{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:53:56Z","timestamp":1790776436085,"version":"4.1.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL164453"],"award-info":[{"award-number":["HL164453"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL155762"],"award-info":[{"award-number":["HL155762"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL132871"],"award-info":[{"award-number":["HL132871"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.yjmcc.2025.05.004","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T11:16:50Z","timestamp":1747826210000},"page":"68-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Colitis induced ventricular alternans increases the risk for ventricular arrhythmia"],"prefix":"10.1016","volume":"204","author":[{"given":"Carlos H.","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kittaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Ouille V","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathas F.Q.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e8s F.","family":"P\u00e9laez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Keshavarzian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar A.","family":"Blatter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Banach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2025.05.004_bb0005","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Berre","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0010","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1097\/MIB.0000000000000392","article-title":"Extraintestinal manifestations of inflammatory bowel disease","volume":"21","author":"Vavricka","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0015","article-title":"Long-term risk of arrhythmias in patients with inflammatory bowel disease: a population-based, sibling-controlled cohort study","volume":"20","author":"Sun","year":"2023","journal-title":"PLoS Med."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0020","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.amjmed.2022.08.012","article-title":"Inflammatory bowel disease and cardiovascular diseases","volume":"135","author":"Chen","year":"2022","journal-title":"Am. J. Med."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.tcm.2019.10.001","article-title":"Inflammatory bowel disease and the risk for cardiovascular disease: does all inflammation lead to heart disease?","volume":"30","author":"Bigeh","year":"2020","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0030","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/ecco-jcc\/jjy164","article-title":"Cardiovascular risk profile among patients with inflammatory bowel disease: a population-based study of more than 100 000 individuals","volume":"13","author":"Aarestrup","year":"2019","journal-title":"J. Crohns Colitis"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0035","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.3748\/wjg.v25.i22.2788","article-title":"Increased risk of atrial fibrillation in patients with inflammatory bowel disease: a nationwide population-based study","volume":"25","author":"Choi","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0040","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1093\/europace\/eut312","article-title":"Increased risk of atrial fibrillation and stroke during active stages of inflammatory bowel disease: a nationwide study","volume":"16","author":"Kristensen","year":"2014","journal-title":"Europace"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0045","doi-asserted-by":"crossref","first-page":"3012509","DOI":"10.1155\/2019\/3012509","article-title":"Cardiovascular manifestations of inflammatory bowel disease: pathogenesis, diagnosis, and preventive strategies","volume":"2019","author":"Bunu","year":"2019","journal-title":"Gastroenterol. Res. Pract."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0050","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.3390\/nu13082661","article-title":"What links an increased cardiovascular risk and inflammatory bowel disease? A narrative review","volume":"13","author":"\u0141ykowska-Szuber","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0055","doi-asserted-by":"crossref","first-page":"136","DOI":"10.5152\/tjg.2015.150349","article-title":"Prevalence of QT interval prolongation in inflammatory bowel disease","volume":"27","author":"Pattanshetty","year":"2016","journal-title":"Turk J Gastroenterol"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0060","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s00508-022-02100-4","article-title":"Evaluation of Tp-e interval and Tp-e\/QTc ratio in patients with inflammatory bowel disease","volume":"135","author":"G\u00fcven","year":"2023","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0065","doi-asserted-by":"crossref","first-page":"6960810","DOI":"10.1155\/2017\/6960810","article-title":"Prolonged P-wave and QT dispersion in children with inflammatory bowel disease in remission","volume":"2017","author":"Bornaun","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0070","doi-asserted-by":"crossref","first-page":"540","DOI":"10.7150\/ijms.8.540","article-title":"Evaluation of QT and P wave dispersion and mean platelet volume among inflammatory bowel disease patients","volume":"8","author":"Dogan","year":"2011","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0075","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11739-010-0382-9","article-title":"A study on QT interval in patients affected with inflammatory bowel disease without cardiac involvement","volume":"5","author":"Curione","year":"2010","journal-title":"Intern. Emerg. Med."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2022.939156","article-title":"Increasing adiposity is associated with QTc interval prolongation and increased ventricular arrhythmic risk in the context of metabolic dysfunction: results from the UK biobank","volume":"9","author":"Patel","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0085","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s42826-021-00102-3","article-title":"A comparative review on heart ion channels, action potentials and electrocardiogram in rodents and human: extrapolation of experimental insights to clinic","volume":"37","author":"Joukar","year":"2021","journal-title":"Lab. Anim. Res."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0090","first-page":"1271","article-title":"Spontaneous repolarization alternans causes VT\/VF rearrest that is suppressed by preserving gap junctions","volume":"10","author":"Laurita","year":"2024","journal-title":"JACC: Clin. Electrophysiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1161\/CIRCRESAHA.122.321668","article-title":"Cardiac Alternans: from bedside to bench and Back","volume":"132","author":"Qu","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.physiol.70.113006.100455","article-title":"Calcium cycling and signaling in cardiac myocytes","volume":"70","author":"Bers","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tcm.2022.06.006","article-title":"Precision therapy in congenital long QT syndrome","volume":"34","author":"Neves","year":"2024","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0110","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1016\/j.hrthm.2014.06.017","article-title":"Selective late sodium current blockade with GS-458967 markedly reduces ischemia-induced atrial and ventricular repolarization alternans and ECG heterogeneity","volume":"11","author":"Bonatti","year":"2014","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0115","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/15419061.2014.905932","article-title":"Intercellular electrical communication in the heart: a new, active role for the intercalated disk","volume":"21","author":"Veeraraghavan","year":"2014","journal-title":"Cell Commun. Adhes."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3390\/biom13010007","article-title":"The \u2018Reverse FDUF\u2019 mechanism of atrial excitation\u2013contraction coupling sustains calcium alternans\u2014a hypothesis","volume":"13","author":"Banach","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0125","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00424-020-02506-x","article-title":"Excitation-contraction coupling and calcium release in atrial muscle","volume":"473","author":"Blatter","year":"2021","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0130","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1152\/physrev.00038.2017","article-title":"Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology","volume":"98","author":"Forrester","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0135","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.immuni.2019.03.017","article-title":"Cytokine networks in the pathophysiology of inflammatory bowel disease","volume":"50","author":"Friedrich","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0140","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1177\/1470320314521086","article-title":"Upregulation of circulating components of the alternative renin-angiotensin system in inflammatory bowel disease: a pilot study","volume":"16","author":"Garg","year":"2014","journal-title":"J. Renin-Angiotensin-Aldosterone Syst."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0145","doi-asserted-by":"crossref","first-page":"G774","DOI":"10.1152\/ajpgi.00053.2019","article-title":"Renin-angiotensin system promotes colonic inflammation by inducing TH17 activation via JAK2\/STAT pathway","volume":"316","author":"He","year":"2019","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0150","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1053\/j.gastro.2020.05.030","article-title":"Age, inflammation, and disease location are critical determinants of intestinal expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in inflammatory bowel disease","volume":"159","author":"Nowak","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0155","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s00011-007-7098-y","article-title":"Dextran sulfate sodium-induced acute colonic inflammation in angiotensin II type 1a receptor deficient mice","volume":"57","author":"Katada","year":"2008","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0160","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/0016-5085(90)91088-N","article-title":"Increased colonic mucosal angiotensin I and II concentrations in Crohn\u2019s colitis","volume":"98","author":"Jaszewski","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0165","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1136\/gutjnl-2019-318512","article-title":"Imbalance of the renin\u2013angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target?","volume":"69","author":"Garg","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0170","article-title":"Activation of the renin-angiotensin system promotes colitis development","volume":"6","author":"Shi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0175","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.yjmcc.2021.10.006","article-title":"Inositol 1,4,5-trisphosphate receptor - reactive oxygen signaling domain regulates excitation-contraction coupling in atrial myocytes","volume":"163","author":"Varma","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0180","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.hrthm.2018.03.041","article-title":"Loss of p21-activated kinase 1 (Pak1) promotes atrial arrhythmic activity","volume":"15","author":"Desantiago","year":"2018","journal-title":"Heart Rhythm."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0185","first-page":"238","article-title":"Clinicopathologic study of dextran sulfate sodium experimental murine colitis","volume":"69","author":"Cooper","year":"1993","journal-title":"Lab. Investig."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0190","doi-asserted-by":"crossref","first-page":"15.25.1","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0195","doi-asserted-by":"crossref","first-page":"718617","DOI":"10.1155\/2012\/718617","article-title":"Dextran sodium sulphate colitis mouse model: traps and tricks","volume":"2012","author":"Per\u0161e","year":"2012","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0200","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41467-023-36409-z","article-title":"Angiotensin-converting enzyme inhibitor promotes angiogenesis through Sp1\/Sp3-mediated inhibition of notch signaling in male mice","volume":"14","author":"Lu","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0205","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yjmcc.2023.04.004","article-title":"The role of P21-activated kinase (Pak1) in sinus node function","volume":"179","author":"Pereira","year":"2023","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0210","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000074542","article-title":"Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures","volume":"13","author":"Halbach","year":"2003","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0215","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.yjmcc.2013.04.014","article-title":"Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1","volume":"60","author":"Desantiago","year":"2013","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0220","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13969","article-title":"Prolonged Ca2+ release refractoriness and T-tubule disruption as determinants of increased propensity to cardiac alternans in the hypertensive heart disease","volume":"238","author":"Mari\u00e1ngelo","year":"2023","journal-title":"Acta Physiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0225","doi-asserted-by":"crossref","first-page":"H1047","DOI":"10.1152\/ajpheart.00384.2012","article-title":"Regulation of cardiac alternans by \u03b2-adrenergic signaling pathways","volume":"303","author":"Florea","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0230","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ab.2009.06.004","article-title":"Multiple reprobing of Western blots after inactivation of peroxidase activity by its substrate, hydrogen peroxide","volume":"393","author":"Sennepin","year":"2009","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0235","doi-asserted-by":"crossref","DOI":"10.1038\/nrm1151","article-title":"Phospholamban: a crucial regulator of cardiac contractility","volume":"4","author":"MacLennan","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0240","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10741-009-9136-z","article-title":"Istaroxime, a first in class new chemical entity exhibiting SERCA-2 activation and Na\u2013K-ATPase inhibition: a new promising treatment for acute heart failure syndromes?","volume":"14","author":"Khan","year":"2009","journal-title":"Heart Fail. Rev."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0245","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1292\/jvms.61.67","article-title":"Tissue distribution of dextran sulfate sodium (DSS) in the acute phase of murine DSS-induced colitis","volume":"61","author":"Kitajima","year":"1999","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0250","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1038\/s41440-024-01874-6","article-title":"Blood pressure alteration associated with abnormal body electrolyte and water balance in colitis mice","volume":"47","author":"Kundo","year":"2024","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0255","doi-asserted-by":"crossref","DOI":"10.1038\/srep24334","article-title":"Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium","volume":"6","author":"Majumder","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0260","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.102.14.1664","article-title":"Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue","volume":"102","author":"Qu","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0265","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1113\/JP277188","article-title":"Action potential shortening rescues atrial calcium alternans","volume":"597","author":"Kanaporis","year":"2019","journal-title":"J. Physiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0270","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1161\/CIRCRESAHA.116.305404","article-title":"The mechanisms of calcium cycling and action potential dynamics in cardiac alternans","volume":"116","author":"Kanaporis","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0275","article-title":"Role of reduced Sarco-endoplasmic reticulum Ca2+-ATPase function on sarcoplasmic reticulum Ca2+ Alternans in the intact rabbit heart","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0280","first-page":"5327","article-title":"Valsartan improves cardiac function in mice with diabetes mellitus by CaMKII\/AngII","volume":"22","author":"Bao","year":"2018","journal-title":"Eur. Rev. M\u00e9d. Pharmacol. Sci."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0285","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cardiores.2003.12.029","article-title":"Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current","volume":"62","author":"Caballero","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0290","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.566410","article-title":"Angiotensin II decreases endothelial nitric oxide synthase phosphorylation via AT1R Nox\/ROS\/PP2A pathway","volume":"11","author":"Ding","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0295","article-title":"Navigating the gut-cardiac Axis: understanding cardiovascular complications in inflammatory bowel disease","volume":"16","author":"Sinha","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0300","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/bcpt.13624","article-title":"Renin\u2013angiotensin system in intestinal inflammation\u2014angiotensin inhibitors to treat inflammatory bowel diseases?","volume":"129","author":"Salmenkari","year":"2021","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0305","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1097\/j.pain.0000000000003159","article-title":"Transcriptomic profiling reveals a pronociceptive role for angiotensin II in inflammatory bowel disease","author":"Higham","year":"2024","journal-title":"Pain"},{"key":"10.1016\/j.yjmcc.2025.05.004_bb0310","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1007\/s10620-006-9124-2","article-title":"Reduced severity of a mouse colitis model with angiotensin converting enzyme inhibition","volume":"52","author":"Spencer","year":"2007","journal-title":"Dig. Dis. Sci."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282825000860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282825000860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:49:56Z","timestamp":1778708996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282825000860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":62,"alternative-id":["S0022282825000860"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2025.05.004","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Colitis induced ventricular alternans increases the risk for ventricular arrhythmia","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2025.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}