{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:36:00Z","timestamp":1790742960913,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2016-04051"],"award-info":[{"award-number":["RGPIN-2016-04051"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2017-04392"],"award-info":[{"award-number":["RGPIN-2017-04392"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2021-02754"],"award-info":[{"award-number":["RGPIN-2021-02754"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000222","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000222","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["G-18-0022098"],"award-info":[{"award-number":["G-18-0022098"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.yjmcc.2022.06.011","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T14:30:08Z","timestamp":1657809008000},"page":"30-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Deficiency of cystathionine gamma-lyase promotes aortic elastolysis and medial degeneration in aged mice"],"prefix":"10.1016","volume":"171","author":[{"given":"Jiechun","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Rivett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangdong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2022.06.011_bb0005","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1161\/ATVBAHA.117.309578","article-title":"Aortic aneurysms","volume":"37","author":"Lu","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0010","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1056\/NEJMcp1401430","article-title":"Clinical practice. Abdominal aortic aneurysms","volume":"371","author":"Kent","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0002-9149(77)80004-0","article-title":"Histologic changes in the normal aging aorta: implications for dissecting aortic aneurysm","volume":"39","author":"Schlatmann","year":"1977","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0020","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/CIRCRESAHA.118.313187","article-title":"Cellular mechanisms of aortic aneurysm formation","volume":"124","author":"Quintana","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0025","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/928315","article-title":"Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling","volume":"2013","author":"Chen","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/bs.pmbts.2017.02.002","article-title":"The role matrix metalloproteinases in the production of aortic aneurysm","volume":"147","author":"Rabkin","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pmbts.2017.02.005","article-title":"Biochemical and biological attributes of matrix metalloproteinases","volume":"147","author":"Cui","year":"2017","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0040","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0045","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3390\/cells9051313","article-title":"Metalloproteinases and their inhibitors: potential for the development of new therapeutics","volume":"9","author":"Raeeszadeh-Sarmazdeh","year":"2020","journal-title":"Cells."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0050","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0055","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0060","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.2353\/ajpath.2007.060939","article-title":"Protective effect of hydrogen sulfide on balloon injury-induced neointima hyperplasia in rat carotid arteries","volume":"170","author":"Meng","year":"2007","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0065","first-page":"1497","article-title":"Effect of hydrogen sulfide on restenosis of peripheral arteries after angioplasty","volume":"5","author":"Ma","year":"2012","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0070","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.yjmcc.2011.12.004","article-title":"Increased neointimal formation in cystathionine gamma-lyase deficient mice: role of hydrogen sulfide in \u03b15\u03b21-integrin and matrix metalloproteinase-2 expression in smooth muscle cells","volume":"52","author":"Yang","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0075","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.biopha.2017.01.057","article-title":"H(2)S causes contraction and relaxation of major arteries of the rabbit","volume":"89","author":"Caprnda","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.taap.2017.11.004","article-title":"H2S protects lipopolysaccharide-induced inflammation by blocking NF\u03baB transactivation in endothelial cells","volume":"338","author":"Bourque","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0085","doi-asserted-by":"crossref","first-page":"7570489","DOI":"10.1155\/2016\/7570489","article-title":"Protective effects of hydrogen sulfide in the ageing kidney","volume":"2016","author":"Hou","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0090","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/13685538.2012.668722","article-title":"Endogenous hydrogen sulfide insufficiency as a predictor of sexual dysfunction in aging rats","volume":"15","author":"Srilatha","year":"2012","journal-title":"Aging Male."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0095","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1097\/HJH.0b013e328330a900","article-title":"Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator","volume":"27","author":"Fang","year":"2009","journal-title":"J. Hypertens."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0100","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.18632\/aging.101630","article-title":"Overexpression of CBS and CSE genes affects lifespan, stress resistance and locomotor activity in Drosophila melanogaster","volume":"10","author":"Shaposhnikov","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0105","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1089\/ars.2013.5448","article-title":"Hydrogen sulfide is an endogenous regulator of aging in Caenorhabditis elegans","volume":"20","author":"Qabazard","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0110","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1089\/rej.2018.2166","article-title":"Cystathionine \u03b2-synthase-derived hydrogen sulfide correlates with successful aging in mice","volume":"22","author":"Lu","year":"2019","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105125","article-title":"Role of hydrogen sulfide in cardiovascular ageing","volume":"160","author":"Testai","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0120","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1042\/BCJ20210517","article-title":"Hydrogen sulfide in ageing, longevity and disease","volume":"478","author":"Wilkie","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158421","article-title":"Reverse regulatory pathway (H2S \/ PGE2 \/ MMP) in human aortic aneurysm and saphenous vein varicosity","volume":"11","author":"Gomez","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0130","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/cvr\/cvp420","article-title":"Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells","volume":"86","author":"Yang","year":"2010","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0135","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/CS20160865","article-title":"Deletion of hypoxia-inducible factor-1\u03b1 in myeloid lineage exaggerates angiotensin II-induced formation of abdominal aortic aneurysm","volume":"131","author":"Takahara","year":"2017","journal-title":"Clin. Sci."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0140","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1161\/ATVBAHA.112.254219","article-title":"Inhibition of Notch1 signaling reduces abdominal aortic aneurysm in mice by attenuating macrophage-mediated inflammation","volume":"32","author":"Hans","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0145","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1161\/ATVBAHA.118.311969","article-title":"Deficiency of IL12p40 (interleukin 12 p40) promotes Ang II (angiotensin II)-induced sbdominal sortic sneurysm","volume":"39","author":"Sharma","year":"2019","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0150","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0155","doi-asserted-by":"crossref","first-page":"H406","DOI":"10.1152\/ajpheart.00245.2016","article-title":"The interaction of estrogen and CSE\/H2S pathway in the development of atherosclerosis","volume":"312","author":"Li","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0160","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.omtn.2018.03.013","article-title":"De novo synthesis of elastin by exogenous delivery of synthetic modified mRNA into skin and elastin-deficient cells","volume":"11","author":"Lescan","year":"2018","journal-title":"Mol. Ther. Nucleic. Acids."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0165","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1007\/s00223-019-00618-w","article-title":"A novel sandwich ELISA for tartrate-resistant acid phosphatase 5a and 5b protein reveals that both isoforms are secreted by differentiating osteoclasts and correlate to the type I collagen degradation marker CTX-I in vivo and in vitro","volume":"106","author":"Mira-Pascual","year":"2020","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0170","first-page":"163","article-title":"Assessment of gelatinases (MMP-2 and MMP-9) by gelatin zymography","volume":"57","author":"Toth","year":"2001","journal-title":"Methods Mol. Med."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0175","first-page":"1","article-title":"H2S-mediated blockage of protein acetylation and oxidative stress attenuates lipid overload-induced cardiac senescence","volume":"2021","author":"Yu","year":"2021","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0180","doi-asserted-by":"crossref","first-page":"26450","DOI":"10.1074\/jbc.M111.266643","article-title":"Specificity protein-1 as a critical regulator of human cystathionine \u03b3-lyase in smooth muscle cells","volume":"286","author":"Yang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0185","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1016\/j.ajpath.2012.01.025","article-title":"Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation","volume":"180","author":"Jeong","year":"2012","journal-title":"Am. J. Pathol."},{"issue":"ra72","key":"10.1016\/j.yjmcc.2022.06.011_bb0190","article-title":"H2S signals through protein S-sulfhydration","volume":"2","author":"Mustafa","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0195","first-page":"4325","article-title":"The CDK6-c-Jun-Sp1-MMP-2 axis as a biomarker and therapeutic target for triple-negative breast cancer","volume":"10","author":"Luo","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0200","doi-asserted-by":"crossref","first-page":"29130","DOI":"10.1074\/jbc.274.41.29130","article-title":"The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells","volume":"274","author":"Qin","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0205","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1096\/fj.05-4712fje","article-title":"Pro-apoptotic effect of endogenous H2S on human aorta smooth muscle cells","volume":"20","author":"Yang","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0210","first-page":"7","article-title":"Hyperhomocysteinemia and cardiovascular diseases","volume":"80","author":"Guieu","year":"2022","journal-title":"Ann. Biol. Clin. (Paris)."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0215","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/ijc.26049","article-title":"Sp1 is upregulated in human glioma, promotes MMP-2-mediated cell invasion and predicts poor clinical outcome","volume":"130","author":"Guan","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0220","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00018-013-1431-0","article-title":"Domain structure and function of matrix metalloprotease 23 (MMP23): role in potassium channel trafficking","volume":"71","author":"Galea","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0225","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.2174\/1389450110607011505","article-title":"The deficit in low molecular weight thiols as a target for antiageing therapy","volume":"7","author":"Dr\u00f6ge","year":"2006","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0230","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.freeradbiomed.2004.11.029","article-title":"Age-associated oxidative damage leads to absence of \u03b3-cystathionase in over 50% of rat lenses: relevance in cataractogenesis","volume":"38","author":"Sastre","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0235","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1378\/chest.128.5.3205","article-title":"Endogenous hydrogen sulfide in patients eith COPD","volume":"128","author":"Chen","year":"2005","journal-title":"Chest."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0240","first-page":"573","article-title":"Evaluation of cardiovascular risk in the elderly: the Framingham study","volume":"54","author":"Kannel","year":"1978","journal-title":"Bull. N. Y. Acad. Med."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0245","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/s11906-011-0215-x","article-title":"Update on pathophysiology and treatment of hypertension in the elderly","volume":"13","author":"Cohen","year":"2011","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0250","doi-asserted-by":"crossref","first-page":"H189","DOI":"10.1152\/ajpheart.00087.2018","article-title":"Elastin, arterial mechanics, and cardiovascular disease","volume":"315","author":"Cocciolone","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0255","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1172\/JCI115204","article-title":"Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon","volume":"87","author":"Shapiro","year":"1991","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0260","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.niox.2021.08.004","article-title":"H2S signaling and extracellular matrix remodeling in cardiovascular diseases: a tale of tense relationship","volume":"116","author":"Zhu","year":"2021","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0265","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/01.RES.0000070112.80711.3D","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry","volume":"92","author":"Visse","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0270","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.3390\/ijms22052685","article-title":"Targeting the extracellular matrix in abdominal aortic aneurysms using molecular imaging insights","volume":"22","author":"Adams","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0275","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-3-319-18144-8_8","article-title":"H2S and inflammation: an overview","volume":"230","author":"Bhatia","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0280","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/925167","article-title":"The cardioprotective effects of hydrogen sulfide in heart diseases: from molecular mechanisms to therapeutic potential","volume":"2015","author":"Shen","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0285","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/bph.13825","article-title":"Protein S-sulfhydration by hydrogen sulfide in cardiovascular system","volume":"175","author":"Meng","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0290","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.ajpath.2013.04.007","article-title":"Loss of Jak2 impairs endothelial function by attenuating Raf-1\/MEK1\/Sp-1 signaling along with altered eNOS activities","volume":"183","author":"Yang","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0295","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1096\/fj.15-278648","article-title":"Cystathionine \u03b2-synthase regulates endothelial function via protein S-sulfhydration","volume":"30","author":"Saha","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0300","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.004160","article-title":"Hydrogen sulfide regulates kr\u00fcppel-like factor 5 transcription activity via specificity protein 1 S-sulfhydration at Cys664 to prevent myocardial hypertrophy","volume":"5","author":"Meng","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0305","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1006\/bbrc.1994.2208","article-title":"Transforming growth factor-beta up-regulates human elastin promoter activity in transgenic mice","volume":"203","author":"Katchman","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0310","doi-asserted-by":"crossref","first-page":"7314","DOI":"10.1128\/MCB.19.11.7314","article-title":"An open reading frame element mediates posttranscriptional regulation of tropoelastin and responsiveness to transforming growth factor beta1","volume":"19","author":"Zhang","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0315","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/246461a0","article-title":"Molecular model for elastin structure and function","volume":"246","author":"Gray","year":"1973","journal-title":"Nature."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1432-1327.1998.2580001.x","article-title":"Biochemistry of tropoelastin","volume":"258","author":"Vrhovski","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0325","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1089\/ten.tea.2008.0040","article-title":"Transforming growth factor beta 1 and hyaluronan oligomers synergistically enhance elastin matrix regeneration by vascular smooth muscle cells","volume":"15","author":"Kothapalli","year":"2009","journal-title":"Tissue Eng. Part. A."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0330","first-page":"L257","article-title":"Influences of endogenous and exogenous TGF-beta on elastin in rat lung fibroblasts and aortic smooth muscle cells","volume":"263","author":"McGowan","year":"1992","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0335","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.juro.2014.12.085","article-title":"Estrogen attenuates TGF-\u03b21 induced elastogenesis in rat urethral smooth muscle cells by inhibiting Smad response elements","volume":"193","author":"Lin","year":"2015","journal-title":"J. Urol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0340","doi-asserted-by":"crossref","first-page":"35444","DOI":"10.1038\/srep35444","article-title":"Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0345","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCRESAHA.113.300675","article-title":"Genetics of thoracic aortic aneurysm: at the crossroad of transforming growth factor-\u03b2 signaling and vascular smooth muscle cell contractility","volume":"113","author":"Gillis","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0350","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1172\/JCI38136","article-title":"TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice","volume":"120","author":"Wang","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0355","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/415168a","article-title":"Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo","volume":"415","author":"Yanagisawa","year":"2002","journal-title":"Nature."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0360","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/antiox10050682","article-title":"Hydrogen sulfide attenuates aortic remodeling in aortic dissection associating with moderated inflammation and oxidative stress through a NO-dependent pathway","volume":"10","author":"Lu","year":"2021","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0365","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ijcard.2021.05.013","article-title":"H2S alleviates aortic aneurysm and dissection: crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome","volume":"338","author":"Cui","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0370","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jvs.2016.02.056","article-title":"The composition of collagen in the aneurysm wall of men and women","volume":"66","author":"Villard","year":"2017","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0375","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1172\/JCI114863","article-title":"A mutation in the gene for type III procollagen (COL3A1) in a family with aortic aneurysms","volume":"86","author":"Kontusaari","year":"1990","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.yjmcc.2022.06.011_bb0380","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/HYPERTENSIONAHA.111.00974","article-title":"Angiotensin II promotes thoracic aortic dissections and ruptures in Col3a1 haploinsufficient mice","volume":"62","author":"Faugeroux","year":"2013","journal-title":"Hypertension."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282822001298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282822001298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:37:00Z","timestamp":1758314220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282822001298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":76,"alternative-id":["S0022282822001298"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2022.06.011","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deficiency of cystathionine gamma-lyase promotes aortic elastolysis and medial degeneration in aged mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2022.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}