{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:26:05Z","timestamp":1787498765560,"version":"build-2736575974"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100023360","name":"St Vincent's Hospital (Melbourne) Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmmc-online.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Molecular and Cellular Cardiology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.yjmcc.2025.10.004","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T03:21:35Z","timestamp":1760498495000},"page":"80-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Modelling diabetes-associated metabolic stress in human multicellular cardiac microtissues"],"prefix":"10.1016","volume":"209","author":[{"given":"Ren Jie","family":"Phang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiang Y.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarmon G.","family":"Lees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.yjmcc.2025.10.004_bb0005","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1038\/nrdp.2015.19","article-title":"Type 2 diabetes mellitus","volume":"1","author":"DeFronzo","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2021.109119","article-title":"IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045","volume":"183","author":"Sun","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12933-018-0728-6","article-title":"Prevalence of cardiovascular disease in type 2 diabetes: a systematic literature review of scientific evidence from across the world in 2007-2017","volume":"17","author":"Einarson","year":"2018","journal-title":"Cardiovasc. Diabetol."},{"issue":"9","key":"10.1016\/j.yjmcc.2025.10.004_bb0020","first-page":"1893","article-title":"Diabetic myocardial disorder. A clinical consensus statement of the heart failure association of the ESC and the ESC working group on myocardial & pericardial diseases","volume":"26","author":"Seferovi\u0107","year":"2024","journal-title":"Eur. J. Heart Fail."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0025","doi-asserted-by":"crossref","first-page":"1375400","DOI":"10.3389\/fcvm.2024.1375400","article-title":"Molecular mechanisms of metabolic dysregulation in diabetic cardiomyopathy","volume":"11","author":"Zeng","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.yjmcc.2025.10.004_bb0030","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1093\/cvr\/cvac049","article-title":"Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy","volume":"119","author":"Phang","year":"2023","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.yjmcc.2025.10.004_bb0035","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1161\/CIRCRESAHA.120.315913","article-title":"Basic mechanisms of diabetic heart disease","volume":"126","author":"Ritchie","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0040","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3389\/fcvm.2018.00120","article-title":"Genetic and tissue engineering approaches to modeling the mechanics of human heart failure for drug discovery","volume":"5","author":"Greenberg","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"issue":"13","key":"10.1016\/j.yjmcc.2025.10.004_bb0045","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.3390\/ijms20133299","article-title":"Cardiomyopathy associated with diabetes: the central role of the cardiomyocyte","volume":"20","author":"Filardi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0050","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3389\/fphar.2019.00934","volume":"10","author":"Ribeiro","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3389\/fcvm.2018.00143","article-title":"Heterocellularity and cellular cross-talk in the cardiovascular system","volume":"5","author":"Perbellini","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"issue":"12","key":"10.1016\/j.yjmcc.2025.10.004_bb0060","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.3390\/ijms21124354","article-title":"Modeling cardiac disease mechanisms using induced pluripotent stem cell-derived cardiomyocytes: Progress, promises and challenges","volume":"21","author":"Parrotta","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0065","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.yjmcc.2020.03.016","article-title":"Human induced pluripotent stem cell-derived cardiomyocytes reveal abnormal TGF\u03b2 signaling in type 2 diabetes mellitus","volume":"142","author":"Tang","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"5","key":"10.1016\/j.yjmcc.2025.10.004_bb0070","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11886-022-01670-z","article-title":"Deconvoluting the cells of the human heart with iPSC technology: cell types, protocols, and uses","volume":"24","author":"Yu","year":"2022","journal-title":"Curr. Cardiol. Rep."},{"issue":"12","key":"10.1016\/j.yjmcc.2025.10.004_bb0075","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.4252\/wjsc.v11.i12.1065","article-title":"Three-dimensional cell culture systems as an in vitro platform for cancer and stem cell modeling","volume":"11","author":"Chaicharoenaudomrung","year":"2019","journal-title":"World J. Stem Cells"},{"issue":"6","key":"10.1016\/j.yjmcc.2025.10.004_bb0080","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00125-020-05126-3","article-title":"Diabetes through a 3D lens: organoid models","volume":"63","author":"Tsakmaki","year":"2020","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.yjmcc.2025.10.004_bb0085","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41574-022-00797-x","article-title":"Towards a better understanding of diabetes mellitus using organoid models","volume":"19","author":"Beydag-Tasoz","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0090","doi-asserted-by":"crossref","first-page":"1718041","DOI":"10.1155\/2016\/1718041","article-title":"Electrical stimulation promotes cardiac differentiation of human induced pluripotent stem cells","volume":"2016","author":"Hern\u00e1ndez","year":"2016","journal-title":"Stem Cells Int."},{"issue":"5858","key":"10.1016\/j.yjmcc.2025.10.004_bb0095","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1126\/science.1151526","article-title":"Induced pluripotent stem cell lines derived from human somatic cells","volume":"318","author":"Yu","year":"2007","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0100","doi-asserted-by":"crossref","first-page":"7259","DOI":"10.1038\/s41467-022-34860-y","article-title":"A soft and ultrasensitive force sensing diaphragm for probing cardiac organoids instantaneously and wirelessly","volume":"13","author":"Lyu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.actbio.2019.05.067","article-title":"Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle","volume":"94","author":"Kong","year":"2019","journal-title":"Acta Biomater."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0110","doi-asserted-by":"crossref","first-page":"12865","DOI":"10.1038\/s41598-018-31256-1","article-title":"Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition","volume":"8","author":"Kirino","year":"2018","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.yjmcc.2025.10.004_bb0115","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.stem.2020.05.004","article-title":"Human-iPSC-derived cardiac stromal cells enhance maturation in 3D cardiac microtissues and reveal non-cardiomyocyte contributions to heart disease","volume":"26","author":"Giacomelli","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/j.yjmcc.2025.10.004_bb0120","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1161\/CIRCRESAHA.117.312067","article-title":"MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo","volume":"122","author":"Sala","year":"2018","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0125","doi-asserted-by":"crossref","first-page":"16977","DOI":"10.1038\/s41598-020-73801-x","article-title":"Machine learning identifies abnormal Ca(2+) transients in human induced pluripotent stem cell-derived cardiomyocytes","volume":"10","author":"Hwang","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0130","doi-asserted-by":"crossref","first-page":"11568","DOI":"10.1038\/s41598-020-67289-8","article-title":"Angiogenesis analyzer for ImageJ - a comparative morphometric analysis of \"endothelial tube formation assay\" and \"fibrin bead assay\"","volume":"10","author":"Carpentier","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41420-018-0042-9","article-title":"Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells","volume":"4","author":"Hoque","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0140","doi-asserted-by":"crossref","first-page":"21531","DOI":"10.1038\/s41598-022-25464-z","article-title":"A novel small molecule inhibitor of human Drp1","volume":"12","author":"Rosdah","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.603247","article-title":"The impact of antidiabetic therapies on diastolic dysfunction and diabetic cardiomyopathy","volume":"11","author":"Gopal","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0150","doi-asserted-by":"crossref","first-page":"6168340","DOI":"10.1155\/2019\/6168340","article-title":"Andrographolide protects against HG-induced inflammation, apoptosis, migration, and impairment of angiogenesis via PI3K\/AKT-eNOS Signalling in HUVECs","volume":"2019","author":"Duan","year":"2019","journal-title":"Mediat. Inflamm."},{"issue":"5","key":"10.1016\/j.yjmcc.2025.10.004_bb0155","doi-asserted-by":"crossref","first-page":"H927","DOI":"10.1152\/ajpheart.00546.2020","article-title":"Functional coculture of sympathetic neurons and cardiomyocytes derived from human-induced pluripotent stem cells","volume":"319","author":"Winbo","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"23","key":"10.1016\/j.yjmcc.2025.10.004_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233764","article-title":"Impact of neurons on patient-derived cardiomyocytes using organ-on-A-Chip and iPSC biotechnologies","volume":"11","author":"Bernardin","year":"2022","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.yjmcc.2025.10.004_bb0165","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/0975-3583.89805","article-title":"Diastolic dysfunction in asymptomatic type 2 diabetes mellitus with normal systolic function","volume":"2","author":"Patil","year":"2011","journal-title":"J. Cardiovasc. Dis. Res."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0170","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.676862","article-title":"Prevalence and predictors of left ventricular diastolic dysfunction in Malaysian patients with type 2 diabetes mellitus without prior known cardiovascular disease","volume":"8","author":"Chee","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0175","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s12933-019-0971-5","article-title":"Association of glycemic variability with left ventricular diastolic function in type 2 diabetes mellitus","volume":"18","author":"Yokota","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0180","doi-asserted-by":"crossref","first-page":"14872","DOI":"10.1038\/s41598-018-33293-2","article-title":"Empagliflozin Ammeliorates high glucose induced-cardiac Dysfuntion in human iPSC-derived cardiomyocytes","volume":"8","author":"Ng","year":"2018","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.yjmcc.2025.10.004_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12090832","article-title":"Modelling diabetic cardiomyopathy: using human stem cell-derived cardiomyocytes to complement animal models","volume":"12","author":"Purnama","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.637021","article-title":"Calcium Dobesilate (CaD) attenuates high glucose and high lipid-induced impairment of sarcoplasmic reticulum calcium handling in cardiomyocytes","volume":"8","author":"Deng","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"issue":"4","key":"10.1016\/j.yjmcc.2025.10.004_bb0195","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.2337\/db06-0739","article-title":"Effects of palmitate on ca(2+) handling in adult control and Ob\/Ob cardiomyocytes: impact of mitochondrial reactive oxygen species","volume":"56","author":"Fauconnier","year":"2007","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.yjmcc.2025.10.004_bb0200","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.3892\/mmr.2020.11275","article-title":"Calcium inhibitor inhibits high glucose-induced hypertrophy of H9C2 cells","volume":"22","author":"Xu","year":"2020","journal-title":"Mol. Med. Rep."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0205","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41420-023-01553-4","article-title":"Diabetic cardiomyopathy: early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions","volume":"9","author":"Huo","year":"2023","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.yjmcc.2025.10.004_bb0210","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.cmet.2020.12.003","article-title":"The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure","volume":"33","author":"Cluntun","year":"2021","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.yjmcc.2025.10.004_bb0215","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s41419-018-0593-y","article-title":"Palmitic acid, but not high-glucose, induced myocardial apoptosis is alleviated by N-acetylcysteine due to attenuated mitochondrial-derived ROS accumulation-induced endoplasmic reticulum stress","volume":"9","author":"He","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0220","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.freeradbiomed.2019.09.025","article-title":"Regulation of mitochondrial cristae remodelling by acetylcholine alleviates palmitate-induced cardiomyocyte hypertrophy","volume":"145","author":"Xue","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.yjmcc.2025.10.004_bb0225","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.celrep.2014.09.055","article-title":"Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells","volume":"9","author":"Drawnel","year":"2014","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0230","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12933-024-02357-1","article-title":"Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction","volume":"23","author":"Rudokas","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0235","doi-asserted-by":"crossref","first-page":"1122494","DOI":"10.1155\/2022\/1122494","article-title":"Empagliflozin ameliorates diabetic cardiomyopathy via attenuating oxidative stress and improving mitochondrial function","volume":"2022","author":"Wang","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"13","key":"10.1016\/j.yjmcc.2025.10.004_bb0240","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.7150\/thno.33684","article-title":"Targeting mitochondrial dynamics by regulating Mfn2 for therapeutic intervention in diabetic cardiomyopathy","volume":"9","author":"Hu","year":"2019","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0245","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1186\/s13287-024-03982-z","article-title":"Cell-cell interactions in the heart: advanced cardiac models and omics technologies","volume":"15","author":"Tan","year":"2024","journal-title":"Stem Cell Res Ther"},{"issue":"3","key":"10.1016\/j.yjmcc.2025.10.004_bb0250","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCRESAHA.115.307778","article-title":"Revisiting cardiac cellular composition","volume":"118","author":"Pinto","year":"2016","journal-title":"Circ. Res."},{"issue":"12","key":"10.1016\/j.yjmcc.2025.10.004_bb0255","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/CIRCRESAHA.109.209809","article-title":"Cardiac fibroblast: the renaissance cell","volume":"105","author":"Souders","year":"2009","journal-title":"Circ. Res."},{"issue":"10","key":"10.1016\/j.yjmcc.2025.10.004_bb0260","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.jacc.2018.12.064","article-title":"Autonomic nervous system dysfunction: JACC focus seminar","volume":"73","author":"Goldberger","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0265","article-title":"Crocin improves endothelial mitochondrial dysfunction via GPx1\/ROS\/KCa3.1 signal Axis in diabetes","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110662","article-title":"UNC0321 inhibits high glucose induced apoptosis in HUVEC by targeting Rab4","volume":"131","author":"Nie","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101811","article-title":"aFGF alleviates diabetic endothelial dysfunction by decreasing oxidative stress via Wnt\/\u03b2-catenin-mediated upregulation of HXK2","volume":"39","author":"Sun","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0280","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12933-017-0531-9","article-title":"Advanced glycation end-products decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells","volume":"16","author":"Ren","year":"2017","journal-title":"Cardiovasc. Diabetol."},{"issue":"3","key":"10.1016\/j.yjmcc.2025.10.004_bb0285","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.stemcr.2019.01.017","article-title":"Calpain inhibition restores autophagy and prevents mitochondrial fragmentation in a human iPSC model of diabetic Endotheliopathy","volume":"12","author":"Ong","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0290","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1749-6632.2002.tb02108.x","article-title":"Oxidative stress and programmed cell death in diabetic neuropathy","volume":"959","author":"Vincent","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0295","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.nbd.2014.01.001","article-title":"PGC-1\u03b1 regulation of mitochondrial degeneration in experimental diabetic neuropathy","volume":"64","author":"Choi","year":"2014","journal-title":"Neurobiol. Dis."},{"issue":"7","key":"10.1016\/j.yjmcc.2025.10.004_bb0300","article-title":"Pharmacological and genetic suppression of VDAC1 alleviates the development of mitochondrial dysfunction in endothelial and fibroblast cell cultures upon hyperglycemic conditions","volume":"12","author":"Belosludtsev","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2023.06.013","article-title":"Metformin suppresses cardiac fibroblast proliferation under high-glucose conditions via regulating the mitochondrial complex I protein Grim-19 involved in the Sirt1\/Stat3 signaling pathway","volume":"206","author":"Li","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"16","key":"10.1016\/j.yjmcc.2025.10.004_bb0310","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.1111\/jcmm.16601","article-title":"Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK\u03b1\/TGF-\u03b2\/Smad signalling in type 2 diabetic rats","volume":"25","author":"Tian","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"6","key":"10.1016\/j.yjmcc.2025.10.004_bb0315","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1161\/CIRCRESAHA.121.318183","article-title":"Cardiac tissues from stem cells: new routes to maturation and cardiac regeneration","volume":"128","author":"Campostrini","year":"2021","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.yjmcc.2025.10.004_bb0320","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031479","article-title":"Engineering and assessing cardiac tissue complexity","volume":"22","author":"Tadevosyan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0325","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1085\/jgp.201812259","article-title":"Metformin improves diastolic function in an HFpEF-like mouse model by increasing titin compliance","volume":"151","author":"Slater","year":"2019","journal-title":"J. Gen. Physiol."},{"issue":"4","key":"10.1016\/j.yjmcc.2025.10.004_bb0330","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1530\/EJE-10-0624","article-title":"Metformin is associated with improved left ventricular diastolic function measured by tissue Doppler imaging in patients with diabetes","volume":"163","author":"Andersson","year":"2010","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0335","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijcard.2019.11.087","article-title":"Association between long-term prescription of metformin and the progression of heart failure with preserved ejection fraction in patients with type 2 diabetes mellitus and hypertension","volume":"306","author":"Gu","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.yjmcc.2025.10.004_bb0340","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3389\/fphys.2020.00425","article-title":"Metformin ameliorates diabetic cardiomyopathy by activating the PK2\/PKR pathway","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.yjmcc.2025.10.004_bb0345","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jcmg.2020.09.032","article-title":"Evolution of myocardial dysfunction in asymptomatic patients at risk of heart failure","volume":"14","author":"Halabi","year":"2021","journal-title":"JACC Cardiovasc. Imaging"},{"issue":"12","key":"10.1016\/j.yjmcc.2025.10.004_bb0350","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1161\/CIRCRESAHA.117.311080","article-title":"Induced pluripotent stem cells 10 years later: for cardiac applications","volume":"120","author":"Yoshida","year":"2017","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.yjmcc.2025.10.004_bb0355","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/bit.26929","article-title":"Unveiling the molecular crosstalk in a human induced pluripotent stem cell-derived cardiac model","volume":"116","author":"Abecasis","year":"2019","journal-title":"Biotechnol. Bioeng."},{"issue":"1","key":"10.1016\/j.yjmcc.2025.10.004_bb0360","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00395-018-0711-0","article-title":"Of mice and men: models and mechanisms of diabetic cardiomyopathy","volume":"114","author":"Riehle","year":"2018","journal-title":"Basic Res. Cardiol."},{"issue":"3","key":"10.1016\/j.yjmcc.2025.10.004_bb0365","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1056\/NEJMoa1501352","article-title":"Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes","volume":"373","author":"Green","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.yjmcc.2025.10.004_bb0370","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19040936","article-title":"Disease modeling using 3D organoids derived from human induced pluripotent stem cells","volume":"19","author":"Ho","year":"2018","journal-title":"Int. J. Mol. Sci."}],"container-title":["Journal of Molecular and Cellular Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282825001828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022282825001828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T10:57:28Z","timestamp":1766055448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022282825001828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":74,"alternative-id":["S0022282825001828"],"URL":"https:\/\/doi.org\/10.1016\/j.yjmcc.2025.10.004","relation":{},"ISSN":["0022-2828"],"issn-type":[{"value":"0022-2828","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modelling diabetes-associated metabolic stress in human multicellular cardiac microtissues","name":"articletitle","label":"Article Title"},{"value":"Journal of Molecular and Cellular Cardiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.yjmcc.2025.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}