{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:20:12Z","timestamp":1784967612446,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["2017SHZDZX01"],"award-info":[{"award-number":["2017SHZDZX01"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.yjmcc.2023.11.005","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T20:35:26Z","timestamp":1700166926000},"page":"45-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Profiling cardiomyocytes at single cell resolution reveals COX7B could be a potential target for attenuating heart failure in cardiac hypertrophy"],"prefix":"10.1016","volume":"186","author":[{"given":"Shi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menghao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumeng","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengshou","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangping","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.yjmcc.2023.11.005_bb0005","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/CIRCRESAHA.117.309711","article-title":"Classification, epidemiology, and global burden of cardiomyopathies","volume":"121","author":"McKenna","year":"2017","journal-title":"Circ. Res."},{"issue":"9862","key":"10.1016\/j.yjmcc.2023.11.005_bb0010","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0140-6736(12)60397-3","article-title":"Hypertrophic cardiomyopathy","volume":"381","author":"Maron","year":"2013","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.yjmcc.2023.11.005_bb0015","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.jcmg.2019.09.020","article-title":"The hypertrophic cardiomyopathy phenotype viewed through the prism of multimodality imaging: clinical and etiologic implications","volume":"13","author":"Rowin","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"4","key":"10.1016\/j.yjmcc.2023.11.005_bb0020","doi-asserted-by":"crossref","first-page":"298","DOI":"10.21037\/acs.2017.07.05","article-title":"Implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy: an updated systematic review and meta-analysis of outcomes and complications","volume":"6","author":"Wang","year":"2017","journal-title":"Ann Cardiothorac Surg"},{"issue":"17","key":"10.1016\/j.yjmcc.2023.11.005_bb0025","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/CIRCULATIONAHA.119.044366","article-title":"Hypertrophic cardiomyopathy with left ventricular systolic dysfunction: insights from the SHaRe registry","volume":"141","author":"Marstrand","year":"2020","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.yjmcc.2023.11.005_bb0030","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jchf.2017.09.011","article-title":"Clinical spectrum and management of heart failure in hypertrophic cardiomyopathy","volume":"6","author":"Maron","year":"2018","journal-title":"JACC Heart Fail"},{"issue":"7","key":"10.1016\/j.yjmcc.2023.11.005_bb0035","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1056\/NEJMra1710575","article-title":"Clinical course and Management of Hypertrophic Cardiomyopathy","volume":"379","author":"Maron","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"10075","key":"10.1016\/j.yjmcc.2023.11.005_bb0040","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/S0140-6736(16)31321-6","article-title":"Hypertrophic obstructive cardiomyopathy","volume":"389","author":"Veselka","year":"2017","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.yjmcc.2023.11.005_bb0045","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1038\/s41467-018-06639-7","article-title":"Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure","volume":"9","author":"Nomura","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2023.11.005_bb0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yjmcc.2016.06.001","article-title":"Physiological and pathological cardiac hypertrophy","volume":"97","author":"Shimizu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"7","key":"10.1016\/j.yjmcc.2023.11.005_bb0055","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41569-018-0007-y","article-title":"Mechanisms of physiological and pathological cardiac hypertrophy","volume":"15","author":"Nakamura","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"issue":"4","key":"10.1016\/j.yjmcc.2023.11.005_bb0060","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1161\/CIRCRESAHA.119.315408","article-title":"Polyploidy in cardiomyocytes: roadblock to heart regeneration?","volume":"126","author":"Derks","year":"2020","journal-title":"Circ. Res."},{"issue":"8","key":"10.1016\/j.yjmcc.2023.11.005_bb0065","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1161\/CIRCRESAHA.116.304937","article-title":"Mechanotransduction in cardiac hypertrophy and failure","volume":"116","author":"Lyon","year":"2015","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.yjmcc.2023.11.005_bb0070","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/iub.545","article-title":"Calcium-regulated transcriptional pathways in the normal and pathologic heart","volume":"63","author":"Zarain-Herzberg","year":"2011","journal-title":"IUBMB Life"},{"issue":"1","key":"10.1016\/j.yjmcc.2023.11.005_bb0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00395-019-0765-7","article-title":"Cell shape determines gene expression: cardiomyocyte morphotypic transcriptomes","volume":"115","author":"Haftbaradaran Esfahani","year":"2019","journal-title":"Basic Res. Cardiol."},{"issue":"5","key":"10.1016\/j.yjmcc.2023.11.005_bb0080","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s00395-019-0744-z","article-title":"Mono- and multi-nucleated ventricular cardiomyocytes constitute a transcriptionally homogenous cell population","volume":"114","author":"Yekelchyk","year":"2019","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.yjmcc.2023.11.005_bb0085","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.yjmcc.2020.08.010","article-title":"Reading the heart at single-cell resolution","volume":"148","author":"Zhou","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2023.11.005_bb0090","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12967-018-1649-6","article-title":"A modified method for isolation of human cardiomyocytes to model cardiac diseases","volume":"16","author":"Guo","year":"2018","journal-title":"J. Transl. Med."},{"issue":"6","key":"10.1016\/j.yjmcc.2023.11.005_bb0095","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41556-018-0105-4","article-title":"Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing","volume":"20","author":"Gao","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.yjmcc.2023.11.005_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/0471250953.bi1114s51","article-title":"Mapping RNA-seq Reads with STAR","volume":"51","author":"Dobin","year":"2015","journal-title":"Curr. Protoc. Bioinformatics"},{"issue":"1","key":"10.1016\/j.yjmcc.2023.11.005_bb0105","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1038\/s41467-020-15851-3","article-title":"Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis","volume":"11","author":"Li","year":"2020","journal-title":"Nat. Commun."},{"issue":"7745","key":"10.1016\/j.yjmcc.2023.11.005_bb0110","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","article-title":"The single-cell transcriptional landscape of mammalian organogenesis","volume":"566","author":"Cao","year":"2019","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.yjmcc.2023.11.005_bb0115","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nmeth.4402","article-title":"Reversed graph embedding resolves complex single-cell trajectories","volume":"14","author":"Qiu","year":"2017","journal-title":"Nat. Methods"},{"issue":"4","key":"10.1016\/j.yjmcc.2023.11.005_bb0120","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.yjmcc.2023.11.005_bb0125","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.yjmcc.2023.11.005_bb0130","doi-asserted-by":"crossref","DOI":"10.2202\/1544-6115.1128","article-title":"A general framework for weighted gene co-expression network analysis","volume":"4","author":"Zhang","year":"2005","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"issue":"13","key":"10.1016\/j.yjmcc.2023.11.005_bb0135","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1093\/bioinformatics\/btl140","article-title":"Improved scoring of functional groups from gene expression data by decorrelating GO graph structure","volume":"22","author":"Alexa","year":"2006","journal-title":"Bioinformatics"},{"issue":"7838","key":"10.1016\/j.yjmcc.2023.11.005_bb0140","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41586-020-2797-4","article-title":"Cells of the adult human heart","volume":"588","author":"Litvinukova","year":"2020","journal-title":"Nature"},{"issue":"7924","key":"10.1016\/j.yjmcc.2023.11.005_bb0145","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41586-022-05060-x","article-title":"Spatial multi-omic map of human myocardial infarction","volume":"608","author":"Kuppe","year":"2022","journal-title":"Nature"},{"issue":"6606","key":"10.1016\/j.yjmcc.2023.11.005_bb0150","doi-asserted-by":"crossref","first-page":"eabo1984","DOI":"10.1126\/science.abo1984","article-title":"Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies","volume":"377","author":"Reichart","year":"2022","journal-title":"Science"},{"issue":"7921","key":"10.1016\/j.yjmcc.2023.11.005_bb0155","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41586-022-04989-3","article-title":"Integrated multi-omic characterization of congenital heart disease","volume":"608","author":"Hill","year":"2022","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.yjmcc.2023.11.005_bb0160","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.annder.2013.02.001","article-title":"COX7B mutations in MIDAS syndrome or microphthalmia with linear skin defects (MLS)","volume":"140","author":"Dereure","year":"2013","journal-title":"Ann. Dermatol. Venereol."},{"issue":"6","key":"10.1016\/j.yjmcc.2023.11.005_bb0165","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1093\/brain\/awy104","article-title":"Mutations in COA7 cause spinocerebellar ataxia with axonal neuropathy","volume":"141","author":"Higuchi","year":"2018","journal-title":"Brain"},{"issue":"21","key":"10.1016\/j.yjmcc.2023.11.005_bb0170","first-page":"4139","article-title":"Cytochrome c oxidase subunit VIIb as a potential target in familial hypercholesterolemia by bioinformatical analysis","volume":"19","author":"Li","year":"2015","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"12","key":"10.1016\/j.yjmcc.2023.11.005_bb0175","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1002\/cam4.1828","article-title":"Single-cell RNA-seq analysis reveals the platinum resistance gene COX7B and the surrogate marker CD63","volume":"7","author":"Tanaka","year":"2018","journal-title":"Cancer Med."},{"issue":"6","key":"10.1016\/j.yjmcc.2023.11.005_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110809","article-title":"Single-cell transcriptomics provides insights into hypertrophic cardiomyopathy","volume":"39","author":"Wehrens","year":"2022","journal-title":"Cell Rep."},{"issue":"10","key":"10.1016\/j.yjmcc.2023.11.005_bb0185","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/S0735-1097(02)03009-7","article-title":"Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy","volume":"41","author":"Crilley","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2023.11.005_bb0190","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/978-3-319-55330-6_11","article-title":"Mitochondria and cardiac hypertrophy","volume":"982","author":"Facundo","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.yjmcc.2023.11.005_bb0195","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/978-981-10-7757-9_7","article-title":"Mitochondrial respiratory chain complexes","volume":"87","author":"Sousa","year":"2018","journal-title":"Subcell. Biochem."},{"issue":"6","key":"10.1016\/j.yjmcc.2023.11.005_bb0200","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.jtcvs.2009.08.060","article-title":"Electron transport chain dysfunction in neonatal pressure-overload hypertrophy precedes cardiomyocyte apoptosis independent of oxidative stress","volume":"139","author":"Griffiths","year":"2010","journal-title":"J. Thorac. Cardiovasc. Surg."},{"issue":"1","key":"10.1016\/j.yjmcc.2023.11.005_bb0205","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.bbrc.2020.01.013","article-title":"Overexpression of COX5A protects H9c2 cells against doxorubicin-induced cardiotoxicity","volume":"524","author":"Zhang","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"17","key":"10.1016\/j.yjmcc.2023.11.005_bb0210","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.009627","article-title":"Impact of the myosin modulator Mavacamten on force generation and cross-bridge behavior in a murine model of hypercontractility","volume":"7","author":"Mamidi","year":"2018","journal-title":"J. Am. Heart Assoc."},{"issue":"10253","key":"10.1016\/j.yjmcc.2023.11.005_bb0215","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(20)31792-X","article-title":"Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial","volume":"396","author":"Olivotto","year":"2020","journal-title":"Lancet"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282823001876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282823001876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T20:39:13Z","timestamp":1758314353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282823001876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":43,"alternative-id":["S0022282823001876"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2023.11.005","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Profiling cardiomyocytes at single cell resolution reveals COX7B could be a potential target for attenuating heart failure in cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2023.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}