7580","DOI":"10.1074\/jbc.M113.546309","article-title":"Meprin metalloproteases inactivate interleukin 6","volume":"289","author":"Keiffer","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2020.11.015_bb0200","first-page":"146","article-title":"Proteolytic processing and inactivation of CCL2\/MCP-1 by meprins","volume":"8","author":"Herzog","year":"2016","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.yjmcc.2020.11.015_bb0205","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.yjmcc.2015.11.015","article-title":"Monocyte and macrophage contributions to cardiac remodeling","volume":"93","author":"Hulsmans","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.11.015_bb0210","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12929-017-0322-3","article-title":"Macrophage activation and polarization in post-infarction cardiac remodeling","volume":"24","author":"Gombozhapova","year":"2017","journal-title":"J. Biomed. Sci."},{"issue":"12","key":"10.1016\/j.yjmcc.2020.11.015_bb0215","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/s12276-019-0269-4","article-title":"Macrophages in cardiac repair: environmental cues and therapeutic strategies","volume":"51","author":"de Couto","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.yjmcc.2020.11.015_bb0220","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.phrs.2018.07.006","article-title":"The anti-inflammatory peptide ac-SDKP: synthesis, role in ACE inhibition, and its therapeutic potential in hypertension and cardiovascular diseases","volume":"134","author":"Kumar","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"10","key":"10.1016\/j.yjmcc.2020.11.015_bb0225","doi-asserted-by":"crossref","first-page":"F1026","DOI":"10.1152\/ajprenal.00562.2015","article-title":"The anti-inflammatory peptide Ac-SDKP is released from thymosin-beta4 by renal meprin-alpha and prolyl oligopeptidase","volume":"310","author":"Kumar","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"42","key":"10.1016\/j.yjmcc.2020.11.015_bb0230","doi-asserted-by":"crossref","first-page":"35201","DOI":"10.1074\/jbc.M112.368910","article-title":"Meprinalpha transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration","volume":"287","author":"Minder","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.yjmcc.2020.11.015_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092164","article-title":"ERK: a key player in the pathophysiology of cardiac hypertrophy","volume":"20","author":"Gallo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yjmcc.2020.11.015_bb0240","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13578-019-0348-1","article-title":"Angiotensin II receptor blocker LCZ696 attenuates cardiac remodeling through the inhibition of the ERK signaling pathway in mice with pregnancy-associated cardiomyopathy","volume":"9","author":"Wang","year":"2019","journal-title":"Cell Biosci"},{"issue":"4","key":"10.1016\/j.yjmcc.2020.11.015_bb0245","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/01.RES.74.4.727","article-title":"Angiotensin II induces fibronectin expression associated with cardiac fibrosis in the rat","volume":"74","author":"Crawford","year":"1994","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.11.015_bb0250","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1161\/01.HYP.31.6.1324","article-title":"Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system","volume":"31","author":"Mazzolai","year":"1998","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.yjmcc.2020.11.015_bb0255","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1073\/pnas.97.2.931","article-title":"Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling","volume":"97","author":"Paradis","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6","key":"10.1016\/j.yjmcc.2020.11.015_bb0260","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1161\/01.HYP.25.6.1252","article-title":"Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats","volume":"25","author":"Kim","year":"1995","journal-title":"Hypertension"},{"issue":"8","key":"10.1016\/j.yjmcc.2020.11.015_bb0265","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1002\/jcp.25275","article-title":"Thymosin beta4 prevents angiotensin II-induced cardiomyocyte growth by regulating Wnt\/WISP signaling","volume":"231","author":"Li","year":"2016","journal-title":"J. Cell. Physiol."},{"issue":"43","key":"10.1016\/j.yjmcc.2020.11.015_bb0270","doi-asserted-by":"crossref","first-page":"40650","DOI":"10.1074\/jbc.M206203200","article-title":"Activation of human meprin-alpha in a cell culture model of colorectal cancer is triggered by the plasminogen-activating system","volume":"277","author":"Rosmann","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.yjmcc.2020.11.015_bb0275","doi-asserted-by":"crossref","first-page":"7682","DOI":"10.1016\/S0021-9258(17)37341-6","article-title":"Expression of meprin subunit precursors. Membrane anchoring through the beta subunit and mechanism of zymogen activation","volume":"269","author":"Johnson","year":"1994","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.11.015_bb0280","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/mi.2009.3","article-title":"MEP1A allele for meprin a metalloprotease is a susceptibility gene for inflammatory bowel disease","volume":"2","author":"Banerjee","year":"2009","journal-title":"Mucosal Immunol."},{"issue":"1","key":"10.1016\/j.yjmcc.2020.11.015_bb0285","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.atherosclerosis.2009.04.036","article-title":"A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE\u2212\/\u2212 mice","volume":"207","author":"Gao","year":"2009","journal-title":"Atherosclerosis"},{"issue":"10","key":"10.1016\/j.yjmcc.2020.11.015_bb0290","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1038\/sj.ki.5002189","article-title":"Role of meprin a in renal tubular epithelial cell injury","volume":"71","author":"Herzog","year":"2007","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.yjmcc.2020.11.015_bb0295","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(99)00630-0","article-title":"Cardiac remodeling--concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an international forum on cardiac remodeling","volume":"35","author":"Cohn","year":"2000","journal-title":"J. Am. Coll. Cardiol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820303382?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282820303382?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:32:24Z","timestamp":1758313944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282820303382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":59,"alternative-id":["S0022282820303382"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.11.015","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mep1a contributes to Ang II-induced cardiac remodeling by promoting cardiac hypertrophy, fibrosis and inflammation","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2020.11.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}