{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:38:35Z","timestamp":1773056315133,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.yjmcc.2021.09.003","type":"journal-article","created":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T10:25:31Z","timestamp":1631355931000},"page":"81-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Interaction of SOX5 with SOX9 promotes warfarin-induced aortic valve interstitial cell calcification by repressing transcriptional activation of LRP6"],"prefix":"10.1016","volume":"162","author":[{"given":"Ming","family":"Qiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongfeng","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangqing","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2021.09.003_bb0005","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1161\/CIRCULATIONAHA.115.014846","article-title":"Population-wide trends in aortic stenosis incidence and outcomes","volume":"131","author":"Bonow","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0010","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1093\/eurheartj\/ehx391","article-title":"2017 ESC\/EACTS guidelines for the management of valvular heart disease","volume":"38","author":"Baumgartner","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0015","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/eurheartj\/eht034","article-title":"Aortic stenosis, atherosclerosis, and skeletal bone: is there a common link with calcification and inflammation?","volume":"34","author":"Dweck","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0020","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1161\/CIRCRESAHA.113.300155","article-title":"Molecular and cellular aspects of calcific aortic valve disease","volume":"113","author":"Towler","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0025","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.jacc.2015.05.066","article-title":"Calcification in aortic stenosis: the skeleton key","volume":"66","author":"Pawade","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0030","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/CIRCRESAHA.110.219071","article-title":"Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification","volume":"107","author":"Yao","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0035","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1074\/jbc.M109683200","article-title":"Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2","volume":"277","author":"Zebboudj","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0040","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1161\/01.ATV.18.9.1400","article-title":"Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves","volume":"18","author":"Price","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0045","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1160\/TH08-09-0611","article-title":"Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification","volume":"101","author":"Koos","year":"2009","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0050","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/CIRCRESAHA.109.213702","article-title":"Reduced sox9 function promotes heart valve calcification phenotypes in vivo","volume":"106","author":"Peacock","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0055","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/ATVBAHA.115.306091","article-title":"Valve endothelial cell-derived Tgfbeta1 signaling promotes nuclear localization of Sox9 in interstitial cells associated with attenuated calcification","volume":"36","author":"Huk","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0060","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1002\/art.20611","article-title":"The combination of SOX5, SOX6, and SOX9 (the SOX trio) provides signals sufficient for induction of permanent cartilage","volume":"50","author":"Ikeda","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0065","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.biocel.2009.07.016","article-title":"The SoxD transcription factors--Sox5, Sox6, and Sox13--are key cell fate modulators","volume":"42","author":"Lefebvre","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0070","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1093\/emboj\/17.19.5718","article-title":"A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene","volume":"17","author":"Lefebvre","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0075","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuron.2007.12.023","article-title":"SOX5 controls the sequential generation of distinct corticofugal neuron subtypes","volume":"57","author":"Lai","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0080","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/humu.22037","article-title":"Haploinsufficiency of SOX5 at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features","volume":"33","author":"Lamb","year":"2012","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0085","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/dneu.22240","article-title":"Sox5 controls dorsal progenitor and interneuron specification in the spinal cord","volume":"75","author":"Quiroga","year":"2014","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0090","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00439-020-02124-8","article-title":"Low-density lipoprotein receptor-related protein 6-mediated signaling pathways and associated cardiovascular diseases: diagnostic and therapeutic opportunities","volume":"139","author":"Kang","year":"2020","journal-title":"Hum. Genet."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0095","article-title":"SPARC-related modular calcium binding 1 regulates aortic valve calcification by disrupting BMPR-II\/p-p38 signalling","author":"Wang","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0100","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1074\/jbc.M117.791145","article-title":"Low-level overexpression of p53 promotes warfarin-induced calcification of porcine aortic valve interstitial cells by activating Slug gene transcription","volume":"293","author":"Gao","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0105","first-page":"1909","article-title":"MicroRNA-327 regulates cardiac hypertrophy and fibrosis induced by pressure overload","volume":"41","author":"Ji","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0110","doi-asserted-by":"crossref","first-page":"5249","DOI":"10.1111\/jcmm.15178","article-title":"Overexpression of peptidase inhibitor 16 attenuates angiotensin II-induced cardiac fibrosis via regulating HDAC1 of cardiac fibroblasts","volume":"24","author":"Deng","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0115","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0945-053X(00)00094-9","article-title":"Transcriptional mechanisms of chondrocyte differentiation","volume":"19","author":"de Crombrugghe","year":"2000","journal-title":"Matrix Biol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0120","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ydbio.2010.02.024","article-title":"Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage","volume":"341","author":"Dy","year":"2010","journal-title":"Dev. Biol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0125","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1534-5807(01)00003-X","article-title":"The transcription factors L-Sox5 and Sox6 are essential for cartilage formation","volume":"1","author":"Smits","year":"2001","journal-title":"Dev. Cell"},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0130","doi-asserted-by":"crossref","first-page":"4541","DOI":"10.1091\/mbc.e09-03-0227","article-title":"Sox9 family members negatively regulate maturation and calcification of chondrocytes through up-regulation of parathyroid hormone-related protein","volume":"20","author":"Amano","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0135","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.1093\/nar\/gkv688","article-title":"The transcription factors SOX9 and SOX5\/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis","volume":"43","author":"Liu","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0140","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/ng0195-15","article-title":"The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos","volume":"9","author":"Wright","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0145","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/jcp.20210","article-title":"Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development","volume":"203","author":"Smith","year":"2005","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0150","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1002\/jbmr.174","article-title":"SOX9 determines RUNX2 transactivity by directing intracellular degradation","volume":"25","author":"Cheng","year":"2010","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0155","doi-asserted-by":"crossref","first-page":"6478","DOI":"10.1074\/jbc.M112.419184","article-title":"SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt\/beta-catenin activation in breast cancer","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0160","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/CIRCRESAHA.117.306712","article-title":"Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR\u2212\/\u2212 mice by restraining noncanonical Wnt signals","volume":"117","author":"Cheng","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0165","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/MNH.0b013e32833a3d67","article-title":"The bone-vascular axis in chronic kidney disease","volume":"19","author":"Demer","year":"2010","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0170","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.1136370","article-title":"LRP6 mutation in a family with early coronary disease and metabolic risk factors","volume":"315","author":"Mani","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0175","doi-asserted-by":"crossref","first-page":"10891","DOI":"10.18632\/oncotarget.22443","article-title":"SOX5 predicts poor prognosis in lung adenocarcinoma and promotes tumor metastasis through epithelial-mesenchymal transition","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0180","first-page":"461","article-title":"SOX5 promotes epithelial-mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma","volume":"32","author":"Wang","year":"2015","journal-title":"Med. Oncol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0185","first-page":"461","article-title":"miR-212-3p reduced proliferation, and promoted apoptosis of fibroblast-like synoviocytes via down-regulating SOX5 in rheumatoid arthritis","volume":"22","author":"Liu","year":"2018","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0190","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s12250-020-00313-3","article-title":"SOX5 regulates cell proliferation, apoptosis, migration and invasion in KSHV-infected cells","volume":"36","author":"Yuan","year":"2021","journal-title":"Virol. Sin."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0195","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/embor.2010.61","article-title":"SOX5 controls cell cycle progression in neural progenitors by interfering with the WNT-beta-catenin pathway","volume":"11","author":"Martinez-Morales","year":"2010","journal-title":"EMBO Rep."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0200","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.006339","article-title":"Valve interstitial cells: the key to understanding the pathophysiology of heart valve calcification","volume":"6","author":"Rutkovskiy","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0205","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/ATVBAHA.116.308394","article-title":"Role of noncanonical Wnt signaling pathway in human aortic valve calcification","volume":"37","author":"Albanese","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0210","doi-asserted-by":"crossref","first-page":"H1829","DOI":"10.1152\/ajpheart.00240.2010","article-title":"Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure","volume":"300","author":"Shuvy","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0215","doi-asserted-by":"crossref","first-page":"C697","DOI":"10.1152\/ajpcell.00292.2016","article-title":"Neurotrophin 3 upregulates proliferation and collagen production in human aortic valve interstitial cells: a potential role in aortic valve sclerosis","volume":"312","author":"Yao","year":"2017","journal-title":"Am. J. Phys. Cell Physiol."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0220","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1093\/nar\/gkn150","article-title":"Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5","volume":"36","author":"Hattori","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0225","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026769","article-title":"Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes","volume":"6","author":"Peacock","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0230","doi-asserted-by":"crossref","first-page":"19004","DOI":"10.1073\/pnas.0605170103","article-title":"Dominance of SOX9 function over RUNX2 during skeletogenesis","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.yjmcc.2021.09.003_bb0235","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1002\/jcb.23221","article-title":"The role of Lrp5\/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE\u2212\/\u2212 \/Lrp5\u2212\/\u2212 mice","volume":"112","author":"Rajamannan","year":"2011","journal-title":"J. Cell. Biochem."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821001759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821001759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:35:32Z","timestamp":1758314132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282821001759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":47,"alternative-id":["S0022282821001759"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.09.003","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction of SOX5 with SOX9 promotes warfarin-induced aortic valve interstitial cell calcification by repressing transcriptional activation of LRP6","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}