{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:10:23Z","timestamp":1790161823792,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1S10 OD025038"],"award-info":[{"award-number":["1S10 OD025038"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL155085"],"award-info":[{"award-number":["1R01HL155085"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01HL131788"],"award-info":[{"award-number":["5R01HL131788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017749","name":"Medical College of Wisconsin, Cardiovascular Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["828662"],"award-info":[{"award-number":["828662"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["00012308"],"award-info":[{"award-number":["00012308"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18CDA34110240"],"award-info":[{"award-number":["18CDA34110240"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.yjmcc.2021.09.012","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T11:14:03Z","timestamp":1633346043000},"page":"9-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction"],"prefix":"10.1016","volume":"163","author":[{"given":"Xinrui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina C.","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Lauth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra L.","family":"Purdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine R.","family":"Kulik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Lough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Auchampach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.yjmcc.2021.09.012_bb0005","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.stem.2019.12.004","article-title":"Toward the goal of human heart regeneration","volume":"26","author":"Sadek","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0010","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.yjmcc.2020.11.016","article-title":"What we know about cardiomyocyte dedifferentiation","volume":"152","author":"Zhu","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5","key":"10.1016\/j.yjmcc.2021.09.012_bb0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrm.2016.7","article-title":"Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease","volume":"17","author":"Almada","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.09.012_bb0020","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1161\/CIRCRESAHA.116.309040","article-title":"Cardiac regeneration: lessons from development","volume":"120","author":"Galdos","year":"2017","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.yjmcc.2021.09.012_bb0025","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41569-019-0235-9","article-title":"Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease","volume":"17","author":"Li","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.09.012_bb0030","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.molcel.2006.11.026","article-title":"Acetylation of the p53 DNA-binding domain regulates apoptosis induction","volume":"24","author":"Sykes","year":"2006","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.yjmcc.2021.09.012_bb0035","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.molcel.2006.11.021","article-title":"Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis","volume":"24","author":"Tang","year":"2006","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.yjmcc.2021.09.012_bb0040","doi-asserted-by":"crossref","first-page":"930","DOI":"10.4161\/cc.9.5.10931","article-title":"Tip60: connecting chromatin to DNA damage signaling","volume":"9","author":"Sun","year":"2010","journal-title":"Cell Cycle"},{"issue":"11","key":"10.1016\/j.yjmcc.2021.09.012_bb0045","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1038\/ncb1982","article-title":"Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60","volume":"11","author":"Sun","year":"2009","journal-title":"Nat. Cell Biol."},{"issue":"37","key":"10.1016\/j.yjmcc.2021.09.012_bb0050","doi-asserted-by":"crossref","first-page":"13182","DOI":"10.1073\/pnas.0504211102","article-title":"A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM","volume":"102","author":"Sun","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1\u20132","key":"10.1016\/j.yjmcc.2021.09.012_bb0055","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11010-006-0233-1","article-title":"Apoptosis at a distance: remote activation of caspase-3 occurs early after myocardial infarction","volume":"281","author":"Schwarz","year":"2006","journal-title":"Mol. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.yjmcc.2021.09.012_bb0060","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","article-title":"The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response","volume":"157","author":"Puente","year":"2014","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.yjmcc.2021.09.012_bb0065","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/cdd.2012.159","article-title":"Stabilization of p21 (Cip1\/WAF1) following Tip60-dependent acetylation is required for p21-mediated DNA damage response","volume":"20","author":"Lee","year":"2013","journal-title":"Cell Death Differ."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.09.012_bb0070","doi-asserted-by":"crossref","DOI":"10.1007\/s12038-019-9963-6","article-title":"Haploinsufficient tumor suppressor Tip60 negatively regulates oncogenic Aurora B kinase","volume":"44","author":"Bose","year":"2019","journal-title":"J. Biosci."},{"issue":"1\u20132","key":"10.1016\/j.yjmcc.2021.09.012_bb0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0378-1119(02)00546-2","article-title":"Characterization and expression of the mouse tat interactive protein 60 kD (TIP60) gene","volume":"289","author":"McAllister","year":"2002","journal-title":"Gene"},{"issue":"2","key":"10.1016\/j.yjmcc.2021.09.012_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031569","article-title":"Stress-induced cell-cycle activation in Tip60 haploinsufficient adult cardiomyocytes","volume":"7","author":"Fisher","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.yjmcc.2021.09.012_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164855","article-title":"Depletion of Tip60 from in vivo cardiomyocytes increases myocyte density, followed by cardiac dysfunction, myocyte fallout and lethality","volume":"11","author":"Fisher","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.yjmcc.2021.09.012_bb0090","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/hh1301.092687","article-title":"Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein","volume":"89","author":"Sohal","year":"2001","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.yjmcc.2021.09.012_bb0095","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1067\/S0894-7317(03)00399-7","article-title":"Validation of the myocardial performance index by echocardiography in mice: a noninvasive measure of left ventricular function","volume":"16","author":"Broberg","year":"2003","journal-title":"J. Am. Soc. Echocardiogr."},{"issue":"6","key":"10.1016\/j.yjmcc.2021.09.012_bb0100","first-page":"357","article-title":"New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function--a study in normals and dilated cardiomyopathy","volume":"26","author":"Tei","year":"1995","journal-title":"J. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.09.012_bb0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0002-9149(99)00599-8","article-title":"Serial changes and prognostic implications of a Doppler-derived index of combined left ventricular systolic and diastolic myocardial performance in acute myocardial infarction","volume":"85","author":"Poulsen","year":"2000","journal-title":"Am. J. Cardiol."},{"issue":"5","key":"10.1016\/j.yjmcc.2021.09.012_bb0110","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.euje.2005.01.007","article-title":"Evaluation of tissue Doppler Tei index for global left ventricular function in mice after myocardial infarction: comparison with pulsed Doppler Tei index","volume":"6","author":"Schaefer","year":"2005","journal-title":"Eur. J. Echocardiogr."},{"issue":"7675","key":"10.1016\/j.yjmcc.2021.09.012_bb0115","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nature24045","article-title":"Hippo pathway deficiency reverses systolic heart failure after infarction","volume":"550","author":"Leach","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.yjmcc.2021.09.012_bb0120","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCRESAHA.115.307778","article-title":"Revisiting cardiac cellular composition","volume":"118","author":"Pinto","year":"2016","journal-title":"Circ. Res."},{"issue":"7636","key":"10.1016\/j.yjmcc.2021.09.012_bb0125","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature20173","article-title":"Hypoxia induces heart regeneration in adult mice","volume":"541","author":"Nakada","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0130","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.yjmcc.2021.02.005","article-title":"Evidence that the acetyltransferase Tip60 induces the DNA damage response and cell-cycle arrest in neonatal cardiomyocytes","volume":"155","author":"Wang","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0135","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.15252\/embr.201743907","article-title":"The MYST family histone acetyltransferase complex regulates stress resistance and longevity through transcriptional control of DAF-16\/FOXO transcription factors","volume":"18","author":"Ikeda","year":"2017","journal-title":"EMBO Rep."},{"issue":"3","key":"10.1016\/j.yjmcc.2021.09.012_bb0140","doi-asserted-by":"crossref","first-page":"R239","DOI":"10.1530\/JME-18-0178","article-title":"Molecular mechanisms of FOXO1 in adipocyte differentiation","volume":"62","author":"Chen","year":"2019","journal-title":"J. Mol. Endocrinol."},{"issue":"3","key":"10.1016\/j.yjmcc.2021.09.012_bb0145","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbrc.2008.11.110","article-title":"Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway","volume":"378","author":"Chen","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0150","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1161\/CIRCULATIONAHA.110.958033","article-title":"Silent information regulator 1 protects the heart from ischemia\/reperfusion","volume":"122","author":"Hsu","year":"2010","journal-title":"Circulation"},{"issue":"7501","key":"10.1016\/j.yjmcc.2021.09.012_bb0155","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature13193","article-title":"The role of senescent cells in ageing","volume":"509","author":"van Deursen","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.yjmcc.2021.09.012_bb0160","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/ncb3149","article-title":"ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation","volume":"17","author":"D\u2019Uva","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0165","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1161\/CIRCULATIONAHA.115.019357","article-title":"Overexpression of Tbx20 in adult cardiomyocytes promotes proliferation and improves cardiac function after myocardial infarction","volume":"133","author":"Xiang","year":"2016","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.yjmcc.2021.09.012_bb0170","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.bbrc.2015.02.081","article-title":"FGF21 attenuates pathological myocardial remodeling following myocardial infarction through the adiponectin-dependent mechanism","volume":"459","author":"Joki","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.yjmcc.2021.09.012_bb0175","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s00395-019-0737-y","article-title":"E2f1 deletion attenuates infarct-induced ventricular remodeling without affecting O-GlcNAcylation","volume":"114","author":"Dassanayaka","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0180","doi-asserted-by":"crossref","first-page":"21972","DOI":"10.1038\/srep21972","article-title":"Loss of CEACAM1, a tumor-associated factor, attenuates post-infarction cardiac remodeling by inhibiting apoptosis","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.yjmcc.2021.09.012_bb0185","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cell.2008.03.025","article-title":"Acetylation is indispensable for p53 activation","volume":"133","author":"Tang","year":"2008","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.yjmcc.2021.09.012_bb0190","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/01.RES.0000215985.18538.c4","article-title":"Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability","volume":"98","author":"Oka","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0195","doi-asserted-by":"crossref","first-page":"dmm046375","DOI":"10.1242\/dmm.046375","article-title":"Myh6-driven Cre-recombinase activates the DNA damage response and the cell-cycle in the myocardium in the absence of loxP sites","volume":"13","author":"Wang","year":"2020","journal-title":"Dis. Model. Mech."},{"issue":"5","key":"10.1016\/j.yjmcc.2021.09.012_bb0200","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.molcel.2011.03.033","article-title":"Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53","volume":"42","author":"Charvet","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0205","doi-asserted-by":"crossref","first-page":"12555","DOI":"10.18632\/oncotarget.2717","article-title":"Phosphorylation of Tip60 by p38alpha regulates p53-mediated PUMA induction and apoptosis in response to DNA damage","volume":"5","author":"Xu","year":"2014","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.yjmcc.2021.09.012_bb0210","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0092-8674(00)00051-9","article-title":"Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis","volume":"102","author":"Ikura","year":"2000","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.yjmcc.2021.09.012_bb0215","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/cvr\/cvn243","article-title":"Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling","volume":"81","author":"Dorn","year":"2009","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2021.09.012_bb0220","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrcardio.2009.12","article-title":"Novel pharmacotherapies to abrogate postinfarction ventricular remodeling","volume":"6","author":"Dorn","year":"2009","journal-title":"Nat. Rev. Cardiol."},{"issue":"7756","key":"10.1016\/j.yjmcc.2021.09.012_bb0225","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41586-019-1191-6","article-title":"MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs","volume":"569","author":"Gabisonia","year":"2019","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.yjmcc.2021.09.012_bb0230","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1161\/CIRCRESAHA.116.308544","article-title":"Loss of adult cardiac myocyte GSK-3 leads to mitotic catastrophe resulting in fatal dilated cardiomyopathy","volume":"118","author":"Zhou","year":"2016","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2021.09.012_bb0235","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/cvr\/cvy255","article-title":"Inhibition of GSK-3 to induce cardiomyocyte proliferation: a recipe for in situ cardiac regeneration","volume":"115","author":"Singh","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2021.09.012_bb0240","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.molcel.2018.12.017","article-title":"Pacer Is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism","volume":"73","author":"Cheng","year":"2019","journal-title":"Mol. Cell"},{"issue":"6080","key":"10.1016\/j.yjmcc.2021.09.012_bb0245","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1126\/science.1217032","article-title":"GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy","volume":"336","author":"Lin","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0250","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1172\/JCI36245","article-title":"Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation","volume":"118","author":"Kerkela","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"15","key":"10.1016\/j.yjmcc.2021.09.012_bb0255","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.012089","article-title":"Inhibition of senescence-associated genes Rb1 and Meis2 in adult cardiomyocytes results in cell cycle reentry and cardiac repair post-myocardial infarction","volume":"8","author":"Alam","year":"2019","journal-title":"J. Am. Heart Assoc."},{"issue":"3","key":"10.1016\/j.yjmcc.2021.09.012_bb0260","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.201012049","article-title":"Rb and p130 control cell cycle gene silencing to maintain the postmitotic phenotype in cardiac myocytes","volume":"194","author":"Sdek","year":"2011","journal-title":"J. Cell Biol."},{"issue":"7448","key":"10.1016\/j.yjmcc.2021.09.012_bb0265","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature12054","article-title":"Meis1 regulates postnatal cardiomyocyte cell cycle arrest","volume":"497","author":"Mahmoud","year":"2013","journal-title":"Nature"},{"issue":"6028","key":"10.1016\/j.yjmcc.2021.09.012_bb0270","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.1199010","article-title":"Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size","volume":"332","author":"Heallen","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0275","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1128\/MCB.01382-07","article-title":"DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity","volume":"27","author":"Sun","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006681","article-title":"TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter","volume":"13","author":"Rajagopalan","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.yjmcc.2021.09.012_bb0285","doi-asserted-by":"crossref","first-page":"15104","DOI":"10.1038\/ncomms15104","article-title":"DNA single-strand break-induced DNA damage response causes heart failure","volume":"8","author":"Higo","year":"2017","journal-title":"Nat. Commun."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821001899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282821001899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:09:42Z","timestamp":1777392582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282821001899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":57,"alternative-id":["S0022282821001899"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.09.012","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Conditional depletion of the acetyltransferase Tip60 protects against the damaging effects of myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2021.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}