{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:16:49Z","timestamp":1793197009785,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.yjmcc.2021.05.012","type":"journal-article","created":{"date-parts":[[2021,5,31]],"date-time":"2021-05-31T02:49:58Z","timestamp":1622429398000},"page":"72-81","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Molecular remodeling of Cx43, but not structural remodeling, promotes arrhythmias in an arrhythmogenic canine model of nonischemic heart failure"],"prefix":"10.1016","volume":"158","author":[{"given":"Jiajie","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Killingsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Walcott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Litovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Pogwizd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2021.05.012_bb0005","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1161\/01.CIR.72.4.681","article-title":"Sudden unexpected death in patients with congestive heart failure: a second frontier","volume":"72","author":"Packer","year":"1985","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0010","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1161\/01.CIR.92.4.1034","article-title":"Nonreentrant mechanisms underlying spontaneous ventricular arrhythmias in a model of nonischemic heart failure in rabbits","volume":"92","author":"Pogwizd","year":"1995","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0015","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/01.CIR.98.22.2404","article-title":"Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy","volume":"98","author":"Pogwizd","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0020","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1161\/hh1101.091193","article-title":"Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current, and residual beta-adrenergic responsiveness","volume":"88","author":"Pogwizd","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0025","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1172\/JCI116540","article-title":"Myocardial electrical propagation in patients with idiopathic dilated cardiomyopathy","volume":"92","author":"Anderson","year":"1993","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0030","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1161\/01.RES.80.5.673","article-title":"Characterization of gap junction channels in adult rabbit atrial and ventricular myocardium","volume":"80","author":"Verheule","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1996.0001q.x","article-title":"Connections with connexins: the molecular basis of direct intercellular signaling","volume":"238","author":"Bruzzone","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0040","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1540-8167.1995.tb00423.x","article-title":"The molecular basis of anisotropy: role of gap junctions","volume":"6","author":"Saffitz","year":"1995","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0045","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/cvr\/cvs366","article-title":"c-Jun N-terminal kinase activation contributes to reduced connexin43 and development of atrial arrhythmias","volume":"97","author":"Yan","year":"2013","journal-title":"Cardiovascular research"},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0050","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.yjmcc.2017.11.006","article-title":"The stress kinase JNK regulates gap junction Cx43 gene expression and promotes atrial fibrillation in the aged heart","volume":"114","author":"Yan","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0055","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1161\/01.RES.70.2.438","article-title":"Cardiac myocytes express multiple gap junction proteins","volume":"70","author":"Kanter","year":"1992","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0060","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1124\/pr.115.012062","article-title":"Connexins in cardiovascular and neurovascular health and disease: pharmacological implications","volume":"69","author":"Leybaert","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0065","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.yjmcc.2017.05.002","article-title":"Regulation of cardiac gap junctions by protein phosphatases","volume":"107","author":"Hood","year":"2017","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0070","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/01.RES.0000152325.07495.5a","article-title":"Connexin 43 downregulation and dephosphorylation in nonischemic heart failure is associated with enhanced colocalized protein phosphatase type 2A","volume":"96","author":"Ai","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0075","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0008-6363(02)00273-0","article-title":"Structural correlate of atrial fibrillation in human patients","volume":"54","author":"Kostin","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0080","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0735-1097(01)01710-7","article-title":"Relative expression of immunolocalized connexins 40 and 43 correlates with human atrial conduction properties","volume":"39","author":"Kanagaratnam","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0085","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1161\/01.CIR.94.3.384","article-title":"Site-dependent intra-atrial conduction delay. Relationship to initiation of atrial fibrillation","volume":"94","author":"Papageorgiou","year":"1996","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0090","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1172\/JCI119367","article-title":"Slow ventricular conduction in mice heterozygous for a connexin43 null mutation","volume":"99","author":"Guerrero","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0095","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1161\/01.RES.0000148664.33695.2a","article-title":"Modulation of cardiac gap junction expression and arrhythmic susceptibility","volume":"95","author":"Danik","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0100","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.hrthm.2008.04.026","article-title":"Transmural dispersion of refractoriness and conduction velocity is associated with heterogeneously reduced connexin43 in a rabbit model of heart failure","volume":"5","author":"Wiegerinck","year":"2008","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1161\/01.CIR.0000078641.19365.4C","article-title":"Differentiation of heart failure related to dilated cardiomyopathy and coronary artery disease using gadolinium-enhanced cardiovascular magnetic resonance","volume":"108","author":"McCrohon","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0110","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.ijcard.2016.11.054","article-title":"Correlation between microvascular dysfunction and B-type natriuretic peptide levels in non-ischemic heart failure patients with cardiac fibrosis","volume":"228","author":"Hirakawa","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0115","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1016\/j.amjcard.2014.02.029","article-title":"Correlation between extent of myocardial fibrosis assessed by cardiac magnetic resonance and cardiac troponin T release in patients with nonischemic heart failure","volume":"113","author":"Takashio","year":"2014","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0120","article-title":"Morning surge of ventricular arrhythmias in a new arrhythmogenic canine model of chronic heart failure is associated with attenuation of time-of-day dependence of heart rate and autonomic adaptation, and reduced cardiac chaos","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0125","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0160-5402(89)90015-6","article-title":"An improved method to correct the QT interval of the electrocardiogram for changes in heart rate","volume":"22","author":"Van de Water","year":"1989","journal-title":"J Pharmacol Methods."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.vascn.2005.02.005","article-title":"Correction of QT values to allow for increases in heart rate in conscious beagle dogs in toxicology assessment","volume":"53","author":"Tattersall","year":"2006","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0135","first-page":"H681","article-title":"A high density in vitro extracellular electrode array: description and implementation","volume":"257","author":"Cohen","year":"1989","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0140","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1109\/10.668746","article-title":"Estimation of conduction velocity vector fields from epicardial mapping data","volume":"45","author":"Bayly","year":"1998","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0145","first-page":"563","article-title":"Voltage and calcium dual channel optical mapping of cultured HL-1 atrial myocyte monolayer","volume":"97","author":"Yan","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0150","article-title":"Novel methods of automated quantification of gap junction distribution and interstitial collagen quantity from animal and human atrial tissue sections","volume":"9","author":"Yan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0155","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/cvr\/cvp353","article-title":"Connexin43 knockdown or overexpression modulates cell coupling in control and failing rabbit left ventricular myocytes","volume":"85","author":"Ai","year":"2010","journal-title":"Cardiovasc. Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.05.012_bb0160","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1161\/CIRCRESAHA.117.312536","article-title":"Stress signaling JNK2 crosstalk with CaMKII underlies enhanced atrial Arrhythmogenesis","volume":"122","author":"Yan","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0165","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1161\/01.CIR.0000147618.93579.56","article-title":"Restitution properties during ventricular fibrillation in the in situ swine heart","volume":"110","author":"Huang","year":"2004","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0170","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s10741-015-9509-4","article-title":"Myocardial interstitial remodelling in non-ischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance","volume":"20","author":"Barison","year":"2015","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0175","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jacc.2012.04.042","article-title":"Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction","volume":"60","author":"Greener","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0180","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1161\/CIRCULATIONAHA.105.534784","article-title":"Remodeling in cells from different regions of the reentrant circuit during ventricular tachycardia","volume":"112","author":"Baba","year":"2005","journal-title":"Circulation."},{"issue":"Suppl. 2","key":"10.1016\/j.yjmcc.2021.05.012_bb0185","first-page":"115","article-title":"The contribution of nonreentrant mechanisms to malignant ventricular arrhythmias","volume":"87","author":"Pogwizd","year":"1992","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0190","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1161\/CIRCULATIONAHA.111.047274","article-title":"Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy","volume":"125","author":"Glukhov","year":"2012","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0195","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0006-3495(83)84273-8","article-title":"The conducted action potential. Models and comparison to experiments","volume":"44","author":"Walton","year":"1983","journal-title":"Biophys. J."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0200","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.RES.0000144125.61927.1c","article-title":"Mechanisms underlying conduction slowing and arrhythmogenesis in nonischemic dilated cardiomyopathy","volume":"95","author":"Akar","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0205","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/cvr\/cvr163","article-title":"Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43","volume":"92","author":"Ai","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0210","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/jmcc.2000.1308","article-title":"Altered connexin expression in human congestive heart failure","volume":"33","author":"Dupont","year":"2001","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0215","doi-asserted-by":"crossref","first-page":"H1762","DOI":"10.1152\/ajpheart.00346.2004","article-title":"Altered connexin43 expression produces arrhythmia substrate in heart failure","volume":"287","author":"Poelzing","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0220","first-page":"83","article-title":"Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics","volume":"2018","author":"Solan","year":"1860","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0225","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fcvm.2016.00005","article-title":"Spatial heterogeneity of Cx43 is an Arrhythmogenic substrate of polymorphic ventricular Tachycardias during compensated cardiac hypertrophy in rats","volume":"3","author":"Boulaksil","year":"2016","journal-title":"Front Cardiovasc Med."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0230","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1161\/CIRCRESAHA.108.182147","article-title":"Ultrastructure and regulation of lateralized connexin43 in the failing heart","volume":"106","author":"Hesketh","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0235","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1046\/j.1540-8167.2002.00865.x","article-title":"Heterogeneous loss of connexin43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardia","volume":"13","author":"Kitamura","year":"2002","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0240","doi-asserted-by":"crossref","first-page":"H1223","DOI":"10.1152\/ajpheart.00079.2007","article-title":"Dynamic changes in conduction velocity and gap junction properties during development of pacing-induced heart failure","volume":"293","author":"Akar","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0245","first-page":"2020","article-title":"Functional consequences of abnormal Cx43 expression in the heart","volume":"2012","author":"Fontes","year":"1818","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0250","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1161\/01.RES.81.5.727","article-title":"Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling","volume":"81","author":"Shaw","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0255","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.yjmcc.2004.12.012","article-title":"Increased late sodium current in myocytes from a canine heart failure model and from failing human heart","volume":"38","author":"Valdivia","year":"2005","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0260","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pbiomolbio.2018.08.003","article-title":"The role of the gap junction perinexus in cardiac conduction: potential as a novel anti-arrhythmic drug target","volume":"144","author":"Hoagland","year":"2019","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0265","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/BF03091824","article-title":"Longitudinal arrhythmogenic remodelling in a mouse model of longstanding pressure overload","volume":"18","author":"Boulaksil","year":"2010","journal-title":"Neth Heart J."},{"key":"10.1016\/j.yjmcc.2021.05.012_bb0270","doi-asserted-by":"crossref","first-page":"H1164","DOI":"10.1152\/ajpheart.00960.2007","article-title":"Altered expression of connexin43 contributes to the arrhythmogenic substrate during the development of heart failure in cardiomyopathic hamster","volume":"294","author":"Sato","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821001061?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821001061?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:33:48Z","timestamp":1758314028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282821001061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":54,"alternative-id":["S0022282821001061"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.05.012","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular remodeling of Cx43, but not structural remodeling, promotes arrhythmias in an arrhythmogenic canine model of nonischemic heart failure","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}