{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T15:14:55Z","timestamp":1793891695676,"version":"4.8.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL105699"],"award-info":[{"award-number":["HL105699"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL143058"],"award-info":[{"award-number":["HL143058"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL150225"],"award-info":[{"award-number":["HL150225"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19CDA34660084"],"award-info":[{"award-number":["19CDA34660084"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011075","name":"David Geffen School of Medicine, University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011075","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.yjmcc.2021.07.002","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T01:07:42Z","timestamp":1626311262000},"page":"73-86","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart"],"prefix":"10.1016","volume":"160","author":[{"given":"Douglas J.","family":"Chapski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Cabaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Morselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosibel J.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Soehalim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxun","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Vondriska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rosa-Garrido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2021.07.002_bb0005","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1038\/ncomms6288","article-title":"Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease","volume":"5","author":"Gilsbach","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0010","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/s41467-017-01724-9","article-title":"DNA methylation signatures follow preformed chromatin compartments in cardiac myocytes","volume":"8","author":"Nothjunge","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0015","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1161\/CIRCULATIONAHA.117.029430","article-title":"High-resolution mapping of chromatin conformation in cardiac myocytes reveals structural remodeling of the epigenome in heart failure","volume":"136","author":"Rosa-Garrido","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0020","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1161\/CIRCULATIONAHA.118.036726","article-title":"Robust CTCF-based chromatin architecture underpins epigenetic changes in the heart failure stress-gene response","volume":"139","author":"Lee","year":"2019","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0025","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev-physiol-020911-153242","article-title":"Epigenetics and cardiovascular development","volume":"74","author":"Chang","year":"2012","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0030","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cell.2012.08.027","article-title":"A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development","volume":"151","author":"Paige","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0035","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cell.2012.07.035","article-title":"Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage","volume":"151","author":"Wamstad","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0040","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.yjmcc.2014.05.002","article-title":"BET-ting on chromatin-based therapeutics for heart failure","volume":"74","author":"Haldar","year":"2014","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0045","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/0470862637.ch9","article-title":"Dual roles of histone deacetylases in the control of cardiac growth","volume":"259","author":"McKinsey","year":"2004","journal-title":"Novartis Found. Symp."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0050","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s00018-013-1516-9","article-title":"Histone deacetylase signaling in cardioprotection","volume":"71","author":"Lehmann","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0055","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/CIRCRESAHA.116.303936","article-title":"Epigenetics and metabolism","volume":"116","author":"Keating","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0060","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10741-007-9034-1","article-title":"Return to the fetal gene program protects the stressed heart: a strong hypothesis","volume":"12","author":"Rajabi","year":"2007","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/978-1-4939-2572-8_3","article-title":"Deep sequencing of cardiac microRNA-mRNA interactomes in clinical and experimental cardiomyopathy","volume":"1299","author":"Matkovich","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0070","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41467-017-02762-z","article-title":"Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo","volume":"9","author":"Gilsbach","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0075","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1161\/CIRCRESAHA.115.305298","article-title":"DNA methylation indicates susceptibility to isoproterenol-inducd cardiac pathology and is associated with chromatin states","volume":"118","author":"Chen","year":"2016","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.yjmcc.2021.07.002_bb0080","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0085","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.M111.014258","article-title":"Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth","volume":"11","author":"Franklin","year":"2012","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0090","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.yjmcc.2019.02.003","article-title":"Direct visualization of cardiac transcription factories reveals regulatory principles of nuclear architecture during pathological remodeling","volume":"128","author":"Karbassi","year":"2019","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0095","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s12859-017-1934-z","article-title":"ImageJ2: ImageJ for the next generation of scientific image data","volume":"18","author":"Rueden","year":"2017","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0100","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1186\/1471-2164-14-774","article-title":"BS-Seeker2: a versatile aligning pipeline for bisulfite sequencing data","volume":"14","author":"Guo","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0105","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0110","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0115","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-r87","article-title":"methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles","volume":"13","author":"Akalin","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0120","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0125","first-page":"D682","article-title":"Ensembl 2020","volume":"48","author":"Yates","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0130","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Res"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0135","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0140","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0145","doi-asserted-by":"crossref","first-page":"W191","DOI":"10.1093\/nar\/gkz369","article-title":"g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)","volume":"47","author":"Raudvere","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0150","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0155","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ramirez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0160","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nmeth.4396","article-title":"An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues","volume":"14","author":"Corces","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0165","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0170","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","article-title":"Model-based analysis of ChIP-Seq (MACS)","volume":"9","author":"Zhang","year":"2008","journal-title":"Genome Biol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0175","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature10730","article-title":"Differential oestrogen receptor binding is associated with clinical outcome in breast cancer","volume":"481","author":"Ross-Innes","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0180","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0185","doi-asserted-by":"crossref","first-page":"20164","DOI":"10.1073\/pnas.1315155110","article-title":"Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy","volume":"110","author":"Papait","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0190","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1093\/bioinformatics\/btw069","article-title":"Integrated genome browser: visual analytics platform for genomics","volume":"32","author":"Freese","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0195","doi-asserted-by":"crossref","first-page":"D794","DOI":"10.1093\/nar\/gkx1081","article-title":"The Encyclopedia of DNA elements (ENCODE): data portal update","volume":"46","author":"Davis","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0200","doi-asserted-by":"crossref","first-page":"4907","DOI":"10.1038\/s41467-019-12812-3","article-title":"A reference map of murine cardiac transcription factor chromatin occupancy identifies dynamic and conserved enhancers","volume":"10","author":"Akerberg","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0205","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/s13059-015-0831-x","article-title":"HiC-Pro: an optimized and flexible pipeline for Hi-C data processing","volume":"16","author":"Servant","year":"2015","journal-title":"Genome Biol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0210","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1101\/gr.160374.113","article-title":"Statistical confidence estimation for Hi-C data reveals regulatory chromatin contacts","volume":"24","author":"Ay","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0215","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02372-17","article-title":"CCCTC-binding factor acts as a heterochromatin barrier on herpes simplex viral latent chromatin and contributes to poised latent infection","volume":"9","author":"Lee","year":"2018","journal-title":"mBio"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0220","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00412-010-0262-0","article-title":"CTCF shapes chromatin by multiple mechanisms: the impact of 20 years of CTCF research on understanding the workings of chromatin","volume":"119","author":"Ohlsson","year":"2010","journal-title":"Chromosoma"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0225","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","article-title":"Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities","volume":"38","author":"Heinz","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0230","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1126\/science.1181369","article-title":"Comprehensive mapping of long-range interactions reveals folding principles of the human genome","volume":"326","author":"Lieberman-Aiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0235","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/CIRCRESAHA.116.303630","article-title":"Readers, writers, and erasers chromatin as the whiteboard of heart disease","volume":"116","author":"Gillette","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0240","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1161\/CIRCULATIONAHA.117.028252","article-title":"Multicellular transcriptional analysis of mammalian heart regeneration","volume":"136","author":"Quaife-Ryan","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0245","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1126\/science.1229765","article-title":"C\/EBP transcription factors mediate epicardial activation during heart development and injury","volume":"338","author":"Huang","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0250","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nprot.2018.008","article-title":"Producing genome structure populations with the dynamic and automated PGS software","volume":"13","author":"Hua","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0255","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fcvm.2018.00186","article-title":"Spatial principles of chromatin architecture associated with organ-specific gene regulation","volume":"5","author":"Chapski","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0260","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrcardio.2017.57","article-title":"Redefining the identity of cardiac fibroblasts","volume":"14","author":"Tallquist","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0265","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics-2021 update: a report from the American Heart Association","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0270","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41576-018-0083-1","article-title":"The role of sex in the genomics of human complex traits","volume":"20","author":"Khramtsova","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0275","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/eurheartj\/ehv548","article-title":"Heart failure: when form fails to follow function","volume":"37","author":"Katz","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0280","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1016\/j.jacc.2014.08.036","article-title":"Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction","volume":"64","author":"Mentz","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3317\/jraas.2002.001","article-title":"Role of endothelin in cardiovascular disease","volume":"3","author":"Agapitov","year":"2002","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0290","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1161\/CIRCGENETICS.114.000623","article-title":"Evaluation of genes encoding for the transient outward current (Ito) identifies the KCND2 gene as a cause of J-wave syndrome associated with sudden cardiac death","volume":"7","author":"Perrin","year":"2014","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.yjmcc.2021.07.002_bb0295","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/S0024-3205(99)00042-9","article-title":"Catecholamine metabolism inhibitors and receptor blockades only partially suppress cardiac hypertrophy of juvenile visceral steatosis mice with systemic carnitine deficiency","volume":"64","author":"Jalil","year":"1999","journal-title":"Life Sci."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821001437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821001437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T06:00:08Z","timestamp":1762668008000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282821001437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":59,"alternative-id":["S0022282821001437"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.07.002","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}