{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:14:28Z","timestamp":1790813668654,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"am","delay-in-days":286,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000005","name":"US Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-20-1-0418"],"award-info":[{"award-number":["W81XWH-20-1-0418"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","award":["19PRE34380909"],"award-info":[{"award-number":["19PRE34380909"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005909","name":"University of California Institute for Mexico and the United States","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005909","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL131782"],"award-info":[{"award-number":["R01 HL131782"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P30 GM127211"],"award-info":[{"award-number":["P30 GM127211"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.yjmcc.2021.01.005","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T16:59:23Z","timestamp":1612630763000},"page":"60-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Rad-GTPase contributes to heart rate via L-type calcium channel regulation"],"prefix":"10.1016","volume":"154","author":[{"given":"Bryana M.","family":"Levitan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke M.","family":"Ahern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajoy","family":"Aloysius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Andres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Satin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2021.01.005_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1113\/jphysiol.1986.sp016177","article-title":"Properties of the hyperpolarizing-activated current (i{\u2212f}) in cells isolated from the rabbit sino-atrial node","volume":"377","author":"DiFrancesco","year":"1986","journal-title":"J. Physiol."},{"issue":"12","key":"10.1016\/j.yjmcc.2021.01.005_bb0010","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1161\/CIRCULATIONAHA.108.804369","article-title":"Molecular architecture of the human sinus node","volume":"119","author":"Chandler","year":"2009","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2021.01.005_bb0015","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0014-5793(00)01979-7","article-title":"Expression of T- and L-type calcium channel mRNA in murine sinoatrial node.PG - 73-6","volume":"481","author":"Bohn","year":"2000","journal-title":"FEBS Lett."},{"issue":"12","key":"10.1016\/j.yjmcc.2021.01.005_bb0020","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1161\/CIRCRESAHA.107.153676","article-title":"Calcium cycling protein density and functional importance to automaticity of isolated sinoatrial nodal cells are independent of cell size","volume":"100","author":"Lyashkov","year":"2007","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.01.005_bb0025","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/01.RES.0000122045.55331.0F","article-title":"Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization","volume":"94","author":"Vinogradova","year":"2004","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.yjmcc.2021.01.005_bb0030","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/cvr\/cvw006","article-title":"L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity","volume":"109","author":"Torrente","year":"2016","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.yjmcc.2021.01.005_bb0035","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.bpj.2017.12.043","article-title":"Positive feedback mechanisms among local ca releases, NCX, and I(CaL) ignite pacemaker action potentials","volume":"114","author":"Lyashkov","year":"2018","journal-title":"Biophys. J."},{"issue":"28","key":"10.1016\/j.yjmcc.2021.01.005_bb0040","article-title":"From two competing oscillators to one coupled-clock pacemaker cell system","volume":"6","author":"Yaniv","year":"2015","journal-title":"Front. Physiol."},{"issue":"10","key":"10.1016\/j.yjmcc.2021.01.005_bb0045","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/CIRCULATIONAHA.106.663070","article-title":"Declining into failure: the age-dependent loss of the L-type calcium channel within the sinoatrial node","volume":"115","author":"Jones","year":"2007","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.yjmcc.2021.01.005_bb0050","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1073\/pnas.0935295100","article-title":"Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity","volume":"100","author":"Mangoni","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.01.005_bb0055","series-title":"Cardiac Electrophysiology: From Cell to Bedside","article-title":"Regulation of cardiac calcium channels","author":"Satin","year":"2017"},{"issue":"24","key":"10.1016\/j.yjmcc.2021.01.005_bb0060","doi-asserted-by":"crossref","first-page":"6327","DOI":"10.1113\/jphysiol.2012.239954","article-title":"Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node","volume":"590","author":"Christel","year":"2012","journal-title":"J. Physiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2021.01.005_bb0065","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1172\/JCI123878","article-title":"Cardiac CaV1.2 channels require \u03b2 subunits for \u03b2-adrenergic\u2013mediated modulation but not trafficking","volume":"129","author":"Yang","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.yjmcc.2021.01.005_bb0070","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cellsig.2007.10.028","article-title":"The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling","volume":"20","author":"Correll","year":"2008","journal-title":"Cell. Signal."},{"issue":"28","key":"10.1016\/j.yjmcc.2021.01.005_bb0075","doi-asserted-by":"crossref","first-page":"10913","DOI":"10.1074\/jbc.RA119.008782","article-title":"Myocardial-restricted ablation of the GTPase RAD results in a pro-adaptive heart response in mice","volume":"294","author":"Ahern","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.01.005_bb0080","first-page":"83","article-title":"Rad GTPase deletion attenuates post-ischemic cardiac dysfunction and remodeling","volume":"3","author":"Manning","year":"2018","journal-title":"JACC: Basic Transl. Sci."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.01.005_bb0085","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000459","article-title":"Rad GTPase deletion increases L-type calcium channel current leading to increased cardiac contraction","volume":"2","author":"Manning","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2021.01.005_bb0090","doi-asserted-by":"crossref","first-page":"14469","DOI":"10.1073\/pnas.2437756100","article-title":"Regulation of voltage-gated calcium channel activity by the rem and rad GTPases","volume":"100","author":"Finlin","year":"2003","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"7792","key":"10.1016\/j.yjmcc.2021.01.005_bb0095","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/s41586-020-1947-z","article-title":"Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics","volume":"577","author":"Liu","year":"2020","journal-title":"Nature"},{"issue":"6327","key":"10.1016\/j.yjmcc.2021.01.005_bb0100","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/351573a0","article-title":"Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation","volume":"351","author":"Hartzell","year":"1991","journal-title":"Nature"},{"issue":"27","key":"10.1016\/j.yjmcc.2021.01.005_bb0105","doi-asserted-by":"crossref","first-page":"22584","DOI":"10.1074\/jbc.M112.366484","article-title":"Deletion of the C-terminal phosphorylation sites in the cardiac beta subunit does not affect the basic beta-adrenergic response of the heart and the Cav1.2 channel","volume":"287","author":"Brandmayr","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.yjmcc.2021.01.005_bb0110","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/CIRCRESAHA.109.208272","article-title":"Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart","volume":"106","author":"Wang","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.01.005_bb0115","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.bone.2017.07.018","article-title":"Rad GTPase is essential for the regulation of bone density and bone marrow adipose tissue in mice","volume":"103","author":"Withers","year":"2017","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.yjmcc.2021.01.005_bb0120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/hh1301.092687","article-title":"Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein","volume":"89","author":"Sohal","year":"2001","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.01.005_bb0125","first-page":"1470","article-title":"Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver","volume":"6","author":"Lexow","year":"2013","journal-title":"Dis. Model. Mech."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.01.005_bb0130","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1038\/s41467-019-10709-9","article-title":"Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking","volume":"10","author":"Linscheid","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.01.005_bb0135","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","article-title":"RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues","volume":"14","author":"Wang","year":"2012","journal-title":"J. Mol. Diagn."},{"issue":"4","key":"10.1016\/j.yjmcc.2021.01.005_bb0140","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0008-6363(00)00135-8","article-title":"The sinoatrial node, a heterogeneous pacemaker structure","volume":"47","author":"Boyett","year":"2000","journal-title":"Cardiovasc. Res."},{"issue":"8","key":"10.1016\/j.yjmcc.2021.01.005_bb0145","article-title":"Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program","volume":"146","author":"van Eif","year":"2019","journal-title":"Development"},{"issue":"7838","key":"10.1016\/j.yjmcc.2021.01.005_bb0150","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41586-020-2797-4","article-title":"Cells of the adult human heart","volume":"588","author":"Litvi\u0148ukov\u00e1","year":"2020","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.yjmcc.2021.01.005_bb0155","first-page":"H1252","article-title":"L-type but not T-type calcium current changes during postnatal development in rabbit sinoatrial node","volume":"281","author":"Protas","year":"2001","journal-title":"Am. J. Phys."},{"issue":"19","key":"10.1016\/j.yjmcc.2021.01.005_bb0160","article-title":"Functional role of voltage gated Ca2+ channels in heart automaticity","volume":"6","author":"Mesirca","year":"2015","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2021.01.005_bb0165","first-page":"H1064","article-title":"Contribution of L-type Ca2+ current to electrical activity in sinoatrial nodal myocytes of rabbits","volume":"276","author":"Verheijck","year":"1999","journal-title":"Am. J. Phys."},{"issue":"8","key":"10.1016\/j.yjmcc.2021.01.005_bb0170","doi-asserted-by":"crossref","first-page":"H1336","DOI":"10.1152\/ajpheart.00389.2015","article-title":"Loss of Rad-GTPase produces a novel adaptive cardiac phenotype resistant to systolic decline with aging","volume":"309","author":"Manning","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"8","key":"10.1016\/j.yjmcc.2021.01.005_bb0175","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1111\/j.1540-8159.2006.00457.x","article-title":"The role of heart rate variability in prognosis for different modes of death in chronic heart failure","volume":"29","author":"Sandercock","year":"2006","journal-title":"Pacing Clin. Electrophysiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.01.005_bb0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1172\/JCI62839","article-title":"Signaling effectors underlying pathologic growth and remodeling of the heart","volume":"123","author":"van Berlo","year":"2013","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.yjmcc.2021.01.005_bb0185","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s12265-016-9716-y","article-title":"Rad-deletion phenocopies tonic sympathetic stimulation of the heart","volume":"9","author":"Levitan","year":"2016","journal-title":"J. Cardiovasc. Transl. Res."},{"issue":"Pt 2","key":"10.1016\/j.yjmcc.2021.01.005_bb0190","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1113\/jphysiol.1996.sp021220","article-title":"Basal responses of the L-type Ca2+ and hyperpolarization-activated currents to autonomic agonists in the rabbit sino-atrial node","volume":"491","author":"Zaza","year":"1996","journal-title":"J. Physiol."},{"issue":"11","key":"10.1016\/j.yjmcc.2021.01.005_bb0195","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1161\/01.RES.0000225862.14314.49","article-title":"Bradycardia and slowing of the atrioventricular conduction in mice lacking CaV3.1 \u03b11G T-type calcium channels","volume":"98","author":"Mangoni","year":"2006","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.yjmcc.2021.01.005_bb0200","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1161\/01.RES.0000055904.21974.BE","article-title":"Sarcoplasmic reticulum Ca2+ release is not a dominating factor in sinoatrial node pacemaker activity","volume":"92","author":"Honjo","year":"2003","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.yjmcc.2021.01.005_bb0205","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4161\/chan.4.3.11867","article-title":"Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation","volume":"4","author":"Pang","year":"2010","journal-title":"Channels (Austin)"},{"key":"10.1016\/j.yjmcc.2021.01.005_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00170","article-title":"Neurohumoral control of sinoatrial node activity and heart rate: insight from experimental models and findings from humans","volume":"11","author":"MacDonald","year":"2020","journal-title":"Front. Physiol."},{"issue":"11","key":"10.1016\/j.yjmcc.2021.01.005_bb0215","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1093\/oxfordjournals.eurheartj.a062200","article-title":"Functional morphology of the mammalian sinuatrial node","volume":"8","author":"Opthof","year":"1987","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.yjmcc.2021.01.005_bb0220","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0022-3565(25)32189-0","article-title":"Interaction of adrenaline and acetylcholine on cardiac pacemaker function. Functional inhomogeneity of the rabbit sinus node","volume":"214","author":"Mackaay","year":"1980","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"400","key":"10.1016\/j.yjmcc.2021.01.005_bb0225","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aam5607","article-title":"Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure","volume":"9","author":"Li","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.01.005_bb0230","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1085\/jgp.111.1.95","article-title":"Pacemaker synchronization of electrically coupled rabbit sinoatrial node cells","volume":"111","author":"Verheijck","year":"1998","journal-title":"J. Gen. Physiol."},{"issue":"9","key":"10.1016\/j.yjmcc.2021.01.005_bb0235","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004112","article-title":"Ivabradine in heart failure","volume":"10","author":"Das","year":"2017","journal-title":"Circ. Heart Fail."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.01.005_bb0240","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jacc.2017.04.025","volume":"70","author":"Yancy","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.yjmcc.2021.01.005_bb0245","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/cvr\/cvy015","article-title":"Elevated plasma catecholamines functionally compensate for the reduced myogenic tone in smooth muscle STIM1 knockout mice but with deleterious cardiac effects","volume":"114","author":"Pichavaram","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"9","key":"10.1016\/j.yjmcc.2021.01.005_bb0250","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1172\/JCI41348","article-title":"Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice","volume":"120","author":"Mathar","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.01.005_bb0255","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1146\/annurev-physiol-021119-034453","article-title":"Cardiac pacemaker activity and aging","volume":"82","author":"Peters","year":"2020","journal-title":"Annu. Rev. Physiol."},{"issue":"44","key":"10.1016\/j.yjmcc.2021.01.005_bb0260","doi-asserted-by":"crossref","first-page":"18011","DOI":"10.1073\/pnas.1308477110","article-title":"Depressed pacemaker activity of sinoatrial node myocytes contributes to the age-dependent decline in maximum heart rate","volume":"110","author":"Larson","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.yjmcc.2021.01.005_bb0265","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ceca.2018.07.002","article-title":"Heterogeneity of calcium clock functions in dormant, dysrhythmically and rhythmically firing single pacemaker cells isolated from SA node","volume":"74","author":"Kim","year":"2018","journal-title":"Cell Calcium"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821000237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821000237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:13:55Z","timestamp":1782486835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282821000237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":53,"alternative-id":["S0022282821000237"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.01.005","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rad-GTPase contributes to heart rate via L-type calcium channel regulation","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}