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Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.yjmcc.2021.05.006_bb0310","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1021\/bi00627a023","article-title":"Nucleotide sequences at the N6-methyladenosine sites of HeLa cell messenger ribonucleic acid","volume":"16","author":"Wei","year":"1977","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/j.yjmcc.2021.05.006_bb0315","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0092-8674(75)90158-0","article-title":"Methylated nucleotides block 5\u2019 terminus of HeLa cell messenger RNA","volume":"4","author":"Wei","year":"1975","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.yjmcc.2021.05.006_bb0320","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0022-2836(77)90110-3","article-title":"Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells","volume":"115","author":"Schibler","year":"1977","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.05.006_bb0325","doi-asserted-by":"crossref","first-page":"6590","DOI":"10.1038\/s41598-020-63355-3","article-title":"Limits in the detection of m(6)A changes using MeRIP\/m(6)A-seq","volume":"10","author":"McIntyre","year":"2020","journal-title":"Sci. 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Eng."},{"issue":"8","key":"10.1016\/j.yjmcc.2021.05.006_bb0345","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nmeth.3453","article-title":"Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome","volume":"12","author":"Linder","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.yjmcc.2021.05.006_bb0350","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-4939-6807-7_5","article-title":"Mapping m(6)A at individual-nucleotide resolution using crosslinking and immunoprecipitation (miCLIP)","volume":"1562","author":"Grozhik","year":"2017","journal-title":"Methods Mol. 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Adv."},{"issue":"3","key":"10.1016\/j.yjmcc.2021.05.006_bb0375","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.cell.2019.06.013","article-title":"Deciphering the \"m(6)A Code\" via antibody-independent quantitative profiling","volume":"178","author":"Garcia-Campos","year":"2019","journal-title":"Cell"},{"issue":"96","key":"10.1016\/j.yjmcc.2021.05.006_bb0380","doi-asserted-by":"crossref","first-page":"12930","DOI":"10.1039\/C7CC07699A","article-title":"Detection of N(6)-methyladenosine based on the methyl-sensitivity of MazF RNA endonuclease","volume":"53","author":"Imanishi","year":"2017","journal-title":"Chem. Commun. (Camb.)"},{"issue":"12","key":"10.1016\/j.yjmcc.2021.05.006_bb0385","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s41592-019-0570-0","article-title":"DART-seq: an antibody-free method for global m(6)A detection","volume":"16","author":"Meyer","year":"2019","journal-title":"Nat. Methods"},{"issue":"12","key":"10.1016\/j.yjmcc.2021.05.006_bb0390","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s41580-018-0075-1","article-title":"Publisher correction: post-transcriptional gene regulation by mRNA modifications","volume":"19","author":"Zhao","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.yjmcc.2021.05.006_bb0395","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0092-8674(76)90022-2","article-title":"Methyl labeling of HeLa cell hnRNA: a comparison with mRNA","volume":"7","author":"Salditt-Georgieff","year":"1976","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.yjmcc.2021.05.006_bb0400","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/jvi.42.3.918-931.1982","article-title":"Accumulation of spliced avian retrovirus mRNA is inhibited in S-adenosylmethionine-depleted chicken embryo fibroblasts","volume":"42","author":"Stoltzfus","year":"1982","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.yjmcc.2021.05.006_bb0405","first-page":"538","article-title":"Effect of undermethylation on mRNA cytoplasmic appearance and half-life","volume":"4","author":"Camper","year":"1984","journal-title":"Mol. Cell. Biol."},{"issue":"9","key":"10.1016\/j.yjmcc.2021.05.006_bb0410","first-page":"4456","article-title":"N6-methyladenosine residues in an intron-specific region of prolactin pre-mRNA","volume":"10","author":"Carroll","year":"1990","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.yjmcc.2021.05.006_bb0415","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.05.006_bb0420","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.cell.2015.08.011","article-title":"HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events","volume":"162","author":"Alarc\u00f3n","year":"2015","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.yjmcc.2021.05.006_bb0425","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrm4010","article-title":"Control of mammalian gene expression by selective mRNA export","volume":"16","author":"Wickramasinghe","year":"2015","journal-title":"Nat. Rev. Mol. 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(Lausanne)"},{"issue":"7544","key":"10.1016\/j.yjmcc.2021.05.006_bb0460","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nature14281","article-title":"N6-methyladenosine marks primary micro RNAs for processing","volume":"519","author":"Alarcon","year":"2015","journal-title":"Nature"},{"issue":"7308","key":"10.1016\/j.yjmcc.2021.05.006_bb0465","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nature09267","article-title":"Mammalian microRNAs predominantly act to decrease target mRNA levels","volume":"466","author":"Guo","year":"2010","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.yjmcc.2021.05.006_bb0470","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000238","article-title":"Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA","volume":"7","author":"Hendrickson","year":"2009","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.05.006_bb0475","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrg3606","article-title":"Long non-coding RNAs: new players in cell differentiation and development","volume":"15","author":"Fatica","year":"2014","journal-title":"Nat. Rev. Genet."},{"issue":"5","key":"10.1016\/j.yjmcc.2021.05.006_bb0480","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/s41556-019-0311-8","article-title":"Cellular functions of long noncoding RNAs","volume":"21","author":"Yao","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2021.05.006_bb0485","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.atherosclerosis.2017.10.012","article-title":"Long non-coding RNAs in the atherosclerotic plaque","volume":"266","author":"Arslan","year":"2017","journal-title":"Atherosclerosis"},{"issue":"7","key":"10.1016\/j.yjmcc.2021.05.006_bb0490","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrcardio.2015.55","article-title":"Long noncoding RNAs in cardiac development and ageing","volume":"12","author":"Devaux","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.05.006_bb0495","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bbagrm.2015.10.019","article-title":"The emerging epitranscriptomics of long noncoding RNAs","volume":"1859","author":"Shafik","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"5","key":"10.1016\/j.yjmcc.2021.05.006_bb0500","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41556-019-0315-4","article-title":"The RNA N(6)-methyladenosine modification landscape of human fetal tissues","volume":"21","author":"Xiao","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"11","key":"10.1016\/j.yjmcc.2021.05.006_bb0505","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18112387","article-title":"The dark side of the epitranscriptome: chemical modifications in long non-coding RNAs","volume":"18","author":"Jacob","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"6245","key":"10.1016\/j.yjmcc.2021.05.006_bb0510","doi-asserted-by":"crossref","DOI":"10.1126\/science.aab2276","article-title":"A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation","volume":"349","author":"Minajigi","year":"2015","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.yjmcc.2021.05.006_bb0515","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.celrep.2015.06.053","article-title":"A pooled shRNA screen identifies Rbm15, spen, and Wtap as factors required for Xist RNA-mediated silencing","volume":"12","author":"Moindrot","year":"2015","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.yjmcc.2021.05.006_bb0520","doi-asserted-by":"crossref","first-page":"13680","DOI":"10.1002\/jcp.28047","article-title":"The long noncoding RNA XIST regulates cardiac hypertrophy by targeting miR-101","volume":"234","author":"Xiao","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.05.006_bb0525","doi-asserted-by":"crossref","first-page":"8659","DOI":"10.1002\/jcp.26327","article-title":"LncRNA XIST regulates myocardial infarction by targeting miR-130a-3p","volume":"234","author":"Zhou","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2021.05.006_bb0530","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/bs.mie.2015.03.005","article-title":"Probing RNA modification status at single-nucleotide resolution in total RNA","volume":"560","author":"Liu","year":"2015","journal-title":"Methods Enzymol."},{"issue":"5 Pt A","key":"10.1016\/j.yjmcc.2021.05.006_bb0535","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.jmb.2015.08.021","article-title":"N(6)-methyladenosine modification in a long noncoding RNA hairpin predisposes its conformation to protein binding","volume":"428","author":"Zhou","year":"2016","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.05.006_bb0540","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227647","article-title":"Characterization of METTL16 as a cytoplasmic RNA binding protein","volume":"15","author":"Nance","year":"2020","journal-title":"PLoS One"},{"issue":"49","key":"10.1016\/j.yjmcc.2021.05.006_bb0545","doi-asserted-by":"crossref","first-page":"14013","DOI":"10.1073\/pnas.1614759113","article-title":"Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA","volume":"113","author":"Brown","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.05.006_bb0550","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijcard.2019.04.015","article-title":"LncRNA MALAT1 aggravates inflammation response through regulating PTGS2 by targeting miR-26b in myocardial ischemia-reperfusion injury","volume":"288","author":"Ruan","year":"2019","journal-title":"Int. J. Cardiol."},{"issue":"10","key":"10.1016\/j.yjmcc.2021.05.006_bb0555","doi-asserted-by":"crossref","first-page":"2912","DOI":"10.1161\/STROKEAHA.119.026433","article-title":"Transient focal ischemia significantly alters the m(6)A epitranscriptomic tagging of RNAs in the brain","volume":"50","author":"Chokkalla","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.yjmcc.2021.05.006_bb0560","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.tox.2017.05.007","article-title":"LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN\/MMP-2 signaling pathway","volume":"386","author":"Tao","year":"2017","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.yjmcc.2021.05.006_bb0565","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12943-019-1079-y","article-title":"Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m(6)A reader YTHDF3","volume":"18","author":"Ni","year":"2019","journal-title":"Mol. 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