{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:40:52Z","timestamp":1785465652298,"version":"3.56.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T00:00:00Z","timestamp":1671062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["220652768"],"award-info":[{"award-number":["220652768"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"DFG","doi-asserted-by":"publisher","award":["236177352"],"award-info":[{"award-number":["236177352"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570244"],"award-info":[{"award-number":["81570244"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["WE5343\/1-1"],"award-info":[{"award-number":["WE5343\/1-1"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.yjmcc.2022.11.006","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T12:12:13Z","timestamp":1670328733000},"page":"29-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Cardiac injection of USSC boosts remuscularization of the infarcted heart by shaping the T-cell response"],"prefix":"10.1016","volume":"175","author":[{"given":"Zhaoping","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezhe","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Temme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Bouvain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Owenier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"H\u00e4nsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Wesselborg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Weidtkamp-Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Fl\u00f6gel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Schira-Heinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"St\u00fchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Hesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gesine","family":"K\u00f6gler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Schrader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2022.11.006_bb0005","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.020402","article-title":"All roads lead to Rome (the heart): cell retention and outcomes from various delivery routes of cell therapy products to the heart","volume":"10","author":"Li","year":"2021","journal-title":"JAHA"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0010","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1016\/j.jacc.2021.09.019","article-title":"Basic and translational research in cardiac repair and regeneration","volume":"78","author":"Zhang","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.semcdb.2019.10.011","article-title":"Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration","volume":"100","author":"Witman","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0020","article-title":"An acute immune response underlies the benefit of cardiac stem-cell therapy","author":"Vagnozzi","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0025","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1367","article-title":"Modified mRNA as a therapeutic tool to induce cardiac regeneration in ischemic heart disease: modified mRNA for induction of cardiac regeneration","volume":"9","author":"Hadas","year":"2017","journal-title":"WIREs Syst. Biol. Med."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCRESAHA.114.300639","article-title":"Exosomes and cardiac repair after myocardial infarction","volume":"114","author":"Sahoo","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0035","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature20173","article-title":"Hypoxia induces heart regeneration in adult mice","volume":"541","author":"Nakada","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0040","doi-asserted-by":"crossref","first-page":"E12245","DOI":"10.1073\/pnas.1805829115","article-title":"Profiling proliferative cells and their progeny in damaged murine hearts","volume":"115","author":"Kretzschmar","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0045","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/nature11044","article-title":"In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes","volume":"485","author":"Qian","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0050","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1126\/science.aaf1502","article-title":"Conversion of human fibroblasts into functional cardiomyocytes by small molecules","volume":"352","author":"Cao","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0055","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1126\/science.abg5159","article-title":"Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice","volume":"373","author":"Chen","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0060","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/hrt.2007.139329","article-title":"Transplanted human cord blood-derived unrestricted somatic stem cells improve left-ventricular function and prevent left-ventricular dilation and scar formation after acute myocardial infarction","volume":"95","author":"Ghodsizad","year":"2009","journal-title":"Heart"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0065","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3727\/096368912X640466","article-title":"Survival, integration, and differentiation of unrestricted somatic stem cells in the heart","volume":"22","author":"Ding","year":"2013","journal-title":"Cell Transplant."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0070","doi-asserted-by":"crossref","first-page":"639","DOI":"10.5966\/sctm.2015-0159","article-title":"Epicardium-derived cells formed after myocardial injury display phagocytic activity permitting in vivo labeling and tracking","volume":"5","author":"Ding","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0075","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00029.2019","article-title":"A2bR-dependent signaling alters immune cell composition and enhances IL-6 formation in the ischemic heart","author":"Alter","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0080","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.116.023365","article-title":"CD73 on T-cells orchestrates cardiac wound healing after myocardial infarction by purinergic metabolic reprogramming","author":"Borg","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0085","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1136\/heartjnl-2019-315227","article-title":"Manganese-enhanced MRI of the myocardium","volume":"105","author":"Spath","year":"2019","journal-title":"Heart"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0090","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13402-3","article-title":"Highly sensitive and specific Alu-based quantification of human cells among rodent cells","volume":"7","author":"Funakoshi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0095","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1074\/mcp.M115.049312","article-title":"Characterization of regenerative phenotype of unrestricted somatic stem cells (USSC) from human umbilical cord blood (hUCB) by functional secretome analysis","volume":"14","author":"Schira","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1074\/mcp.M500230-MCP200","article-title":"Absolute quantification of proteins by LCMS E: a virtue of parallel ms acquisition","volume":"5","author":"Silva","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0105","doi-asserted-by":"crossref","first-page":"19448","DOI":"10.1038\/s41598-019-55351-z","article-title":"OutCyte: a novel tool for predicting unconventional protein secretion","volume":"9","author":"Zhao","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0110","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/jgh.13842","article-title":"Secreted protein acidic and rich in cysteine functions in colitis via IL17A regulation in mucosal CD4 + T cells: SPARC accelerates experimental colitis","volume":"33","author":"Tanaka","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0115","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/14728222.2017.1336227","article-title":"MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics","volume":"21","author":"Tilstam","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0120","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCULATIONAHA.119.045116","article-title":"Agrin promotes coordinated therapeutic processes leading to improved cardiac repair in pigs","volume":"142","author":"Baehr","year":"2020","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0125","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nm.3778","article-title":"Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction","volume":"21","author":"Korf-Klingebiel","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0130","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/00007890-199902150-00009","article-title":"Prolonged allograft survival but no tolerance induction by modulating CD28 antibody JJ319 after high-responder rat heart transplantation","volume":"67","author":"Dengler","year":"1999","journal-title":"Transplantation"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0135","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.yjmcc.2018.02.003","article-title":"Analysis of rat cardiac myocytes and fibroblasts identifies combinatorial enhancer organization and transcription factor families","volume":"116","author":"Golan-Lagziel","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0140","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature13309","article-title":"C-kit+ cells minimally contribute cardiomyocytes to the heart","volume":"509","author":"van Berlo","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0145","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0162-3109(00)00192-2","article-title":"Mechanisms of action of cyclosporine","volume":"47","author":"Matsuda","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0150","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/s41401-018-0197-1","article-title":"Temporal dynamics of immune response following prolonged myocardial ischemia\/reperfusion with and without cyclosporine A","volume":"40","author":"Rusinkevich","year":"2019","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0155","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1038\/s41467-018-04908-z","article-title":"Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction","volume":"9","author":"Zacchigna","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0160","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1093\/eurheartj\/ehac153","article-title":"Adult T-cells impair neonatal cardiac regeneration","volume":"43","author":"Dolejsi","year":"2022","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0165","article-title":"Exosomes from mesenchymal stem cells overexpressing MIF enhance myocardial repair","author":"Liu","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0170","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1161\/CIRCRESAHA.114.302530","article-title":"Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair","volume":"114","author":"Furtado","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0175","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.65921","article-title":"Single-cell transcriptomics defines heterogeneity of epicardial cells and fibroblasts within the infarcted murine heart","volume":"10","author":"Hesse","year":"2021","journal-title":"ELife"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0180","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.116.308263","article-title":"Transdifferentiation requires iNOS activation: role of RING1A S-nitrosylation","volume":"119","author":"Meng","year":"2016","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0185","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.4049\/jimmunol.1202903","article-title":"Requirement of inducible nitric oxide synthase for skeletal muscle regeneration after acute damage","volume":"190","author":"Rigamonti","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0190","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa2340","article-title":"Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration","volume":"348","author":"Zhang","year":"2015","journal-title":"Science."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0195","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1038\/s41598-020-59868-6","article-title":"Cardiac injury modulates critical components of prostaglandin E2 signaling during zebrafish heart regeneration","volume":"10","author":"FitzSimons","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0200","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13287-021-02675-1","article-title":"IL-6 coaxes cellular dedifferentiation as a pro-regenerative intermediate that contributes to pericardial ADSC-induced cardiac repair","volume":"13","author":"Zhu","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0205","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1038\/s41467-021-26621-0","article-title":"Nuclear S-nitrosylation impacts tissue regeneration in zebrafish","volume":"12","author":"Matrone","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0210","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature22978","article-title":"The extracellular matrix protein agrin promotes heart regeneration in mice","volume":"547","author":"Bassat","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0215","doi-asserted-by":"crossref","first-page":"576","DOI":"10.5966\/sctm.2014-0209","article-title":"DNA damage response in neonatal and adult stromal cells compared with induced pluripotent stem cells: DNA damage defense in iPSCs versus stromal cells","volume":"4","author":"Liedtke","year":"2015","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0220","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.scr.2010.03.004","article-title":"The HOX code as a \u201cbiological fingerprint\u201d to distinguish functionally distinct stem cell populations derived from cord blood","volume":"5","author":"Liedtke","year":"2010","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0225","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1161\/01.CIR.0000163546.27639.AA","article-title":"Monitoring of bone marrow cell homing into the infarcted human myocardium","volume":"111","author":"Hofmann","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2022.11.006_bb0230","doi-asserted-by":"crossref","DOI":"10.1161\/01.CIRCULATIONAHA.105.524678","article-title":"Cell transplantation improves ventricular function after a myocardial infarction: a preclinical study of human unrestricted somatic stem cells in a porcine model","volume":"112","author":"Kim","year":"2005","journal-title":"Circulation"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282822005661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282822005661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:52:03Z","timestamp":1778640723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282822005661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":46,"alternative-id":["S0022282822005661"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2022.11.006","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cardiac injection of USSC boosts remuscularization of the infarcted heart by shaping the T-cell response","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2022.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}