{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T12:31:53Z","timestamp":1794227513115,"version":"4.9.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":57,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["RO1HL-157999"],"award-info":[{"award-number":["RO1HL-157999"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.yjmcc.2024.02.005","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T01:47:21Z","timestamp":1708566441000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["Neutrophils are indispensable for adverse cardiac remodeling in heart failure"],"prefix":"10.1016","volume":"189","author":[{"given":"Sergey","family":"Antipenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Mayfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Jinno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Gunzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ameen","family":"Ismahil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumanth D.","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg","family":"Rokosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.yjmcc.2024.02.005_bb0005","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41569-019-0315-x","article-title":"Reappraising the role of inflammation in heart failure","volume":"17","author":"Adamo","year":"2020","journal-title":"Nat. Rev. Cardiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2024.02.005_bb0010","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.116.003688","article-title":"Activated T lymphocytes are essential drivers of pathological remodeling in ischemic heart failure","volume":"10","author":"Bansal","year":"2017","journal-title":"Circ. Heart Fail."},{"issue":"1","key":"10.1016\/j.yjmcc.2024.02.005_bb0015","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1161\/CIRCRESAHA.116.308030","article-title":"Chronic heart failure and inflammation: what do we really know?","volume":"119","author":"Dick","year":"2016","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0020","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCRESAHA.113.301720","article-title":"Remodeling of the mononuclear phagocyte network underlies chronic inflammation and disease progression in heart failure: critical importance of the cardiosplenic axis","volume":"114","author":"Ismahil","year":"2014","journal-title":"Circ. Res."},{"issue":"6","key":"10.1016\/j.yjmcc.2024.02.005_bb0025","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41591-018-0064-0","article-title":"Myeloid cell contributions to cardiovascular health and disease","volume":"24","author":"Nahrendorf","year":"2018","journal-title":"Nat. Med."},{"issue":"8","key":"10.1016\/j.yjmcc.2024.02.005_bb0030","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/s41591-018-0059-x","article-title":"The human heart contains distinct macrophage subsets with divergent origins and functions","volume":"24","author":"Bajpai","year":"2018","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.yjmcc.2024.02.005_bb0035","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1161\/CIRCRESAHA.116.309001","article-title":"Proliferation and recruitment contribute to myocardial macrophage expansion in chronic heart failure","volume":"119","author":"Sager","year":"2016","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0040","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1161\/CIRCRESAHA.118.314028","article-title":"Tissue resident CCR2- and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury","volume":"124","author":"Bajpai","year":"2019","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2024.02.005_bb0045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41590-018-0272-2","article-title":"Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction","volume":"20","author":"Dick","year":"2019","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.yjmcc.2024.02.005_bb0050","first-page":"187","article-title":"Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype","volume":"38","author":"Horckmans","year":"2017","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.yjmcc.2024.02.005_bb0055","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.yjmcc.2024.02.005_bb0060","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00395-018-0699-5","article-title":"LXR\/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling","volume":"113","author":"DeLeon-Pennell","year":"2018","journal-title":"Basic Res. Cardiol."},{"issue":"8","key":"10.1016\/j.yjmcc.2024.02.005_bb0065","doi-asserted-by":"crossref","first-page":"937","DOI":"10.15252\/emmm.201506083","article-title":"The time-of-day of myocardial infarction onset affects healing through oscillations in cardiac neutrophil recruitment","volume":"8","author":"Schloss","year":"2016","journal-title":"EMBO Mol. Med."},{"issue":"3","key":"10.1016\/j.yjmcc.2024.02.005_bb0070","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.cardiores.2003.10.011","article-title":"Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury","volume":"61","author":"Vinten-Johansen","year":"2004","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.yjmcc.2024.02.005_bb0075","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nm.4294","article-title":"An emerging role for neutrophil extracellular traps in noninfectious disease","volume":"23","author":"Jorch","year":"2017","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.yjmcc.2024.02.005_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004651","article-title":"Neutrophils: between host defence, immune modulation, and tissue injury","volume":"11","author":"Kruger","year":"2015","journal-title":"PLoS Pathog."},{"issue":"21","key":"10.1016\/j.yjmcc.2024.02.005_bb0085","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1182\/blood-2009-06-221630","article-title":"Mechanisms underlying neutrophil-mediated monocyte recruitment","volume":"114","author":"Soehnlein","year":"2009","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.yjmcc.2024.02.005_bb0090","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1182\/blood-2008-02-139634","article-title":"Neutrophil secretion products pave the way for inflammatory monocytes","volume":"112","author":"Soehnlein","year":"2008","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.yjmcc.2024.02.005_bb0095","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1161\/CIRCULATIONAHA.118.038820","article-title":"Wnt5a-mediated neutrophil recruitment has an obligatory role in pressure overload-induced cardiac dysfunction","volume":"140","author":"Wang","year":"2019","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.yjmcc.2024.02.005_bb0100","doi-asserted-by":"crossref","DOI":"10.1172\/JCI147191","article-title":"KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression","volume":"132","author":"Tang","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0105","first-page":"R528","article-title":"Sex-related changes in cardiac function following myocardial infarction in mice","volume":"295","author":"Shioura","year":"2008","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"issue":"5","key":"10.1016\/j.yjmcc.2024.02.005_bb0110","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nmeth.3322","article-title":"Catchup: a mouse model for imaging-based tracking and modulation of neutrophil granulocytes","volume":"12","author":"Hasenberg","year":"2015","journal-title":"Nat. Methods"},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0115","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/CIRCULATIONAHA.118.036065","article-title":"Dysfunctional and pro-inflammatory regulatory T-lymphocytes are essential for adverse cardiac remodeling in ishcemic cardiomyopathy","volume":"139","author":"Bansal","year":"2019","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0120","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00395-017-0609-2","article-title":"Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure","volume":"112","author":"Kingery","year":"2017","journal-title":"Basic Res. Cardiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0125","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jacbts.2017.12.006","article-title":"CCR2(+) monocyte-derived infiltrating macrophages are required for adverse cardiac remodeling during pressure overload","volume":"3","author":"Patel","year":"2018","journal-title":"JACC Basic Transl. Sci."},{"issue":"1","key":"10.1016\/j.yjmcc.2024.02.005_bb0130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0170781","article-title":"Mononuclear phagocytes are dispensable for cardiac remodeling in established pressure-overload heart failure","volume":"12","author":"Patel","year":"2017","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.yjmcc.2024.02.005_bb0135","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1038\/s41467-020-16596-9","article-title":"Durable and controlled depletion of neutrophils in mice","volume":"11","author":"Boivin","year":"2020","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0140","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1161\/CIRCULATIONAHA.118.036065","article-title":"Dysfunctional and proinflammatory regulatory T-lymphocytes are essential for adverse cardiac remodeling in ischemic cardiomyopathy","volume":"139","author":"Bansal","year":"2019","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0145","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1084\/jem.20160530","article-title":"Peptidylarginine deiminase 4 promotes age-related organ fibrosis","volume":"214","author":"Martinod","year":"2017","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.yjmcc.2024.02.005_bb0150","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1161\/CIRCULATIONAHA.108.802918","article-title":"Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activation","volume":"119","author":"Hamid","year":"2009","journal-title":"Circulation"},{"issue":"17","key":"10.1016\/j.yjmcc.2024.02.005_bb0155","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1161\/CIRCULATIONAHA.109.905471","article-title":"Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart","volume":"121","author":"Wang","year":"2010","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0160","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1152\/physrev.00012.2018","article-title":"The Neutrophil\u2019s role during health and disease","volume":"99","author":"Liew","year":"2019","journal-title":"Physiol. Rev."},{"issue":"6774","key":"10.1016\/j.yjmcc.2024.02.005_bb0165","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35004599","article-title":"A clonogenic common myeloid progenitor that gives rise to all myeloid lineages","volume":"404","author":"Akashi","year":"2000","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.yjmcc.2024.02.005_bb0170","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.immuni.2016.08.007","article-title":"Hematopoietic stem cells are the major source of multilineage hematopoiesis in adult animals","volume":"45","author":"Sawai","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.yjmcc.2024.02.005_bb0175","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cellsig.2018.11.004","article-title":"How do chemokines navigate neutrophils to the target site: dissecting the structural mechanisms and signaling pathways","volume":"54","author":"Rajarathnam","year":"2019","journal-title":"Cell. Signal."},{"key":"10.1016\/j.yjmcc.2024.02.005_bb0180","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3389\/fimmu.2014.00508","article-title":"Neutrophil-derived cytokines: facts beyond expression","volume":"5","author":"Tecchio","year":"2014","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0185","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41418-022-01094-w","article-title":"Mitochondria and cell death-associated inflammation","volume":"30","author":"Vringer","year":"2023","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.yjmcc.2024.02.005_bb0190","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000338166","article-title":"Inflammatory cytokines in heart failure: mediators and markers","volume":"122","author":"Gullestad","year":"2012","journal-title":"Cardiology"},{"key":"10.1016\/j.yjmcc.2024.02.005_bb0195","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.yjmcc.2013.04.023","article-title":"Temporal dynamics of cardiac immune cell accumulation following acute myocardial infarction","volume":"62","author":"Yan","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"8","key":"10.1016\/j.yjmcc.2024.02.005_bb0200","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1161\/CIRCRESAHA.120.315895","article-title":"Hematopoiesis and cardiovascular disease","volume":"126","author":"Poller","year":"2020","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2024.02.005_bb0205","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/eurjhf\/hfp031","article-title":"Increased neutrophil lifespan in patients with congestive heart failure","volume":"11","author":"Tracchi","year":"2009","journal-title":"Eur. J. Heart Fail."},{"issue":"8","key":"10.1016\/j.yjmcc.2024.02.005_bb0210","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.freeradbiomed.2007.07.016","article-title":"Activation of polymorphonuclear neutrophils in patients with impaired left ventricular function","volume":"43","author":"Rudolph","year":"2007","journal-title":"Free Radic. Biol. Med."},{"issue":"9","key":"10.1016\/j.yjmcc.2024.02.005_bb0215","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.jacc.2016.12.022","article-title":"Neutrophil counts and initial presentation of 12 cardiovascular diseases: a CALIBER cohort study","volume":"69","author":"Shah","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2024.02.005_bb0220","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.amjcard.2014.10.008","article-title":"Usefulness of neutrophil-to-lymphocyte ratio in risk stratification of patients with advanced heart failure","volume":"115","author":"Benites-Zapata","year":"2015","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/j.yjmcc.2024.02.005_bb0225","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.amjcard.2007.11.004","article-title":"Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction","volume":"101","author":"Nunez","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2024.02.005_bb0230","doi-asserted-by":"crossref","first-page":"5902947","DOI":"10.1155\/2016\/5902947","article-title":"Chemokines and heart disease: a network connecting cardiovascular biology to immune and autonomic nervous systems","volume":"2016","author":"Dusi","year":"2016","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.yjmcc.2024.02.005_bb0235","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0008-6363(99)00262-X","article-title":"CXC-chemokines, a new group of cytokines in congestive heart failure\u2013possible role of platelets and monocytes","volume":"45","author":"Damas","year":"2000","journal-title":"Cardiovasc. Res."},{"issue":"9","key":"10.1016\/j.yjmcc.2024.02.005_bb0240","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.CIR.0000086321.04702.AC","article-title":"Complexity of inducible nitric oxide synthase: cellular source determines benefit versus toxicity","volume":"108","author":"Poon","year":"2003","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.yjmcc.2024.02.005_bb0245","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.amjcard.2006.04.018","article-title":"Plasma myeloperoxidase levels in patients with chronic heart failure","volume":"98","author":"Tang","year":"2006","journal-title":"Am. J. Cardiol."},{"issue":"1","key":"10.1016\/j.yjmcc.2024.02.005_bb0250","doi-asserted-by":"crossref","first-page":"11599","DOI":"10.1038\/s41598-019-47853-7","article-title":"Neutrophil extracellular traps and dsDNA predict outcomes among patients with ST-elevation myocardial infarction","volume":"9","author":"Liu","year":"2019","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.yjmcc.2024.02.005_bb0255","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cell.2020.10.003","article-title":"Co-option of neutrophil fates by tissue environments","volume":"183","author":"Ballesteros","year":"2020","journal-title":"Cell"}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282824000221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282824000221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T21:52:03Z","timestamp":1716933123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282824000221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":51,"alternative-id":["S0022282824000221"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2024.02.005","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.31.565035","asserted-by":"object"}]},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophils are indispensable for adverse cardiac remodeling in heart failure","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2024.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}