{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:24:42Z","timestamp":1792193082698,"version":"4.4.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"am","delay-in-days":273,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.yjmcc.2021.03.009","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T23:40:09Z","timestamp":1616802009000},"page":"33-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility"],"prefix":"10.1016","volume":"156","author":[{"suffix":"IV","given":"Thomas L.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diederik W.D.","family":"Kuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayandi","family":"Sivaguru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit R.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Previs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Hwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Kuffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Zilliox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Leei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weikang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burns C.","family":"Blaxall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"Nieman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana M.","family":"Leichter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen P.","family":"Leary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M.L.","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter P.","family":"de Tombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Irving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Warshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakthivel","family":"Sadayappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2021.03.009_bb0005","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.yjmcc.2009.11.014","article-title":"Phosphorylation and function of cardiac myosin binding protein-C in health and disease","volume":"48","author":"Barefield","year":"2010","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0010","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/CIRCRESAHA.110.231670","article-title":"In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filament","volume":"108","author":"Harris","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0015","doi-asserted-by":"crossref","first-page":"8818","DOI":"10.1074\/jbc.M113.541128","article-title":"Myocardial infarction-induced N-terminal fragment of cardiac myosin binding protein-C (cMyBP-C) impairs myofilament function in human myocardium","volume":"289","author":"Witayavanitkul","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/CIRCRESAHA.116.300561","article-title":"Cardiac MyBP-C regulates the rate and force of contraction in mammalian myocardium","volume":"116","author":"Moss","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0025","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1614020114","article-title":"Phosphorylation of cardiac myosin binding protein C releases myosin heads from the surface of cardiac thick filaments","volume":"114","author":"Kensler","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0030","doi-asserted-by":"crossref","first-page":"11731","DOI":"10.1073\/pnas.1821660116","article-title":"Cardiac myosin binding protein-C phosphorylation regulates the super-relaxed state of myosin","volume":"116","author":"McNamara","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0035","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1126\/science.1223602","article-title":"Molecular mechanics of cardiac myosin binding protein-C in native thick filaments","volume":"337","author":"Previs","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0040","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1073\/pnas.1316001111","article-title":"Myosin binding protein-C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism","volume":"111","author":"Mun","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0045","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.yjmcc.2019.03.006","article-title":"Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury","volume":"129","author":"Barefield","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0050","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.yjmcc.2011.09.011","article-title":"Cardiac myosin binding protein-C is a potential diagnostic biomarker for myocardial infarction","volume":"52","author":"Govindan","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0055","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1161\/CIRCRESAHA.113.301225","article-title":"An endogenously produced fragment of cardiac myosin-binding protein C is pathogenic and can lead to heart failure","volume":"113","author":"Razzaque","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.yjmcc.2018.12.003","article-title":"MYBPC3 truncation mutations enhance actomyosin contractile mechanics in human hypertrophic cardiomyopathy","volume":"127","author":"O'Leary","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0065","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10974-012-9292-y","article-title":"Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro","volume":"33","author":"Govindan","year":"2012","journal-title":"J. Muscle Res. Cell Motil."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0070","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/prca.201400011","article-title":"Surviving the infarct: a profile of cardiac myosin binding protein-C pathogenicity, diagnostic utility, and proteomics in the ischemic myocardium","volume":"8","author":"Lynch","year":"2014","journal-title":"Proteomics Clin. Appl."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0075","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1161\/01.CIR.0000155609.95618.75","article-title":"Myosin-binding protein C phosphorylation, myofibril structure, and contractile function during low-flow ischemia","volume":"111","author":"Decker","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0080","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.yjmcc.2011.09.019","article-title":"Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain","volume":"52","author":"Weith","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0085","doi-asserted-by":"crossref","first-page":"16918","DOI":"10.1073\/pnas.0607069103","article-title":"Cardiac myosin binding protein-C phosphorylation is cardioprotective","volume":"103","author":"Sadayappan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0090","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002836","article-title":"Alterations in multi-scale cardiac architecture in association with phosphorylation of myosin binding protein-C","volume":"5","author":"Taylor","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0095","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/01.RES.0000222059.54917.ef","article-title":"Activation of myocardial contraction by the N-terminal domains of myosin binding protein-C","volume":"98","author":"Herron","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0100","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130182","article-title":"AAV9 gene transfer of cMyBPC N-terminal domains ameliorates cardiomyopathy in cMyBPC-deficient mice","volume":"5","author":"Li","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0105","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yjmcc.2016.12.002","article-title":"Cardiac inflammation in genetic dilated cardiomyopathy caused by MYBPC3 mutation","volume":"102","author":"Lynch","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0110","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1172\/JCI7377","article-title":"Dilated cardiomyopathy in homozygous myosin binding protein-C mutant mice","volume":"104","author":"McConnell","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0115","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1093\/cvr\/cvz111","article-title":"Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy","volume":"115","author":"Kuster","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0120","doi-asserted-by":"crossref","first-page":"11275","DOI":"10.1074\/jbc.RA120.013296","article-title":"Phosphorylation of cardiac myosin-binding protein-C contributes to calcium homeostasis","volume":"295","author":"Kumar","year":"2020","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yjmcc.2016.03.009","article-title":"Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes","volume":"94","author":"McNamara","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0130","article-title":"Cardiac myosin binding protein-C plays no regulatory role in skeletal muscle structure and function","volume":"8","author":"Lin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0135","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/CIRCRESAHA.108.178996","article-title":"Protein kinase A-mediated phosphorylation of cMyBP-C increases proximity of myosin heads to actin in resting myocardium","volume":"103","author":"Colson","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jmb.2006.12.063","article-title":"Radial displacement of myosin cross-bridges in mouse myocardium due to ablation of myosin binding protein-C","volume":"367","author":"Colson","year":"2007","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0145","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1161\/01.RES.0000012222.70819.64","article-title":"Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice","volume":"90","author":"Harris","year":"2002","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0150","doi-asserted-by":"crossref","first-page":"12650","DOI":"10.1074\/jbc.M110.156646","article-title":"Structure and interactions of myosin binding protein-C domain C0: cardiac-specific regulation of myosin at its neck?","volume":"286","author":"Ratti","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0155","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.yjmcc.2012.08.028","article-title":"Determination of the critical residues responsible for cardiac myosin binding protein-C\u2019s interactions","volume":"53","author":"Bhuiyan","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0160","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/S0014-5793(99)00727-9","article-title":"cAPK-phosphorylation controls the interaction of the regulatory domain of cardiac myosin binding protein-C with myosin-S2 in an on-off fashion","volume":"453","author":"Gruen","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0165","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s00424-016-1873-y","article-title":"In vivo definition of cardiac myosin-binding protein C\u2019s critical interactions with myosin","volume":"468","author":"Bhuiyan","year":"2016","journal-title":"Pflugers Arch. - Eur. J. Physiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0170","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/CIRCRESAHA.108.177683","article-title":"Acceleration of crossbridge kinetics by protein kinase a phosphorylation of cardiac myosin binding protein C modulates cardiac function","volume":"103","author":"Tong","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0175","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2016.09.003","article-title":"N-terminal fragment of cardiac myosin binding protein-C triggers pro-inflammatory responses in vitro","volume":"99","author":"Lipps","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0180","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1074\/jbc.M008691200","article-title":"Hypercontractile properties of cardiac muscle fibers in a knock-in mouse model of cardiac myosin-binding protein-C","volume":"276","author":"Witt","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0185","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.yjmcc.2015.09.006","article-title":"Normal cardiac contraction in mice lacking the proline-alanine rich region and C1 domain of cardiac myosin binding protein C","volume":"88","author":"van Dijk","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0190","doi-asserted-by":"crossref","first-page":"11423","DOI":"10.1073\/pnas.1103216108","article-title":"Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle","volume":"108","author":"Luther","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0195","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202012726","article-title":"The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle","volume":"153","author":"Rahmanseresht","year":"2021","journal-title":"J Gen Physiol"},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0200","first-page":"20130697","article-title":"The length-tension curve in muscle depends on lattice spacing","volume":"280","author":"Williams","year":"2013","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0205","first-page":"5","article-title":"Calcium, cross-bridges, and the frank-Starling relationship","volume":"16","author":"Fuchs","year":"2001","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0210","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1161\/01.RES.0000219863.94390.ce","article-title":"Ablation of cardiac myosin-binding protein-C accelerates stretch activation in murine skinned myocardium","volume":"98","author":"Stelzer","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0215","doi-asserted-by":"crossref","first-page":"H857","DOI":"10.1152\/ajpheart.00841.2002","article-title":"Effect of extraction of myosin binding protein-C on contractility of rat heart","volume":"285","author":"Kulikovskaya","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0220","doi-asserted-by":"crossref","first-page":"35846","DOI":"10.1074\/jbc.M606949200","article-title":"Effects of the N-terminal domains of myosin binding protein-C in an in vitro motility assay: evidence for long-l ived cross-bridges","volume":"281","author":"Razumova","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0225","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.jmb.2008.09.065","article-title":"Myosin binding protein-C positioned to play a key role in regulation of muscle contraction: structure and interactions of domain C1","volume":"384","author":"Ababou","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0230","doi-asserted-by":"crossref","first-page":"18360","DOI":"10.1073\/pnas.0808903105","article-title":"Cardiac myosin binding protein-C decorates F-actin: implications for cardiac function","volume":"105","author":"Whitten","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0235","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.jmb.2008.01.080","article-title":"Small-angle X-ray scattering reveals the N-terminal domain organization of cardiac myosin binding protein-C","volume":"377","author":"Jeffries","year":"2008","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0240","doi-asserted-by":"crossref","first-page":"12318","DOI":"10.1074\/jbc.M808850200","article-title":"The myosin binding protein-C motif binds to F-actin in a phosphorylation-sensitive manner","volume":"284","author":"Shaffer","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0245","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jsb.2010.12.003","article-title":"Binding of the N-terminal fragment C0-C2 of cardiac MyBP-C to cardiac F-actin","volume":"174","author":"Kensler","year":"2011","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0250","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bpj.2014.11.1852","article-title":"Effects of cardiac myosin binding protein-C on actin motility are explained with a drag-activation-competition model","volume":"108","author":"Walcott","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0255","doi-asserted-by":"crossref","first-page":"6828","DOI":"10.1073\/pnas.1816480116","article-title":"Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding","volume":"116","author":"Inchingolo","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.03.009_bb0260","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1085\/jgp.200810013","article-title":"Contribution of the myosin binding protein-C motif to functional effects in permeabilized rat trabeculae","volume":"132","author":"Razumova","year":"2008","journal-title":"J Gen Physiol"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821000663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821000663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:33:20Z","timestamp":1758314000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282821000663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":52,"alternative-id":["S0022282821000663"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.03.009","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}