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Res."},{"issue":"4","key":"10.1016\/j.yjmcc.2024.07.007_bb0320","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202213250","article-title":"RLC phosphorylation amplifies Ca2+ sensitivity of force in myocardium from cMyBP-C knockout mice","volume":"155","author":"Turner","year":"2023","journal-title":"J. Gen. Physiol."},{"issue":"6","key":"10.1016\/j.yjmcc.2024.07.007_bb0325","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1073\/pnas.1316001111","article-title":"Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism","volume":"111","author":"Mun","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.yjmcc.2024.07.007_bb0330","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1400205","article-title":"Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling","volume":"1","author":"Previs","year":"2015","journal-title":"Sci. Adv."},{"issue":"Pt 2","key":"10.1016\/j.yjmcc.2024.07.007_bb0335","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1469-7793.2001.0263l.x","article-title":"Cross-bridge interaction kinetics in rat myocardium are accelerated by strong binding of myosin to the thin filament","volume":"530","author":"Fitzsimons","year":"2001","journal-title":"J. Physiol."},{"issue":"10","key":"10.1016\/j.yjmcc.2024.07.007_bb0340","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1136\/hrt.2007.127241","article-title":"Homozygous mutation of MYBPC3 associated with severe infantile hypertrophic cardiomyopathy at high frequency among the Amish","volume":"94","author":"Zahka","year":"2008","journal-title":"Heart"},{"issue":"9","key":"10.1016\/j.yjmcc.2024.07.007_bb0345","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1172\/JCI7377","article-title":"Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice","volume":"104","author":"McConnell","year":"1999","journal-title":"J. Clin. 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